Reviewed, UniProtKB/Swiss-Prot Q9IA26 (HXA9_HETFR)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A9

Gene names

Name:

HOXA9

Organism

Heterodontus francisci (Horn shark)

Taxonomic identifier

7792 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Chondrichthyes › Elasmobranchii › Galeomorphii › Heterodontoidea › Heterodontiformes › Heterodontidae › Heterodontus

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Abd-B homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription activator activity Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 260	260	Homeobox protein Hox-A9		PRO_0000200087
Regions
	DNA binding	193 – 252	60	Homeobox

Sequences

	Sequence		Length	Mass (Da)
	Q9IA26-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 3A91281C53220A53	FASTA	260	29,761
	10 20 30 40 50 60 MSTSGTISNY YVDSLIMHEN EDLLSSRYAS GSLAQASRQA ALTEHPDFSP CNFQSKATVF 70 80 90 100 110 120 STSWSPVHAQ SSANMPTVYH PYMHQAPIAA APDGRYMRSW LDPMPGTLSF PGLPSSRHYG 130 140 150 160 170 180 IKPEPVASRR SDCTTFETHT LALSEYTCGT SPADKRVSEV SFSENNGETE SNADKLHMDP 190 200 210 220 230 240 NNPSANWLHA RSTRKKRCPY TKHQTLELEK EFLFNMYLTR DRRYEVARVL NLTERQVKIW 250 260 FQNRRMKMKK INKERPKDDR

References

[1]

"Hox cluster genomics in the horn shark, Heterodontus francisci." Kim C.B., Amemiya C., Bailey W., Kawasaki K., Mezey J., Miller W., Minoshima S., Shimizu N., Wagner G., Ruddle F. Proc. Natl. Acad. Sci. U.S.A. 97:1655-1660(2000) [PubMed: 10677514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF224262 Genomic DNA. Translation: AAF44646.1.
3D structure databases
SMR	Q9IA26. Positions 181-257.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q9IA26.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR017112. Homeobox_Hox9. IPR020479. Homeobox_region. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. IPR006711. Hox9_act. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. PF04617. Hox9_act. 1 hit. [Graphical view]
PIRSF	PIRSF037109. Homeobox_Hox9. 1 hit.
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA9_HETFR

Accession

Primary (citable) accession number: Q9IA26

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2001
Last sequence update:	October 1, 2000
Last modified:	November 24, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)