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Protein

Homeobox protein Hox-A3

Gene

HOXA3

Organism
Heterodontus francisci (Horn shark) (Cestracion francisci)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi168 – 227HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A3
Gene namesi
Name:HOXA3
OrganismiHeterodontus francisci (Horn shark) (Cestracion francisci)
Taxonomic identifieri7792 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiGaleomorphiiHeterodontoideaHeterodontiformesHeterodontidaeHeterodontus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002000471 – 410Homeobox protein Hox-A3Add BLAST410

Structurei

3D structure databases

ProteinModelPortaliQ9IA21.
SMRiQ9IA21.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi133 – 138Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi85 – 90Poly-Gln6
Compositional biasi91 – 100Poly-Pro10
Compositional biasi149 – 153Poly-Ser5

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG107984.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR025281. DUF4074.
IPR009057. Homeobox-like.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9IA21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKATYYDSS AIFGGYTYQG ANGFNYNASQ QQYPPSSHVE SDYHRPACSL
60 70 80 90 100
QSPGTVPHHK PNDINESCMR TSASQPSHHP VIAEQQQQKQ PPPPPPPPPP
110 120 130 140 150
SVSPPQNTSS NSTQSSTSKN PTLTSQATIS KQIFPWMKES RQNAKQKTSS
160 170 180 190 200
SSSVESSAGE KSPPGPASKR ARTAYTSAQL VELEKEFHFN RYLCRPRRVE
210 220 230 240 250
MANLLNLTER QIKIWFQNRR MKYKKDQKAK GMLTSSGGQS PCRSPIPPSA
260 270 280 290 300
AGGYANSMHS LATSAPYDPH SPTSFSKPHQ NAYAIPTSYP GPLNSCPPPQ
310 320 330 340 350
KRYAGTAAVT PEYDTHPLQG NGGYGTPHLQ GSPVYVGGNF VESMPSSGPS
360 370 380 390 400
LFSLTHLGHP PSGNMDYNGA GPMTSNHHHG PCDPHPTYTD LSSHHPSQGR
410
IQEAPKLTHL
Length:410
Mass (Da):44,548
Last modified:October 1, 2000 - v1
Checksum:i285ABC06B41C9FD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF224262 Genomic DNA. Translation: AAF44641.1.

Similar proteinsi

Entry informationi

Entry nameiHXA3_HETFR
AccessioniPrimary (citable) accession number: Q9IA21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: October 1, 2000
Last modified: September 27, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families