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Q9IMM4

- RDRP_NODAM

UniProt

Q9IMM4 - RDRP_NODAM

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Protein

RNA-directed RNA polymerase

Gene
N/A
Organism
Nodamura virus (strain Mag115) (NoV)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

RNA-dependent RNA polymerase which replicates the viral genome composed of 2 RNA segments, RNA1 AND RNA2.Curated

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. RNA binding Source: InterPro
  3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
  2. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Short name:
RdRp
Alternative name(s):
RNA replicase
Short name:
Protein A
OrganismiNodamura virus (strain Mag115) (NoV)
Taxonomic identifieri914672 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageNodaviridaeAlphanodavirus
Virus hostiAedes [TaxID: 7158]
Lepidoptera (butterflies and moths) [TaxID: 7088]
Sus scrofa (Pig) [TaxID: 9823]
ProteomesiUP000008594: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10431043RNA-directed RNA polymerasePRO_0000222448Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9IMM4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini588 – 713126RdRp catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the nodaviridae RNA polymerase family.Curated
Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
[Graphical view]
PfamiPF00680. RdRP_1. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. Align

Isoform RNA-directed RNA polymerase (identifier: Q9IMM4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLNYETIING ASSALNIVSR ALGYRVPLAK SLALVAGSCV VYKIIVHRRT
60 70 80 90 100
LVAFLVIGPY ATVVQHRLPM ALQRAIIEYT REDREISLFP QNSIVSAEHA
110 120 130 140 150
RKADNGHPIS GGTRDVARET ISLAIRAAGF RHYEISPARQ SPAEAASHQH
160 170 180 190 200
YAAADLVRAA TEDKIQDGDV VVAIDIDYYL RDIDRYLGRG VPFMAYTFNP
210 220 230 240 250
VEVAGRDGDS FFRITNNQVT FDVSGGGSWS HEVWDWCAFG EFIETRDASW
260 270 280 290 300
LAWFARAVGL TKSQIHKVHY CRPWPQSPHR ALVWCLPVAS YWRFTFIPTD
310 320 330 340 350
LHTRTLRRVR YQDTSRPGWN SIVSTGSEGL NISLGREGAD HCVTIPKVHY
360 370 380 390 400
DMLMGLSSAQ SLSSRMIGLK YTDPSVLATV AQYYQGKNVE VADADRIGRA
410 420 430 440 450
INPKVHWPAH VEVDEAEVSA RVYASPLVSD ENMMPMIKRW ETLSLSLDRR
460 470 480 490 500
VTFQRNPKVP GKRLRAYAIE FVDLVVPERG VGVPYSLEDT AAMLDKPSQT
510 520 530 540 550
LAIQQVWETV DMPPRRLIEA FVKNEPTMKA GRIISSFADM RFLLRFSSYT
560 570 580 590 600
LAFRDQVLHA EHNRHWFCPG LTPEQIATKV VDYVSGVEEP SEGDFSNFDG
610 620 630 640 650
TVSEWLQRHV MNAVYLRYFN HRAQRDLRSY TDMLVSCPAR AKRFGFAYDA
660 670 680 690 700
GVGVKSGSPT TCDLNTVCNG FLQYCSIRMT HPELTPIDAF RLIGLAFGDD
710 720 730 740 750
SLFERRFAKN YAKVSAEVGM VLKIERFDPA QGITFLARVY PDPYTSTTSF
760 770 780 790 800
QDPLRTWRKL HLTTRDPTIP LATAAIDRVE GYLVTDGLSP LTGAYCRMVK
810 820 830 840 850
RVYEAGGAED AAKRRSRKSH SREKPYWLTV GGAWPQDVKD VDLMFQCAAA
860 870 880 890 900
RTGVDLETLR SLDQRLGEIT DVWADITINR DNEPNPYKDT LDLEGPADGR
910 920 930 940 950
VDDRVFQNDK HVMRLRANQV TSSQAGAAGS GDASNDPNAH DRGSQRQQGS
960 970 980 990 1000
ASVLRVPDRA APAGVSSDEQ PAHQTASRSS ASRGGAGPGR GGRRRPGPPA
1010 1020 1030 1040
KTTAGGARDG NQARAPTSGP SKRQAEGRSR SSRGPAGSRG RGK
Length:1,043
Mass (Da):115,774
Last modified:October 1, 2000 - v1
Checksum:i0DF0CBDB5DBF3EBB
GO
Isoform B1 (identifier: Q9IMM4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-912: Missing.

Note: Produced by alternative initiation at Met-913 of isoform 1.

Show »
Length:131
Mass (Da):13,089
Checksum:i5A2F43D064CAEE53
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 912912Missing in isoform B1. CuratedVSP_040283Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF174533 Genomic RNA. Translation: AAF97860.1.
RefSeqiNP_077730.1. NC_002690.1.

Genome annotation databases

GeneIDi962117.

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF174533 Genomic RNA. Translation: AAF97860.1 .
RefSeqi NP_077730.1. NC_002690.1.

3D structure databases

ProteinModelPortali Q9IMM4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 962117.

Family and domain databases

InterProi IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
[Graphical view ]
Pfami PF00680. RdRP_1. 1 hit.
[Graphical view ]
PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparisons among the larger genome segments of six nodaviruses and their encoded RNA replicases."
    Johnson K.N., Johnson K.L., Dasgupta R., Gratsch T., Ball L.A.
    J. Gen. Virol. 82:1855-1866(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Recovery of infectivity from cDNA clones of nodamura virus and identification of small nonstructural proteins."
    Johnson K.L., Price B.D., Ball L.A.
    Virology 305:436-451(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 917-942; 947-955; 960-978 AND 994-1001, ALTERNATIVE INITIATION.

Entry informationi

Entry nameiRDRP_NODAM
AccessioniPrimary (citable) accession number: Q9IMM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: October 1, 2000
Last modified: October 1, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3