Q9IA23 (HXA5_HETFR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-A5

Gene names

Name:

HOXA5

Organism

Heterodontus francisci (Horn shark)

Taxonomic identifier

7792 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Chondrichthyes › Elasmobranchii › Galeomorphii › Heterodontoidea › Heterodontiformes › Heterodontidae › Heterodontus

Protein attributes

Sequence length	275 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 275	275	Homeobox protein Hox-A5		PRO_0000200063
Regions
	DNA binding	200 – 259	60	Homeobox
	Motif	181 – 186	6	Antp-type hexapeptide
	Compositional bias	75 – 78	4	Poly-Ala
	Compositional bias	81 – 84	4	Poly-Ala
	Compositional bias	134 – 142	9	Poly-Ser
	Compositional bias	227 – 230	4	Poly-Arg

Sequences

	Sequence		Length	Mass (Da)
	Q9IA23 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 51BC2720808A31B6	FASTA	275	30,214
	10 20 30 40 50 60 MSSYFVNSFC GRYPNGPDYQ LHNYGDHSSV SEQYRDSATM HSSRYGYGYN GMDLSISRPA 70 80 90 100 110 120 SNHFNASERS RSYSAAAATT AAAAGPEAGA DTRYNQPATS SPSPDPLPCS AVVSPSAGDN 130 140 150 160 170 180 HHGIKNSIAS PTTSSNSSSS SSHISRDGVG TSPGTEDDTP ASSDPPSSQN GQSTAQQQPQ 190 200 210 220 230 240 IYPWMRKLHI SHDSMGGPEG KRARTAYTRY QTLELEKEFH FNRYLTRRRR IEIAHALCLT 250 260 270 ERQIKIWFQN RRMKWKKDNK LKSMSMAAAG GGYRP

References

[1]	"Hox cluster genomics in the horn shark, Heterodontus francisci." Kim C.B., Amemiya C., Bailey W., Kawasaki K., Mezey J., Miller W., Minoshima S., Shimizu N., Wagner G., Ruddle F. Proc. Natl. Acad. Sci. U.S.A. 97:1655-1660(2000) [PubMed: 10677514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF224262 Genomic DNA. Translation: AAF44643.1.
3D structure databases
ProteinModelPortal	Q9IA23.
SMR	Q9IA23. Positions 179-260.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG016849.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017995. Homeobox_antennapedia. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_eu. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA5_HETFR

Accession

Primary (citable) accession number: Q9IA23

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2001
Last sequence update:	October 1, 2000
Last modified:	December 14, 2011
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program