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Protein

Secreted frizzled-related protein 2

Gene

SFRP2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 appears to be associated with myogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Wnt signaling pathway

Protein family/group databases

MEROPSiI93.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Secreted frizzled-related protein 2
Short name:
sFRP-2
Gene namesi
Name:SFRP2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003254421 – 292Secreted frizzled-related protein 2Add BLAST272

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 100By similarity
Disulfide bondi47 ↔ 93By similarity
Disulfide bondi84 ↔ 122By similarity
Disulfide bondi111 ↔ 149By similarity
Disulfide bondi115 ↔ 139By similarity
Disulfide bondi169 ↔ 242By similarity
Disulfide bondi187 ↔ 292By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9IA96.

Expressioni

Developmental stagei

In embryo, expressed in developing neural structures as well as in heart, branchial arches and limb buds. First expressed at stage 7 in the neural plate with lower expression in the midline. By stage 9, expressed through out the developing neural tube with lower levels in the future posterior mesencephalon and rhombomere 3. In anterior regions, highest expression in the dorsal neural tube and, more posteriorly throughout the closing neural tube. Also expressed in the ectoderm flanking the neural tube. In the developing brain, expression found in the presumptive forbrain. By stage 12, expression restricted to the dorsal prosencephalon, hindbrain and posterior neural tube. In the placodes, first expressed at stage 11, in the otic placode. By stage 15, expressed in the olfactory and epibranchial placodes. In facial primordia, expression found at stage 2,0 throughout the ectoderm. By stage 24, high mesenchymal expression in a small region of the posterior maxillary primordia, and in the lateral region of the mandibular primordia. By stage 28, expressed in a subset of muscles, including the intermandibularis muscle and the muscle medial to the eye. In the developing trunk, expression found throughout the dermamyotome in the more developed somites. By stage 20, expression restricted to the small region in the dorsal medial lip in all somites. In addition, also expressed in the ventral lateral lip of the dermamyotome that gives rise to the muscles of the limbs and body wall. During limb development, expressed between stages 20 and 30, in the proximal mesenchyme in association with developing muscles. Between stages 27 and 30, expression found in mesenchyme containing undifferentiated myogenic cells. In the developing heart, expression restricted to the myocardial and endocardial cell layers of the trabeculae in the ventricular compartment between stages 20 and 28.1 Publication

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015022.

Structurei

3D structure databases

ProteinModelPortaliQ9IA96.
SMRiQ9IA96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 152FZPROSITE-ProRule annotationAdd BLAST121
Domaini169 – 292NTRPROSITE-ProRule annotationAdd BLAST124

Domaini

The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3577. Eukaryota.
ENOG410XRC8. LUCA.
HOGENOMiHOG000231058.
HOVERGENiHBG052928.
InParanoidiQ9IA96.
KOiK02176.
PhylomeDBiQ9IA96.

Family and domain databases

InterProiView protein in InterPro
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR026558. SFRP2.
IPR008993. TIMP-like_OB-fold.
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF124. PTHR11309:SF124. 1 hit.
PfamiView protein in Pfam
PF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
SMARTiView protein in SMART
SM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
SUPFAMiSSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEiView protein in PROSITE
PS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9IA96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRRLCALLL LASQCLGSTA GLFPFGEPDF SYKRSNCKPI PAPMLLCRGI
60 70 80 90 100
EYQSMRLPNL LGHETVQEVL EQATTWIPLV QKQCHPDTRK FLCSLFAPVC
110 120 130 140 150
IDDLDEIIQP CHSLCEEVKE SCAPVMSAFG FPWPDMLDCS RFPKDNDLCI
160 170 180 190 200
PLASSDHILP VTREAPKVCD ACKNKNEDDN DIMENLCKND FALKIKVKEI
210 220 230 240 250
AYINGDTKIT PETKSKTIYK LNGLTERDLR KIVLWLKGGL QCTCDEMNDI
260 270 280 290
NVPYLVMGQK QAGELVITSL KRWQKGQRAF KRFSRSIRKL QC
Length:292
Mass (Da):33,119
Last modified:October 1, 2000 - v1
Checksum:i0490657229F475B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218056 mRNA. Translation: AAF27642.1.
RefSeqiNP_990104.1. NM_204773.1.
UniGeneiGga.4345.

Genome annotation databases

GeneIDi395546.
KEGGigga:395546.

Similar proteinsi

Entry informationi

Entry nameiSFRP2_CHICK
AccessioniPrimary (citable) accession number: Q9IA96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2000
Last modified: August 30, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families