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Protein

Kielin/chordin-like protein

Gene

kcp

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be a signaling molecule that mediates inductive activities of the embryonic midline. Able to dorsalize mesoderm.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Kielin/chordin-like protein
Alternative name(s):
Cysteine-rich motor neuron 2 protein
Short name:
CRIM-2
Kielin
Gene namesi
Name:kcp
Synonyms:crim2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865639. kcp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000031858820 – 2327Kielin/chordin-like proteinAdd BLAST2308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi2016 ↔ 2024PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Developmental stagei

Expression starts at the mid-gastrula stage in the dorsal midline. Expressed in the axial mesoderm at this stage. At neurula stages, expression is detected both in the axial mesoderm (notochord and prechordal mesoderm) and in the ventral central nervous system (floor plate and ventral forebrain). At tailbud stages, expression is diminished in the notochord and remains in the ventral central nervous system (CNS). During and after tailbud stages, other regions shows detectable levels of expression. The epiphyseal placode has a strong expression. Additional expression is found in dorsal parts of the CNS, especially in the anterior spinal cord and hindbrain as well as in the tailbud mesoderm. At the larval stage, expression is also found in the forming heart. Induced in mesoderm and in ectoderm by nodal-related genes.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9IBG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini339 – 400VWFC 1PROSITE-ProRule annotationAdd BLAST62
Domaini401 – 438VWFC 2PROSITE-ProRule annotationAdd BLAST38
Domaini439 – 493VWFC 3PROSITE-ProRule annotationAdd BLAST55
Domaini494 – 553VWFC 4PROSITE-ProRule annotationAdd BLAST60
Domaini554 – 610VWFC 5PROSITE-ProRule annotationAdd BLAST57
Domaini611 – 669VWFC 6PROSITE-ProRule annotationAdd BLAST59
Domaini670 – 728VWFC 7PROSITE-ProRule annotationAdd BLAST59
Domaini729 – 786VWFC 8PROSITE-ProRule annotationAdd BLAST58
Domaini787 – 847VWFC 9PROSITE-ProRule annotationAdd BLAST61
Domaini848 – 907VWFC 10PROSITE-ProRule annotationAdd BLAST60
Domaini908 – 966VWFC 11PROSITE-ProRule annotationAdd BLAST59
Domaini967 – 1025VWFC 12PROSITE-ProRule annotationAdd BLAST59
Domaini1026 – 1083VWFC 13PROSITE-ProRule annotationAdd BLAST58
Domaini1084 – 1142VWFC 14PROSITE-ProRule annotationAdd BLAST59
Domaini1146 – 1203VWFC 15PROSITE-ProRule annotationAdd BLAST58
Domaini1204 – 1260VWFC 16PROSITE-ProRule annotationAdd BLAST57
Domaini1261 – 1319VWFC 17PROSITE-ProRule annotationAdd BLAST59
Domaini1321 – 1377VWFC 18PROSITE-ProRule annotationAdd BLAST57
Domaini1378 – 1439VWFC 19PROSITE-ProRule annotationAdd BLAST62
Domaini1440 – 1495VWFC 20PROSITE-ProRule annotationAdd BLAST56
Domaini1496 – 1555VWFC 21PROSITE-ProRule annotationAdd BLAST60
Domaini1556 – 1614VWFC 22PROSITE-ProRule annotationAdd BLAST59
Domaini1615 – 1673VWFC 23PROSITE-ProRule annotationAdd BLAST59
Domaini1674 – 1731VWFC 24PROSITE-ProRule annotationAdd BLAST58
Domaini1732 – 1799VWFC 25PROSITE-ProRule annotationAdd BLAST68
Domaini1800 – 1860VWFC 26PROSITE-ProRule annotationAdd BLAST61
Domaini1861 – 1924VWFC 27PROSITE-ProRule annotationAdd BLAST64
Domaini1928 – 1988VWFC 28PROSITE-ProRule annotationAdd BLAST61
Domaini1993 – 2205VWFDPROSITE-ProRule annotationAdd BLAST213
Domaini2259 – 2319TILAdd BLAST61

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili291 – 332Sequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi283 – 286Poly-Gln4
Compositional biasi2163 – 2166Poly-Ser4

Sequence similaritiesi

Contains 28 VWFC domains.PROSITE-ProRule annotation
Contains 1 VWFD domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, Signal

Family and domain databases

InterProiIPR013320. ConA-like_dom.
IPR001791. Laminin_G.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_dom.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF00093. VWC. 17 hits.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM00832. C8. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 28 hits.
SM00215. VWC_out. 12 hits.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57567. SSF57567. 1 hit.
PROSITEiPS01208. VWFC_1. 20 hits.
PS50184. VWFC_2. 23 hits.
PS51233. VWFD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9IBG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTLLWTILL PLLFSFCVCQ QPEHQDLEMS VQYYDDNVID LLEALNVTRS
60 70 80 90 100
VKGVTKAKGS DPASPAWKFR QRVPHLTLPR DYSVYLLSTT QESLGLHFVA
110 120 130 140 150
KQAKNNRGTL VAFLSPAATK IDGRPLLRLI SDTHTDQLYF EYRTAQTMEP
160 170 180 190 200
ASLHFPGSSP FSGSQWARVA LNVNTHKVTL FLDCEEPVVF GKEGAEEMLS
210 220 230 240 250
LILPLDLEIT FASTPSDKES KFLGYWQTAE ISPTGFTRRP WHCENRSDSL
260 270 280 290 300
PLPYSLSGER QMEDEEIQRE PRAPDLSDTD HYQQQQSEVP AQLLAKDDRL
310 320 330 340 350
QRLEEAVKGL TNMIDMIKSQ NADLQARVIA LESCECRRST CVWEDKEYQD
360 370 380 390 400
SETWKKDACN ICVCVGGSVT CSVRKDWPQC LGCFHEGRNY NNKDIFSVGP
410 420 430 440 450
CMSCICQSGE VSCTPKLCPP VTCSDPVTLP NECCPLCATG CSDGHKEGDT
460 470 480 490 500
WRKDTCTTCT CQNGTISCER EQCPELTCLK RHTPPGQCCA KCQQGCEYEG
510 520 530 540 550
LIYRNGDYFL SQSNPCVNCS CLNNLVRCLP VQCPLPACTN PVPIPGQCCP
560 570 580 590 600
SCPVCELDGH PLIPGQNVTT KDGCRLCSCQ DGKVQCTESV QCPHICTHGV
610 620 630 640 650
RSNSCCLDCS ACEMHGDIIP NGLTFQGNMD PCESCTCQDG NVHCVRVSCP
660 670 680 690 700
ELSCVLHEKI PGECCSQCQS CMDGTVKRKH GEEWKPQGDP CQSCRCLEGR
710 720 730 740 750
VQCRKRHCAA LCRNPLPPRP GTCCPMCDGC LYNGRSYLNG QPVRSTDQCN
760 770 780 790 800
RCFCENGNVQ CEPIACPQAP CRNPVRRTGE CCPRCEGCEY DSRHFAEGVV
810 820 830 840 850
FTTAHDPCLQ CTCLSGEVSC EHLDRKCPPS QCSHPGKAAG QCCPSCDVCD
860 870 880 890 900
FEGILYTDRQ TFQPPGHGPC LKCFCTIGNV RCVEETCPPA PCPNPVRDPE
910 920 930 940 950
QCCPVCKVCV QDGVEFLEGI EWELDGNPCS SCTCRNGDTV CGVSECPPVS
960 970 980 990 1000
CLHPTRREGE CCPVCDSCSY NQRLYSNEQI FTDPDNPCQD CQCKDGTVQC
1010 1020 1030 1040 1050
SSIVCPPVLC TIPERTPGQC CAKCPDCRYQ DQIFLEGEQF SNPLNQCQEC
1060 1070 1080 1090 1100
WCRDGHVTCT DRGCTGALCS YPLPGTCCQN NCNGCNYAGK EYPNGADFPH
1110 1120 1130 1140 1150
PTDKCRQCHC INGNVQCLAQ RCPPLLCAEP FPVPGECCPQ CPVPPADCPY
1160 1170 1180 1190 1200
SGVTYRHMQR FYDPSDKCRD CICNNGTVTC QRKPCAPTPC LHPLQGDCCR
1210 1220 1230 1240 1250
SCDGCLMSGK ELANGEQFPQ PSDPCSVCVC WEGSVTCQPK TCPVLNCPFP
1260 1270 1280 1290 1300
APGQCCKECQ DCQYFGEVYL NGQEFSAPED SCSRCVCADG FVTCSKKPCY
1310 1320 1330 1340 1350
KAGCTHPSTP PGKCCPVCDG CSYNGDALIN SQSVPDPSNP LCSECTCRAG
1360 1370 1380 1390 1400
SVQCVRKLCG PTSCPHPVTG PCDCPICQGC HFQGHNYIDG EVFTSAQSQC
1410 1420 1430 1440 1450
EQCRCMRGHV TCGPRPCDQV TCPHPAEDPC MCPVCDGCNY SGRDCTNGES
1460 1470 1480 1490 1500
FPDPEDECSH CTCRNGEVAC ISVPCPRVSC MYPITPRGEC CPRCTGICKH
1510 1520 1530 1540 1550
NGRVYQSGDT FHPPGDLCTK CSCQNEMVNC QRVRCSQECS HPVLSPASSC
1560 1570 1580 1590 1600
CPVCDRCFYE NREYANHETF TSTSDPCQRC VCLDGSVTCT HVVCPYVSCA
1610 1620 1630 1640 1650
NPITKPGQCC RECPVCRYQG KEFSEGAHWV PHTDPCLKCT CSNGHVDCEP
1660 1670 1680 1690 1700
PQCPPLPCTQ QVTDPGTCCP RCRGCVYNGR EYRDNSNWLS SSDHCMSCMC
1710 1720 1730 1740 1750
VDGVTTCSKL QCITSCTNQI TIPGECCPVC ADCISNSKVY LPGDSYNPSK
1760 1770 1780 1790 1800
DPCEICTCES LPNGQQYRHC TKKQCPSLLD CPRSYILPPA EGQCCSSCAQ
1810 1820 1830 1840 1850
ALSNCTNTLV GNEIQATDDP CYTCHCKDLT WVCVHQPCPA LSCPRSEQFT
1860 1870 1880 1890 1900
HSGSCCPVCN ECVVEIEGRR VPDGETWTDR QDPCVTCTCT LGHVECQIEE
1910 1920 1930 1940 1950
CQPVQCQEGE RKVKRPGTCC HECQASAVSC WYQGQRFLSN EHWQVDECTA
1960 1970 1980 1990 2000
CTCVSGEVHC HSERCPQVSC TAEETPALIP GMCCPHCIPR PATCIAFGDP
2010 2020 2030 2040 2050
HYRTFDGKMY HFQGSCTYVL SEDCEGGDFS IHVTNDDRGL RGVSWTKEVT
2060 2070 2080 2090 2100
VLIGDAVVQL LQDWVVMVDY QTVELPFLKE PYIYIERKTN TILLNSNIGV
2110 2120 2130 2140 2150
KVQWNGRSHL EVSVPGTYRD HLCGLCGNFN NYPQDDLRDR RGQILMSEAA
2160 2170 2180 2190 2200
FGNSWRVQSS NDSSSSCWDG QDVDPCKQAG YRARKEANGR CKLLKSSVFE
2210 2220 2230 2240 2250
PCHRVVPPEM FFASCVYDLC ACGAGDECLC DVLEAYASEC REAGVILQWR
2260 2270 2280 2290 2300
SPALCAVGCP HDRGYVFDEC GPPCPKTCFN KDVPLGVLES HCFKPCVPGC
2310 2320
QCPAGLVEHE SHCIPPESCP KIIHGNL
Length:2,327
Mass (Da):255,802
Last modified:October 1, 2000 - v1
Checksum:i0293109329209983
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026192 mRNA. Translation: BAA95483.1.
RefSeqiNP_001079355.1. NM_001085886.1.
UniGeneiXl.993.

Genome annotation databases

GeneIDi378806.
KEGGixla:378806.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026192 mRNA. Translation: BAA95483.1.
RefSeqiNP_001079355.1. NM_001085886.1.
UniGeneiXl.993.

3D structure databases

ProteinModelPortaliQ9IBG7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi378806.
KEGGixla:378806.

Organism-specific databases

CTDi375616.
XenbaseiXB-GENE-865639. kcp.

Family and domain databases

InterProiIPR013320. ConA-like_dom.
IPR001791. Laminin_G.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_dom.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF00093. VWC. 17 hits.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM00832. C8. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 28 hits.
SM00215. VWC_out. 12 hits.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57567. SSF57567. 1 hit.
PROSITEiPS01208. VWFC_1. 20 hits.
PS50184. VWFC_2. 23 hits.
PS51233. VWFD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKCP_XENLA
AccessioniPrimary (citable) accession number: Q9IBG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2000
Last modified: May 11, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

'Kiel' means keel in English. As the expression in the central nervous system (CNS) resembled a keel of ship, the gene was named Kielin.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.