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Q9IBD8

- PTPRC_CYPCA

UniProt

Q9IBD8 - PTPRC_CYPCA

Protein

Receptor-type tyrosine-protein phosphatase C

Gene

ptprc

Organism
Cyprinus carpio (Common carp)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei728 – 7281SubstrateBy similarity
    Active sitei760 – 7601Phosphocysteine intermediateBy similarity
    Binding sitei804 – 8041SubstrateBy similarity
    Active sitei1070 – 10701Phosphocysteine intermediateBy similarity

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. T cell receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Receptor-type tyrosine-protein phosphatase C (EC:3.1.3.48)
    Alternative name(s):
    Leukocyte common antigen
    CD_antigen: CD45
    Gene namesi
    Name:ptprc
    OrganismiCyprinus carpio (Common carp)
    Taxonomic identifieri7962 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCyprinus

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 12161190Receptor-type tyrosine-protein phosphatase CPRO_0000395800Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi92 – 921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi205 – 2051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi240 – 2401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi283 – 2831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi301 – 3011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi349 – 3491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi375 – 3751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi393 – 3931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi478 – 4781N-linked (GlcNAc...)Sequence Analysis
    Modified residuei881 – 8811PhosphoserineBy similarity
    Modified residuei903 – 9031PhosphoserineBy similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiQ9IBD8.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9IBD8.
    SMRiQ9IBD8. Positions 537-1131.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 493467ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini515 – 1216702CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei494 – 51421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini71 – 16595Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini298 – 39598Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini401 – 49191Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini563 – 819257Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini850 – 1129280Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni760 – 7667Substrate bindingBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi915 – 9184Poly-Glu

    Sequence similaritiesi

    Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG000066.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.90.190.10. 2 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR016335. Leukocyte_common_ag.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00102. Y_phosphatase. 2 hits.
    [Graphical view]
    PIRSFiPIRSF002004. Leukocyte_common_antigen. 1 hit.
    PRINTSiPR00700. PRTYPHPHTASE.
    SMARTiSM00060. FN3. 2 hits.
    SM00194. PTPc. 2 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 1 hit.
    SSF52799. SSF52799. 2 hits.
    PROSITEiPS50853. FN3. 3 hits.
    PS00383. TYR_PHOSPHATASE_1. 2 hits.
    PS50056. TYR_PHOSPHATASE_2. 2 hits.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9IBD8-1 [UniParc]FASTAAdd to Basket

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    MARFFALGPL VLVLCLVLFL SPTSTSEQDT DTKVTGSSNS PTIMQSATPT     50
    PALPTGSVKG VKANDSGTTE VPCQYRLIVN GYEKNSLLVN INGSKSQNYT 100
    IRIKDKKSEK KIPVSIVSDT TTIDILFEWL KPCTNYSVNI DNCNVVGENH 150
    FNLNVLKSVN HSAEPKGDEQ VCFKDSKWNL TKCVNITTED SCVQKPIQIN 200
    LETCNYTMNV HMPPVKPEIT FSESIPTKFV WSNKPLSSDN VTSQCKDTFK 250
    VKCTDDTEYD LDKDVFLKPS EEYTCTGKYK YYNTSIDSKS KQVNIHCEWI 300
    NETVFSEVTS NSIVIFWNLS PGDKCKGITW EKFSAICKKS HDQKCRKVND 350
    TTAECVFSEL KSYINYTCTL SAEVNKSIGV FPIYTRDFNQ RTNSSNPSFE 400
    DHDNVKVKET SHNSFNVNCK NLKPDEWNGP KGIYIAKLLS NRPPVTKENP 450
    KSCSFTFENL YYHTEYTIEI IAINGNKNES SAKATHSTRY NDKALIGFLV 500
    FLILVTSLAL LFVLYKLFLL KRKRTAEDEE ILLTQPLRRV EPIYAGGLVE 550
    AYKNKIADEG RLFMDEFQSI PRIFSNYTIK EAKKSENQYK NRYVDILPYD 600
    YNRVTLSTGG EDNYINASFI EGYREPKKYI AAQGPKDETV VDFWRMVWEQ 650
    KSSIIVMVTR CEEGNKTKCA QYWPSLDREA EIFEEFVVKI RSEEHCPDYV 700
    IRHLILNNKR EKGSEREVTH IQFISWPDHG VPGDPSLLLK LRRRVNSFKN 750
    FFSGPVVVHC SAGVGRTGTY MSIDAMIESL EAEGRVDIYG FVAKLRRQRC 800
    LMVQVEAQYI LIHTALIEYN QFGETEVSLS EFHSVLNTLR QKNGSDPSLL 850
    EKEFQKLPKF KKWRTMNTGS SEDNKKKNRD SAVIPYDFNR VIFRLDIEGN 900
    QTSDPEDEEE YSSDEEEESN QYINASFIDG YWCNKSLIAA QGPLQSTAEE 950
    FLLMLYQQQT KTLVMLTDCQ EDGKDYCFQY WGDEKKTYGD MEIEVKKTET 1000
    FPTYVRRHLE IQSLKKKEVL KVDQYQFLKW RGRELPENAQ ELVEMASIIR 1050
    ENGHYDNSKT NRNVPIVVHC NNGSSRTGIF CALWNLLDSA YTEKLVDVLQ 1100
    EVKNLRKLRQ GMVETIEQYQ FLYTALEGAF PVQNGAVKTP PAKDAAQVIN 1150
    ETTALLTEPN STSGADQKEA EESTAAESNE QGAKESSTAE APAAEGDGEK 1200
    ATSEGPTNGP TATVEV 1216
    Length:1,216
    Mass (Da):138,252
    Last modified:October 1, 2000 - v1
    Checksum:i9D2E45F41721D2CF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB031424 mRNA. Translation: BAA92179.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB031424 mRNA. Translation: BAA92179.1 .

    3D structure databases

    ProteinModelPortali Q9IBD8.
    SMRi Q9IBD8. Positions 537-1131.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9IBD8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG000066.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.90.190.10. 2 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR016335. Leukocyte_common_ag.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00102. Y_phosphatase. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF002004. Leukocyte_common_antigen. 1 hit.
    PRINTSi PR00700. PRTYPHPHTASE.
    SMARTi SM00060. FN3. 2 hits.
    SM00194. PTPc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 1 hit.
    SSF52799. SSF52799. 2 hits.
    PROSITEi PS50853. FN3. 3 hits.
    PS00383. TYR_PHOSPHATASE_1. 2 hits.
    PS50056. TYR_PHOSPHATASE_2. 2 hits.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of carp (Cyprinus carpio) leucocyte cell-derived chemotaxin 2, glia maturation factor beta, CD45 and lysozyme C by use of suppression subtractive hybridisation."
      Fujiki K., Shin D.H., Nakao M., Yano T.
      Fish Shellfish Immunol. 10:643-650(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiPTPRC_CYPCA
    AccessioniPrimary (citable) accession number: Q9IBD8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 13, 2010
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3