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Protein

Frizzled-4

Gene

FZD4

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-GGA-4086398. Ca2+ pathway.
R-GGA-4641263. Regulation of FZD by ubiquitination.
R-GGA-5099900. WNT5A-dependent internalization of FZD4.

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-4
Short name:
Fz-4
Short name:
cFz-4
Gene namesi
Name:FZD4
Synonyms:FZ4
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 210ExtracellularSequence analysisAdd BLAST186
Transmembranei211 – 231Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini232 – 242CytoplasmicSequence analysisAdd BLAST11
Transmembranei243 – 263Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini264 – 290ExtracellularSequence analysisAdd BLAST27
Transmembranei291 – 311Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini312 – 332CytoplasmicSequence analysisAdd BLAST21
Transmembranei333 – 353Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini354 – 377ExtracellularSequence analysisAdd BLAST24
Transmembranei378 – 398Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini399 – 424CytoplasmicSequence analysisAdd BLAST26
Transmembranei425 – 445Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini446 – 465ExtracellularSequence analysisAdd BLAST20
Transmembranei466 – 486Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini487 – 525CytoplasmicSequence analysisAdd BLAST39

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001298825 – 525Frizzled-4Add BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 94PROSITE-ProRule annotation
Disulfide bondi41 ↔ 87PROSITE-ProRule annotation
Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi78 ↔ 116PROSITE-ProRule annotation
Disulfide bondi105 ↔ 146PROSITE-ProRule annotation
Disulfide bondi109 ↔ 133PROSITE-ProRule annotation
Glycosylationi132N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9IA05.

Expressioni

Tissue specificityi

Expressed in the developing kidney, interdigital spaces and optic cup.

Developmental stagei

Expressed in optic cup at stages 10-19 and in nephric tubules from stage 10 to 20 and more. Expression in interdigital space begins at stage 20.

Gene expression databases

BgeeiENSGALG00000017242.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000027820.

Structurei

3D structure databases

ProteinModelPortaliQ9IA05.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 149FZPROSITE-ProRule annotationAdd BLAST122

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi487 – 492Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity6
Motifi523 – 525PDZ-binding3

Domaini

Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3577. Eukaryota.
ENOG410XRC8. LUCA.
GeneTreeiENSGT00760000118864.
HOGENOMiHOG000233236.
HOVERGENiHBG006977.
InParanoidiQ9IA05.
KOiK02354.
OMAiLHTWQRC.
OrthoDBiEOG091G0N5M.
PhylomeDBiQ9IA05.
TreeFamiTF317907.

Family and domain databases

InterProiView protein in InterPro
IPR015526. Frizzled/SFRP.
IPR000539. Frizzled/Smoothened_TM.
IPR020067. Frizzled_dom.
IPR026551. FZD4.
IPR017981. GPCR_2-like.
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF104. PTHR11309:SF104. 1 hit.
PfamiView protein in Pfam
PF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
PRINTSiPR00489. FRIZZLED.
SMARTiView protein in SMART
SM00063. FRI. 1 hit.
SM01330. Frizzled. 1 hit.
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiView protein in PROSITE
PS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9IA05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERRGGGGRM LALLLAGLLG GARGFGDEEE RRCDAIRIAM CQNLGYNVTK
60 70 80 90 100
MPNLVGHELQ ADAELQLTTF TPLIQYGCSS QLQFFLCSVY VPMCTEKINI
110 120 130 140 150
PIGPCGGMCL SVKRRCEPVL KEFGFAWPDS LNCSKFPPQN DHNHMCMEGP
160 170 180 190 200
GDEEVPLHSK TSLQPGEECH SMGSNSDQYI WVKRNLDCVL KCGYDAGLYS
210 220 230 240 250
RSAKEFTDIW MAVWASLCFI STAFTVLTFL IDSSRFSYPE RPIIFLSMCY
260 270 280 290 300
NIYSIAYIVR LTVGRERISC DFEEAAEPVL IQEGLKNTGC AIIFLLMYFF
310 320 330 340 350
GMASSIWWVI LTLTWFLAAG LKWGHEAIEM HSSYFHIAAW AIPAVKTIVI
360 370 380 390 400
LIMRLVDADE LTGLCYVGNQ NLDALTGFVV APLFTYLVIG TLFIAAGLVA
410 420 430 440 450
LFKIRSNLQK DGTKTDKLER LMVKIGVFSV LYTVPATCVI ACYFYEISNW
460 470 480 490 500
AVFRYSADDS NMAVEMLKIF MSLLVGITSG MWIWSAKTLH TWQKCSNRLV
510 520
NSGKVKREKR ADGWVKPGKG NETVV
Length:525
Mass (Da):58,766
Last modified:October 1, 2000 - v1
Checksum:i83DD31DDD3345E8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF224316 mRNA. Translation: AAF61096.1.
AB029451 mRNA. Translation: BAA89401.1.
RefSeqiNP_989430.1. NM_204099.1.
UniGeneiGga.1941.

Genome annotation databases

EnsembliENSGALT00000027873; ENSGALP00000027820; ENSGALG00000017242.
GeneIDi373887.
KEGGigga:373887.

Similar proteinsi

Entry informationi

Entry nameiFZD4_CHICK
AccessioniPrimary (citable) accession number: Q9IA05
Secondary accession number(s): Q9PTW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: October 1, 2000
Last modified: August 30, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families