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Q9IH62 (GLYCP_NIPAV) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Protein attributes

Sequence length602 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Interacts with host ephrinB2/EFNB2 or ephrin B3/EFNB3 to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-mediated endocytosis. Ref.9 Ref.10

Subunit structure

Interacts with host EFNB2 and host EFNB3. Ref.7 Ref.8

Subcellular location

Virion membrane; Single-pass type II membrane protein Potential. Host cell membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.

Caution

Henipavirus glycoproteins have no neuraminidase activity.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 602602Glycoprotein G
PRO_0000236009

Regions

Topological domain1 – 4949Intravirion Potential
Transmembrane50 – 7021Helical; Potential
Topological domain71 – 602532Virion surface Potential

Amino acid modifications

Glycosylation721N-linked (GlcNAc...); by host Potential
Glycosylation1591N-linked (GlcNAc...); by host Potential
Glycosylation3061N-linked (GlcNAc...); by host Potential
Glycosylation3781N-linked (GlcNAc...); by host Potential
Glycosylation4171N-linked (GlcNAc...); by host Potential
Glycosylation4811N-linked (GlcNAc...); by host Potential
Glycosylation5291N-linked (GlcNAc...); by host Potential

Natural variations

Natural variant51N → S in strain: Isolate NiV/KHM/CSUR38.
Natural variant201I → N in strain: Isolate NiV/MY/99/VRI-0626.
Natural variant241V → I in strain: Isolate NiV/KHM/CSUR38.
Natural variant2481R → K in strain: Isolate NiV/KHM/CSUR38.
Natural variant2721T → A in strain: Isolate NiV/MY/99/VRI-0626.
Natural variant3271G → D in strain: Isolate NiV/KHM/CSUR38.
Natural variant4081I → V in strain: Isolate NiV/KHM/CSUR38.
Natural variant4261V → I in strain: Isolate NiV/KHM/CSUR38.
Natural variant4701L → Q in strain: Isolate NiV/KHM/CSUR38.
Natural variant4781N → S in strain: Isolate NiV/KHM/CSUR38.
Natural variant4811N → D in strain: Isolate NiV/KHM/CSUR38.

Secondary structure

.................................................................................... 602
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9IH62 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 3BD2A917D30A73BE

FASTA60267,039
        10         20         30         40         50         60 
MPAENKKVRF ENTTSDKGKI PSKVIKSYYG TMDIKKINEG LLDSKILSAF NTVIALLGSI 

        70         80         90        100        110        120 
VIIVMNIMII QNYTRSTDNQ AVIKDALQGI QQQIKGLADK IGTEIGPKVS LIDTSSTITI 

       130        140        150        160        170        180 
PANIGLLGSK ISQSTASINE NVNEKCKFTL PPLKIHECNI SCPNPLPFRE YRPQTEGVSN 

       190        200        210        220        230        240 
LVGLPNNICL QKTSNQILKP KLISYTLPVV GQSGTCITDP LLAMDEGYFA YSHLERIGSC 

       250        260        270        280        290        300 
SRGVSKQRII GVGEVLDRGD EVPSLFMTNV WTPPNPNTVY HCSAVYNNEF YYVLCAVSTV 

       310        320        330        340        350        360 
GDPILNSTYW SGSLMMTRLA VKPKSNGGGY NQHQLALRSI EKGRYDKVMP YGPSGIKQGD 

       370        380        390        400        410        420 
TLYFPAVGFL VRTEFKYNDS NCPITKCQYS KPENCRLSMG IRPNSHYILR SGLLKYNLSD 

       430        440        450        460        470        480 
GENPKVVFIE ISDQRLSIGS PSKIYDSLGQ PVFYQASFSW DTMIKFGDVL TVNPLVVNWR 

       490        500        510        520        530        540 
NNTVISRPGQ SQCPRFNTCP EICWEGVYND AFLIDRINWI SAGVFLDSNQ TAENPVFTVF 

       550        560        570        580        590        600 
KDNEILYRAQ LASEDTNAQK TITNCFLLKN KIWCISLVEI YDTGDNVIRP KLFAVKIPEQ 


CT 

« Hide

References

[1]"Molecular characterization of Nipah virus, a newly emergent paramyxovirus."
Harcourt B.H., Tamin A., Rollin P.E., Ksiazek T.G., Anderson L.J., Bellini W.J., Rota P.A.
Virology 271:334-349(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Nipah virus: a recently emergent deadly paramyxovirus."
Chua K.B., Bellini W.J., Rota P.A., Harcourt B.H., Tamin A., Lam S.K., Ksiazek T.G., Rollin P.E., Zaki S.R., Shieh W., Goldsmith C.S., Gubler D.J., Roehrig J.T., Eaton B., Gould A.R., Olson J., Field H., Daniels P. expand/collapse author list , Ling A.E., Peters C.J., Anderson L.J., Mahy B.W.
Science 288:1432-1435(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[3]"Complete nucleotide sequences of Nipah virus isolates from Malaysia."
Chan Y.P., Chua K.B., Koh C.L., Lim M.E., Lam S.K.
J. Gen. Virol. 82:2151-2155(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate UMMC1 and Isolate UMMC2.
[4]"Isolation of Nipah virus from Malaysian island flying-foxes."
Chua K.B., Koh C.L., Hooi P.S., Wee K.F., Khong J.H., Chua B.H., Chan Y.P., Lim M.E., Lam S.K.
Microbes Infect. 4:145-151(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate Malaysian flying-fox.
[5]"Isolation and molecular identification of Nipah virus from pigs."
Abubakar S., Chang L.Y., Mohdali A.R., Sharifah S.H., Yusoff K., Zamrod Z.
Emerg. Infect. Dis. 10:2228-2230(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate NiV/MY/99/UM-0128, Isolate NiV/MY/99/VRI-1413 and Isolate NiV/MY/99/VRI-2794.
[6]"Nipah virus in Lyle's flying foxes, Cambodia."
Reynes J.-M., Counor D., Ong S., Faure C., Seng V., Molia S., Walston J., Georges-Courbot M., Deubel V., Sarthou J.-L.
Emerg. Infect. Dis. 11:1042-1047(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate NiV/KHM/CSUR381.
[7]"EphrinB2 is the entry receptor for Nipah virus, an emergent deadly paramyxovirus."
Negrete O.A., Levroney E.L., Aguilar H.C., Bertolotti-Ciarlet A., Nazarian R., Tajyar S., Lee B.
Nature 436:401-405(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HOST EFNB2.
[8]"Two key residues in ephrinB3 are critical for its use as an alternative receptor for Nipah virus."
Negrete O.A., Wolf M.C., Aguilar H.C., Enterlein S., Wang W., Muehlberger E., Su S.V., Bertolotti-Ciarlet A., Flick R., Lee B.
PLoS Pathog. 2:78-86(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HOST EFNB3.
[9]"Molecular characteristics of the Nipah virus glycoproteins."
Diederich S., Maisner A.
Ann. N. Y. Acad. Sci. 1102:39-50(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[10]"The nipah virus fusion protein is cleaved within the endosomal compartment."
Diederich S., Moll M., Klenk H.D., Maisner A.
J. Biol. Chem. 280:29899-29903(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF238467 mRNA. Translation: AAF73957.1.
AF212302 Genomic RNA. Translation: AAK29088.1.
AY029767 Genomic RNA. Translation: AAK50545.1.
AF376747 Genomic RNA. Translation: AAM13406.1.
AY029768 Genomic RNA. Translation: AAK50554.1.
AJ564621 Genomic RNA. Translation: CAD92351.1.
AJ564622 Genomic RNA. Translation: CAD92357.1.
AJ564623 Genomic RNA. Translation: CAD92363.1.
AJ627196 Genomic RNA. Translation: CAF25497.1.
AY858111 Genomic RNA. Translation: AAX51853.1.
RefSeqNP_112027.1. NC_002728.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2VSMX-ray1.80A188-602[»]
2VWDX-ray2.25A/B183-602[»]
3D11X-ray2.31A176-602[»]
3D12X-ray3.00A/D176-602[»]
DisProtDP00686.
ProteinModelPortalQ9IH62.
SMRQ9IH62. Positions 176-602.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-46380N.

Chemistry

BindingDBQ9IH62.
ChEMBLCHEMBL6047.

Protein family/group databases

CAZyGH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID920955.

Family and domain databases

Gene3D2.120.10.10. 1 hit.
InterProIPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view]
PfamPF00423. HN. 1 hit.
[Graphical view]
PIRSFPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMSSF50939. SSF50939. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ9IH62.

Entry information

Entry nameGLYCP_NIPAV
AccessionPrimary (citable) accession number: Q9IH62
Secondary accession number(s): Q4KTA8, Q5K4D8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references