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Q9IBG7

- KCP_XENLA

UniProt

Q9IBG7 - KCP_XENLA

Protein

Kielin/chordin-like protein

Gene

kcp

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    May be a signaling molecule that mediates inductive activities of the embryonic midline. Able to dorsalize mesoderm.1 Publication

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kielin/chordin-like protein
    Alternative name(s):
    Cysteine-rich motor neuron 2 protein
    Short name:
    CRIM-2
    Kielin
    Gene namesi
    Name:kcp
    Synonyms:crim2
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-865639. kcp.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 23272308Kielin/chordin-like proteinPRO_0000318588Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi2016 ↔ 2024PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Developmental stagei

    Expression starts at the mid-gastrula stage in the dorsal midline. Expressed in the axial mesoderm at this stage. At neurula stages, expression is detected both in the axial mesoderm (notochord and prechordal mesoderm) and in the ventral central nervous system (floor plate and ventral forebrain). At tailbud stages, expression is diminished in the notochord and remains in the ventral central nervous system (CNS). During and after tailbud stages, other regions shows detectable levels of expression. The epiphyseal placode has a strong expression. Additional expression is found in dorsal parts of the CNS, especially in the anterior spinal cord and hindbrain as well as in the tailbud mesoderm. At the larval stage, expression is also found in the forming heart. Induced in mesoderm and in ectoderm by nodal-related genes.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ9IBG7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini339 – 40062VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini401 – 43838VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini439 – 49355VWFC 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini494 – 55360VWFC 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini554 – 61057VWFC 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini611 – 66959VWFC 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini670 – 72859VWFC 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini729 – 78658VWFC 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini787 – 84761VWFC 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini848 – 90760VWFC 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini908 – 96659VWFC 11PROSITE-ProRule annotationAdd
    BLAST
    Domaini967 – 102559VWFC 12PROSITE-ProRule annotationAdd
    BLAST
    Domaini1026 – 108358VWFC 13PROSITE-ProRule annotationAdd
    BLAST
    Domaini1084 – 114259VWFC 14PROSITE-ProRule annotationAdd
    BLAST
    Domaini1146 – 120358VWFC 15PROSITE-ProRule annotationAdd
    BLAST
    Domaini1204 – 126057VWFC 16PROSITE-ProRule annotationAdd
    BLAST
    Domaini1261 – 131959VWFC 17PROSITE-ProRule annotationAdd
    BLAST
    Domaini1321 – 137757VWFC 18PROSITE-ProRule annotationAdd
    BLAST
    Domaini1378 – 143962VWFC 19PROSITE-ProRule annotationAdd
    BLAST
    Domaini1440 – 149556VWFC 20PROSITE-ProRule annotationAdd
    BLAST
    Domaini1496 – 155560VWFC 21PROSITE-ProRule annotationAdd
    BLAST
    Domaini1556 – 161459VWFC 22PROSITE-ProRule annotationAdd
    BLAST
    Domaini1615 – 167359VWFC 23PROSITE-ProRule annotationAdd
    BLAST
    Domaini1674 – 173158VWFC 24PROSITE-ProRule annotationAdd
    BLAST
    Domaini1732 – 179968VWFC 25PROSITE-ProRule annotationAdd
    BLAST
    Domaini1800 – 186061VWFC 26PROSITE-ProRule annotationAdd
    BLAST
    Domaini1861 – 192464VWFC 27PROSITE-ProRule annotationAdd
    BLAST
    Domaini1928 – 198861VWFC 28PROSITE-ProRule annotationAdd
    BLAST
    Domaini1993 – 2205213VWFDPROSITE-ProRule annotationAdd
    BLAST
    Domaini2259 – 231961TILAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili291 – 33242Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi283 – 2864Poly-Gln
    Compositional biasi2163 – 21664Poly-Ser

    Sequence similaritiesi

    Contains 28 VWFC domains.PROSITE-ProRule annotation
    Contains 1 VWFD domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat, Signal

    Family and domain databases

    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR001791. Laminin_G.
    IPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR001007. VWF_C.
    IPR001846. VWF_type-D.
    [Graphical view]
    PfamiPF00093. VWC. 17 hits.
    PF00094. VWD. 1 hit.
    [Graphical view]
    SMARTiSM00832. C8. 1 hit.
    SM00210. TSPN. 1 hit.
    SM00214. VWC. 27 hits.
    SM00216. VWD. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    SSF57567. SSF57567. 1 hit.
    PROSITEiPS01208. VWFC_1. 20 hits.
    PS50184. VWFC_2. 23 hits.
    PS51233. VWFD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9IBG7-1 [UniParc]FASTAAdd to Basket

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    MNTLLWTILL PLLFSFCVCQ QPEHQDLEMS VQYYDDNVID LLEALNVTRS     50
    VKGVTKAKGS DPASPAWKFR QRVPHLTLPR DYSVYLLSTT QESLGLHFVA 100
    KQAKNNRGTL VAFLSPAATK IDGRPLLRLI SDTHTDQLYF EYRTAQTMEP 150
    ASLHFPGSSP FSGSQWARVA LNVNTHKVTL FLDCEEPVVF GKEGAEEMLS 200
    LILPLDLEIT FASTPSDKES KFLGYWQTAE ISPTGFTRRP WHCENRSDSL 250
    PLPYSLSGER QMEDEEIQRE PRAPDLSDTD HYQQQQSEVP AQLLAKDDRL 300
    QRLEEAVKGL TNMIDMIKSQ NADLQARVIA LESCECRRST CVWEDKEYQD 350
    SETWKKDACN ICVCVGGSVT CSVRKDWPQC LGCFHEGRNY NNKDIFSVGP 400
    CMSCICQSGE VSCTPKLCPP VTCSDPVTLP NECCPLCATG CSDGHKEGDT 450
    WRKDTCTTCT CQNGTISCER EQCPELTCLK RHTPPGQCCA KCQQGCEYEG 500
    LIYRNGDYFL SQSNPCVNCS CLNNLVRCLP VQCPLPACTN PVPIPGQCCP 550
    SCPVCELDGH PLIPGQNVTT KDGCRLCSCQ DGKVQCTESV QCPHICTHGV 600
    RSNSCCLDCS ACEMHGDIIP NGLTFQGNMD PCESCTCQDG NVHCVRVSCP 650
    ELSCVLHEKI PGECCSQCQS CMDGTVKRKH GEEWKPQGDP CQSCRCLEGR 700
    VQCRKRHCAA LCRNPLPPRP GTCCPMCDGC LYNGRSYLNG QPVRSTDQCN 750
    RCFCENGNVQ CEPIACPQAP CRNPVRRTGE CCPRCEGCEY DSRHFAEGVV 800
    FTTAHDPCLQ CTCLSGEVSC EHLDRKCPPS QCSHPGKAAG QCCPSCDVCD 850
    FEGILYTDRQ TFQPPGHGPC LKCFCTIGNV RCVEETCPPA PCPNPVRDPE 900
    QCCPVCKVCV QDGVEFLEGI EWELDGNPCS SCTCRNGDTV CGVSECPPVS 950
    CLHPTRREGE CCPVCDSCSY NQRLYSNEQI FTDPDNPCQD CQCKDGTVQC 1000
    SSIVCPPVLC TIPERTPGQC CAKCPDCRYQ DQIFLEGEQF SNPLNQCQEC 1050
    WCRDGHVTCT DRGCTGALCS YPLPGTCCQN NCNGCNYAGK EYPNGADFPH 1100
    PTDKCRQCHC INGNVQCLAQ RCPPLLCAEP FPVPGECCPQ CPVPPADCPY 1150
    SGVTYRHMQR FYDPSDKCRD CICNNGTVTC QRKPCAPTPC LHPLQGDCCR 1200
    SCDGCLMSGK ELANGEQFPQ PSDPCSVCVC WEGSVTCQPK TCPVLNCPFP 1250
    APGQCCKECQ DCQYFGEVYL NGQEFSAPED SCSRCVCADG FVTCSKKPCY 1300
    KAGCTHPSTP PGKCCPVCDG CSYNGDALIN SQSVPDPSNP LCSECTCRAG 1350
    SVQCVRKLCG PTSCPHPVTG PCDCPICQGC HFQGHNYIDG EVFTSAQSQC 1400
    EQCRCMRGHV TCGPRPCDQV TCPHPAEDPC MCPVCDGCNY SGRDCTNGES 1450
    FPDPEDECSH CTCRNGEVAC ISVPCPRVSC MYPITPRGEC CPRCTGICKH 1500
    NGRVYQSGDT FHPPGDLCTK CSCQNEMVNC QRVRCSQECS HPVLSPASSC 1550
    CPVCDRCFYE NREYANHETF TSTSDPCQRC VCLDGSVTCT HVVCPYVSCA 1600
    NPITKPGQCC RECPVCRYQG KEFSEGAHWV PHTDPCLKCT CSNGHVDCEP 1650
    PQCPPLPCTQ QVTDPGTCCP RCRGCVYNGR EYRDNSNWLS SSDHCMSCMC 1700
    VDGVTTCSKL QCITSCTNQI TIPGECCPVC ADCISNSKVY LPGDSYNPSK 1750
    DPCEICTCES LPNGQQYRHC TKKQCPSLLD CPRSYILPPA EGQCCSSCAQ 1800
    ALSNCTNTLV GNEIQATDDP CYTCHCKDLT WVCVHQPCPA LSCPRSEQFT 1850
    HSGSCCPVCN ECVVEIEGRR VPDGETWTDR QDPCVTCTCT LGHVECQIEE 1900
    CQPVQCQEGE RKVKRPGTCC HECQASAVSC WYQGQRFLSN EHWQVDECTA 1950
    CTCVSGEVHC HSERCPQVSC TAEETPALIP GMCCPHCIPR PATCIAFGDP 2000
    HYRTFDGKMY HFQGSCTYVL SEDCEGGDFS IHVTNDDRGL RGVSWTKEVT 2050
    VLIGDAVVQL LQDWVVMVDY QTVELPFLKE PYIYIERKTN TILLNSNIGV 2100
    KVQWNGRSHL EVSVPGTYRD HLCGLCGNFN NYPQDDLRDR RGQILMSEAA 2150
    FGNSWRVQSS NDSSSSCWDG QDVDPCKQAG YRARKEANGR CKLLKSSVFE 2200
    PCHRVVPPEM FFASCVYDLC ACGAGDECLC DVLEAYASEC REAGVILQWR 2250
    SPALCAVGCP HDRGYVFDEC GPPCPKTCFN KDVPLGVLES HCFKPCVPGC 2300
    QCPAGLVEHE SHCIPPESCP KIIHGNL 2327
    Length:2,327
    Mass (Da):255,802
    Last modified:October 1, 2000 - v1
    Checksum:i0293109329209983
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026192 mRNA. Translation: BAA95483.1.
    RefSeqiNP_001079355.1. NM_001085886.1.
    UniGeneiXl.993.

    Genome annotation databases

    GeneIDi378806.
    KEGGixla:378806.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026192 mRNA. Translation: BAA95483.1 .
    RefSeqi NP_001079355.1. NM_001085886.1.
    UniGenei Xl.993.

    3D structure databases

    ProteinModelPortali Q9IBG7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 378806.
    KEGGi xla:378806.

    Organism-specific databases

    CTDi 375616.
    Xenbasei XB-GENE-865639. kcp.

    Family and domain databases

    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR001791. Laminin_G.
    IPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR001007. VWF_C.
    IPR001846. VWF_type-D.
    [Graphical view ]
    Pfami PF00093. VWC. 17 hits.
    PF00094. VWD. 1 hit.
    [Graphical view ]
    SMARTi SM00832. C8. 1 hit.
    SM00210. TSPN. 1 hit.
    SM00214. VWC. 27 hits.
    SM00216. VWD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    SSF57567. SSF57567. 1 hit.
    PROSITEi PS01208. VWFC_1. 20 hits.
    PS50184. VWFC_2. 23 hits.
    PS51233. VWFD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Xenopus kielin: A dorsalizing factor containing multiple chordin-type repeats secreted from the embryonic midline."
      Matsui M., Mizuseki K., Nakatani J., Nakanishi S., Sasai Y.
      Proc. Natl. Acad. Sci. U.S.A. 97:5291-5296(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, FUNCTION.
      Tissue: Embryonic floor plate.

    Entry informationi

    Entry nameiKCP_XENLA
    AccessioniPrimary (citable) accession number: Q9IBG7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    'Kiel' means keel in English. As the expression in the central nervous system (CNS) resembled a keel of ship, the gene was named Kielin.

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3