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Protein

Genome polyprotein

Gene
N/A
Organism
Hepatitis C virus
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Genome polyproteinUniRule annotation
OrganismiHepatitis C virusImported
Taxonomic identifieri11103 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageFlaviviridaeHepacivirus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Viral envelope proteinUniRule annotation, Virion

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GAJX-ray2.51P94-107[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

TransmembraneUniRule annotation

Family and domain databases

InterProiIPR002519. HCV_env.
IPR002531. HCV_NS1.
[Graphical view]
PfamiPF01539. HCV_env. 1 hit.
PF01560. HCV_NS1. 1 hit.
[Graphical view]
ProDomiPD001388. HCV_env. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Fragment.

Q9IY15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWDMIMNWS PTTALVVSRL LRIPQAIVDM VAGAHWGVLA GLAYYSMVGN
60 70 80 90 100
WAKVLIVMLL FAGVDAGTYT TGGATGRSTY RLASLFTSGA SQNIQLINTN
110 120 130 140 150
GSWHINRTAL NCNDSLQTGF LAALFYTHKF NASGCPERMA SCRSIDQFAQ
160 170 180
GWGPITYAVH RDLDQRPYCW HYPPRPCGIV PASQVC
Length:186
Mass (Da):20,395
Last modified:October 1, 2000 - v1
Checksum:iFD6099D6CDB65BA3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei186 – 1861Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF246033 Genomic RNA. Translation: AAF66332.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF246033 Genomic RNA. Translation: AAF66332.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GAJX-ray2.51P94-107[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

euHCVdbiAF246033.

Family and domain databases

InterProiIPR002519. HCV_env.
IPR002531. HCV_NS1.
[Graphical view]
PfamiPF01539. HCV_env. 1 hit.
PF01560. HCV_NS1. 1 hit.
[Graphical view]
ProDomiPD001388. HCV_env. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. "The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies."
    Farci P., Shimoda A., Coiana A., Diaz G., Peddis G., Melpolder J.C., Strazzera A., Chien D.Y., Munoz S.J., Balestrieri A., Purcell R.H., Alter H.J.
    Science 288:339-344(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Toward a hepatitis C virus vaccine: the structural basis of hepatitis C virus neutralization by AP33, a broadly neutralizing antibody."
    Potter J.A., Owsianka A.M., Jeffery N., Matthews D.J., Keck Z.Y., Lau P., Foung S.K., Taylor G.L., Patel A.H.
    J. Virol. 86:12923-12932(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.51 ANGSTROMS) OF 94-107.

Entry informationi

Entry nameiQ9IY15_9HEPC
AccessioniPrimary (citable) accession number: Q9IY15
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: June 24, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.