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Protein

Protein CBFA2T2

Gene

cbfa2t2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as a transcriptional corepressor.By similarity

Caution

It is uncertain whether Met-1 or Met-19 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri497 – 533MYND-typePROSITE-ProRule annotationAdd BLAST37

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CBFA2T2
Alternative name(s):
MTG8-like protein
MTG8-related protein 1
Gene namesi
Name:cbfa2t2
Synonyms:mtgr1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002183031 – 586Protein CBFA2T2Add BLAST586

Structurei

3D structure databases

ProteinModelPortaliQ9IAB2
SMRiQ9IAB2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini102 – 197TAFHPROSITE-ProRule annotationAdd BLAST96

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili429 – 481Sequence analysisAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi84 – 90Poly-Ser7

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri497 – 533MYND-typePROSITE-ProRule annotationAdd BLAST37

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

HOVERGENiHBG000169

Family and domain databases

Gene3Di1.20.120.1110, 1 hit
InterProiView protein in InterPro
IPR013289 CBFA2T1/2/3
IPR013291 MTGR1
IPR014896 NHR2
IPR037249 TAFH/NHR1_dom_sf
IPR003894 TAFH_NHR1
IPR002893 Znf_MYND
PANTHERiPTHR10379 PTHR10379, 1 hit
PfamiView protein in Pfam
PF08788 NHR2, 1 hit
PF07531 TAFH, 1 hit
PF01753 zf-MYND, 1 hit
PRINTSiPR01875 ETOFAMILY
PR01877 MTGR1PROTEIN
SMARTiView protein in SMART
SM00549 TAFH, 1 hit
SUPFAMiSSF158553 SSF158553, 1 hit
PROSITEiView protein in PROSITE
PS51119 TAFH, 1 hit
PS01360 ZF_MYND_1, 1 hit
PS50865 ZF_MYND_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9IAB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGIPGPYQF TGDKRVPAMP GSPMEVKIHS RSSPPIMAPL PPVNPGGLRP
60 70 80 90 100
VGFPPSSHSN GINHSPPTLN GAPSPPQRSS NGPSSSSSSS LANQQLPATC
110 120 130 140 150
GVRQLSKLKR FLTTLQQFGN DISPEIGEKV RTLVLALVNS TVTIEEFHCK
160 170 180 190 200
LQEATNFPLR PFVIPFLKAN LPLLQRELLH CARAGKQTPS QYLAQHEHIL
210 220 230 240 250
LNTSTSSPAD SSELLMEMNG NGKRHSPDRR EEERETAPAE PPVKRVCTIS
260 270 280 290 300
PAPRHSPALS LPLVNSTSHF HPTPPPLQHY SLEDIPSSQL YRDHLNKIGE
310 320 330 340 350
HRDVRDRHHS SGVNGNLNNG YQEELVDHRL TEREWAEEWK HLDHALNCIM
360 370 380 390 400
EMVEKTRRSM AVLRRCQEVD RDELNYWKRR FNESNEIRKG SEHPSRQHSP
410 420 430 440 450
SSTDSGASDS VRDFGSRTGA GYVTDEIWRK AEEAVNEVKR QAMSEVQKAV
460 470 480 490 500
SEAEQKAFEM IASERARMEQ TIVDAKRRAA EDAVLVVNEQ EESTESCWNC
510 520 530 540 550
GRKASETCSG CNIARYCGSF CQHKDWEKHH RICGQSMHTQ AKPLTPSRSL
560 570 580
IPKASDPVLL SPTLERSSSA TSRSSTPASV TAVDGL
Length:586
Mass (Da):65,055
Last modified:June 1, 2001 - v2
Checksum:i7280D4C81F40F286
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212198 mRNA Translation: AAF63193.2
UniGeneiXl.4960

Similar proteinsi

Entry informationi

Entry nameiMTG8R_XENLA
AccessioniPrimary (citable) accession number: Q9IAB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 73 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health