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Q9IKB5

- GP_TSWVR

UniProt

Q9IKB5 - GP_TSWVR

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Protein
Envelope glycoprotein
Gene
GP
Organism
Tomato spotted wilt virus (strain Regular2A) (TSWV)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei484 – 4852Cleavage; by host signal peptidase By similarity

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. modulation by virus of host morphology or physiology Source: InterPro
  3. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 2 chains:
Gene namesi
Name:GP
OrganismiTomato spotted wilt virus (strain Regular2A) (TSWV)
Taxonomic identifieri267287 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeTospovirus
Virus hostiFrankliniella occidentalis (Western flower thrips) [TaxID: 133901]
Scirtothrips dorsalis [TaxID: 163899]
Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
Thrips tabaci [TaxID: 161014]

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane; Single-pass type I membrane protein Reviewed prediction. Host Golgi apparatus membrane; Single-pass type I membrane protein Reviewed prediction. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Reviewed prediction
Note: Glycoprotein G1 alone is retained in the membrane of the endoplasmic reticulum, but not transported to the Golgi. Coexpression of G1 and G2 results in efficient transport of G1 to the Golgi complex, indicating that their interaction is essential for proper targeting to this organelle, where virion budding occurs By similarity.
Chain Glycoprotein G2 : Virion membrane; Single-pass type I membrane protein Reviewed prediction. Host Golgi apparatus membrane; Single-pass type I membrane protein Reviewed prediction
Note: Glycoprotein G2 is retained in the Golgi complex and probably contains a Golgi retention signal By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini36 – 345310Lumenal Reviewed prediction
Add
BLAST
Transmembranei346 – 36621Helical; Reviewed prediction
Add
BLAST
Topological domaini367 – 484118Cytoplasmic Reviewed prediction
Add
BLAST
Topological domaini485 – 1067583Lumenal Reviewed prediction
Add
BLAST
Transmembranei1068 – 108821Helical; Reviewed prediction
Add
BLAST
Topological domaini1089 – 113547Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. host cell Golgi membrane Source: UniProtKB-SubCell
  2. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535 Reviewed prediction
Add
BLAST
Chaini36 – 11351100Envelope glycoprotein
PRO_0000036865Add
BLAST
Chaini36 – 484449Glycoprotein G1 By similarity
PRO_0000036866Add
BLAST
Chaini485 – 1135651Glycoprotein G2 By similarity
PRO_0000036867Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi116 – 1161N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi210 – 2101N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi340 – 3401N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi588 – 5881N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi605 – 6051N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi980 – 9801N-linked (GlcNAc...); by host Reviewed prediction

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2 By similarity.
Glycosylated. Glycosylation is essential for proper subcellular location By similarity.

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other By similarity.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 433Cell attachment site Reviewed prediction

Domaini

The cell attachment site present in these glycoproteins may help in the adhesion of virus to cells.

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR005167. Bunya_G1.
IPR014414. M_poly_TospoV.
[Graphical view]
PfamiPF03557. Bunya_G1. 1 hit.
[Graphical view]
PIRSFiPIRSF003960. M_poly_TospoV. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9IKB5-1 [UniParc]FASTAAdd to Basket

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MRILKLLELV VKVSLFTIAL SSVLLAFLIF RATDAKVEII RGDHPEVYDD     50
SAENEVPTAA SIQRKAILET LTNLMLESQT PGTRQIREEE STIPIFAEST 100
TQKIISVSDL PNNCLNASSL KCEIKGISTY NVYYQVENND VIYSCVSDSA 150
EGLEKCDNSL NLPKRFSKVP VIPITKLDNK RHFSVGTKFF ISESLTQDNY 200
PITYNSYPTN GTVSLQTVKL SGDCKITKSN FANPYTVSIT SPEKIMGYLI 250
KKPGENVEHK VISFSGSASI TFTEEMLDGE HNLLCGDKSA KIPKTNKRVR 300
DCIIKYSKSI YKQTACINFS WIRLILIALL IYFPIRWLVN KTTKPLFLWY 350
DLIGLITYPI LLLINCLWKY FPFKCSNRGN LCIITHKCTK LCICNKSKAS 400
KEHSLECPIL SKETDHGYNK HKWTSMEWFH LIVNTKLSFS LLKFVTEILI 450
GLIILSQMPM SMAQTTQCLS GCFYVPGCPF LVTSKFEKCP ERDQCYCNVK 500
EDKIIESIFG TNIIIEGPND CIENQNCAAN PSIDNLIKCR LGCEYLDLFR 550
NKPLYNGFSD YTGSSLGLTS IGLYEAKRLR NGIIDSYNRT DKISGMIAGD 600
SLNKNETSIP ENILPRQSLI FDSVVDGKYR YMIEQSLLGG GGTIFMLNDK 650
TSETAKKFVI YIKSVGIHYE VSEKYTTAPI QSTHTDFYST CTGNCDTCRK 700
NQALTGFQDF CITPTSYWGC EEAWCFAINE GATCGFCRNI YDMDKSYRIY 750
SVLKSTIVAD VCISGILGGQ CSRITEEVPY ENALFQADIQ ADLHNDGITI 800
GELIAHGPDS HIYSGNIANL NDPVKMFGHP QLTRDGVPIF TKKTLEGDDM 850
SWDCAAIGKK SITIKTCGYD TYRFRSGLEQ ISDIPVSFKD FSSFFLEKAF 900
SLGKLKIVVD LPSDLFKVAP KKPSITSTSL NCNGCLLCGQ GLSCILEFFS 950
DLTFSTAISI DACSLSTYQL AVKKGSNKYN ITMFCSANPD KKKMTLYPEG 1000
NPDISVEVLV NNVIVEEPEN IIDQNDEYAH EEQQYNSDSS AWGFWDYIKS 1050
PFNFIASYFG SFFDTIRVIL LIAFIFLVIY FCSILTTICK GYVKNESYKS 1100
RSKIEDDDDS EIKAPMLMKD TMTRRRPPMD FSHLV 1135
Length:1,135
Mass (Da):127,641
Last modified:October 1, 2000 - v1
Checksum:i4FA0B9433BBCB197
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF208498 Genomic RNA. Translation: AAF80981.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF208498 Genomic RNA. Translation: AAF80981.1 .

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR005167. Bunya_G1.
IPR014414. M_poly_TospoV.
[Graphical view ]
Pfami PF03557. Bunya_G1. 1 hit.
[Graphical view ]
PIRSFi PIRSF003960. M_poly_TospoV. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Overcoming host- and pathogen-mediated resistance in tomato and tobacco maps to the M RNA of Tomato spotted wilt virus."
    Hoffmann K., Qiu W.P., Moyer J.W.
    Mol. Plant Microbe Interact. 14:242-249(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiGP_TSWVR
AccessioniPrimary (citable) accession number: Q9IKB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2000
Last modified: February 19, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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