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Q9IBG7 (KCP_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kielin/chordin-like protein
Alternative name(s):
Cysteine-rich motor neuron 2 protein
Short name=CRIM-2
Kielin
Gene names
Name:kcp
Synonyms:crim2
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length2327 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be a signaling molecule that mediates inductive activities of the embryonic midline. Able to dorsalize mesoderm. Ref.1

Subcellular location

Secreted Ref.1.

Developmental stage

Expression starts at the mid-gastrula stage in the dorsal midline. Expressed in the axial mesoderm at this stage. At neurula stages, expression is detected both in the axial mesoderm (notochord and prechordal mesoderm) and in the ventral central nervous system (floor plate and ventral forebrain). At tailbud stages, expression is diminished in the notochord and remains in the ventral central nervous system (CNS). During and after tailbud stages, other regions shows detectable levels of expression. The epiphyseal placode has a strong expression. Additional expression is found in dorsal parts of the CNS, especially in the anterior spinal cord and hindbrain as well as in the tailbud mesoderm. At the larval stage, expression is also found in the forming heart. Induced in mesoderm and in ectoderm by nodal-related genes. Ref.1

Miscellaneous

'Kiel' means keel in English. As the expression in the central nervous system (CNS) resembled a keel of ship, the gene was named Kielin.

Sequence similarities

Contains 1 TIL (trypsin inhibitory-like) domain.

Contains 28 VWFC domains.

Contains 1 VWFD domain.

Ontologies

Keywords
   Cellular componentSecreted
   DomainCoiled coil
Repeat
Signal
   PTMDisulfide bond
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 23272308Kielin/chordin-like protein
PRO_0000318588

Regions

Domain339 – 40062VWFC 1
Domain401 – 43838VWFC 2
Domain439 – 49355VWFC 3
Domain494 – 55360VWFC 4
Domain554 – 61057VWFC 5
Domain611 – 66959VWFC 6
Domain670 – 72859VWFC 7
Domain729 – 78658VWFC 8
Domain787 – 84761VWFC 9
Domain848 – 90760VWFC 10
Domain908 – 96659VWFC 11
Domain967 – 102559VWFC 12
Domain1026 – 108358VWFC 13
Domain1084 – 114259VWFC 14
Domain1146 – 120358VWFC 15
Domain1204 – 126057VWFC 16
Domain1261 – 131959VWFC 17
Domain1321 – 137757VWFC 18
Domain1378 – 143962VWFC 19
Domain1440 – 149556VWFC 20
Domain1496 – 155560VWFC 21
Domain1556 – 161459VWFC 22
Domain1615 – 167359VWFC 23
Domain1674 – 173158VWFC 24
Domain1732 – 179968VWFC 25
Domain1800 – 186061VWFC 26
Domain1861 – 192464VWFC 27
Domain1928 – 198861VWFC 28
Domain1993 – 2205213VWFD
Domain2259 – 231961TIL
Coiled coil291 – 33242 Potential
Compositional bias283 – 2864Poly-Gln
Compositional bias2163 – 21664Poly-Ser

Amino acid modifications

Disulfide bond2016 ↔ 2024 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9IBG7 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 0293109329209983

FASTA2,327255,802
        10         20         30         40         50         60 
MNTLLWTILL PLLFSFCVCQ QPEHQDLEMS VQYYDDNVID LLEALNVTRS VKGVTKAKGS 

        70         80         90        100        110        120 
DPASPAWKFR QRVPHLTLPR DYSVYLLSTT QESLGLHFVA KQAKNNRGTL VAFLSPAATK 

       130        140        150        160        170        180 
IDGRPLLRLI SDTHTDQLYF EYRTAQTMEP ASLHFPGSSP FSGSQWARVA LNVNTHKVTL 

       190        200        210        220        230        240 
FLDCEEPVVF GKEGAEEMLS LILPLDLEIT FASTPSDKES KFLGYWQTAE ISPTGFTRRP 

       250        260        270        280        290        300 
WHCENRSDSL PLPYSLSGER QMEDEEIQRE PRAPDLSDTD HYQQQQSEVP AQLLAKDDRL 

       310        320        330        340        350        360 
QRLEEAVKGL TNMIDMIKSQ NADLQARVIA LESCECRRST CVWEDKEYQD SETWKKDACN 

       370        380        390        400        410        420 
ICVCVGGSVT CSVRKDWPQC LGCFHEGRNY NNKDIFSVGP CMSCICQSGE VSCTPKLCPP 

       430        440        450        460        470        480 
VTCSDPVTLP NECCPLCATG CSDGHKEGDT WRKDTCTTCT CQNGTISCER EQCPELTCLK 

       490        500        510        520        530        540 
RHTPPGQCCA KCQQGCEYEG LIYRNGDYFL SQSNPCVNCS CLNNLVRCLP VQCPLPACTN 

       550        560        570        580        590        600 
PVPIPGQCCP SCPVCELDGH PLIPGQNVTT KDGCRLCSCQ DGKVQCTESV QCPHICTHGV 

       610        620        630        640        650        660 
RSNSCCLDCS ACEMHGDIIP NGLTFQGNMD PCESCTCQDG NVHCVRVSCP ELSCVLHEKI 

       670        680        690        700        710        720 
PGECCSQCQS CMDGTVKRKH GEEWKPQGDP CQSCRCLEGR VQCRKRHCAA LCRNPLPPRP 

       730        740        750        760        770        780 
GTCCPMCDGC LYNGRSYLNG QPVRSTDQCN RCFCENGNVQ CEPIACPQAP CRNPVRRTGE 

       790        800        810        820        830        840 
CCPRCEGCEY DSRHFAEGVV FTTAHDPCLQ CTCLSGEVSC EHLDRKCPPS QCSHPGKAAG 

       850        860        870        880        890        900 
QCCPSCDVCD FEGILYTDRQ TFQPPGHGPC LKCFCTIGNV RCVEETCPPA PCPNPVRDPE 

       910        920        930        940        950        960 
QCCPVCKVCV QDGVEFLEGI EWELDGNPCS SCTCRNGDTV CGVSECPPVS CLHPTRREGE 

       970        980        990       1000       1010       1020 
CCPVCDSCSY NQRLYSNEQI FTDPDNPCQD CQCKDGTVQC SSIVCPPVLC TIPERTPGQC 

      1030       1040       1050       1060       1070       1080 
CAKCPDCRYQ DQIFLEGEQF SNPLNQCQEC WCRDGHVTCT DRGCTGALCS YPLPGTCCQN 

      1090       1100       1110       1120       1130       1140 
NCNGCNYAGK EYPNGADFPH PTDKCRQCHC INGNVQCLAQ RCPPLLCAEP FPVPGECCPQ 

      1150       1160       1170       1180       1190       1200 
CPVPPADCPY SGVTYRHMQR FYDPSDKCRD CICNNGTVTC QRKPCAPTPC LHPLQGDCCR 

      1210       1220       1230       1240       1250       1260 
SCDGCLMSGK ELANGEQFPQ PSDPCSVCVC WEGSVTCQPK TCPVLNCPFP APGQCCKECQ 

      1270       1280       1290       1300       1310       1320 
DCQYFGEVYL NGQEFSAPED SCSRCVCADG FVTCSKKPCY KAGCTHPSTP PGKCCPVCDG 

      1330       1340       1350       1360       1370       1380 
CSYNGDALIN SQSVPDPSNP LCSECTCRAG SVQCVRKLCG PTSCPHPVTG PCDCPICQGC 

      1390       1400       1410       1420       1430       1440 
HFQGHNYIDG EVFTSAQSQC EQCRCMRGHV TCGPRPCDQV TCPHPAEDPC MCPVCDGCNY 

      1450       1460       1470       1480       1490       1500 
SGRDCTNGES FPDPEDECSH CTCRNGEVAC ISVPCPRVSC MYPITPRGEC CPRCTGICKH 

      1510       1520       1530       1540       1550       1560 
NGRVYQSGDT FHPPGDLCTK CSCQNEMVNC QRVRCSQECS HPVLSPASSC CPVCDRCFYE 

      1570       1580       1590       1600       1610       1620 
NREYANHETF TSTSDPCQRC VCLDGSVTCT HVVCPYVSCA NPITKPGQCC RECPVCRYQG 

      1630       1640       1650       1660       1670       1680 
KEFSEGAHWV PHTDPCLKCT CSNGHVDCEP PQCPPLPCTQ QVTDPGTCCP RCRGCVYNGR 

      1690       1700       1710       1720       1730       1740 
EYRDNSNWLS SSDHCMSCMC VDGVTTCSKL QCITSCTNQI TIPGECCPVC ADCISNSKVY 

      1750       1760       1770       1780       1790       1800 
LPGDSYNPSK DPCEICTCES LPNGQQYRHC TKKQCPSLLD CPRSYILPPA EGQCCSSCAQ 

      1810       1820       1830       1840       1850       1860 
ALSNCTNTLV GNEIQATDDP CYTCHCKDLT WVCVHQPCPA LSCPRSEQFT HSGSCCPVCN 

      1870       1880       1890       1900       1910       1920 
ECVVEIEGRR VPDGETWTDR QDPCVTCTCT LGHVECQIEE CQPVQCQEGE RKVKRPGTCC 

      1930       1940       1950       1960       1970       1980 
HECQASAVSC WYQGQRFLSN EHWQVDECTA CTCVSGEVHC HSERCPQVSC TAEETPALIP 

      1990       2000       2010       2020       2030       2040 
GMCCPHCIPR PATCIAFGDP HYRTFDGKMY HFQGSCTYVL SEDCEGGDFS IHVTNDDRGL 

      2050       2060       2070       2080       2090       2100 
RGVSWTKEVT VLIGDAVVQL LQDWVVMVDY QTVELPFLKE PYIYIERKTN TILLNSNIGV 

      2110       2120       2130       2140       2150       2160 
KVQWNGRSHL EVSVPGTYRD HLCGLCGNFN NYPQDDLRDR RGQILMSEAA FGNSWRVQSS 

      2170       2180       2190       2200       2210       2220 
NDSSSSCWDG QDVDPCKQAG YRARKEANGR CKLLKSSVFE PCHRVVPPEM FFASCVYDLC 

      2230       2240       2250       2260       2270       2280 
ACGAGDECLC DVLEAYASEC REAGVILQWR SPALCAVGCP HDRGYVFDEC GPPCPKTCFN 

      2290       2300       2310       2320 
KDVPLGVLES HCFKPCVPGC QCPAGLVEHE SHCIPPESCP KIIHGNL

« Hide

References

[1]"Xenopus kielin: A dorsalizing factor containing multiple chordin-type repeats secreted from the embryonic midline."
Matsui M., Mizuseki K., Nakatani J., Nakanishi S., Sasai Y.
Proc. Natl. Acad. Sci. U.S.A. 97:5291-5296(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, FUNCTION.
Tissue: Embryonic floor plate.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB026192 mRNA. Translation: BAA95483.1.
RefSeqNP_001079355.1. NM_001085886.1.
UniGeneXl.993.

3D structure databases

HSSPHSSP built from PDB template 1CCV based on UniProtKB P56682.
ProteinModelPortalQ9IBG7.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID378806.
KEGGxla:378806.

Organism-specific databases

CTD375616.
XenbaseXB-GENE-865639. kcp.

Family and domain databases

InterProIPR008985. ConA-like_lec_gl_sf.
IPR001791. Laminin_G.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view]
PfamPF00093. VWC. 17 hits.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTSM00832. C8. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 27 hits.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMSSF49899. ConA_like_lec_gl. 1 hit.
SSF57567. Cysrich_TIL. 1 hit.
PROSITEPS01208. VWFC_1. 20 hits.
PS50184. VWFC_2. 23 hits.
PS51233. VWFD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKCP_XENLA
AccessionPrimary (citable) accession number: Q9IBG7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2000
Last modified: April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents