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Protein

Homeobox protein Hox-D11

Gene

HOXD11

Organism
Heterodontus francisci (Horn shark) (Cestracion francisci)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi193 – 252HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D11
Gene namesi
Name:HOXD11
OrganismiHeterodontus francisci (Horn shark) (Cestracion francisci)
Taxonomic identifieri7792 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiGaleomorphiiHeterodontoideaHeterodontiformesHeterodontidaeHeterodontus

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002351 – 265Homeobox protein Hox-D11Add BLAST265

Structurei

3D structure databases

ProteinModelPortaliQ9IA15.
SMRiQ9IA15.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG052048.

Family and domain databases

InterProiView protein in InterPro
IPR021918. DUF3528.
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF12045. DUF3528. 1 hit.
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9IA15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLPSCTYYV SAPDFSSVST FLPPTTSCQM TFPYSSNLAQ VQPVRELSFR
60 70 80 90 100
DYGLEHPTKW HYRSNYAPYC SAEEIMHRDY IQPPTRTGML FKNDTVYSQR
110 120 130 140 150
GSSNPSCNFY TTVGRNGILP QGFDQFFETA YGISDSSNYE QLTEKSVSTC
160 170 180 190 200
QSITASEKVS SGQEKESATE KSTVESSGTS ATEKNSLSTA LRCRKKRCPY
210 220 230 240 250
TKYQIRELER EFFFNVYINK EKRLQLSRML NLTDRQVKIW FQNRRMKEKK
260
LSRDRLHFFT GNPLL
Length:265
Mass (Da):30,722
Last modified:October 1, 2000 - v1
Checksum:iCC1AF6B48A91E28F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF224263 Genomic DNA. Translation: AAF44635.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiHXD11_HETFR
AccessioniPrimary (citable) accession number: Q9IA15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: October 1, 2000
Last modified: May 10, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families