Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Basic phospholipase A2 homolog BnSP-7

Gene
N/A
Organism
Bothrops pauloensis (Neuwied's lancehead) (Bothrops neuwiedi pauloensis)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Snake venom phospholipase A2 (PLA2) that lacks enzymatic activity. Is myotoxic. Displays bactericidal activity and promotes the blockage of the neuromuscular contraction of the chick biventer cervicis muscle. Also disrupts artificial membranes, and provokes tissue damages characterized by edema, necrosis and inflammation. May act as pro-inflammatory mediators, inducing metalloproteinase and cytokine production from the inflammatory and satellite cells.3 Publications

Caution

Does not bind calcium as one of the calcium-binding sites is lost (Asp->Lys in position 47, which corresponds to 'Lys-49' in the current nomenclature).Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Myotoxin, Neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Basic phospholipase A2 homolog BnSP-7
Short name:
svPLA2 homolog
Alternative name(s):
Phospholipase A2 II
OrganismiBothrops pauloensis (Neuwied's lancehead) (Bothrops neuwiedi pauloensis)
Taxonomic identifieri1042543 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeBothrops

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

LD50 is 7.8 mg/kg by intraperitoneal injection into mice.1 Publication

Chemistry databases

ChEMBLiCHEMBL2146345

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001616251 – 120Basic phospholipase A2 homolog BnSP-7Add BLAST120

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 1141 Publication
Disulfide bondi27 ↔ 431 Publication
Disulfide bondi42 ↔ 941 Publication
Disulfide bondi48 ↔ 1201 Publication
Disulfide bondi49 ↔ 871 Publication
Disulfide bondi56 ↔ 801 Publication
Disulfide bondi74 ↔ 851 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Homodimer.1 Publication

Structurei

Secondary structure

1120
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1 – 12Combined sources12
Helixi16 – 20Combined sources5
Turni24 – 26Combined sources3
Beta strandi27 – 30Combined sources4
Helixi38 – 51Combined sources14
Turni58 – 60Combined sources3
Beta strandi65 – 67Combined sources3
Beta strandi72 – 74Combined sources3
Helixi79 – 97Combined sources19
Helixi98 – 101Combined sources4
Helixi104 – 106Combined sources3
Helixi111 – 113Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PA0X-ray2.20A/B2-120[»]
1PC9X-ray2.50A/B2-120[»]
3MLMX-ray2.21A/B1-120[»]
5VFHX-ray1.59A/B1-120[»]
5VFJX-ray2.08A/B1-120[»]
5VFMX-ray2.06A/B1-120[»]
5VFNX-ray2.39A/B1-120[»]
SMRiQ9IAT9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9IAT9

Family & Domainsi

Sequence similaritiesi

Family and domain databases

CDDicd00125 PLA2c, 1 hit
Gene3Di1.20.90.10, 1 hit
InterProiView protein in InterPro
IPR001211 PLipase_A2
IPR033112 PLipase_A2_Asp_AS
IPR016090 PLipase_A2_dom
IPR036444 PLipase_A2_dom_sf
IPR033113 PLipase_A2_His_AS
PANTHERiPTHR11716 PTHR11716, 1 hit
PfamiView protein in Pfam
PF00068 Phospholip_A2_1, 1 hit
PRINTSiPR00389 PHPHLIPASEA2
SMARTiView protein in SMART
SM00085 PA2c, 1 hit
SUPFAMiSSF48619 SSF48619, 1 hit
PROSITEiView protein in PROSITE
PS00119 PA2_ASP, 1 hit
PS00118 PA2_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Q9IAT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SFELGKMILQ ETGKNPAKSY GAYGCNCGVL GRGQPKDATD RCCYVHKCCY
60 70 80 90 100
KKLTGCDPKK DRYSYSWKDK TIVCGENNPC LKELCECDKA VAICLRENLG
110 120
TYNKKYRYHL KPFCKKADPC
Length:120
Mass (Da):13,614
Last modified:June 16, 2009 - v2
Checksum:iD6DF3C42CC26CAF5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti34Q → G in BnSP-6. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145781 mRNA Translation: AAF66703.1

Similar proteinsi

Entry informationi

Entry nameiPA2H_BOTPA
AccessioniPrimary (citable) accession number: Q9IAT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: June 16, 2009
Last modified: March 28, 2018
This is version 84 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health