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Protein

Receptor-type tyrosine-protein phosphatase C

Gene

ptprc

Organism
Cyprinus carpio (Common carp)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei728SubstrateBy similarity1
Active sitei760Phosphocysteine intermediateBy similarity1
Binding sitei804SubstrateBy similarity1
Active sitei1070Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase C (EC:3.1.3.48)
Alternative name(s):
Leukocyte common antigen
CD_antigen: CD45
Gene namesi
Name:ptprc
OrganismiCyprinus carpio (Common carp)
Taxonomic identifieri7962 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCyprinus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 493ExtracellularSequence analysisAdd BLAST467
Transmembranei494 – 514HelicalSequence analysisAdd BLAST21
Topological domaini515 – 1216CytoplasmicSequence analysisAdd BLAST702

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000039580027 – 1216Receptor-type tyrosine-protein phosphatase CAdd BLAST1190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi64N-linked (GlcNAc...)Sequence analysis1
Glycosylationi92N-linked (GlcNAc...)Sequence analysis1
Glycosylationi98N-linked (GlcNAc...)Sequence analysis1
Glycosylationi135N-linked (GlcNAc...)Sequence analysis1
Glycosylationi160N-linked (GlcNAc...)Sequence analysis1
Glycosylationi179N-linked (GlcNAc...)Sequence analysis1
Glycosylationi185N-linked (GlcNAc...)Sequence analysis1
Glycosylationi205N-linked (GlcNAc...)Sequence analysis1
Glycosylationi240N-linked (GlcNAc...)Sequence analysis1
Glycosylationi283N-linked (GlcNAc...)Sequence analysis1
Glycosylationi301N-linked (GlcNAc...)Sequence analysis1
Glycosylationi349N-linked (GlcNAc...)Sequence analysis1
Glycosylationi365N-linked (GlcNAc...)Sequence analysis1
Glycosylationi375N-linked (GlcNAc...)Sequence analysis1
Glycosylationi393N-linked (GlcNAc...)Sequence analysis1
Glycosylationi478N-linked (GlcNAc...)Sequence analysis1
Modified residuei881PhosphoserineBy similarity1
Modified residuei903PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ9IBD8.

Structurei

3D structure databases

ProteinModelPortaliQ9IBD8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 165Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST95
Domaini298 – 395Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST98
Domaini401 – 491Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST91
Domaini563 – 819Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST257
Domaini850 – 1129Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST280

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni760 – 766Substrate bindingBy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi915 – 918Poly-Glu4

Sequence similaritiesi

Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG000066.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
3.90.190.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016335. Ptprc.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 2 hits.
[Graphical view]
PIRSFiPIRSF002004. Leukocyte_common_antigen. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9IBD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARFFALGPL VLVLCLVLFL SPTSTSEQDT DTKVTGSSNS PTIMQSATPT
60 70 80 90 100
PALPTGSVKG VKANDSGTTE VPCQYRLIVN GYEKNSLLVN INGSKSQNYT
110 120 130 140 150
IRIKDKKSEK KIPVSIVSDT TTIDILFEWL KPCTNYSVNI DNCNVVGENH
160 170 180 190 200
FNLNVLKSVN HSAEPKGDEQ VCFKDSKWNL TKCVNITTED SCVQKPIQIN
210 220 230 240 250
LETCNYTMNV HMPPVKPEIT FSESIPTKFV WSNKPLSSDN VTSQCKDTFK
260 270 280 290 300
VKCTDDTEYD LDKDVFLKPS EEYTCTGKYK YYNTSIDSKS KQVNIHCEWI
310 320 330 340 350
NETVFSEVTS NSIVIFWNLS PGDKCKGITW EKFSAICKKS HDQKCRKVND
360 370 380 390 400
TTAECVFSEL KSYINYTCTL SAEVNKSIGV FPIYTRDFNQ RTNSSNPSFE
410 420 430 440 450
DHDNVKVKET SHNSFNVNCK NLKPDEWNGP KGIYIAKLLS NRPPVTKENP
460 470 480 490 500
KSCSFTFENL YYHTEYTIEI IAINGNKNES SAKATHSTRY NDKALIGFLV
510 520 530 540 550
FLILVTSLAL LFVLYKLFLL KRKRTAEDEE ILLTQPLRRV EPIYAGGLVE
560 570 580 590 600
AYKNKIADEG RLFMDEFQSI PRIFSNYTIK EAKKSENQYK NRYVDILPYD
610 620 630 640 650
YNRVTLSTGG EDNYINASFI EGYREPKKYI AAQGPKDETV VDFWRMVWEQ
660 670 680 690 700
KSSIIVMVTR CEEGNKTKCA QYWPSLDREA EIFEEFVVKI RSEEHCPDYV
710 720 730 740 750
IRHLILNNKR EKGSEREVTH IQFISWPDHG VPGDPSLLLK LRRRVNSFKN
760 770 780 790 800
FFSGPVVVHC SAGVGRTGTY MSIDAMIESL EAEGRVDIYG FVAKLRRQRC
810 820 830 840 850
LMVQVEAQYI LIHTALIEYN QFGETEVSLS EFHSVLNTLR QKNGSDPSLL
860 870 880 890 900
EKEFQKLPKF KKWRTMNTGS SEDNKKKNRD SAVIPYDFNR VIFRLDIEGN
910 920 930 940 950
QTSDPEDEEE YSSDEEEESN QYINASFIDG YWCNKSLIAA QGPLQSTAEE
960 970 980 990 1000
FLLMLYQQQT KTLVMLTDCQ EDGKDYCFQY WGDEKKTYGD MEIEVKKTET
1010 1020 1030 1040 1050
FPTYVRRHLE IQSLKKKEVL KVDQYQFLKW RGRELPENAQ ELVEMASIIR
1060 1070 1080 1090 1100
ENGHYDNSKT NRNVPIVVHC NNGSSRTGIF CALWNLLDSA YTEKLVDVLQ
1110 1120 1130 1140 1150
EVKNLRKLRQ GMVETIEQYQ FLYTALEGAF PVQNGAVKTP PAKDAAQVIN
1160 1170 1180 1190 1200
ETTALLTEPN STSGADQKEA EESTAAESNE QGAKESSTAE APAAEGDGEK
1210
ATSEGPTNGP TATVEV
Length:1,216
Mass (Da):138,252
Last modified:October 1, 2000 - v1
Checksum:i9D2E45F41721D2CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031424 mRNA. Translation: BAA92179.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031424 mRNA. Translation: BAA92179.1.

3D structure databases

ProteinModelPortaliQ9IBD8.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9IBD8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG000066.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
3.90.190.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016335. Ptprc.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 2 hits.
[Graphical view]
PIRSFiPIRSF002004. Leukocyte_common_antigen. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTPRC_CYPCA
AccessioniPrimary (citable) accession number: Q9IBD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.