Reviewed, UniProtKB/Swiss-Prot Q9IA21 (HXA3_HETFR)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A3

Gene names

Name:

HOXA3

Organism

Heterodontus francisci (Horn shark)

Taxonomic identifier

7792 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Chondrichthyes › Elasmobranchii › Galeomorphii › Heterodontoidea › Heterodontiformes › Heterodontidae › Heterodontus

Protein attributes

Sequence length	410 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 410	410	Homeobox protein Hox-A3		PRO_0000200047
Regions
	DNA binding	168 – 227	60	Homeobox
	Motif	133 – 138	6	Antp-type hexapeptide
	Compositional bias	85 – 90	6	Poly-Gln
	Compositional bias	91 – 100	10	Poly-Pro
	Compositional bias	149 – 153	5	Poly-Ser

Sequences

	Sequence		Length	Mass (Da)
	Q9IA21-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 285ABC06B41C9FD9	FASTA	410	44,548
	10 20 30 40 50 60 MQKATYYDSS AIFGGYTYQG ANGFNYNASQ QQYPPSSHVE SDYHRPACSL QSPGTVPHHK 70 80 90 100 110 120 PNDINESCMR TSASQPSHHP VIAEQQQQKQ PPPPPPPPPP SVSPPQNTSS NSTQSSTSKN 130 140 150 160 170 180 PTLTSQATIS KQIFPWMKES RQNAKQKTSS SSSVESSAGE KSPPGPASKR ARTAYTSAQL 190 200 210 220 230 240 VELEKEFHFN RYLCRPRRVE MANLLNLTER QIKIWFQNRR MKYKKDQKAK GMLTSSGGQS 250 260 270 280 290 300 PCRSPIPPSA AGGYANSMHS LATSAPYDPH SPTSFSKPHQ NAYAIPTSYP GPLNSCPPPQ 310 320 330 340 350 360 KRYAGTAAVT PEYDTHPLQG NGGYGTPHLQ GSPVYVGGNF VESMPSSGPS LFSLTHLGHP 370 380 390 400 410 PSGNMDYNGA GPMTSNHHHG PCDPHPTYTD LSSHHPSQGR IQEAPKLTHL

References

[1]

"Hox cluster genomics in the horn shark, Heterodontus francisci." Kim C.B., Amemiya C., Bailey W., Kawasaki K., Mezey J., Miller W., Minoshima S., Shimizu N., Wagner G., Ruddle F. Proc. Natl. Acad. Sci. U.S.A. 97:1655-1660(2000) [PubMed: 10677514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF224262 Genomic DNA. Translation: AAF44641.1.
3D structure databases
SMR	Q9IA21. Positions 170-227.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q9IA21.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_region. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA3_HETFR

Accession

Primary (citable) accession number: Q9IA21

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2001
Last sequence update:	October 1, 2000
Last modified:	November 24, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)