Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glycoprotein G

Gene

G

Organism
Nipah virus
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Interacts with host ephrinB2/EFNB2 or ephrin B3/EFNB3 to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-mediated endocytosis.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hemagglutinin

Keywords - Biological processi

Clathrin-mediated endocytosis of virus by host, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus endocytosis by host, Virus entry into host cell

Protein family/group databases

CAZyiGH83. Glycoside Hydrolase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein G
Gene namesi
Name:G
OrganismiNipah virus
Taxonomic identifieri121791 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeHenipavirus
Virus hostiCynopterus brachyotis (Lesser short-nosed fruit bat) (Pachysoma brachyotis) [TaxID: 58060]
Eonycteris spelaea (Lesser dawn bat) (Macroglossus spelaeus) [TaxID: 58065]
Homo sapiens (Human) [TaxID: 9606]
Pteropus hypomelanus (Island flying fox) (Variable flying fox) [TaxID: 9405]
Pteropus vampyrus (Large flying fox) [TaxID: 132908]
Scotophilus kuhlii (Lesser asiatic yellow bat) [TaxID: 153297]
Sus scrofa (Pig) [TaxID: 9823]
Proteomesi
  • UP000002330 Componenti: Genome
  • UP000008676 Componenti: Genome
  • UP000007527 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 49IntravirionSequence analysisAdd BLAST49
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Topological domaini71 – 602Virion surfaceSequence analysisAdd BLAST532

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL6047.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002360091 – 602Glycoprotein GAdd BLAST602

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi159N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi306N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi378N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi417N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi481N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi529N-linked (GlcNAc...); by hostSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with host EFNB2 and host EFNB3.2 Publications

Protein-protein interaction databases

DIPiDIP-46380N.

Chemistry databases

BindingDBiQ9IH62.

Structurei

Secondary structure

1602
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi178 – 180Combined sources3
Beta strandi201 – 203Combined sources3
Helixi204 – 206Combined sources3
Turni208 – 211Combined sources4
Beta strandi215 – 225Combined sources11
Beta strandi228 – 238Combined sources11
Turni240 – 242Combined sources3
Beta strandi243 – 257Combined sources15
Beta strandi259 – 261Combined sources3
Beta strandi263 – 271Combined sources9
Beta strandi278 – 287Combined sources10
Beta strandi290 – 297Combined sources8
Beta strandi299 – 301Combined sources3
Turni303 – 305Combined sources3
Turni307 – 309Combined sources3
Beta strandi314 – 322Combined sources9
Helixi328 – 331Combined sources4
Beta strandi332 – 336Combined sources5
Beta strandi346 – 350Combined sources5
Beta strandi352 – 354Combined sources3
Beta strandi356 – 358Combined sources3
Beta strandi361 – 371Combined sources11
Helixi372 – 374Combined sources3
Helixi379 – 381Combined sources3
Helixi394 – 397Combined sources4
Beta strandi400 – 402Combined sources3
Beta strandi406 – 417Combined sources12
Helixi418 – 420Combined sources3
Beta strandi426 – 431Combined sources6
Beta strandi442 – 447Combined sources6
Beta strandi450 – 455Combined sources6
Beta strandi465 – 471Combined sources7
Turni472 – 474Combined sources3
Beta strandi475 – 479Combined sources5
Beta strandi491 – 493Combined sources3
Beta strandi511 – 515Combined sources5
Turni516 – 519Combined sources4
Beta strandi520 – 526Combined sources7
Beta strandi529 – 533Combined sources5
Beta strandi535 – 541Combined sources7
Beta strandi544 – 550Combined sources7
Beta strandi557 – 568Combined sources12
Beta strandi571 – 581Combined sources11
Beta strandi586 – 588Combined sources3
Beta strandi591 – 596Combined sources6
Beta strandi599 – 601Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VSMX-ray1.80A188-602[»]
2VWDX-ray2.25A/B183-602[»]
3D11X-ray2.31A176-602[»]
3D12X-ray3.00A/D176-602[»]
DisProtiDP00686.
ProteinModelPortaliQ9IH62.
SMRiQ9IH62.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9IH62.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK19247.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR016285. Hemagglutn-neuramid.
IPR000665. Hemagglutn/HN.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9IH62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAENKKVRF ENTTSDKGKI PSKVIKSYYG TMDIKKINEG LLDSKILSAF
60 70 80 90 100
NTVIALLGSI VIIVMNIMII QNYTRSTDNQ AVIKDALQGI QQQIKGLADK
110 120 130 140 150
IGTEIGPKVS LIDTSSTITI PANIGLLGSK ISQSTASINE NVNEKCKFTL
160 170 180 190 200
PPLKIHECNI SCPNPLPFRE YRPQTEGVSN LVGLPNNICL QKTSNQILKP
210 220 230 240 250
KLISYTLPVV GQSGTCITDP LLAMDEGYFA YSHLERIGSC SRGVSKQRII
260 270 280 290 300
GVGEVLDRGD EVPSLFMTNV WTPPNPNTVY HCSAVYNNEF YYVLCAVSTV
310 320 330 340 350
GDPILNSTYW SGSLMMTRLA VKPKSNGGGY NQHQLALRSI EKGRYDKVMP
360 370 380 390 400
YGPSGIKQGD TLYFPAVGFL VRTEFKYNDS NCPITKCQYS KPENCRLSMG
410 420 430 440 450
IRPNSHYILR SGLLKYNLSD GENPKVVFIE ISDQRLSIGS PSKIYDSLGQ
460 470 480 490 500
PVFYQASFSW DTMIKFGDVL TVNPLVVNWR NNTVISRPGQ SQCPRFNTCP
510 520 530 540 550
EICWEGVYND AFLIDRINWI SAGVFLDSNQ TAENPVFTVF KDNEILYRAQ
560 570 580 590 600
LASEDTNAQK TITNCFLLKN KIWCISLVEI YDTGDNVIRP KLFAVKIPEQ

CT
Length:602
Mass (Da):67,039
Last modified:October 1, 2000 - v1
Checksum:i3BD2A917D30A73BE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti5N → S in strain: Isolate NiV/KHM/CSUR38. 1
Natural varianti20I → N in strain: Isolate NiV/MY/99/VRI-0626. 1
Natural varianti24V → I in strain: Isolate NiV/KHM/CSUR38. 1
Natural varianti248R → K in strain: Isolate NiV/KHM/CSUR38. 1
Natural varianti272T → A in strain: Isolate NiV/MY/99/VRI-0626. 1
Natural varianti327G → D in strain: Isolate NiV/KHM/CSUR38. 1
Natural varianti408I → V in strain: Isolate NiV/KHM/CSUR38. 1
Natural varianti426V → I in strain: Isolate NiV/KHM/CSUR38. 1
Natural varianti470L → Q in strain: Isolate NiV/KHM/CSUR38. 1
Natural varianti478N → S in strain: Isolate NiV/KHM/CSUR38. 1
Natural varianti481N → D in strain: Isolate NiV/KHM/CSUR38. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF238467 mRNA. Translation: AAF73957.1.
AF212302 Genomic RNA. Translation: AAK29088.1.
AY029767 Genomic RNA. Translation: AAK50545.1.
AF376747 Genomic RNA. Translation: AAM13406.1.
AY029768 Genomic RNA. Translation: AAK50554.1.
AJ564621 Genomic RNA. Translation: CAD92351.1.
AJ564622 Genomic RNA. Translation: CAD92357.1.
AJ564623 Genomic RNA. Translation: CAD92363.1.
AJ627196 Genomic RNA. Translation: CAF25497.1.
AY858111 Genomic RNA. Translation: AAX51853.1.
RefSeqiNP_112027.1. NC_002728.1.

Genome annotation databases

GeneIDi920955.
KEGGivg:920955.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF238467 mRNA. Translation: AAF73957.1.
AF212302 Genomic RNA. Translation: AAK29088.1.
AY029767 Genomic RNA. Translation: AAK50545.1.
AF376747 Genomic RNA. Translation: AAM13406.1.
AY029768 Genomic RNA. Translation: AAK50554.1.
AJ564621 Genomic RNA. Translation: CAD92351.1.
AJ564622 Genomic RNA. Translation: CAD92357.1.
AJ564623 Genomic RNA. Translation: CAD92363.1.
AJ627196 Genomic RNA. Translation: CAF25497.1.
AY858111 Genomic RNA. Translation: AAX51853.1.
RefSeqiNP_112027.1. NC_002728.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VSMX-ray1.80A188-602[»]
2VWDX-ray2.25A/B183-602[»]
3D11X-ray2.31A176-602[»]
3D12X-ray3.00A/D176-602[»]
DisProtiDP00686.
ProteinModelPortaliQ9IH62.
SMRiQ9IH62.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46380N.

Chemistry databases

BindingDBiQ9IH62.
ChEMBLiCHEMBL6047.

Protein family/group databases

CAZyiGH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi920955.
KEGGivg:920955.

Phylogenomic databases

KOiK19247.

Miscellaneous databases

EvolutionaryTraceiQ9IH62.
PROiQ9IH62.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR016285. Hemagglutn-neuramid.
IPR000665. Hemagglutn/HN.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGLYCP_NIPAV
AccessioniPrimary (citable) accession number: Q9IH62
Secondary accession number(s): Q4KTA8, Q5K4D8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Caution

Henipavirus glycoproteins have no neuraminidase activity.Curated

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.