Reviewed, UniProtKB/Swiss-Prot Q9IA19 (HXA1_HETFR)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A1

Gene names

Name:

HOXA1

Organism

Heterodontus francisci (Horn shark)

Taxonomic identifier

7792 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Chondrichthyes › Elasmobranchii › Galeomorphii › Heterodontoidea › Heterodontiformes › Heterodontidae › Heterodontus

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Antp homeobox family. Labial subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 326	326	Homeobox protein Hox-A1		PRO_0000200034
Regions
	DNA binding	221 – 280	60	Homeobox
	Motif	196 – 201	6	Antp-type hexapeptide
	Compositional bias	66 – 70	5	Poly-His

Sequences

	Sequence		Length	Mass (Da)
	Q9IA19-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 02485F6224C65028	FASTA	326	35,419
	10 20 30 40 50 60 MDNARMNSFL DYSIINGETG TCSSRSYHAD QGITTYQSCA VSNNNCNADD RYIVSRSVQI 70 80 90 100 110 120 GAPPPHHHHH QSNYTHPNNL GISYSAHPNC GAGYPAQSFN TGYSHHYSLN QETDGNGGYP 130 140 150 160 170 180 QCAPAVYPGN IASAISPHHH SYGGMVGSGQ YPHHPYGQEQ QGLALAAGCH SLSPVHGSHQ 190 200 210 220 230 240 EACCSPSAET PPPAQTFDWM KVKRNPPKTG KAGEYGFAGQ PNTVRTNFTT KQLTELEKEF 250 260 270 280 290 300 HFNKYLTRAR RVEIAAALQL NETQVKIWFQ NRRMKQKKRE KEGLTSASPA TPGSEANTED 310 320 TSDKCNSTSS TPSPSSSTSE TINTSG

References

[1]

"Hox cluster genomics in the horn shark, Heterodontus francisci." Kim C.B., Amemiya C., Bailey W., Kawasaki K., Mezey J., Miller W., Minoshima S., Shimizu N., Wagner G., Ruddle F. Proc. Natl. Acad. Sci. U.S.A. 97:1655-1660(2000) [PubMed: 10677514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF224262 Genomic DNA. Translation: AAF44639.1.
3D structure databases
SMR	Q9IA19. Positions 225-278.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q9IA19.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR020479. Homeobox_region. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00032. ANTENNAPEDIA. False negative. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA1_HETFR

Accession

Primary (citable) accession number: Q9IA19

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2001
Last sequence update:	October 1, 2000
Last modified:	November 24, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)