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Q9IMM4 (RDRP_NODAM) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA-directed RNA polymerase

Short name=RdRp
EC=2.7.7.48
Alternative name(s):
RNA replicase
Short name=Protein A
OrganismNodamura virus (strain Mag115) (NoV) [Reference proteome]
Taxonomic identifier914672 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stageNodaviridaeAlphanodavirus
Virus hostAedes [TaxID: 7158]
Lepidoptera (butterflies and moths) [TaxID: 7088]
Sus scrofa (Pig) [TaxID: 9823]

Protein attributes

Sequence length1043 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

RNA-dependent RNA polymerase which replicates the viral genome composed of 2 RNA segments, RNA1 AND RNA2 Potential.

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Sequence similarities

Belongs to the nodaviridae RNA polymerase family.

Contains 1 RdRp catalytic domain.

Alternative products

This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]
Isoform RNA-directed RNA polymerase (identifier: Q9IMM4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform B1 (identifier: Q9IMM4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-912: Missing.
Note: Produced by alternative initiation at Met-913 of isoform 1.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10431043RNA-directed RNA polymerase
PRO_0000222448

Regions

Domain588 – 713126RdRp catalytic

Natural variations

Alternative sequence1 – 912912Missing in isoform B1.
VSP_040283

Sequences

Sequence LengthMass (Da)Tools
Isoform RNA-directed RNA polymerase [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 0DF0CBDB5DBF3EBB

FASTA1,043115,774
        10         20         30         40         50         60 
MLNYETIING ASSALNIVSR ALGYRVPLAK SLALVAGSCV VYKIIVHRRT LVAFLVIGPY 

        70         80         90        100        110        120 
ATVVQHRLPM ALQRAIIEYT REDREISLFP QNSIVSAEHA RKADNGHPIS GGTRDVARET 

       130        140        150        160        170        180 
ISLAIRAAGF RHYEISPARQ SPAEAASHQH YAAADLVRAA TEDKIQDGDV VVAIDIDYYL 

       190        200        210        220        230        240 
RDIDRYLGRG VPFMAYTFNP VEVAGRDGDS FFRITNNQVT FDVSGGGSWS HEVWDWCAFG 

       250        260        270        280        290        300 
EFIETRDASW LAWFARAVGL TKSQIHKVHY CRPWPQSPHR ALVWCLPVAS YWRFTFIPTD 

       310        320        330        340        350        360 
LHTRTLRRVR YQDTSRPGWN SIVSTGSEGL NISLGREGAD HCVTIPKVHY DMLMGLSSAQ 

       370        380        390        400        410        420 
SLSSRMIGLK YTDPSVLATV AQYYQGKNVE VADADRIGRA INPKVHWPAH VEVDEAEVSA 

       430        440        450        460        470        480 
RVYASPLVSD ENMMPMIKRW ETLSLSLDRR VTFQRNPKVP GKRLRAYAIE FVDLVVPERG 

       490        500        510        520        530        540 
VGVPYSLEDT AAMLDKPSQT LAIQQVWETV DMPPRRLIEA FVKNEPTMKA GRIISSFADM 

       550        560        570        580        590        600 
RFLLRFSSYT LAFRDQVLHA EHNRHWFCPG LTPEQIATKV VDYVSGVEEP SEGDFSNFDG 

       610        620        630        640        650        660 
TVSEWLQRHV MNAVYLRYFN HRAQRDLRSY TDMLVSCPAR AKRFGFAYDA GVGVKSGSPT 

       670        680        690        700        710        720 
TCDLNTVCNG FLQYCSIRMT HPELTPIDAF RLIGLAFGDD SLFERRFAKN YAKVSAEVGM 

       730        740        750        760        770        780 
VLKIERFDPA QGITFLARVY PDPYTSTTSF QDPLRTWRKL HLTTRDPTIP LATAAIDRVE 

       790        800        810        820        830        840 
GYLVTDGLSP LTGAYCRMVK RVYEAGGAED AAKRRSRKSH SREKPYWLTV GGAWPQDVKD 

       850        860        870        880        890        900 
VDLMFQCAAA RTGVDLETLR SLDQRLGEIT DVWADITINR DNEPNPYKDT LDLEGPADGR 

       910        920        930        940        950        960 
VDDRVFQNDK HVMRLRANQV TSSQAGAAGS GDASNDPNAH DRGSQRQQGS ASVLRVPDRA 

       970        980        990       1000       1010       1020 
APAGVSSDEQ PAHQTASRSS ASRGGAGPGR GGRRRPGPPA KTTAGGARDG NQARAPTSGP 

      1030       1040 
SKRQAEGRSR SSRGPAGSRG RGK 

« Hide

Isoform B1 [UniParc].

Checksum: 5A2F43D064CAEE53
Show »

FASTA13113,089

References

[1]"Comparisons among the larger genome segments of six nodaviruses and their encoded RNA replicases."
Johnson K.N., Johnson K.L., Dasgupta R., Gratsch T., Ball L.A.
J. Gen. Virol. 82:1855-1866(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Recovery of infectivity from cDNA clones of nodamura virus and identification of small nonstructural proteins."
Johnson K.L., Price B.D., Ball L.A.
Virology 305:436-451(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 917-942; 947-955; 960-978 AND 994-1001, ALTERNATIVE INITIATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF174533 Genomic RNA. Translation: AAF97860.1.
RefSeqNP_077730.1. NC_002690.1.

3D structure databases

ProteinModelPortalQ9IMM4.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID962117.

Family and domain databases

InterProIPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
[Graphical view]
PfamPF00680. RdRP_1. 1 hit.
[Graphical view]
PROSITEPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRDRP_NODAM
AccessionPrimary (citable) accession number: Q9IMM4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families