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Q9IBD8 (PTPRC_CYPCA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Receptor-type tyrosine-protein phosphatase C

EC=3.1.3.48
Alternative name(s):
Leukocyte common antigen
CD_antigen=CD45
Gene names
Name:ptprc
OrganismCyprinus carpio (Common carp)
Taxonomic identifier7962 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCyprinus

Protein attributes

Sequence length1216 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.

Contains 3 fibronectin type-III domains.

Contains 2 tyrosine-protein phosphatase domains.

Ontologies

Keywords
   Cellular componentMembrane
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionHydrolase
Protein phosphatase
   PTMGlycoprotein
Phosphoprotein
Gene Ontology (GO)
   Biological_processT cell receptor signaling pathway

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionprotein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 12161190Receptor-type tyrosine-protein phosphatase C
PRO_0000395800

Regions

Topological domain27 – 493467Extracellular Potential
Transmembrane494 – 51421Helical; Potential
Topological domain515 – 1216702Cytoplasmic Potential
Domain71 – 16595Fibronectin type-III 1
Domain298 – 39598Fibronectin type-III 2
Domain401 – 49191Fibronectin type-III 3
Domain563 – 819257Tyrosine-protein phosphatase 1
Domain850 – 1129280Tyrosine-protein phosphatase 2
Region760 – 7667Substrate binding By similarity
Compositional bias915 – 9184Poly-Glu

Sites

Active site7601Phosphocysteine intermediate By similarity
Active site10701Phosphocysteine intermediate By similarity
Binding site7281Substrate By similarity
Binding site8041Substrate By similarity

Amino acid modifications

Modified residue8811Phosphoserine By similarity
Modified residue9031Phosphoserine By similarity
Glycosylation641N-linked (GlcNAc...) Potential
Glycosylation921N-linked (GlcNAc...) Potential
Glycosylation981N-linked (GlcNAc...) Potential
Glycosylation1351N-linked (GlcNAc...) Potential
Glycosylation1601N-linked (GlcNAc...) Potential
Glycosylation1791N-linked (GlcNAc...) Potential
Glycosylation1851N-linked (GlcNAc...) Potential
Glycosylation2051N-linked (GlcNAc...) Potential
Glycosylation2401N-linked (GlcNAc...) Potential
Glycosylation2831N-linked (GlcNAc...) Potential
Glycosylation3011N-linked (GlcNAc...) Potential
Glycosylation3491N-linked (GlcNAc...) Potential
Glycosylation3651N-linked (GlcNAc...) Potential
Glycosylation3751N-linked (GlcNAc...) Potential
Glycosylation3931N-linked (GlcNAc...) Potential
Glycosylation4781N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9IBD8 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 9D2E45F41721D2CF

FASTA1,216138,252
        10         20         30         40         50         60 
MARFFALGPL VLVLCLVLFL SPTSTSEQDT DTKVTGSSNS PTIMQSATPT PALPTGSVKG 

        70         80         90        100        110        120 
VKANDSGTTE VPCQYRLIVN GYEKNSLLVN INGSKSQNYT IRIKDKKSEK KIPVSIVSDT 

       130        140        150        160        170        180 
TTIDILFEWL KPCTNYSVNI DNCNVVGENH FNLNVLKSVN HSAEPKGDEQ VCFKDSKWNL 

       190        200        210        220        230        240 
TKCVNITTED SCVQKPIQIN LETCNYTMNV HMPPVKPEIT FSESIPTKFV WSNKPLSSDN 

       250        260        270        280        290        300 
VTSQCKDTFK VKCTDDTEYD LDKDVFLKPS EEYTCTGKYK YYNTSIDSKS KQVNIHCEWI 

       310        320        330        340        350        360 
NETVFSEVTS NSIVIFWNLS PGDKCKGITW EKFSAICKKS HDQKCRKVND TTAECVFSEL 

       370        380        390        400        410        420 
KSYINYTCTL SAEVNKSIGV FPIYTRDFNQ RTNSSNPSFE DHDNVKVKET SHNSFNVNCK 

       430        440        450        460        470        480 
NLKPDEWNGP KGIYIAKLLS NRPPVTKENP KSCSFTFENL YYHTEYTIEI IAINGNKNES 

       490        500        510        520        530        540 
SAKATHSTRY NDKALIGFLV FLILVTSLAL LFVLYKLFLL KRKRTAEDEE ILLTQPLRRV 

       550        560        570        580        590        600 
EPIYAGGLVE AYKNKIADEG RLFMDEFQSI PRIFSNYTIK EAKKSENQYK NRYVDILPYD 

       610        620        630        640        650        660 
YNRVTLSTGG EDNYINASFI EGYREPKKYI AAQGPKDETV VDFWRMVWEQ KSSIIVMVTR 

       670        680        690        700        710        720 
CEEGNKTKCA QYWPSLDREA EIFEEFVVKI RSEEHCPDYV IRHLILNNKR EKGSEREVTH 

       730        740        750        760        770        780 
IQFISWPDHG VPGDPSLLLK LRRRVNSFKN FFSGPVVVHC SAGVGRTGTY MSIDAMIESL 

       790        800        810        820        830        840 
EAEGRVDIYG FVAKLRRQRC LMVQVEAQYI LIHTALIEYN QFGETEVSLS EFHSVLNTLR 

       850        860        870        880        890        900 
QKNGSDPSLL EKEFQKLPKF KKWRTMNTGS SEDNKKKNRD SAVIPYDFNR VIFRLDIEGN 

       910        920        930        940        950        960 
QTSDPEDEEE YSSDEEEESN QYINASFIDG YWCNKSLIAA QGPLQSTAEE FLLMLYQQQT 

       970        980        990       1000       1010       1020 
KTLVMLTDCQ EDGKDYCFQY WGDEKKTYGD MEIEVKKTET FPTYVRRHLE IQSLKKKEVL 

      1030       1040       1050       1060       1070       1080 
KVDQYQFLKW RGRELPENAQ ELVEMASIIR ENGHYDNSKT NRNVPIVVHC NNGSSRTGIF 

      1090       1100       1110       1120       1130       1140 
CALWNLLDSA YTEKLVDVLQ EVKNLRKLRQ GMVETIEQYQ FLYTALEGAF PVQNGAVKTP 

      1150       1160       1170       1180       1190       1200 
PAKDAAQVIN ETTALLTEPN STSGADQKEA EESTAAESNE QGAKESSTAE APAAEGDGEK 

      1210 
ATSEGPTNGP TATVEV 

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References

[1]"Molecular cloning of carp (Cyprinus carpio) leucocyte cell-derived chemotaxin 2, glia maturation factor beta, CD45 and lysozyme C by use of suppression subtractive hybridisation."
Fujiki K., Shin D.H., Nakao M., Yano T.
Fish Shellfish Immunol. 10:643-650(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB031424 mRNA. Translation: BAA92179.1.

3D structure databases

ProteinModelPortalQ9IBD8.
SMRQ9IBD8. Positions 537-1131.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ9IBD8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG000066.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.90.190.10. 2 hits.
InterProIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR016335. Leukocyte_common_ag.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF00102. Y_phosphatase. 2 hits.
[Graphical view]
PIRSFPIRSF002004. Leukocyte_common_antigen. 1 hit.
PRINTSPR00700. PRTYPHPHTASE.
SMARTSM00060. FN3. 2 hits.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMSSF49265. SSF49265. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEPS50853. FN3. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePTPRC_CYPCA
AccessionPrimary (citable) accession number: Q9IBD8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: October 1, 2000
Last modified: June 11, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families