ID   Q9IJQ0_9HIV1            Unreviewed;       122 AA.
AC   Q9IJQ0;
DT   01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2000, sequence version 1.
DT   27-MAR-2024, entry version 68.
DE   RecName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE   Flags: Fragment;
GN   Name=env {ECO:0000313|EMBL:AAF74234.1};
OS   Human immunodeficiency virus 1.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11676 {ECO:0000313|EMBL:AAF74234.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:AAF74234.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=10890362; DOI=10.1089/08892220050058425;
RA   Masciotra S., Livellara B., Belloso W., Clara L., Tanuri A., Ramos A.C.,
RA   Baggs J., Lal R., Pieniazek D.;
RT   "Evidence of a high frequency of HIV-1 subtype F infections in a
RT   heterosexual population in Buenos Aires, Argentina.";
RL   AIDS Res. Hum. Retroviruses 16:1007-1014(2000).
RN   [2] {ECO:0007829|PDB:3LEX, ECO:0007829|PDB:3LEY}
RP   X-RAY CRYSTALLOGRAPHY (1.97 ANGSTROMS) OF 100-108.
RX   PubMed=20876137; DOI=10.1073/pnas.1004728107;
RA   Ofek G., Guenaga F.J., Schief W.R., Skinner J., Baker D., Wyatt R.,
RA   Kwong P.D.;
RT   "Elicitation of structure-specific antibodies by epitope scaffolds.";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:17880-17887(2010).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC       Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC       membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004251}. Host cell membrane
CC       {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC       {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004402}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC       {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC       {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004563}.
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DR   EMBL; AF220682; AAF74234.1; -; Genomic_DNA.
DR   PDB; 3LEX; X-ray; 1.97 A; C/P=100-107.
DR   PDB; 3LEY; X-ray; 1.99 A; P=100-107.
DR   PDBsum; 3LEX; -.
DR   PDBsum; 3LEY; -.
DR   SMR; Q9IJQ0; -.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR   Gene3D; 1.10.287.210; -; 1.
DR   Gene3D; 1.20.5.490; Single helix bin; 1.
DR   InterPro; IPR000328; GP41-like.
DR   Pfam; PF00517; GP41; 1.
DR   SUPFAM; SSF58069; Virus ectodomain; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:3LEX, ECO:0007829|PDB:3LEY};
KW   Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW   Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Viral envelope protein {ECO:0000313|EMBL:AAF74234.1};
KW   Virion {ECO:0000313|EMBL:AAF74234.1}.
FT   DOMAIN          2..122
FT                   /note="Retroviral envelope protein GP41-like"
FT                   /evidence="ECO:0000259|Pfam:PF00517"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAF74234.1"
FT   NON_TER         122
FT                   /evidence="ECO:0000313|EMBL:AAF74234.1"
SQ   SEQUENCE   122 AA;  14550 MW;  7C8AE589350B76B5 CRC64;
     AQHHLLQLTV WGIKQLQARV LAVERYLKDH QLLGIWGCSG KLICTTAVPW NASWSNKSLN
     KIWDNMTWME WEREIDNYTG LIYTLLEESQ NQQEKNEQEL LELDKWAGLW NWFDISNWLG
     YI
//