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Protein

Nucleoprotein

Gene

NP

Organism
Influenza C virus (strain C/Johannesburg/1/1966)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway. Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding, Viral nucleoprotein
Biological processHost-virus interaction, Viral penetration into host nucleus, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
NucleoproteinUniRule annotation
Alternative name(s):
Nucleocapsid proteinUniRule annotation
Short name:
Protein NUniRule annotation
Gene namesi
Name:NPUniRule annotation
OrganismiInfluenza C virus (strain C/Johannesburg/1/1966)
Taxonomic identifieri100673 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus C
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]
Proteomesi
  • UP000138885 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002699081 – 556NucleoproteinAdd BLAST556

Post-translational modificationi

Late in virus-infected cells, may be cleaved from a 56-kDa protein to a 53-kDa protein by a cellular caspase. This cleavage might be a marker for the onset of apoptosis in infected cells or have a specific function in virus host interaction.UniRule annotation

Interactioni

Subunit structurei

Homomultimerizes to form the nucleocapsid. May bind host exportin-1/XPO1. Binds to viral genomic RNA. Protein-RNA contacts are mediated by a combination of electrostatic interactions between positively charged residues and the phosphate backbone and planar interactions between aromatic side chains and bases.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ9IMP6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the influenza viruses nucleoprotein family.UniRule annotation

Family and domain databases

HAMAPiMF_04070. INFV_NCAP. 1 hit.
InterProiView protein in InterPro
IPR002141. Flu_NP.
PfamiView protein in Pfam
PF00506. Flu_NP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9IMP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDRRQNRKT PDEQRKANAL IINENIEAYI AICKEVGLNG DEMLILENGI
60 70 80 90 100
AIEKAIRICC DGKYQEKREK KAREAQRADS NFNADSIGIR LVKRAGSGTN
110 120 130 140 150
ITYHAVVELT SRSRIVQILK SHWGNELNRA KIAGKRLGFS ALFASNLEAI
160 170 180 190 200
IYQRGRNAAR RNGSAELFTL TQGAGIETRY KWIMEKHIGI GVLIADAKGL
210 220 230 240 250
INGKREGKKG VDANVKLRAG TTGSPLERAM QGIEKKAFPG PLRALARRVV
260 270 280 290 300
KANYNDAREA LNVIAEASLL LKPQITNKMT MPWCMWLAAR LTLKDEFANF
310 320 330 340 350
CAYAGRRAFE VFNIAMEKIG ICSFQGTIMN DDEIESIEDK AQVLMMACFG
360 370 380 390 400
LAYEDFSLVS AMVSHPLKLR NRMKIGNFRV GEKVSTVLSP LLRFTRWAEF
410 420 430 440 450
AQRFALQTNT SREGAQISNS AVFAVERKIT TDVQRVEELL NKVQAHEDEP
460 470 480 490 500
LQTLYKKVRE QISIIGRNKS EIKEFLGSSM YDLNDQEKQN PINFRSGAHP
510 520 530 540 550
FFFEFDPDYN PIRVKRPKKP IAKRNSNISR LEEEGMDENS EIGQAKKMKP

LDQLAK
Length:556
Mass (Da):62,739
Last modified:January 9, 2007 - v2
Checksum:iE9D35FEF246821B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF170573 Genomic RNA. Translation: AAF89736.2.

Similar proteinsi

Entry informationi

Entry nameiNCAP_INCJH
AccessioniPrimary (citable) accession number: Q9IMP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: June 7, 2017
This is version 64 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families