Q9IA22 (HXA4_HETFR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-A4

Gene names

Name:

HOXA4

Organism

Heterodontus francisci (Horn shark)

Taxonomic identifier

7792 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Chondrichthyes › Elasmobranchii › Galeomorphii › Heterodontoidea › Heterodontiformes › Heterodontidae › Heterodontus

Protein attributes

Sequence length	247 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Antp homeobox family. Deformed subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 247	247	Homeobox protein Hox-A4		PRO_0000200054
Regions
	DNA binding	149 – 208	60	Homeobox
	Motif	128 – 133	6	Antp-type hexapeptide

Sequences

	Sequence		Length	Mass (Da)
	Q9IA22 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: BE518038CA73D2E6	FASTA	247	28,408
	10 20 30 40 50 60 MTMSSFLINS NYVEPKFPPC EEYSQNNYIP SQSPEYYERP RDPGFHHEAL YPQSNYPEPT 70 80 90 100 110 120 YSFNNVQGTG NQDMSQRGHV QSQASLQNHI PRQNQLCEVV PVATPALCSQ NAKNPTAQKG 130 140 150 160 170 180 TLSKEPIVYP WMKKIHVTTV NPNYTGGEPK RSRTAYTRQQ VLELEKEFHF NRYLTRRRRI 190 200 210 220 230 240 EIAHTLCLSE RQVKIWFQNR RMKWKKDHKL PNTKMRSASS SSSTSQQTQV SSQGPQPDGS APNSSSL

References

[1]	"Hox cluster genomics in the horn shark, Heterodontus francisci." Kim C.B., Amemiya C., Bailey W., Kawasaki K., Mezey J., Miller W., Minoshima S., Shimizu N., Wagner G., Ruddle F. Proc. Natl. Acad. Sci. U.S.A. 97:1655-1660(2000) [PubMed: 10677514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF224262 Genomic DNA. Translation: AAF44642.1.
3D structure databases
ProteinModelPortal	Q9IA22.
SMR	Q9IA22. Positions 126-209.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG016849.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017995. Homeobox_antennapedia. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_eu. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA4_HETFR

Accession

Primary (citable) accession number: Q9IA22

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2001
Last sequence update:	October 1, 2000
Last modified:	December 14, 2011
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program