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Protein

Serine/threonine-protein kinase SIK2

Gene

SIK2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Phosphorylates IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3 (By similarity).By similarity1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Cofactori

Mg2+1 Publication

Enzyme regulationi

Activated by phosphorylation on Thr-181.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei55ATPPROSITE-ProRule annotationBy similarity1
Active sitei148Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 40ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • magnesium ion binding Source: UniProtKB
  • protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  • cellular response to hormone stimulus Source: GO_Central
  • intracellular signal transduction Source: UniProtKB
  • protein phosphorylation Source: UniProtKB
  • regulation of insulin receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SIK2 (EC:2.7.11.1)
Alternative name(s):
Qin-induced kinase
Salt-inducible kinase 2
Short name:
SIK-2
Serine/threonine-protein kinase SNF1-like kinase 2
Gene namesi
Name:SIK2
Synonyms:QIK, SNF1LK2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000866651 – 798Serine/threonine-protein kinase SIK2Add BLAST798

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei181PhosphothreonineBy similarity1
Modified residuei185PhosphoserineBy similarity1
Modified residuei575PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated at Thr-181 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9IA88.
PRIDEiQ9IA88.

Expressioni

Tissue specificityi

Ubiquitously expressed in embryonic tissue.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000026069.

Structurei

3D structure databases

ProteinModelPortaliQ9IA88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 277Protein kinasePROSITE-ProRule annotationAdd BLAST252
Domaini302 – 342UBAPROSITE-ProRule annotationAdd BLAST41

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 UBA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0586. Eukaryota.
ENOG410XNQ0. LUCA.
HOGENOMiHOG000039981.
InParanoidiQ9IA88.
KOiK19008.
PhylomeDBiQ9IA88.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR017090. Ser/Thr_kinase_SIK1/2.
IPR015940. UBA.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF037014. Ser/Thr_PK_SNF1-like. 1 hit.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50030. UBA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9IA88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVIMSEDASV PAPSAAQPRP LRVGFYDIER TLGKGNFAVV KLARHRVTKT
60 70 80 90 100
QVAIKIIDKT RLDPSNLEKI YREVQIMKLL NHPHIIKLYQ VMETKDMLYI
110 120 130 140 150
VTEFAKNGEM FDHLTSNGHL SESEARKKFW QILSAVEYCH SHHIVHRDLK
160 170 180 190 200
TENLLLDANM NIKLADFGFG NFYKSGEPLS TWCGSPPYAA PEVFEGKEYE
210 220 230 240 250
GPHLDIWSLG VVLYVLVCGS LPFDGPNLPT LRQRVLEGRF RIPYFMSEDC
260 270 280 290 300
ETLIRRMLVV DPTKRITISQ IKQHKWMQAD PSLRQQQSLS FSMQNYNSNL
310 320 330 340 350
GDYNEQVLGI MQTLGIDRQR TVESLQNSSY NHFAAIYYLL LERLKEYRSS
360 370 380 390 400
QLSSRPATGR QQRPRSSEIS NAEMPQDSLT SETLRSSLLY QQPQSLIQPS
410 420 430 440 450
LQAEMDCDMN NPLQPVFFPV DPNFNGLFRN RSISPSSLLE TTISEEVRQE
460 470 480 490 500
KELEDEIKAY DHPIRIPSNT SRRHTLAEVT THFYQHAPPC IVISSSASPT
510 520 530 540 550
EGTSSDSCLT SSSNDSSVAL SSCLAGQVMT GSPATARMTS AFLASQSDAP
560 570 580 590 600
VLQVQGCMGG ASLLPVSFQE GRRASDTSLT QGLKAFRQQL RKNARAKGFL
610 620 630 640 650
GLNKIKGFAR QVCQSSSSRA ARSAMSPFQH AQPNTCIYSS SGSSREGRNL
660 670 680 690 700
LEEVLQQQRM LQLQHHQLLQ PACPQTSQTS ATNGLPPSDS AGTCKASNSL
710 720 730 740 750
LLSELQRENS FELAFGGNSQ LLQPHFFGVS VSPVSSAAHL LDTHLYISSN
760 770 780 790
VSPVGTTFSQ QQSFSAQSPS YDAVTLQHGD CEMEDLTSNQ LGKFVLVK
Length:798
Mass (Da):88,866
Last modified:October 1, 2000 - v1
Checksum:i31FE1AF0FAA136BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF219232 mRNA. Translation: AAF28351.1.
PIRiJC7500.
RefSeqiNP_990013.1. NM_204682.1.
UniGeneiGga.2833.

Genome annotation databases

GeneIDi395417.
KEGGigga:395417.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF219232 mRNA. Translation: AAF28351.1.
PIRiJC7500.
RefSeqiNP_990013.1. NM_204682.1.
UniGeneiGga.2833.

3D structure databases

ProteinModelPortaliQ9IA88.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000026069.

Proteomic databases

PaxDbiQ9IA88.
PRIDEiQ9IA88.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395417.
KEGGigga:395417.

Organism-specific databases

CTDi150094.

Phylogenomic databases

eggNOGiKOG0586. Eukaryota.
ENOG410XNQ0. LUCA.
HOGENOMiHOG000039981.
InParanoidiQ9IA88.
KOiK19008.
PhylomeDBiQ9IA88.

Miscellaneous databases

PROiQ9IA88.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR017090. Ser/Thr_kinase_SIK1/2.
IPR015940. UBA.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF037014. Ser/Thr_PK_SNF1-like. 1 hit.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50030. UBA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSIK2_CHICK
AccessioniPrimary (citable) accession number: Q9IA88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: October 1, 2000
Last modified: October 5, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.