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Q9IMM4

- RDRP_NODAM

UniProt

Q9IMM4 - RDRP_NODAM

Protein

RNA-directed RNA polymerase

Gene
N/A
Organism
Nodamura virus (strain Mag115) (NoV)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    RNA-dependent RNA polymerase which replicates the viral genome composed of 2 RNA segments, RNA1 AND RNA2.Curated

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. RNA binding Source: InterPro
    3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. transcription, DNA-templated Source: InterPro
    2. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

    Keywords - Biological processi

    Viral RNA replication

    Keywords - Ligandi

    Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-directed RNA polymerase (EC:2.7.7.48)
    Short name:
    RdRp
    Alternative name(s):
    RNA replicase
    Short name:
    Protein A
    OrganismiNodamura virus (strain Mag115) (NoV)
    Taxonomic identifieri914672 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageNodaviridaeAlphanodavirus
    Virus hostiAedes [TaxID: 7158]
    Lepidoptera (butterflies and moths) [TaxID: 7088]
    Sus scrofa (Pig) [TaxID: 9823]
    ProteomesiUP000008594: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10431043RNA-directed RNA polymerasePRO_0000222448Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ9IMM4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini588 – 713126RdRp catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the nodaviridae RNA polymerase family.Curated
    Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR001205. RNA-dir_pol_C.
    IPR007094. RNA-dir_pol_PSvirus.
    [Graphical view]
    PfamiPF00680. RdRP_1. 1 hit.
    [Graphical view]
    PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative initiation. Align

    Isoform RNA-directed RNA polymerase (identifier: Q9IMM4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLNYETIING ASSALNIVSR ALGYRVPLAK SLALVAGSCV VYKIIVHRRT     50
    LVAFLVIGPY ATVVQHRLPM ALQRAIIEYT REDREISLFP QNSIVSAEHA 100
    RKADNGHPIS GGTRDVARET ISLAIRAAGF RHYEISPARQ SPAEAASHQH 150
    YAAADLVRAA TEDKIQDGDV VVAIDIDYYL RDIDRYLGRG VPFMAYTFNP 200
    VEVAGRDGDS FFRITNNQVT FDVSGGGSWS HEVWDWCAFG EFIETRDASW 250
    LAWFARAVGL TKSQIHKVHY CRPWPQSPHR ALVWCLPVAS YWRFTFIPTD 300
    LHTRTLRRVR YQDTSRPGWN SIVSTGSEGL NISLGREGAD HCVTIPKVHY 350
    DMLMGLSSAQ SLSSRMIGLK YTDPSVLATV AQYYQGKNVE VADADRIGRA 400
    INPKVHWPAH VEVDEAEVSA RVYASPLVSD ENMMPMIKRW ETLSLSLDRR 450
    VTFQRNPKVP GKRLRAYAIE FVDLVVPERG VGVPYSLEDT AAMLDKPSQT 500
    LAIQQVWETV DMPPRRLIEA FVKNEPTMKA GRIISSFADM RFLLRFSSYT 550
    LAFRDQVLHA EHNRHWFCPG LTPEQIATKV VDYVSGVEEP SEGDFSNFDG 600
    TVSEWLQRHV MNAVYLRYFN HRAQRDLRSY TDMLVSCPAR AKRFGFAYDA 650
    GVGVKSGSPT TCDLNTVCNG FLQYCSIRMT HPELTPIDAF RLIGLAFGDD 700
    SLFERRFAKN YAKVSAEVGM VLKIERFDPA QGITFLARVY PDPYTSTTSF 750
    QDPLRTWRKL HLTTRDPTIP LATAAIDRVE GYLVTDGLSP LTGAYCRMVK 800
    RVYEAGGAED AAKRRSRKSH SREKPYWLTV GGAWPQDVKD VDLMFQCAAA 850
    RTGVDLETLR SLDQRLGEIT DVWADITINR DNEPNPYKDT LDLEGPADGR 900
    VDDRVFQNDK HVMRLRANQV TSSQAGAAGS GDASNDPNAH DRGSQRQQGS 950
    ASVLRVPDRA APAGVSSDEQ PAHQTASRSS ASRGGAGPGR GGRRRPGPPA 1000
    KTTAGGARDG NQARAPTSGP SKRQAEGRSR SSRGPAGSRG RGK 1043
    Length:1,043
    Mass (Da):115,774
    Last modified:October 1, 2000 - v1
    Checksum:i0DF0CBDB5DBF3EBB
    GO
    Isoform B1 (identifier: Q9IMM4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-912: Missing.

    Note: Produced by alternative initiation at Met-913 of isoform 1.

    Show »
    Length:131
    Mass (Da):13,089
    Checksum:i5A2F43D064CAEE53
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 912912Missing in isoform B1. CuratedVSP_040283Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF174533 Genomic RNA. Translation: AAF97860.1.
    RefSeqiNP_077730.1. NC_002690.1.

    Genome annotation databases

    GeneIDi962117.

    Keywords - Coding sequence diversityi

    Alternative initiation

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF174533 Genomic RNA. Translation: AAF97860.1 .
    RefSeqi NP_077730.1. NC_002690.1.

    3D structure databases

    ProteinModelPortali Q9IMM4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 962117.

    Family and domain databases

    InterProi IPR001205. RNA-dir_pol_C.
    IPR007094. RNA-dir_pol_PSvirus.
    [Graphical view ]
    Pfami PF00680. RdRP_1. 1 hit.
    [Graphical view ]
    PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparisons among the larger genome segments of six nodaviruses and their encoded RNA replicases."
      Johnson K.N., Johnson K.L., Dasgupta R., Gratsch T., Ball L.A.
      J. Gen. Virol. 82:1855-1866(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Recovery of infectivity from cDNA clones of nodamura virus and identification of small nonstructural proteins."
      Johnson K.L., Price B.D., Ball L.A.
      Virology 305:436-451(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 917-942; 947-955; 960-978 AND 994-1001, ALTERNATIVE INITIATION.

    Entry informationi

    Entry nameiRDRP_NODAM
    AccessioniPrimary (citable) accession number: Q9IMM4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3