Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9IH62

- GLYCP_NIPAV

UniProt

Q9IH62 - GLYCP_NIPAV

Protein

Glycoprotein G

Gene

G

Organism
Nipah virus
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Interacts with host ephrinB2/EFNB2 or ephrin B3/EFNB3 to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-mediated endocytosis.2 Publications

    GO - Molecular functioni

    1. exo-alpha-sialidase activity Source: InterPro

    GO - Biological processi

    1. clathrin-mediated endocytosis of virus by host cell Source: UniProtKB-KW
    2. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hemagglutinin

    Keywords - Biological processi

    Clathrin-mediated endocytosis of virus by host, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus endocytosis by host, Virus entry into host cell

    Protein family/group databases

    CAZyiGH83. Glycoside Hydrolase Family 83.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycoprotein G
    Gene namesi
    Name:G
    OrganismiNipah virus
    Taxonomic identifieri121791 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeHenipavirus
    Virus hostiCynopterus brachyotis (Lesser short-nosed fruit bat) (Pachysoma brachyotis) [TaxID: 58060]
    Eonycteris spelaea (Lesser dawn bat) (Macroglossus spelaeus) [TaxID: 58065]
    Homo sapiens (Human) [TaxID: 9606]
    Pteropus hypomelanus (Island flying fox) (Variable flying fox) [TaxID: 9405]
    Pteropus vampyrus (Large flying fox) [TaxID: 132908]
    Scotophilus kuhlii (Lesser asiatic yellow bat) [TaxID: 153297]
    Sus scrofa (Pig) [TaxID: 9823]
    ProteomesiUP000002330: Genome, UP000007527: Genome, UP000008676: Genome

    Subcellular locationi

    GO - Cellular componenti

    1. host cell plasma membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. viral envelope Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 602602Glycoprotein GPRO_0000236009Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi72 – 721N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi159 – 1591N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi306 – 3061N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi378 – 3781N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi417 – 4171N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi481 – 4811N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi529 – 5291N-linked (GlcNAc...); by hostSequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Interacts with host EFNB2 and host EFNB3.2 Publications

    Protein-protein interaction databases

    DIPiDIP-46380N.

    Structurei

    Secondary structure

    1
    602
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi178 – 1803
    Beta strandi201 – 2033
    Helixi204 – 2063
    Turni208 – 2114
    Beta strandi215 – 22511
    Beta strandi228 – 23811
    Turni240 – 2423
    Beta strandi243 – 25715
    Beta strandi259 – 2613
    Beta strandi263 – 2719
    Beta strandi278 – 28710
    Beta strandi290 – 2978
    Beta strandi299 – 3013
    Turni303 – 3053
    Turni307 – 3093
    Beta strandi314 – 3229
    Helixi328 – 3314
    Beta strandi332 – 3365
    Beta strandi346 – 3505
    Beta strandi352 – 3543
    Beta strandi356 – 3583
    Beta strandi361 – 37111
    Helixi372 – 3743
    Helixi379 – 3813
    Helixi394 – 3974
    Beta strandi400 – 4023
    Beta strandi406 – 41712
    Helixi418 – 4203
    Beta strandi426 – 4316
    Beta strandi442 – 4476
    Beta strandi450 – 4556
    Beta strandi465 – 4717
    Turni472 – 4743
    Beta strandi475 – 4795
    Beta strandi491 – 4933
    Beta strandi511 – 5155
    Turni516 – 5194
    Beta strandi520 – 5267
    Beta strandi529 – 5335
    Beta strandi535 – 5417
    Beta strandi544 – 5507
    Beta strandi557 – 56812
    Beta strandi571 – 58111
    Beta strandi586 – 5883
    Beta strandi591 – 5966
    Beta strandi599 – 6013

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2VSMX-ray1.80A188-602[»]
    2VWDX-ray2.25A/B183-602[»]
    3D11X-ray2.31A176-602[»]
    3D12X-ray3.00A/D176-602[»]
    DisProtiDP00686.
    ProteinModelPortaliQ9IH62.
    SMRiQ9IH62. Positions 176-602.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9IH62.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4949IntravirionSequence AnalysisAdd
    BLAST
    Topological domaini71 – 602532Virion surfaceSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei50 – 7021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di2.120.10.10. 1 hit.
    InterProiIPR000665. Hemagglutn-neuramid.
    IPR016285. Hemagglutn-neuramid_paramyxo.
    IPR011040. Sialidases.
    [Graphical view]
    PfamiPF00423. HN. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
    SUPFAMiSSF50939. SSF50939. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9IH62-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPAENKKVRF ENTTSDKGKI PSKVIKSYYG TMDIKKINEG LLDSKILSAF    50
    NTVIALLGSI VIIVMNIMII QNYTRSTDNQ AVIKDALQGI QQQIKGLADK 100
    IGTEIGPKVS LIDTSSTITI PANIGLLGSK ISQSTASINE NVNEKCKFTL 150
    PPLKIHECNI SCPNPLPFRE YRPQTEGVSN LVGLPNNICL QKTSNQILKP 200
    KLISYTLPVV GQSGTCITDP LLAMDEGYFA YSHLERIGSC SRGVSKQRII 250
    GVGEVLDRGD EVPSLFMTNV WTPPNPNTVY HCSAVYNNEF YYVLCAVSTV 300
    GDPILNSTYW SGSLMMTRLA VKPKSNGGGY NQHQLALRSI EKGRYDKVMP 350
    YGPSGIKQGD TLYFPAVGFL VRTEFKYNDS NCPITKCQYS KPENCRLSMG 400
    IRPNSHYILR SGLLKYNLSD GENPKVVFIE ISDQRLSIGS PSKIYDSLGQ 450
    PVFYQASFSW DTMIKFGDVL TVNPLVVNWR NNTVISRPGQ SQCPRFNTCP 500
    EICWEGVYND AFLIDRINWI SAGVFLDSNQ TAENPVFTVF KDNEILYRAQ 550
    LASEDTNAQK TITNCFLLKN KIWCISLVEI YDTGDNVIRP KLFAVKIPEQ 600
    CT 602
    Length:602
    Mass (Da):67,039
    Last modified:October 1, 2000 - v1
    Checksum:i3BD2A917D30A73BE
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti5 – 51N → S in strain: Isolate NiV/KHM/CSUR38.
    Natural varianti20 – 201I → N in strain: Isolate NiV/MY/99/VRI-0626.
    Natural varianti24 – 241V → I in strain: Isolate NiV/KHM/CSUR38.
    Natural varianti248 – 2481R → K in strain: Isolate NiV/KHM/CSUR38.
    Natural varianti272 – 2721T → A in strain: Isolate NiV/MY/99/VRI-0626.
    Natural varianti327 – 3271G → D in strain: Isolate NiV/KHM/CSUR38.
    Natural varianti408 – 4081I → V in strain: Isolate NiV/KHM/CSUR38.
    Natural varianti426 – 4261V → I in strain: Isolate NiV/KHM/CSUR38.
    Natural varianti470 – 4701L → Q in strain: Isolate NiV/KHM/CSUR38.
    Natural varianti478 – 4781N → S in strain: Isolate NiV/KHM/CSUR38.
    Natural varianti481 – 4811N → D in strain: Isolate NiV/KHM/CSUR38.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF238467 mRNA. Translation: AAF73957.1.
    AF212302 Genomic RNA. Translation: AAK29088.1.
    AY029767 Genomic RNA. Translation: AAK50545.1.
    AF376747 Genomic RNA. Translation: AAM13406.1.
    AY029768 Genomic RNA. Translation: AAK50554.1.
    AJ564621 Genomic RNA. Translation: CAD92351.1.
    AJ564622 Genomic RNA. Translation: CAD92357.1.
    AJ564623 Genomic RNA. Translation: CAD92363.1.
    AJ627196 Genomic RNA. Translation: CAF25497.1.
    AY858111 Genomic RNA. Translation: AAX51853.1.
    RefSeqiNP_112027.1. NC_002728.1.

    Genome annotation databases

    GeneIDi920955.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF238467 mRNA. Translation: AAF73957.1 .
    AF212302 Genomic RNA. Translation: AAK29088.1 .
    AY029767 Genomic RNA. Translation: AAK50545.1 .
    AF376747 Genomic RNA. Translation: AAM13406.1 .
    AY029768 Genomic RNA. Translation: AAK50554.1 .
    AJ564621 Genomic RNA. Translation: CAD92351.1 .
    AJ564622 Genomic RNA. Translation: CAD92357.1 .
    AJ564623 Genomic RNA. Translation: CAD92363.1 .
    AJ627196 Genomic RNA. Translation: CAF25497.1 .
    AY858111 Genomic RNA. Translation: AAX51853.1 .
    RefSeqi NP_112027.1. NC_002728.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2VSM X-ray 1.80 A 188-602 [» ]
    2VWD X-ray 2.25 A/B 183-602 [» ]
    3D11 X-ray 2.31 A 176-602 [» ]
    3D12 X-ray 3.00 A/D 176-602 [» ]
    DisProti DP00686.
    ProteinModelPortali Q9IH62.
    SMRi Q9IH62. Positions 176-602.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-46380N.

    Chemistry

    BindingDBi Q9IH62.
    ChEMBLi CHEMBL6047.

    Protein family/group databases

    CAZyi GH83. Glycoside Hydrolase Family 83.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 920955.

    Miscellaneous databases

    EvolutionaryTracei Q9IH62.

    Family and domain databases

    Gene3Di 2.120.10.10. 1 hit.
    InterProi IPR000665. Hemagglutn-neuramid.
    IPR016285. Hemagglutn-neuramid_paramyxo.
    IPR011040. Sialidases.
    [Graphical view ]
    Pfami PF00423. HN. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
    SUPFAMi SSF50939. SSF50939. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of Nipah virus, a newly emergent paramyxovirus."
      Harcourt B.H., Tamin A., Rollin P.E., Ksiazek T.G., Anderson L.J., Bellini W.J., Rota P.A.
      Virology 271:334-349(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    3. "Complete nucleotide sequences of Nipah virus isolates from Malaysia."
      Chan Y.P., Chua K.B., Koh C.L., Lim M.E., Lam S.K.
      J. Gen. Virol. 82:2151-2155(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate UMMC1 and Isolate UMMC2.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate Malaysian flying-fox.
    5. "Isolation and molecular identification of Nipah virus from pigs."
      Abubakar S., Chang L.Y., Mohdali A.R., Sharifah S.H., Yusoff K., Zamrod Z.
      Emerg. Infect. Dis. 10:2228-2230(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate NiV/MY/99/UM-0128, Isolate NiV/MY/99/VRI-1413 and Isolate NiV/MY/99/VRI-2794.
    6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate NiV/KHM/CSUR381.
    7. "EphrinB2 is the entry receptor for Nipah virus, an emergent deadly paramyxovirus."
      Negrete O.A., Levroney E.L., Aguilar H.C., Bertolotti-Ciarlet A., Nazarian R., Tajyar S., Lee B.
      Nature 436:401-405(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HOST EFNB2.
    8. "Two key residues in ephrinB3 are critical for its use as an alternative receptor for Nipah virus."
      Negrete O.A., Wolf M.C., Aguilar H.C., Enterlein S., Wang W., Muehlberger E., Su S.V., Bertolotti-Ciarlet A., Flick R., Lee B.
      PLoS Pathog. 2:78-86(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HOST EFNB3.
    9. "Molecular characteristics of the Nipah virus glycoproteins."
      Diederich S., Maisner A.
      Ann. N. Y. Acad. Sci. 1102:39-50(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. "The nipah virus fusion protein is cleaved within the endosomal compartment."
      Diederich S., Moll M., Klenk H.D., Maisner A.
      J. Biol. Chem. 280:29899-29903(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiGLYCP_NIPAV
    AccessioniPrimary (citable) accession number: Q9IH62
    Secondary accession number(s): Q4KTA8, Q5K4D8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Caution

    Henipavirus glycoproteins have no neuraminidase activity.Curated

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3