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Protein

Protein CBFA2T2

Gene

cbfa2t2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a transcriptional corepressor.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri497 – 53337MYND-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CBFA2T2
Alternative name(s):
MTG8-like protein
MTG8-related protein 1
Gene namesi
Name:cbfa2t2
Synonyms:mtgr1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 586586Protein CBFA2T2PRO_0000218303Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9IAB2.
SMRiQ9IAB2. Positions 101-206, 327-384, 492-540.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini102 – 19796TAFHPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili429 – 48153Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi84 – 907Poly-Ser

Sequence similaritiesi

Contains 1 MYND-type zinc finger.PROSITE-ProRule annotation
Contains 1 TAFH (NHR1) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri497 – 53337MYND-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

HOVERGENiHBG000169.

Family and domain databases

InterProiIPR013289. CBFA2T1/2/3.
IPR013291. MTGR1.
IPR014896. NHR2.
IPR003894. TAFH_NHR1.
IPR002893. Znf_MYND.
[Graphical view]
PfamiPF08788. NHR2. 1 hit.
PF07531. TAFH. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view]
PRINTSiPR01875. ETOFAMILY.
PR01877. MTGR1PROTEIN.
SMARTiSM00549. TAFH. 1 hit.
[Graphical view]
PROSITEiPS51119. TAFH. 1 hit.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9IAB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGIPGPYQF TGDKRVPAMP GSPMEVKIHS RSSPPIMAPL PPVNPGGLRP
60 70 80 90 100
VGFPPSSHSN GINHSPPTLN GAPSPPQRSS NGPSSSSSSS LANQQLPATC
110 120 130 140 150
GVRQLSKLKR FLTTLQQFGN DISPEIGEKV RTLVLALVNS TVTIEEFHCK
160 170 180 190 200
LQEATNFPLR PFVIPFLKAN LPLLQRELLH CARAGKQTPS QYLAQHEHIL
210 220 230 240 250
LNTSTSSPAD SSELLMEMNG NGKRHSPDRR EEERETAPAE PPVKRVCTIS
260 270 280 290 300
PAPRHSPALS LPLVNSTSHF HPTPPPLQHY SLEDIPSSQL YRDHLNKIGE
310 320 330 340 350
HRDVRDRHHS SGVNGNLNNG YQEELVDHRL TEREWAEEWK HLDHALNCIM
360 370 380 390 400
EMVEKTRRSM AVLRRCQEVD RDELNYWKRR FNESNEIRKG SEHPSRQHSP
410 420 430 440 450
SSTDSGASDS VRDFGSRTGA GYVTDEIWRK AEEAVNEVKR QAMSEVQKAV
460 470 480 490 500
SEAEQKAFEM IASERARMEQ TIVDAKRRAA EDAVLVVNEQ EESTESCWNC
510 520 530 540 550
GRKASETCSG CNIARYCGSF CQHKDWEKHH RICGQSMHTQ AKPLTPSRSL
560 570 580
IPKASDPVLL SPTLERSSSA TSRSSTPASV TAVDGL
Length:586
Mass (Da):65,055
Last modified:June 1, 2001 - v2
Checksum:i7280D4C81F40F286
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212198 mRNA. Translation: AAF63193.2.
UniGeneiXl.4960.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212198 mRNA. Translation: AAF63193.2.
UniGeneiXl.4960.

3D structure databases

ProteinModelPortaliQ9IAB2.
SMRiQ9IAB2. Positions 101-206, 327-384, 492-540.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG000169.

Family and domain databases

InterProiIPR013289. CBFA2T1/2/3.
IPR013291. MTGR1.
IPR014896. NHR2.
IPR003894. TAFH_NHR1.
IPR002893. Znf_MYND.
[Graphical view]
PfamiPF08788. NHR2. 1 hit.
PF07531. TAFH. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view]
PRINTSiPR01875. ETOFAMILY.
PR01877. MTGR1PROTEIN.
SMARTiSM00549. TAFH. 1 hit.
[Graphical view]
PROSITEiPS51119. TAFH. 1 hit.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTG8R_XENLA
AccessioniPrimary (citable) accession number: Q9IAB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: June 1, 2001
Last modified: April 13, 2016
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-19 is the initiator.Curated

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.