Receptor-type tyrosine-protein phosphatase C precursor - Cyprinus carpio (Common carp)

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Q9IBD8 (PTPRC_CYPCA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 67. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Receptor-type tyrosine-protein phosphatase C
EC=3.1.3.48

Alternative name(s):
Leukocyte common antigen
CD_antigen=CD45

Gene names

Name:

ptprc

Organism

Cyprinus carpio (Common carp)

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Cyprinus

Protein attributes

Sequence length	1216 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor By similarity.
Catalytic activity	Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate.
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily. Contains 3 fibronectin type-III domains. Contains 2 tyrosine-protein phosphatase domains.

Ontologies

Keywords
Cellular component	Membrane
Domain	Repeat Signal Transmembrane Transmembrane helix
Molecular function	Hydrolase Protein phosphatase
PTM	Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological_process	T cell receptor signaling pathway Inferred from electronic annotation. Source: InterPro peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

26

Potential

Chain

1190

Receptor-type tyrosine-protein phosphatase C

PRO_0000395800

Regions

Topological domain

467

Extracellular Potential

Transmembrane

21

Helical; Potential

Topological domain

702

Cytoplasmic Potential

Domain

92

Fibronectin type-III 1

Domain

89

Fibronectin type-III 2

Domain

86

Fibronectin type-III 3

Domain

257

Tyrosine-protein phosphatase 1

Domain

280

Tyrosine-protein phosphatase 2

Region

7

Substrate binding By similarity

Compositional bias

4

Poly-Glu

Sites

Active site

1

Phosphocysteine intermediate By similarity

Active site

1

Phosphocysteine intermediate By similarity

Binding site

1

Substrate By similarity

Binding site

1

Substrate By similarity

Amino acid modifications

Modified residue

1

Phosphoserine By similarity

Modified residue

1

Phosphoserine By similarity

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q9IBD8 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 9D2E45F41721D2CF
Show »

1,216

138,252

        10         20         30         40         50         60 
MARFFALGPL VLVLCLVLFL SPTSTSEQDT DTKVTGSSNS PTIMQSATPT PALPTGSVKG 

        70         80         90        100        110        120 
VKANDSGTTE VPCQYRLIVN GYEKNSLLVN INGSKSQNYT IRIKDKKSEK KIPVSIVSDT 

       130        140        150        160        170        180 
TTIDILFEWL KPCTNYSVNI DNCNVVGENH FNLNVLKSVN HSAEPKGDEQ VCFKDSKWNL 

       190        200        210        220        230        240 
TKCVNITTED SCVQKPIQIN LETCNYTMNV HMPPVKPEIT FSESIPTKFV WSNKPLSSDN 

       250        260        270        280        290        300 
VTSQCKDTFK VKCTDDTEYD LDKDVFLKPS EEYTCTGKYK YYNTSIDSKS KQVNIHCEWI 

       310        320        330        340        350        360 
NETVFSEVTS NSIVIFWNLS PGDKCKGITW EKFSAICKKS HDQKCRKVND TTAECVFSEL 

       370        380        390        400        410        420 
KSYINYTCTL SAEVNKSIGV FPIYTRDFNQ RTNSSNPSFE DHDNVKVKET SHNSFNVNCK 

       430        440        450        460        470        480 
NLKPDEWNGP KGIYIAKLLS NRPPVTKENP KSCSFTFENL YYHTEYTIEI IAINGNKNES 

       490        500        510        520        530        540 
SAKATHSTRY NDKALIGFLV FLILVTSLAL LFVLYKLFLL KRKRTAEDEE ILLTQPLRRV 

       550        560        570        580        590        600 
EPIYAGGLVE AYKNKIADEG RLFMDEFQSI PRIFSNYTIK EAKKSENQYK NRYVDILPYD 

       610        620        630        640        650        660 
YNRVTLSTGG EDNYINASFI EGYREPKKYI AAQGPKDETV VDFWRMVWEQ KSSIIVMVTR 

       670        680        690        700        710        720 
CEEGNKTKCA QYWPSLDREA EIFEEFVVKI RSEEHCPDYV IRHLILNNKR EKGSEREVTH 

       730        740        750        760        770        780 
IQFISWPDHG VPGDPSLLLK LRRRVNSFKN FFSGPVVVHC SAGVGRTGTY MSIDAMIESL 

       790        800        810        820        830        840 
EAEGRVDIYG FVAKLRRQRC LMVQVEAQYI LIHTALIEYN QFGETEVSLS EFHSVLNTLR 

       850        860        870        880        890        900 
QKNGSDPSLL EKEFQKLPKF KKWRTMNTGS SEDNKKKNRD SAVIPYDFNR VIFRLDIEGN 

       910        920        930        940        950        960 
QTSDPEDEEE YSSDEEEESN QYINASFIDG YWCNKSLIAA QGPLQSTAEE FLLMLYQQQT 

       970        980        990       1000       1010       1020 
KTLVMLTDCQ EDGKDYCFQY WGDEKKTYGD MEIEVKKTET FPTYVRRHLE IQSLKKKEVL 

      1030       1040       1050       1060       1070       1080 
KVDQYQFLKW RGRELPENAQ ELVEMASIIR ENGHYDNSKT NRNVPIVVHC NNGSSRTGIF 

      1090       1100       1110       1120       1130       1140 
CALWNLLDSA YTEKLVDVLQ EVKNLRKLRQ GMVETIEQYQ FLYTALEGAF PVQNGAVKTP 

      1150       1160       1170       1180       1190       1200 
PAKDAAQVIN ETTALLTEPN STSGADQKEA EESTAAESNE QGAKESSTAE APAAEGDGEK 

      1210 
ATSEGPTNGP TATVEV

References

[1]

"Molecular cloning of carp (Cyprinus carpio) leucocyte cell-derived chemotaxin 2, glia maturation factor beta, CD45 and lysozyme C by use of suppression subtractive hybridisation."
Fujiki K., Shin D.H., Nakao M., Yano T.
Fish Shellfish Immunol. 10:643-650(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB031424 mRNA. Translation: BAA92179.1.
3D structure databases
HSSP	HSSP built from PDB template 1YFO based on UniProtKB P18052.
ProteinModelPortal	Q9IBD8.
SMR	Q9IBD8. Positions 537-1131.
ModBase	Search...
Proteomic databases
PRIDE	Q9IBD8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG000066.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR003961. Fibronectin_type3. IPR013783. Ig-like_fold. IPR016335. Leukocyte_common_ag. IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. IPR000242. Tyr_Pase_rcpt/non-rcpt. [Graphical view]
Pfam	PF00102. Y_phosphatase. 2 hits. [Graphical view]
PIRSF	PIRSF002004. Leukocyte_common_antigen. 1 hit.
PRINTS	PR00700. PRTYPHPHTASE.
SMART	SM00060. FN3. 2 hits. SM00194. PTPc. 2 hits. [Graphical view]
PROSITE	PS50853. FN3. 3 hits. PS00383. TYR_PHOSPHATASE_1. 2 hits. PS50056. TYR_PHOSPHATASE_2. 2 hits. PS50055. TYR_PHOSPHATASE_PTP. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PTPRC_CYPCA

Accession

Primary (citable) accession number: Q9IBD8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 13, 2010
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents