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Q9IBD8

- PTPRC_CYPCA

UniProt

Q9IBD8 - PTPRC_CYPCA

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Protein
Receptor-type tyrosine-protein phosphatase C
Gene
ptprc
Organism
Cyprinus carpio (Common carp)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor By similarity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei728 – 7281Substrate By similarity
Active sitei760 – 7601Phosphocysteine intermediate By similarity
Binding sitei804 – 8041Substrate By similarity
Active sitei1070 – 10701Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. T cell receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase C (EC:3.1.3.48)
Alternative name(s):
Leukocyte common antigen
CD_antigen: CD45
Gene namesi
Name:ptprc
OrganismiCyprinus carpio (Common carp)
Taxonomic identifieri7962 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCyprinus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 493467Extracellular Reviewed prediction
Add
BLAST
Transmembranei494 – 51421Helical; Reviewed prediction
Add
BLAST
Topological domaini515 – 1216702Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed prediction
Add
BLAST
Chaini27 – 12161190Receptor-type tyrosine-protein phosphatase C
PRO_0000395800Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi64 – 641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi92 – 921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi98 – 981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi135 – 1351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi160 – 1601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi179 – 1791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi185 – 1851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi205 – 2051N-linked (GlcNAc...) Reviewed prediction
Glycosylationi240 – 2401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi283 – 2831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi301 – 3011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi349 – 3491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi365 – 3651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi375 – 3751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi393 – 3931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi478 – 4781N-linked (GlcNAc...) Reviewed prediction
Modified residuei881 – 8811Phosphoserine By similarity
Modified residuei903 – 9031Phosphoserine By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ9IBD8.

Structurei

3D structure databases

ProteinModelPortaliQ9IBD8.
SMRiQ9IBD8. Positions 537-1131.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini71 – 16595Fibronectin type-III 1
Add
BLAST
Domaini298 – 39598Fibronectin type-III 2
Add
BLAST
Domaini401 – 49191Fibronectin type-III 3
Add
BLAST
Domaini563 – 819257Tyrosine-protein phosphatase 1
Add
BLAST
Domaini850 – 1129280Tyrosine-protein phosphatase 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni760 – 7667Substrate binding By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi915 – 9184Poly-Glu

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG000066.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.90.190.10. 2 hits.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR016335. Leukocyte_common_ag.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 2 hits.
[Graphical view]
PIRSFiPIRSF002004. Leukocyte_common_antigen. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 2 hits.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9IBD8-1 [UniParc]FASTAAdd to Basket

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MARFFALGPL VLVLCLVLFL SPTSTSEQDT DTKVTGSSNS PTIMQSATPT     50
PALPTGSVKG VKANDSGTTE VPCQYRLIVN GYEKNSLLVN INGSKSQNYT 100
IRIKDKKSEK KIPVSIVSDT TTIDILFEWL KPCTNYSVNI DNCNVVGENH 150
FNLNVLKSVN HSAEPKGDEQ VCFKDSKWNL TKCVNITTED SCVQKPIQIN 200
LETCNYTMNV HMPPVKPEIT FSESIPTKFV WSNKPLSSDN VTSQCKDTFK 250
VKCTDDTEYD LDKDVFLKPS EEYTCTGKYK YYNTSIDSKS KQVNIHCEWI 300
NETVFSEVTS NSIVIFWNLS PGDKCKGITW EKFSAICKKS HDQKCRKVND 350
TTAECVFSEL KSYINYTCTL SAEVNKSIGV FPIYTRDFNQ RTNSSNPSFE 400
DHDNVKVKET SHNSFNVNCK NLKPDEWNGP KGIYIAKLLS NRPPVTKENP 450
KSCSFTFENL YYHTEYTIEI IAINGNKNES SAKATHSTRY NDKALIGFLV 500
FLILVTSLAL LFVLYKLFLL KRKRTAEDEE ILLTQPLRRV EPIYAGGLVE 550
AYKNKIADEG RLFMDEFQSI PRIFSNYTIK EAKKSENQYK NRYVDILPYD 600
YNRVTLSTGG EDNYINASFI EGYREPKKYI AAQGPKDETV VDFWRMVWEQ 650
KSSIIVMVTR CEEGNKTKCA QYWPSLDREA EIFEEFVVKI RSEEHCPDYV 700
IRHLILNNKR EKGSEREVTH IQFISWPDHG VPGDPSLLLK LRRRVNSFKN 750
FFSGPVVVHC SAGVGRTGTY MSIDAMIESL EAEGRVDIYG FVAKLRRQRC 800
LMVQVEAQYI LIHTALIEYN QFGETEVSLS EFHSVLNTLR QKNGSDPSLL 850
EKEFQKLPKF KKWRTMNTGS SEDNKKKNRD SAVIPYDFNR VIFRLDIEGN 900
QTSDPEDEEE YSSDEEEESN QYINASFIDG YWCNKSLIAA QGPLQSTAEE 950
FLLMLYQQQT KTLVMLTDCQ EDGKDYCFQY WGDEKKTYGD MEIEVKKTET 1000
FPTYVRRHLE IQSLKKKEVL KVDQYQFLKW RGRELPENAQ ELVEMASIIR 1050
ENGHYDNSKT NRNVPIVVHC NNGSSRTGIF CALWNLLDSA YTEKLVDVLQ 1100
EVKNLRKLRQ GMVETIEQYQ FLYTALEGAF PVQNGAVKTP PAKDAAQVIN 1150
ETTALLTEPN STSGADQKEA EESTAAESNE QGAKESSTAE APAAEGDGEK 1200
ATSEGPTNGP TATVEV 1216
Length:1,216
Mass (Da):138,252
Last modified:October 1, 2000 - v1
Checksum:i9D2E45F41721D2CF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB031424 mRNA. Translation: BAA92179.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB031424 mRNA. Translation: BAA92179.1 .

3D structure databases

ProteinModelPortali Q9IBD8.
SMRi Q9IBD8. Positions 537-1131.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9IBD8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG000066.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.90.190.10. 2 hits.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR016335. Leukocyte_common_ag.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00102. Y_phosphatase. 2 hits.
[Graphical view ]
PIRSFi PIRSF002004. Leukocyte_common_antigen. 1 hit.
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 2 hits.
SM00194. PTPc. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEi PS50853. FN3. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of carp (Cyprinus carpio) leucocyte cell-derived chemotaxin 2, glia maturation factor beta, CD45 and lysozyme C by use of suppression subtractive hybridisation."
    Fujiki K., Shin D.H., Nakao M., Yano T.
    Fish Shellfish Immunol. 10:643-650(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPTPRC_CYPCA
AccessioniPrimary (citable) accession number: Q9IBD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: October 1, 2000
Last modified: June 11, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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