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Protein

Double-strand break repair protein MRE11

Gene

MRE11

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation (By similarity).By similarity

Cofactori

Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei129Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Exonuclease, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repair, Meiosis

Keywords - Ligandi

Manganese

Enzyme and pathway databases

ReactomeiR-GGA-217106. Chk1-controlled and DNA-damage induced centrosome duplication.
R-GGA-351442. ATM mediated response to DNA double-strand break.
R-GGA-351444. Recruitment of repair and signaling proteins to double-strand breaks.

Names & Taxonomyi

Protein namesi
Recommended name:
Double-strand break repair protein MRE11
Gene namesi
Name:MRE11
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Nucleus By similarity

  • Note: Localizes to discrete nuclear foci after treatment with genotoxic agents.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001386761 – 700Double-strand break repair protein MRE11Add BLAST700

Proteomic databases

PaxDbiQ9IAM7.
PRIDEiQ9IAM7.

Interactioni

Subunit structurei

Component of the MRN complex composed of two heterodimers RAD50/MRE11A associated with a single NBN. Component of the BASC complex, at least composed of BRCA1, MSH2, MSH6, MLH1, ATM, BLM, RAD50, MRE11A and NBN. Interacts with DCLRE1C/Artemis (By similarity).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000035634.

Structurei

3D structure databases

ProteinModelPortaliQ9IAM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MRE11/RAD32 family.Curated

Phylogenomic databases

eggNOGiKOG2310. Eukaryota.
COG0420. LUCA.
HOGENOMiHOG000216581.
HOVERGENiHBG052508.
InParanoidiQ9IAM7.
KOiK10865.
PhylomeDBiQ9IAM7.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR003701. Mre11.
IPR007281. Mre11_DNA-bd.
[Graphical view]
PANTHERiPTHR10139:SF1. PTHR10139:SF1. 1 hit.
PfamiPF00149. Metallophos. 1 hit.
PF04152. Mre11_DNA_bind. 1 hit.
[Graphical view]
PIRSFiPIRSF000882. DSB_repair_MRE11. 1 hit.
SMARTiSM01347. Mre11_DNA_bind. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 2 hits.
TIGRFAMsiTIGR00583. mre11. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9IAM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAVSLQDDE DTFKILIATD IHLGYLEKDA VRGNDTFVTF NEILEHAQKN
60 70 80 90 100
EVDFILLGGD LFHENKPSRK TIHTCLESLR KYCMGDRPVS FEVLSDQAVN
110 120 130 140 150
FQLSKFPWVN YQDENLNIFM PIFSIHGNHD DPTGVDALCA LDILSCAGLL
160 170 180 190 200
NHFGRSTSVE KIDISPILLR KGRTKIALYG LGAIPDERLY RMFVNKQVTM
210 220 230 240 250
LRPKEDEDSW FNMFVIHQNR SKHGATNYIP EQFLDDFINL AVWGHEHECK
260 270 280 290 300
ITPAQNEQQH FYVTQPGSSV VTSLSPGEAV KKHIGLLRVK GKKMKMQRIA
310 320 330 340 350
LETVRTFYME DVVLADHPEL FNPDNPKVTQ AIQAFCMEKV EMMLDNAERE
360 370 380 390 400
RLGNPRQPQK PLIILRVDYT GGFEPFIVHR FSQKYMDRVA NPKDIIHFFR
410 420 430 440 450
HREQKEKNDN DINFGKLLSR PASEEVTLRV EDLVKQYFQT AEKKVQLSLL
460 470 480 490 500
TERRMGEAVQ EFVDKEEKDA IEELVKFQLE KTQRFLKERH IDAEEEKIDE
510 520 530 540 550
EVRKFRESRR KNTEEEDEEV REAMTRARAH RSEGVVLDSA SSDEGLMDTG
560 570 580 590 600
MKASGDSDDD IPTTLSRGRG RGRARGARGQ NSAARGSSRR GRGNTSQGSS
610 620 630 640 650
TSSRTYKSVP DKNSSIMDAF RSLKPEPSQS TSKFFSEDII DDEMDLEESP
660 670 680 690 700
ISLSSKTNQR SSAMSSFSKR GSQSQMSRGV DFESDEDDPF KNTATSRRKK
Length:700
Mass (Da):80,024
Last modified:October 1, 2000 - v1
Checksum:i53039A0FFEFE5292
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF166094 mRNA. Translation: AAF31354.1.
RefSeqiNP_990109.1. NM_204778.1.
UniGeneiGga.3157.

Genome annotation databases

GeneIDi395555.
KEGGigga:395555.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF166094 mRNA. Translation: AAF31354.1.
RefSeqiNP_990109.1. NM_204778.1.
UniGeneiGga.3157.

3D structure databases

ProteinModelPortaliQ9IAM7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000035634.

Proteomic databases

PaxDbiQ9IAM7.
PRIDEiQ9IAM7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395555.
KEGGigga:395555.

Organism-specific databases

CTDi4361.

Phylogenomic databases

eggNOGiKOG2310. Eukaryota.
COG0420. LUCA.
HOGENOMiHOG000216581.
HOVERGENiHBG052508.
InParanoidiQ9IAM7.
KOiK10865.
PhylomeDBiQ9IAM7.

Enzyme and pathway databases

ReactomeiR-GGA-217106. Chk1-controlled and DNA-damage induced centrosome duplication.
R-GGA-351442. ATM mediated response to DNA double-strand break.
R-GGA-351444. Recruitment of repair and signaling proteins to double-strand breaks.

Miscellaneous databases

PROiQ9IAM7.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR003701. Mre11.
IPR007281. Mre11_DNA-bd.
[Graphical view]
PANTHERiPTHR10139:SF1. PTHR10139:SF1. 1 hit.
PfamiPF00149. Metallophos. 1 hit.
PF04152. Mre11_DNA_bind. 1 hit.
[Graphical view]
PIRSFiPIRSF000882. DSB_repair_MRE11. 1 hit.
SMARTiSM01347. Mre11_DNA_bind. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 2 hits.
TIGRFAMsiTIGR00583. mre11. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMRE11_CHICK
AccessioniPrimary (citable) accession number: Q9IAM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.