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Q9IBG7

- KCP_XENLA

UniProt

Q9IBG7 - KCP_XENLA

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Protein

Kielin/chordin-like protein

Gene

kcp

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be a signaling molecule that mediates inductive activities of the embryonic midline. Able to dorsalize mesoderm.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Kielin/chordin-like protein
Alternative name(s):
Cysteine-rich motor neuron 2 protein
Short name:
CRIM-2
Kielin
Gene namesi
Name:kcp
Synonyms:crim2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865639. kcp.

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 23272308Kielin/chordin-like proteinPRO_0000318588Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi2016 ↔ 2024PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Developmental stagei

Expression starts at the mid-gastrula stage in the dorsal midline. Expressed in the axial mesoderm at this stage. At neurula stages, expression is detected both in the axial mesoderm (notochord and prechordal mesoderm) and in the ventral central nervous system (floor plate and ventral forebrain). At tailbud stages, expression is diminished in the notochord and remains in the ventral central nervous system (CNS). During and after tailbud stages, other regions shows detectable levels of expression. The epiphyseal placode has a strong expression. Additional expression is found in dorsal parts of the CNS, especially in the anterior spinal cord and hindbrain as well as in the tailbud mesoderm. At the larval stage, expression is also found in the forming heart. Induced in mesoderm and in ectoderm by nodal-related genes.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9IBG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini339 – 40062VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini401 – 43838VWFC 2PROSITE-ProRule annotationAdd
BLAST
Domaini439 – 49355VWFC 3PROSITE-ProRule annotationAdd
BLAST
Domaini494 – 55360VWFC 4PROSITE-ProRule annotationAdd
BLAST
Domaini554 – 61057VWFC 5PROSITE-ProRule annotationAdd
BLAST
Domaini611 – 66959VWFC 6PROSITE-ProRule annotationAdd
BLAST
Domaini670 – 72859VWFC 7PROSITE-ProRule annotationAdd
BLAST
Domaini729 – 78658VWFC 8PROSITE-ProRule annotationAdd
BLAST
Domaini787 – 84761VWFC 9PROSITE-ProRule annotationAdd
BLAST
Domaini848 – 90760VWFC 10PROSITE-ProRule annotationAdd
BLAST
Domaini908 – 96659VWFC 11PROSITE-ProRule annotationAdd
BLAST
Domaini967 – 102559VWFC 12PROSITE-ProRule annotationAdd
BLAST
Domaini1026 – 108358VWFC 13PROSITE-ProRule annotationAdd
BLAST
Domaini1084 – 114259VWFC 14PROSITE-ProRule annotationAdd
BLAST
Domaini1146 – 120358VWFC 15PROSITE-ProRule annotationAdd
BLAST
Domaini1204 – 126057VWFC 16PROSITE-ProRule annotationAdd
BLAST
Domaini1261 – 131959VWFC 17PROSITE-ProRule annotationAdd
BLAST
Domaini1321 – 137757VWFC 18PROSITE-ProRule annotationAdd
BLAST
Domaini1378 – 143962VWFC 19PROSITE-ProRule annotationAdd
BLAST
Domaini1440 – 149556VWFC 20PROSITE-ProRule annotationAdd
BLAST
Domaini1496 – 155560VWFC 21PROSITE-ProRule annotationAdd
BLAST
Domaini1556 – 161459VWFC 22PROSITE-ProRule annotationAdd
BLAST
Domaini1615 – 167359VWFC 23PROSITE-ProRule annotationAdd
BLAST
Domaini1674 – 173158VWFC 24PROSITE-ProRule annotationAdd
BLAST
Domaini1732 – 179968VWFC 25PROSITE-ProRule annotationAdd
BLAST
Domaini1800 – 186061VWFC 26PROSITE-ProRule annotationAdd
BLAST
Domaini1861 – 192464VWFC 27PROSITE-ProRule annotationAdd
BLAST
Domaini1928 – 198861VWFC 28PROSITE-ProRule annotationAdd
BLAST
Domaini1993 – 2205213VWFDPROSITE-ProRule annotationAdd
BLAST
Domaini2259 – 231961TILAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili291 – 33242Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi283 – 2864Poly-Gln
Compositional biasi2163 – 21664Poly-Ser

Sequence similaritiesi

Contains 28 VWFC domains.PROSITE-ProRule annotation
Contains 1 VWFD domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, Signal

Family and domain databases

InterProiIPR013320. ConA-like_dom.
IPR001791. Laminin_G.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF00093. VWC. 17 hits.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM00832. C8. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 27 hits.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57567. SSF57567. 1 hit.
PROSITEiPS01208. VWFC_1. 20 hits.
PS50184. VWFC_2. 23 hits.
PS51233. VWFD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9IBG7-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MNTLLWTILL PLLFSFCVCQ QPEHQDLEMS VQYYDDNVID LLEALNVTRS
60 70 80 90 100
VKGVTKAKGS DPASPAWKFR QRVPHLTLPR DYSVYLLSTT QESLGLHFVA
110 120 130 140 150
KQAKNNRGTL VAFLSPAATK IDGRPLLRLI SDTHTDQLYF EYRTAQTMEP
160 170 180 190 200
ASLHFPGSSP FSGSQWARVA LNVNTHKVTL FLDCEEPVVF GKEGAEEMLS
210 220 230 240 250
LILPLDLEIT FASTPSDKES KFLGYWQTAE ISPTGFTRRP WHCENRSDSL
260 270 280 290 300
PLPYSLSGER QMEDEEIQRE PRAPDLSDTD HYQQQQSEVP AQLLAKDDRL
310 320 330 340 350
QRLEEAVKGL TNMIDMIKSQ NADLQARVIA LESCECRRST CVWEDKEYQD
360 370 380 390 400
SETWKKDACN ICVCVGGSVT CSVRKDWPQC LGCFHEGRNY NNKDIFSVGP
410 420 430 440 450
CMSCICQSGE VSCTPKLCPP VTCSDPVTLP NECCPLCATG CSDGHKEGDT
460 470 480 490 500
WRKDTCTTCT CQNGTISCER EQCPELTCLK RHTPPGQCCA KCQQGCEYEG
510 520 530 540 550
LIYRNGDYFL SQSNPCVNCS CLNNLVRCLP VQCPLPACTN PVPIPGQCCP
560 570 580 590 600
SCPVCELDGH PLIPGQNVTT KDGCRLCSCQ DGKVQCTESV QCPHICTHGV
610 620 630 640 650
RSNSCCLDCS ACEMHGDIIP NGLTFQGNMD PCESCTCQDG NVHCVRVSCP
660 670 680 690 700
ELSCVLHEKI PGECCSQCQS CMDGTVKRKH GEEWKPQGDP CQSCRCLEGR
710 720 730 740 750
VQCRKRHCAA LCRNPLPPRP GTCCPMCDGC LYNGRSYLNG QPVRSTDQCN
760 770 780 790 800
RCFCENGNVQ CEPIACPQAP CRNPVRRTGE CCPRCEGCEY DSRHFAEGVV
810 820 830 840 850
FTTAHDPCLQ CTCLSGEVSC EHLDRKCPPS QCSHPGKAAG QCCPSCDVCD
860 870 880 890 900
FEGILYTDRQ TFQPPGHGPC LKCFCTIGNV RCVEETCPPA PCPNPVRDPE
910 920 930 940 950
QCCPVCKVCV QDGVEFLEGI EWELDGNPCS SCTCRNGDTV CGVSECPPVS
960 970 980 990 1000
CLHPTRREGE CCPVCDSCSY NQRLYSNEQI FTDPDNPCQD CQCKDGTVQC
1010 1020 1030 1040 1050
SSIVCPPVLC TIPERTPGQC CAKCPDCRYQ DQIFLEGEQF SNPLNQCQEC
1060 1070 1080 1090 1100
WCRDGHVTCT DRGCTGALCS YPLPGTCCQN NCNGCNYAGK EYPNGADFPH
1110 1120 1130 1140 1150
PTDKCRQCHC INGNVQCLAQ RCPPLLCAEP FPVPGECCPQ CPVPPADCPY
1160 1170 1180 1190 1200
SGVTYRHMQR FYDPSDKCRD CICNNGTVTC QRKPCAPTPC LHPLQGDCCR
1210 1220 1230 1240 1250
SCDGCLMSGK ELANGEQFPQ PSDPCSVCVC WEGSVTCQPK TCPVLNCPFP
1260 1270 1280 1290 1300
APGQCCKECQ DCQYFGEVYL NGQEFSAPED SCSRCVCADG FVTCSKKPCY
1310 1320 1330 1340 1350
KAGCTHPSTP PGKCCPVCDG CSYNGDALIN SQSVPDPSNP LCSECTCRAG
1360 1370 1380 1390 1400
SVQCVRKLCG PTSCPHPVTG PCDCPICQGC HFQGHNYIDG EVFTSAQSQC
1410 1420 1430 1440 1450
EQCRCMRGHV TCGPRPCDQV TCPHPAEDPC MCPVCDGCNY SGRDCTNGES
1460 1470 1480 1490 1500
FPDPEDECSH CTCRNGEVAC ISVPCPRVSC MYPITPRGEC CPRCTGICKH
1510 1520 1530 1540 1550
NGRVYQSGDT FHPPGDLCTK CSCQNEMVNC QRVRCSQECS HPVLSPASSC
1560 1570 1580 1590 1600
CPVCDRCFYE NREYANHETF TSTSDPCQRC VCLDGSVTCT HVVCPYVSCA
1610 1620 1630 1640 1650
NPITKPGQCC RECPVCRYQG KEFSEGAHWV PHTDPCLKCT CSNGHVDCEP
1660 1670 1680 1690 1700
PQCPPLPCTQ QVTDPGTCCP RCRGCVYNGR EYRDNSNWLS SSDHCMSCMC
1710 1720 1730 1740 1750
VDGVTTCSKL QCITSCTNQI TIPGECCPVC ADCISNSKVY LPGDSYNPSK
1760 1770 1780 1790 1800
DPCEICTCES LPNGQQYRHC TKKQCPSLLD CPRSYILPPA EGQCCSSCAQ
1810 1820 1830 1840 1850
ALSNCTNTLV GNEIQATDDP CYTCHCKDLT WVCVHQPCPA LSCPRSEQFT
1860 1870 1880 1890 1900
HSGSCCPVCN ECVVEIEGRR VPDGETWTDR QDPCVTCTCT LGHVECQIEE
1910 1920 1930 1940 1950
CQPVQCQEGE RKVKRPGTCC HECQASAVSC WYQGQRFLSN EHWQVDECTA
1960 1970 1980 1990 2000
CTCVSGEVHC HSERCPQVSC TAEETPALIP GMCCPHCIPR PATCIAFGDP
2010 2020 2030 2040 2050
HYRTFDGKMY HFQGSCTYVL SEDCEGGDFS IHVTNDDRGL RGVSWTKEVT
2060 2070 2080 2090 2100
VLIGDAVVQL LQDWVVMVDY QTVELPFLKE PYIYIERKTN TILLNSNIGV
2110 2120 2130 2140 2150
KVQWNGRSHL EVSVPGTYRD HLCGLCGNFN NYPQDDLRDR RGQILMSEAA
2160 2170 2180 2190 2200
FGNSWRVQSS NDSSSSCWDG QDVDPCKQAG YRARKEANGR CKLLKSSVFE
2210 2220 2230 2240 2250
PCHRVVPPEM FFASCVYDLC ACGAGDECLC DVLEAYASEC REAGVILQWR
2260 2270 2280 2290 2300
SPALCAVGCP HDRGYVFDEC GPPCPKTCFN KDVPLGVLES HCFKPCVPGC
2310 2320
QCPAGLVEHE SHCIPPESCP KIIHGNL
Length:2,327
Mass (Da):255,802
Last modified:October 1, 2000 - v1
Checksum:i0293109329209983
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026192 mRNA. Translation: BAA95483.1.
RefSeqiNP_001079355.1. NM_001085886.1.
UniGeneiXl.993.

Genome annotation databases

GeneIDi378806.
KEGGixla:378806.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026192 mRNA. Translation: BAA95483.1 .
RefSeqi NP_001079355.1. NM_001085886.1.
UniGenei Xl.993.

3D structure databases

ProteinModelPortali Q9IBG7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 378806.
KEGGi xla:378806.

Organism-specific databases

CTDi 375616.
Xenbasei XB-GENE-865639. kcp.

Family and domain databases

InterProi IPR013320. ConA-like_dom.
IPR001791. Laminin_G.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view ]
Pfami PF00093. VWC. 17 hits.
PF00094. VWD. 1 hit.
[Graphical view ]
SMARTi SM00832. C8. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 27 hits.
SM00216. VWD. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF57567. SSF57567. 1 hit.
PROSITEi PS01208. VWFC_1. 20 hits.
PS50184. VWFC_2. 23 hits.
PS51233. VWFD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Xenopus kielin: A dorsalizing factor containing multiple chordin-type repeats secreted from the embryonic midline."
    Matsui M., Mizuseki K., Nakatani J., Nakanishi S., Sasai Y.
    Proc. Natl. Acad. Sci. U.S.A. 97:5291-5296(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, FUNCTION.
    Tissue: Embryonic floor plate.

Entry informationi

Entry nameiKCP_XENLA
AccessioniPrimary (citable) accession number: Q9IBG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

'Kiel' means keel in English. As the expression in the central nervous system (CNS) resembled a keel of ship, the gene was named Kielin.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3