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Q9IAX2

- IOD2_CHICK

UniProt

Q9IAX2 - IOD2_CHICK

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Protein

Type II iodothyronine deiodinase

Gene

DIO2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.By similarity1 Publication

Catalytic activityi

3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.PROSITE-ProRule annotation

Enzyme regulationi

Not inhibited by N(6)-propylthiouracil.

Kineticsi

  1. KM=1.1 nM for thyroxine1 Publication

Vmax=0.34 pmol/min/mg enzyme1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei132 – 1321

GO - Molecular functioni

  1. thyroxine 5'-deiodinase activity Source: UniProtKB

GO - Biological processi

  1. hormone biosynthetic process Source: UniProtKB-KW
  2. thyroid hormone generation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Thyroid hormones biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Type II iodothyronine deiodinase (EC:1.97.1.10)
Alternative name(s):
5DII
DIOII
Type 2 DI
Type-II 5'-deiodinase
Gene namesi
Name:DIO2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 279279Type II iodothyronine deiodinasePRO_0000154320Add
BLAST

Proteomic databases

PRIDEiQ9IAX2.

Expressioni

Tissue specificityi

Highly expressed in liver and in various parts of the brain including telencephalon, hippocampus, cerebellum, and brain stem, and weakly expressed in thyroid, lung, and small intestine. Not detected in skeletal muscle, heart atria or ventricle, gizzard or kidney.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9IAX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the iodothyronine deiodinase family.Sequence Analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG000099.
InParanoidiQ9IAX2.
PhylomeDBiQ9IAX2.

Family and domain databases

InterProiIPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11781. PTHR11781. 1 hit.
PfamiPF00837. T4_deiodinase. 1 hit.
[Graphical view]
PIRSFiPIRSF001330. IOD. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS01205. T4_DEIODINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9IAX2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLLSADLLI TLQILPVFFS NCLFLALYDS VILLKHMVLF LSRSKSARGE
60 70 80 90 100
WRRMLTSEGL RCVWNSFLLD AYKQVKLGGE APNSSVIHIA KGNDGSNSSW
110 120 130 140 150
KSVGGKCGTK CHLLDFANSE RPLVVNFGSA TUPPFTSQLS AFSKLVEEFS
160 170 180 190 200
GVADFLLVYI DEAHPSDGWA APGISPSSFE VKKHRNQEDR CAAAHQLLER
210 220 230 240 250
FSLPPQCQVV ADCMDNNANV AYGVSFERVC IVQRQKIAYL GGKGPFFYNL
260 270
QEVRLWLEQN FSKRUNPLST EDLSTDVSL
Length:279
Mass (Da):31,033
Last modified:February 26, 2008 - v3
Checksum:iBC249728E2A8E9C1
GO

Non-standard residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-standard residuei132 – 1321Selenocysteine1 Publication
Non-standard residuei265 – 2651Selenocysteine1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125575 mRNA. Translation: AAD33251.1.
UniGeneiGga.1819.
Gga.51485.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125575 mRNA. Translation: AAD33251.1 .
UniGenei Gga.1819.
Gga.51485.

3D structure databases

ProteinModelPortali Q9IAX2.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9IAX2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG000099.
InParanoidi Q9IAX2.
PhylomeDBi Q9IAX2.

Family and domain databases

InterProi IPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
PANTHERi PTHR11781. PTHR11781. 1 hit.
Pfami PF00837. T4_deiodinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001330. IOD. 1 hit.
SUPFAMi SSF52833. SSF52833. 1 hit.
PROSITEi PS01205. T4_DEIODINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of the chicken type 2 iodothyronine 5'-deiodinase."
    Gereben B., Bartha T., Tu H.M., Harney J.W., Rudas P., Larsen P.R.
    J. Biol. Chem. 274:13768-13776(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
    Tissue: Embryo1 Publication and Pituitary1 Publication.

Entry informationi

Entry nameiIOD2_CHICK
AccessioniPrimary (citable) accession number: Q9IAX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: February 26, 2008
Last modified: November 26, 2014
This is version 76 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3