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Protein

Frizzled-2

Gene

FZD2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-2
Short name:
Fz-2
Short name:
cFz-2
Gene namesi
Name:FZD2
Synonyms:FZ2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 205ExtracellularSequence analysisAdd BLAST205
Transmembranei206 – 226Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini227 – 237CytoplasmicSequence analysisAdd BLAST11
Transmembranei238 – 258Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini259 – 285ExtracellularSequence analysisAdd BLAST27
Transmembranei286 – 306Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini307 – 328CytoplasmicSequence analysisAdd BLAST22
Transmembranei329 – 349Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini350 – 372ExtracellularSequence analysisAdd BLAST23
Transmembranei373 – 393Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini394 – 419CytoplasmicSequence analysisAdd BLAST26
Transmembranei420 – 440Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini441 – 477ExtracellularSequence analysisAdd BLAST37
Transmembranei478 – 498Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini499 – 523CytoplasmicSequence analysisAdd BLAST25

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000205975‹1 – 523Frizzled-2Add BLAST›523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi6 ↔ 67PROSITE-ProRule annotation
Disulfide bondi14 ↔ 60PROSITE-ProRule annotation
Glycosylationi20N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi51 ↔ 88PROSITE-ProRule annotation
Disulfide bondi77 ↔ 117PROSITE-ProRule annotation
Disulfide bondi81 ↔ 105PROSITE-ProRule annotation
Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9IA06.

Expressioni

Tissue specificityi

Expressed broadly in cranial ectoderm. Also expressed in the developing somites (dermomyotome) and in other cranial placodes, including the olfactory, lens, and otic placodes (rostral rim of the vesicle).

Developmental stagei

At stage 8, faintly expressed in cranial ectoderm and in the somites. At stages 9-10, broadly expressed throughout the cranial ectoderm. By stages 11-12, more robust expression is detected in ectoderm adjacent to the hindbrain, including the otic placodes. Transiently expressed in the lens placode and ectoderm of the head at stages 13-15. Down-regulated in differentiating structures of older embryos.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000034947.

Structurei

3D structure databases

ProteinModelPortaliQ9IA06.
SMRiQ9IA06.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 120FZPROSITE-ProRule annotationAdd BLAST120

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi501 – 506Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity6
Motifi521 – 523PDZ-binding3

Domaini

Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3577. Eukaryota.
ENOG410XRC8. LUCA.
HOGENOMiHOG000233237.
HOVERGENiHBG006977.
InParanoidiQ9IA06.

Family and domain databases

InterProiView protein in InterPro
IPR015526. Frizzled/SFRP.
IPR000539. Frizzled/Smoothened_TM.
IPR020067. Frizzled_dom.
IPR026550. FZD2.
IPR017981. GPCR_2-like.
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF103. PTHR11309:SF103. 1 hit.
PfamiView protein in Pfam
PF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
PRINTSiPR00489. FRIZZLED.
SMARTiView protein in SMART
SM00063. FRI. 1 hit.
SM01330. Frizzled. 1 hit.
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiView protein in PROSITE
PS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q9IA06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PDHGFCQPIS IPLCTDIAYN QTIMPNLLGH TNQEDAGLEV HQFYPLVKVQ
60 70 80 90 100
CSLELKFFLC SMYAPVCTVL EQAIPPCRSI CERARQGCEA LMNKFGFQWP
110 120 130 140 150
ERLRCENFPR HGAEQICVGQ NHSEDGGSSA ALLTSAAPPA AHGTPGAPRY
160 170 180 190 200
ATPDRPFHCP RALKVPGYLN YKFLGEKDCA APCEPSRPDG HMFFNEDEIR
210 220 230 240 250
FARVWILVWS VLCCASTFFT VTTYLVDMQR FRYPERPIIF LSGCYTMVSV
260 270 280 290 300
AYIAGFVLEE RVVCNERFQE DGYRTVVQGT KKEGCTILFM MLYFFSMASS
310 320 330 340 350
IWWVILSLTW FLAAGMKWGH EAIEANSQYF HLAAWAVPAV KTITILAMGQ
360 370 380 390 400
IDGDLLSGVC FVGLNGIDPL RGFVLAPLFV YLFIGTSFLL AGFVSLFRIR
410 420 430 440 450
TIMKHGGTKT EKLERLMVRI GVFSVLYTVP ATIVIACYFY EQAFRQHWER
460 470 480 490 500
SWISQHCKSL AIPCPLHFTP RMTPDFTVYM IKYLMTLIVG ITSGFWIFSG
510 520
KTLHSWRKFY TRLTNSRQGE TTV
Length:523
Mass (Da):59,281
Last modified:October 1, 2000 - v1
Checksum:i8547F5B018001CB7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF224315 mRNA. Translation: AAF61095.1.
AB029449 mRNA. Translation: BAA89399.1.
UniGeneiGga.312.

Similar proteinsi

Entry informationi

Entry nameiFZD2_CHICK
AccessioniPrimary (citable) accession number: Q9IA06
Secondary accession number(s): Q9PTW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: October 1, 2000
Last modified: August 30, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families