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Protein

RNA-directed RNA polymerase

Gene

ORF1

Organism
Pothos latent virus (isolate Pigeonpea/India) (PoLV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase that plays an essential role in the virus replication.Curated

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Alternative name(s):
Protein p84
Cleaved into the following chain:
Gene namesi
ORF Names:ORF1
OrganismiPothos latent virus (isolate Pigeonpea/India) (PoLV)
Taxonomic identifieri652109 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageTombusviridaeAureusvirus
Virus hostiCajanus cajan (Pigeon pea) (Cajanus indicus) [TaxID: 3821]
Pothos [TaxID: 174212]
ProteomesiUP000000572 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 739739RNA-directed RNA polymerasePRO_0000399488Add
BLAST
Chaini1 – 222222Protein p25PRO_0000399489Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9IWA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini452 – 567116RdRp catalyticPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi119 – 1224Poly-Asp

Sequence similaritiesi

Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
IPR013707. Tombusvirus_p33.
[Graphical view]
PfamiPF00998. RdRP_3. 1 hit.
PF08500. Tombus_P33. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9IWA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANWCMSVLM FSFVTVYTIV TSLGQGIRRG FRAIVDEVEN IYGDMCAGFK
60 70 80 90 100
VALSKLSVSW IVVVGMIFVL NSLVVGLVPT LTMVAIIAAC VGAKYGGRVP
110 120 130 140 150
RYIRAHVDRI RKSWEKGVDD DDCCAPLPET SLERVPTKLR PRLACKIAVR
160 170 180 190 200
AIAKVGLLKR SEANSMVYQR VCLDVMESMK MRWHDRLVIL PQAVLACLER
210 220 230 240 250
PEEVEEVMKA IEASCKGRFD VYXGCLLQHR GYNTAIISAI PDGVLLNHEG
260 270 280 290 300
MVVRKGAPIT TERKWYSFAG YASTYEYIVH NSSLVNVCRG LVERVFCVVR
310 320 330 340 350
DGKLQRPLRP KNNVFERKLG NVGRRISSIV GYCPAMTRSE FCESYSGTRR
360 370 380 390 400
ATYERARLSL DVLPCTRKDA YLKTFVKAEK INITLKPDPA PRVIQPRDPR
410 420 430 440 450
YNVEVGRYLK PLEPRLMKAI DKLWGEKTAI KGYTVEKVGE ILHQKSLRFK
460 470 480 490 500
NPCFVGLDAS RFDQHCSRQA LEWEHSVYNA IFRDPYLSEL LTWQIDNVGT
510 520 530 540 550
AYLKDGFVRY RVDGCRMSGD MNTSMGNYLI MSCLVYQFCK DIGIDASLAN
560 570 580 590 600
CGDDCVLYLE KEDLPKLKAL PDWFGKMGYS MKVEKPVFTV EEIEFCQQHP
610 620 630 640 650
VQLSRGYVMV RRPDVCLTKD LCVVRGGMTT ERLQRWLYAQ HDGGLALTGD
660 670 680 690 700
CPVLGAFYRR FPSGESHGEL SEYSDAHKFK AGKQYGEINS LARYSFWLAF
710 720 730
GITPDEQLAI ERDLMNWTPN VVPGSCDPRP TLLDYCSDN
Length:739
Mass (Da):83,699
Last modified:October 1, 2000 - v1
Checksum:iD70C31F915221506
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243370 Genomic RNA. Translation: CAB59792.1.
AJ243370 Genomic RNA. Translation: CAB59793.1.

Keywords - Coding sequence diversityi

RNA suppression of termination

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243370 Genomic RNA. Translation: CAB59792.1.
AJ243370 Genomic RNA. Translation: CAB59793.1.

3D structure databases

ProteinModelPortaliQ9IWA0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
IPR013707. Tombusvirus_p33.
[Graphical view]
PfamiPF00998. RdRP_3. 1 hit.
PF08500. Tombus_P33. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of a virus from pigeonpea with affinities to species in the genus Aureusvirus, family Tombusviridae."
    Lava Kumar P., Jones A.T., Sreenivasulu P., Fenton B., Reddy D.V.R.
    Plant Dis. 85:208-215(2001)
    [AGRICOLA] [Europe PMC]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiRDRP_POLVP
AccessioniPrimary (citable) accession number: Q9IWA0
Secondary accession number(s): Q9QBU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: October 1, 2000
Last modified: June 24, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Readthrough of the terminator UAG occurs at position 223.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.