Q9IA25 (HXA7_HETFR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-A7

Gene names

Name:

HOXA7

Organism

Heterodontus francisci (Horn shark) (Cestracion francisci)

Taxonomic identifier

7792 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Chondrichthyes › Elasmobranchii › Selachii › Galeomorphii › Heterodontoidea › Heterodontiformes › Heterodontidae › Heterodontus

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 208	208	Homeobox protein Hox-A7		PRO_0000200077
Regions
	DNA binding	135 – 194	60	Homeobox
	Motif	124 – 129	6	Antp-type hexapeptide

Sequences

	Sequence		Length	Mass (Da)
	Q9IA25 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 71B661AB78E064D0	FASTA	208	23,787
	10 20 30 40 50 60 MSSSYYVNAL FPKYTAGTSV FQNASGFTEA TSCAFATNSQ RSSYGAGASA FPAPMAGLYN 70 80 90 100 110 120 VNSAIYHGPT MYNTGYNLNS DSYNLRCSAL DQNIPVLCSD LSKQGCEKLD QTNVHPQAES 130 140 150 160 170 180 NFRIYPWMRN AGPDRKRGRQ TYTRYQTLEL EKEFHFNRYL TRRRRIEIAH ALCLTERQIK 190 200 IWFQNRRMKW KKETKAGSSS TTSEEKQE

References

[1]

"Hox cluster genomics in the horn shark, Heterodontus francisci." Kim C.B., Amemiya C., Bailey W., Kawasaki K., Mezey J., Miller W., Minoshima S., Shimizu N., Wagner G., Ruddle F. Proc. Natl. Acad. Sci. U.S.A. 97:1655-1660(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF224262 Genomic DNA. Translation: AAF44645.1.
3D structure databases
ProteinModelPortal	Q9IA25.
SMR	Q9IA25. Positions 135-195.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG016849.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017995. Homeobox_antennapedia. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA7_HETFR

Accession

Primary (citable) accession number: Q9IA25

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2001
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program