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Q9IBD8

- PTPRC_CYPCA

UniProt

Q9IBD8 - PTPRC_CYPCA

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Protein

Receptor-type tyrosine-protein phosphatase C

Gene

ptprc

Organism
Cyprinus carpio (Common carp)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei728 – 7281SubstrateBy similarity
Active sitei760 – 7601Phosphocysteine intermediateBy similarity
Binding sitei804 – 8041SubstrateBy similarity
Active sitei1070 – 10701Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. T cell receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase C (EC:3.1.3.48)
Alternative name(s):
Leukocyte common antigen
CD_antigen: CD45
Gene namesi
Name:ptprc
OrganismiCyprinus carpio (Common carp)
Taxonomic identifieri7962 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCyprinus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 493467ExtracellularSequence AnalysisAdd
BLAST
Transmembranei494 – 51421HelicalSequence AnalysisAdd
BLAST
Topological domaini515 – 1216702CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 12161190Receptor-type tyrosine-protein phosphatase CPRO_0000395800Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi92 – 921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi205 – 2051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi240 – 2401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi283 – 2831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi301 – 3011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi349 – 3491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi375 – 3751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi393 – 3931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi478 – 4781N-linked (GlcNAc...)Sequence Analysis
Modified residuei881 – 8811PhosphoserineBy similarity
Modified residuei903 – 9031PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ9IBD8.

Structurei

3D structure databases

ProteinModelPortaliQ9IBD8.
SMRiQ9IBD8. Positions 537-1131.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini71 – 16595Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini298 – 39598Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini401 – 49191Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini563 – 819257Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
BLAST
Domaini850 – 1129280Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni760 – 7667Substrate bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi915 – 9184Poly-Glu

Sequence similaritiesi

Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG000066.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.90.190.10. 2 hits.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR016335. Leukocyte_common_ag.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 2 hits.
[Graphical view]
PIRSFiPIRSF002004. Leukocyte_common_antigen. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 2 hits.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9IBD8-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MARFFALGPL VLVLCLVLFL SPTSTSEQDT DTKVTGSSNS PTIMQSATPT
60 70 80 90 100
PALPTGSVKG VKANDSGTTE VPCQYRLIVN GYEKNSLLVN INGSKSQNYT
110 120 130 140 150
IRIKDKKSEK KIPVSIVSDT TTIDILFEWL KPCTNYSVNI DNCNVVGENH
160 170 180 190 200
FNLNVLKSVN HSAEPKGDEQ VCFKDSKWNL TKCVNITTED SCVQKPIQIN
210 220 230 240 250
LETCNYTMNV HMPPVKPEIT FSESIPTKFV WSNKPLSSDN VTSQCKDTFK
260 270 280 290 300
VKCTDDTEYD LDKDVFLKPS EEYTCTGKYK YYNTSIDSKS KQVNIHCEWI
310 320 330 340 350
NETVFSEVTS NSIVIFWNLS PGDKCKGITW EKFSAICKKS HDQKCRKVND
360 370 380 390 400
TTAECVFSEL KSYINYTCTL SAEVNKSIGV FPIYTRDFNQ RTNSSNPSFE
410 420 430 440 450
DHDNVKVKET SHNSFNVNCK NLKPDEWNGP KGIYIAKLLS NRPPVTKENP
460 470 480 490 500
KSCSFTFENL YYHTEYTIEI IAINGNKNES SAKATHSTRY NDKALIGFLV
510 520 530 540 550
FLILVTSLAL LFVLYKLFLL KRKRTAEDEE ILLTQPLRRV EPIYAGGLVE
560 570 580 590 600
AYKNKIADEG RLFMDEFQSI PRIFSNYTIK EAKKSENQYK NRYVDILPYD
610 620 630 640 650
YNRVTLSTGG EDNYINASFI EGYREPKKYI AAQGPKDETV VDFWRMVWEQ
660 670 680 690 700
KSSIIVMVTR CEEGNKTKCA QYWPSLDREA EIFEEFVVKI RSEEHCPDYV
710 720 730 740 750
IRHLILNNKR EKGSEREVTH IQFISWPDHG VPGDPSLLLK LRRRVNSFKN
760 770 780 790 800
FFSGPVVVHC SAGVGRTGTY MSIDAMIESL EAEGRVDIYG FVAKLRRQRC
810 820 830 840 850
LMVQVEAQYI LIHTALIEYN QFGETEVSLS EFHSVLNTLR QKNGSDPSLL
860 870 880 890 900
EKEFQKLPKF KKWRTMNTGS SEDNKKKNRD SAVIPYDFNR VIFRLDIEGN
910 920 930 940 950
QTSDPEDEEE YSSDEEEESN QYINASFIDG YWCNKSLIAA QGPLQSTAEE
960 970 980 990 1000
FLLMLYQQQT KTLVMLTDCQ EDGKDYCFQY WGDEKKTYGD MEIEVKKTET
1010 1020 1030 1040 1050
FPTYVRRHLE IQSLKKKEVL KVDQYQFLKW RGRELPENAQ ELVEMASIIR
1060 1070 1080 1090 1100
ENGHYDNSKT NRNVPIVVHC NNGSSRTGIF CALWNLLDSA YTEKLVDVLQ
1110 1120 1130 1140 1150
EVKNLRKLRQ GMVETIEQYQ FLYTALEGAF PVQNGAVKTP PAKDAAQVIN
1160 1170 1180 1190 1200
ETTALLTEPN STSGADQKEA EESTAAESNE QGAKESSTAE APAAEGDGEK
1210
ATSEGPTNGP TATVEV
Length:1,216
Mass (Da):138,252
Last modified:October 1, 2000 - v1
Checksum:i9D2E45F41721D2CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031424 mRNA. Translation: BAA92179.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031424 mRNA. Translation: BAA92179.1 .

3D structure databases

ProteinModelPortali Q9IBD8.
SMRi Q9IBD8. Positions 537-1131.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9IBD8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG000066.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.90.190.10. 2 hits.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR016335. Leukocyte_common_ag.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00102. Y_phosphatase. 2 hits.
[Graphical view ]
PIRSFi PIRSF002004. Leukocyte_common_antigen. 1 hit.
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 2 hits.
SM00194. PTPc. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEi PS50853. FN3. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of carp (Cyprinus carpio) leucocyte cell-derived chemotaxin 2, glia maturation factor beta, CD45 and lysozyme C by use of suppression subtractive hybridisation."
    Fujiki K., Shin D.H., Nakao M., Yano T.
    Fish Shellfish Immunol. 10:643-650(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPTPRC_CYPCA
AccessioniPrimary (citable) accession number: Q9IBD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: October 1, 2000
Last modified: October 1, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3