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Q9IWA0

- RDRP_POLVP

UniProt

Q9IWA0 - RDRP_POLVP

Protein

RNA-directed RNA polymerase

Gene

ORF1

Organism
Pothos latent virus (isolate Pigeonpea/India) (PoLV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    RNA-dependent RNA polymerase that plays an essential role in the virus replication.Curated

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. RNA binding Source: InterPro
    3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

    Keywords - Biological processi

    Viral RNA replication

    Keywords - Ligandi

    Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-directed RNA polymerase (EC:2.7.7.48)
    Alternative name(s):
    Protein p84
    Cleaved into the following chain:
    Gene namesi
    ORF Names:ORF1
    OrganismiPothos latent virus (isolate Pigeonpea/India) (PoLV)
    Taxonomic identifieri652109 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeAureusvirus
    Virus hostiCajanus cajan (Pigeon pea) (Cajanus indicus) [TaxID: 3821]
    Pothos [TaxID: 174212]
    ProteomesiUP000000572: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 739739RNA-directed RNA polymerasePRO_0000399488Add
    BLAST
    Chaini1 – 222222Protein p25PRO_0000399489Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ9IWA0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini452 – 567116RdRp catalyticPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi119 – 1224Poly-Asp

    Sequence similaritiesi

    Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR007094. RNA-dir_pol_PSvirus.
    IPR002166. RNA_pol_HCV.
    IPR013707. Tombusvirus_p33.
    [Graphical view]
    PfamiPF00998. RdRP_3. 1 hit.
    PF08500. Tombus_P33. 1 hit.
    [Graphical view]
    PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9IWA0-1 [UniParc]FASTAAdd to Basket

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    MANWCMSVLM FSFVTVYTIV TSLGQGIRRG FRAIVDEVEN IYGDMCAGFK    50
    VALSKLSVSW IVVVGMIFVL NSLVVGLVPT LTMVAIIAAC VGAKYGGRVP 100
    RYIRAHVDRI RKSWEKGVDD DDCCAPLPET SLERVPTKLR PRLACKIAVR 150
    AIAKVGLLKR SEANSMVYQR VCLDVMESMK MRWHDRLVIL PQAVLACLER 200
    PEEVEEVMKA IEASCKGRFD VYXGCLLQHR GYNTAIISAI PDGVLLNHEG 250
    MVVRKGAPIT TERKWYSFAG YASTYEYIVH NSSLVNVCRG LVERVFCVVR 300
    DGKLQRPLRP KNNVFERKLG NVGRRISSIV GYCPAMTRSE FCESYSGTRR 350
    ATYERARLSL DVLPCTRKDA YLKTFVKAEK INITLKPDPA PRVIQPRDPR 400
    YNVEVGRYLK PLEPRLMKAI DKLWGEKTAI KGYTVEKVGE ILHQKSLRFK 450
    NPCFVGLDAS RFDQHCSRQA LEWEHSVYNA IFRDPYLSEL LTWQIDNVGT 500
    AYLKDGFVRY RVDGCRMSGD MNTSMGNYLI MSCLVYQFCK DIGIDASLAN 550
    CGDDCVLYLE KEDLPKLKAL PDWFGKMGYS MKVEKPVFTV EEIEFCQQHP 600
    VQLSRGYVMV RRPDVCLTKD LCVVRGGMTT ERLQRWLYAQ HDGGLALTGD 650
    CPVLGAFYRR FPSGESHGEL SEYSDAHKFK AGKQYGEINS LARYSFWLAF 700
    GITPDEQLAI ERDLMNWTPN VVPGSCDPRP TLLDYCSDN 739
    Length:739
    Mass (Da):83,699
    Last modified:October 1, 2000 - v1
    Checksum:iD70C31F915221506
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ243370 Genomic RNA. Translation: CAB59792.1.
    AJ243370 Genomic RNA. Translation: CAB59793.1.

    Keywords - Coding sequence diversityi

    RNA suppression of termination

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ243370 Genomic RNA. Translation: CAB59792.1 .
    AJ243370 Genomic RNA. Translation: CAB59793.1 .

    3D structure databases

    ProteinModelPortali Q9IWA0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR007094. RNA-dir_pol_PSvirus.
    IPR002166. RNA_pol_HCV.
    IPR013707. Tombusvirus_p33.
    [Graphical view ]
    Pfami PF00998. RdRP_3. 1 hit.
    PF08500. Tombus_P33. 1 hit.
    [Graphical view ]
    PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a virus from pigeonpea with affinities to species in the genus Aureusvirus, family Tombusviridae."
      Lava Kumar P., Jones A.T., Sreenivasulu P., Fenton B., Reddy D.V.R.
      Plant Dis. 85:208-215(2001)
      [AGRICOLA] [Europe PMC]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiRDRP_POLVP
    AccessioniPrimary (citable) accession number: Q9IWA0
    Secondary accession number(s): Q9QBU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 5, 2010
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Readthrough of the terminator UAG occurs at position 223.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3