Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9IB83 (PSB1B_CARAU) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome subunit beta type-1-B

EC=3.4.25.1
Alternative name(s):
20S proteasome beta-6 subunit B
Short name=B6-B
Gene names
Name:psmb1-B
OrganismCarassius auratus (Goldfish)
Taxonomic identifier7957 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCarassius

Protein attributes

Sequence length237 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity.

Catalytic activity

Cleavage of peptide bonds with very broad specificity.

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the peptidase T1B family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 237237Proteasome subunit beta type-1-B
PRO_0000148034

Sequences

Sequence LengthMass (Da)Tools
Q9IB83 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 1E7C5B8A62789CC6

FASTA23726,002
        10         20         30         40         50         60 
MISAQACGAN GKMKDYHYSG PVEHKFSPYA FNGGTVLAVA GEDFALVASD TRLSEGYSIH 

        70         80         90        100        110        120 
SRDSPKCYKL TDTTVIGCSG FHGDCLTLTK IIEARLKMYK HSNNKSMTSG AIAAMLSTIL 

       130        140        150        160        170        180 
YGRRFFPYYV YNIIGGLDEE GRGAVYSFDP VGSYQRDTYK AGGSASAMLQ PLLDNQIGFK 

       190        200        210        220        230 
NMENVEQVPL SQEKAVQLVK DVFISAAERD VYTGDALKIC IITKEGIREE IVPLRKD 

« Hide

References

[1]"Identification of the goldfish 20S proteasome beta6 subunit bound to nuclear matrix."
Tokumoto M., Yamaguchi A., Nagahama Y., Tokumoto T.
FEBS Lett. 472:62-66(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ovary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB035497 mRNA. Translation: BAA95592.1.

3D structure databases

ProteinModelPortalQ9IB83.
SMRQ9IB83. Positions 25-237.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPST01.986.

Proteomic databases

PRIDEQ9IB83.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG000961.

Family and domain databases

Gene3D3.60.20.10. 1 hit.
InterProIPR029055. Ntn_hydrolases_N.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamPF00227. Proteasome. 1 hit.
[Graphical view]
SUPFAMSSF56235. SSF56235. 1 hit.
PROSITEPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePSB1B_CARAU
AccessionPrimary (citable) accession number: Q9IB83
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 1, 2000
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries