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Protein

Capsid protein

Gene

VP1

Organism
Chicken anemia virus (isolate Australia/CAU269-7/2000) (CAV)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Self-assembles to form the virion icosahedral capsid with a T=1 symmetry. This very small capsid (25 nm in diameter) allows the virus to be very stable in the environment and resistant to some disinfectants, including detergents. Essential for the initial attachment to host receptors. After attachment, the virus is endocytosed and traffics to the nucleus. The capsid protein binds and transports the viral genome and Rep across the nuclear envelope (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processHost-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Viral penetration into host nucleus, Virus endocytosis by host, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Capsid protein
Alternative name(s):
CA1
Coat protein
Gene namesi
Name:VP1
OrganismiChicken anemia virus (isolate Australia/CAU269-7/2000) (CAV)
Taxonomic identifieri486492 [NCBI]
Taxonomic lineageiVirusesssDNA virusesAnelloviridaeGyrovirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]
Proteomesi
  • UP000007539 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host nucleus, T=1 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003144731 – 449Capsid proteinAdd BLAST449

Expressioni

Inductioni

VP1 and VP2 are detected 12 hours post infection, while VP3 only after 24 hours.

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Homomultimer (Potential). Interacts with Rep; this interaction relocates Rep into the nucleus (By similarity).By similarityCurated

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 43DNA-bindingBy similarityAdd BLAST43
Regioni6 – 47Nuclear localization signalsSequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 46Arg-richAdd BLAST44

Sequence similaritiesi

Belongs to the gyrovirus capsid protein family.Curated

Phylogenomic databases

OrthoDBiVOG090000A0

Family and domain databases

InterProiView protein in InterPro
IPR007291 Capsid_protein
PfamiView protein in Pfam
PF04162 Gyro_capsid, 1 hit

Sequencei

Sequence statusi: Complete.

Q9IZU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARRARRPRG RFYAFRRGRW HHLKRLRRRY KFRHRRRQRY RRRAFRKAFH
60 70 80 90 100
NPRPGTYSVR LPNPQSTMTI RFQGVIFLTE GLILPKNSTA GGYADHMYGA
110 120 130 140 150
RVAKISVNLK EFLLASMNLT YVSKIGGPIA GELIADGSKS QAAENWPNCW
160 170 180 190 200
LPLDNNVPSA TPSAWWRWAL MMMQPTDSCR FFNHPKQMTL QDMGRMFGGW
210 220 230 240 250
HLFRHIETRF QLLATKNEGS FSPVASLLSQ GEYLTRRDDV KYSSDHQNRW
260 270 280 290 300
RKGEQPMTGG IAYATGKMRL DEQQYPAMPP DPPIITTTTA QGTQVRCMNS
310 320 330 340 350
TQAWWSWDTY MSFATLTALG AQWSFPPGQR SVSRRSFNHH KARGAGDPKG
360 370 380 390 400
QRWHTLVPLG TETITDSYMR APASELDTNF FTLYVAQGTN KSQQYKFGTA
410 420 430 440
TYALKEPVMK SDSWAVVRVQ SVWQLGNRQR PYPWDVNWAN STMYWGSQP
Length:449
Mass (Da):51,938
Last modified:October 1, 2000 - v1
Checksum:iBE77D3B272A5BBD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227982 Genomic DNA Translation: AAF34789.1

Similar proteinsi

Entry informationi

Entry nameiCAPSD_CAVCA
AccessioniPrimary (citable) accession number: Q9IZU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health