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Q9IAX2

- IOD2_CHICK

UniProt

Q9IAX2 - IOD2_CHICK

Protein

Type II iodothyronine deiodinase

Gene

DIO2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 3 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.By similarity1 Publication

    Catalytic activityi

    3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.PROSITE-ProRule annotation

    Enzyme regulationi

    Not inhibited by N(6)-propylthiouracil.

    Kineticsi

    1. KM=1.1 nM for thyroxine1 Publication

    Vmax=0.34 pmol/min/mg enzyme1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei132 – 1321

    GO - Molecular functioni

    1. thyroxine 5'-deiodinase activity Source: UniProtKB

    GO - Biological processi

    1. hormone biosynthetic process Source: UniProtKB-KW
    2. thyroid hormone generation Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Thyroid hormones biosynthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type II iodothyronine deiodinase (EC:1.97.1.10)
    Alternative name(s):
    5DII
    DIOII
    Type 2 DI
    Type-II 5'-deiodinase
    Gene namesi
    Name:DIO2
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 279279Type II iodothyronine deiodinasePRO_0000154320Add
    BLAST

    Proteomic databases

    PRIDEiQ9IAX2.

    Expressioni

    Tissue specificityi

    Highly expressed in liver and in various parts of the brain including telencephalon, hippocampus, cerebellum, and brain stem, and weakly expressed in thyroid, lung, and small intestine. Not detected in skeletal muscle, heart atria or ventricle, gizzard or kidney.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ9IAX2.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the iodothyronine deiodinase family.Sequence Analysis

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG000099.
    PhylomeDBiQ9IAX2.

    Family and domain databases

    InterProiIPR000643. Iodothyronine_deiodinase.
    IPR008261. Iodothyronine_deiodinase_AS.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PANTHERiPTHR11781. PTHR11781. 1 hit.
    PfamiPF00837. T4_deiodinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001330. IOD. 1 hit.
    SUPFAMiSSF52833. SSF52833. 1 hit.
    PROSITEiPS01205. T4_DEIODINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9IAX2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLLSADLLI TLQILPVFFS NCLFLALYDS VILLKHMVLF LSRSKSARGE    50
    WRRMLTSEGL RCVWNSFLLD AYKQVKLGGE APNSSVIHIA KGNDGSNSSW 100
    KSVGGKCGTK CHLLDFANSE RPLVVNFGSA TUPPFTSQLS AFSKLVEEFS 150
    GVADFLLVYI DEAHPSDGWA APGISPSSFE VKKHRNQEDR CAAAHQLLER 200
    FSLPPQCQVV ADCMDNNANV AYGVSFERVC IVQRQKIAYL GGKGPFFYNL 250
    QEVRLWLEQN FSKRUNPLST EDLSTDVSL 279
    Length:279
    Mass (Da):31,033
    Last modified:February 26, 2008 - v3
    Checksum:iBC249728E2A8E9C1
    GO

    Non-standard residue

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-standard residuei132 – 1321Selenocysteine1 Publication
    Non-standard residuei265 – 2651Selenocysteine1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF125575 mRNA. Translation: AAD33251.1.
    UniGeneiGga.1819.
    Gga.51485.

    Keywords - Coding sequence diversityi

    Selenocysteine

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF125575 mRNA. Translation: AAD33251.1 .
    UniGenei Gga.1819.
    Gga.51485.

    3D structure databases

    ProteinModelPortali Q9IAX2.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9IAX2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG000099.
    PhylomeDBi Q9IAX2.

    Family and domain databases

    InterProi IPR000643. Iodothyronine_deiodinase.
    IPR008261. Iodothyronine_deiodinase_AS.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    PANTHERi PTHR11781. PTHR11781. 1 hit.
    Pfami PF00837. T4_deiodinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001330. IOD. 1 hit.
    SUPFAMi SSF52833. SSF52833. 1 hit.
    PROSITEi PS01205. T4_DEIODINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of the chicken type 2 iodothyronine 5'-deiodinase."
      Gereben B., Bartha T., Tu H.M., Harney J.W., Rudas P., Larsen P.R.
      J. Biol. Chem. 274:13768-13776(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
      Tissue: Embryo1 Publication and Pituitary1 Publication.

    Entry informationi

    Entry nameiIOD2_CHICK
    AccessioniPrimary (citable) accession number: Q9IAX2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 74 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3