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Protein

Delta-like protein C

Gene

dlc

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a ligand for Notch receptors and is involved in somitogenesis. Can activate Notch receptors. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized.1 Publication

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • identical protein binding Source: ZFIN
  • PDZ domain binding Source: ZFIN

GO - Biological processi

  • arterial endothelial cell differentiation Source: ZFIN
  • blood vessel morphogenesis Source: ZFIN
  • dorsal aorta development Source: ZFIN
  • hematopoietic progenitor cell differentiation Source: ZFIN
  • hematopoietic stem cell differentiation Source: ZFIN
  • neuron development Source: ZFIN
  • Notch signaling pathway Source: ZFIN
  • sclerotome development Source: ZFIN
  • somite specification Source: ZFIN
  • somitogenesis Source: ZFIN
  • ventral spinal cord interneuron differentiation Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Notch signaling pathway

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-like protein C
Short name:
DeltaC
Short name:
delC
Gene namesi
Name:dlc
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-000125-4. dlc.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 511491ExtracellularSequence analysisAdd
BLAST
Transmembranei512 – 53221HelicalSequence analysisAdd
BLAST
Topological domaini533 – 664132CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: ZFIN
  • integral component of membrane Source: UniProtKB-KW
  • perinuclear region of cytoplasm Source: ZFIN
  • plasma membrane Source: ZFIN
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 664644Delta-like protein CPRO_0000007516Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi156 ↔ 165By similarity
Disulfide bondi169 ↔ 181By similarity
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence analysis
Disulfide bondi189 ↔ 198By similarity
Disulfide bondi203 ↔ 214By similarity
Disulfide bondi207 ↔ 220By similarity
Disulfide bondi222 ↔ 231By similarity
Disulfide bondi234 ↔ 245By similarity
Disulfide bondi240 ↔ 251By similarity
Disulfide bondi253 ↔ 262By similarity
Disulfide bondi269 ↔ 281By similarity
Disulfide bondi275 ↔ 291By similarity
Disulfide bondi293 ↔ 302By similarity
Disulfide bondi309 ↔ 320By similarity
Disulfide bondi314 ↔ 329By similarity
Disulfide bondi331 ↔ 340By similarity
Disulfide bondi347 ↔ 358By similarity
Disulfide bondi352 ↔ 368By similarity
Disulfide bondi370 ↔ 379By similarity
Disulfide bondi386 ↔ 397By similarity
Disulfide bondi391 ↔ 406By similarity
Disulfide bondi408 ↔ 417By similarity
Disulfide bondi424 ↔ 435By similarity
Disulfide bondi429 ↔ 444By similarity
Disulfide bondi446 ↔ 455By similarity
Disulfide bondi462 ↔ 473By similarity
Disulfide bondi467 ↔ 482By similarity
Disulfide bondi484 ↔ 493By similarity

Post-translational modificationi

Ubiquitinated by mib, leading to its endocytosis and subsequent degradation.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9IAT6.

Expressioni

Tissue specificityi

Strongly expressed in the early retina, where it precedes other delta proteins. Also expressed in cranial ganglia, in sensory epithelia including ear and lateral line and in scattered epidermal cells. In the mesoderm, expression is visible by 50% epiboly; it is expressed subsequently in the tail bud, in stripes in the presomitic mesoderm and in the posterior half of each somite. Also expressed in notochord, blood vessels and pronephros. In contrast to other delta proteins, it is not expressed in the majority of nascent primary neurons. In somites, it marks the posterior part of each formed somite, while deltaD (dld) marks the anterior part.1 Publication

Interactioni

GO - Molecular functioni

  • identical protein binding Source: ZFIN
  • PDZ domain binding Source: ZFIN

Protein-protein interaction databases

BioGridi78356. 3 interactions.
STRINGi7955.ENSDARP00000018643.

Structurei

3D structure databases

ProteinModelPortaliQ9IAT6.
SMRiQ9IAT6. Positions 156-304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini154 – 19845DSLPROSITE-ProRule annotationAdd
BLAST
Domaini199 – 23234EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini233 – 26331EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini265 – 30339EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini305 – 34137EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini343 – 38038EGF-like 5PROSITE-ProRule annotationAdd
BLAST
Domaini382 – 41837EGF-like 6PROSITE-ProRule annotationAdd
BLAST
Domaini420 – 45637EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini458 – 49437EGF-like 8PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DSL domain.PROSITE-ProRule annotation
Contains 8 EGF-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IR66. Eukaryota.
ENOG410YWUI. LUCA.
HOGENOMiHOG000267024.
HOVERGENiHBG007139.
InParanoidiQ9IAT6.
KOiK06051.
PhylomeDBiQ9IAT6.

Family and domain databases

InterProiIPR001774. DSL.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
[Graphical view]
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 5 hits.
PF12661. hEGF. 1 hit.
[Graphical view]
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 8 hits.
SM00179. EGF_CA. 6 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 8 hits.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 7 hits.
PS01187. EGF_CA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9IAT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARVLLTCFF ILISSHLGKS SGVFELKVLS FTSTSSVCKG SSDCQIFFRV
60 70 80 90 100
CLKHSQALIL PEPPCTYGTG MSEILSADSI SSSAYISVPF NFKWPGIVSL
110 120 130 140 150
IIETWNAETS DQSTENNNNM ISRLATKRRL AISEDWSQDV HLGRQSQLRF
160 170 180 190 200
SYRVVCDEFY HGEECSDFCR PRNDTFGHFN CDAAGNRICL PGWKGDYCTE
210 220 230 240 250
PICLSGCSEE NGYCEAPGEC KCRIGWEGPL CDECTRHPGC LHGTCNQPFQ
260 270 280 290 300
CTCKEGWGGL FCNEDLNFCT NHKPCRNDAT CTNTGQGSYT CICKPGFSGK
310 320 330 340 350
NCEIETNECD SNPCKNGGSC NDQENDYTCT CPQGFYGKNC EVSAMTCADG
360 370 380 390 400
PCFNGGTCME KGSGSYSCRC PPGYMGSNCE KKIDRCSSDP CANGGQCLDL
410 420 430 440 450
GNKATCRCRP GFTGSRCETN IDDCSSNPCQ NAGTCVDGIN GYTCTCTLGF
460 470 480 490 500
SGKDCRVRSD ACSFMPCQNG GTCYTHFSGP VCQCPAGFMG TQCEYKQKPT
510 520 530 540 550
PVNSPALPAA LIVSFTLGLI TLTLVICAAI VVLRQMRQNH KASSTTVRNN
560 570 580 590 600
LDSVNNRISL SPTSPLGREK EAFLIPGGPF KVSNKDMALR STSVDTHSSD
610 620 630 640 650
KSNYKQKMVD YNLSIDEKHT NNKLEKNSES TLLVPPLNYP KEGVYHPVYI
660
IPEHIEQRVF ATEV
Length:664
Mass (Da):72,548
Last modified:October 1, 2000 - v1
Checksum:i0AD6C34C8579116B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146429 mRNA. Translation: AAF27299.1.
RefSeqiNP_571019.1. NM_130944.1.
UniGeneiDr.81314.

Genome annotation databases

GeneIDi30120.
KEGGidre:30120.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146429 mRNA. Translation: AAF27299.1.
RefSeqiNP_571019.1. NM_130944.1.
UniGeneiDr.81314.

3D structure databases

ProteinModelPortaliQ9IAT6.
SMRiQ9IAT6. Positions 156-304.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi78356. 3 interactions.
STRINGi7955.ENSDARP00000018643.

Proteomic databases

PaxDbiQ9IAT6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi30120.
KEGGidre:30120.

Organism-specific databases

CTDi30120.
ZFINiZDB-GENE-000125-4. dlc.

Phylogenomic databases

eggNOGiENOG410IR66. Eukaryota.
ENOG410YWUI. LUCA.
HOGENOMiHOG000267024.
HOVERGENiHBG007139.
InParanoidiQ9IAT6.
KOiK06051.
PhylomeDBiQ9IAT6.

Miscellaneous databases

NextBioi20806599.
PROiQ9IAT6.

Family and domain databases

InterProiIPR001774. DSL.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
[Graphical view]
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 5 hits.
PF12661. hEGF. 1 hit.
[Graphical view]
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 8 hits.
SM00179. EGF_CA. 6 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 8 hits.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 7 hits.
PS01187. EGF_CA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence and embryonic expression of deltaC in the zebrafish."
    Smithers L.E., Haddon C., Jiang Y.-J., Lewis J.
    Mech. Dev. 90:119-123(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Notch signalling and the synchronization of the somite segmentation clock."
    Jiang Y.-J., Aerne B.L., Smithers L., Haddon C., Ish-Horowicz D., Lewis J.
    Nature 408:475-479(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiDLLC_DANRE
AccessioniPrimary (citable) accession number: Q9IAT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 1, 2000
Last modified: May 11, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.