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Protein

Solute carrier family 40 member 1

Gene

slc40a1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in iron export and also in transfer of iron between maternal and fetal circulation.

GO - Molecular functioni

  • iron ion transmembrane transporter activity Source: ZFIN

GO - Biological processi

  • embryonic hemopoiesis Source: ZFIN
  • hemoglobin biosynthetic process Source: ZFIN
  • iron ion homeostasis Source: UniProtKB-KW
  • iron ion transport Source: ZFIN
  • nucleate erythrocyte maturation Source: ZFIN
  • response to copper ion Source: ZFIN
  • response to iron ion Source: ZFIN
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 40 member 1
Alternative name(s):
Ferroportin-1
Gene namesi
Name:slc40a1
Synonyms:fpn1, slc39a1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-000511-8. slc40a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei56 – 7621HelicalSequence analysisAdd
BLAST
Transmembranei93 – 11321HelicalSequence analysisAdd
BLAST
Transmembranei123 – 14321HelicalSequence analysisAdd
BLAST
Transmembranei185 – 20521HelicalSequence analysisAdd
BLAST
Transmembranei301 – 32121HelicalSequence analysisAdd
BLAST
Transmembranei337 – 35721HelicalSequence analysisAdd
BLAST
Transmembranei367 – 38721HelicalSequence analysisAdd
BLAST
Transmembranei443 – 46321HelicalSequence analysisAdd
BLAST
Transmembranei485 – 50521HelicalSequence analysisAdd
BLAST
Transmembranei510 – 53021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: ZFIN
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562Solute carrier family 40 member 1PRO_0000191313Add
BLAST

Proteomic databases

PaxDbiQ9I9R3.

Expressioni

Tissue specificityi

Expressed in the yolk sac and placenta.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000000250.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2601. Eukaryota.
ENOG410XS3F. LUCA.
HOGENOMiHOG000234273.
HOVERGENiHBG055582.
InParanoidiQ9I9R3.
KOiK14685.
PhylomeDBiQ9I9R3.

Family and domain databases

InterProiIPR009716. Ferroportin-1.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF06963. FPN1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.

Sequencei

Sequence statusi: Complete.

Q9I9R3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSPASKKPR CERFREFFKS AKFLIYVGHA LSTWGDRMWN FAVAVFLVEL
60 70 80 90 100
YGNSLLLTAV YGLVVAGSVL LLGAIIGDWV DKNPRLKVAQ TSLVVQNSAV
110 120 130 140 150
ILCGALLMAV FQFKQQLSSM YDGWLLTTCY IMVISIANIA NLASTAMSIT
160 170 180 190 200
IQRDWVVVVA GDDRSKLADM NATVRIIDQL TNILAPMLVG QIMAFGSHFI
210 220 230 240 250
GCGFISGWNL FSMCLEYFLL WKVYQKTPAL AFKAGQKDSD DQELKHLNIQ
260 270 280 290 300
KEIGNTESPV EASQLMTESS EPKKDTGCCY QMAEPIRTFK DGWVAYYNQS
310 320 330 340 350
IFFAGMSLAF LYMTVLGFDC ITTGYAYTQG LNGSVLSLLM GASAVSGICG
360 370 380 390 400
TVAFTWIRKK CGLIRTGFIA GVTQLSCLTL CVASVFAPGS PFDLSVSPFE
410 420 430 440 450
EVLRHLFGDS GSLRESPTFI PTTEPPIQAN VTVFEEAPPV ESYMSVGLLF
460 470 480 490 500
AGVIAARVGL WSFDLTVTQL IQENVIESER GVINGVQNSM NYLLDLLHFI
510 520 530 540 550
MVILAPNPEA FGLLVIISVS FVAMGHMMYF RFAYKSLGSR LFLFCSPEQK
560
PDPNIPSLPN SV
Length:562
Mass (Da):61,761
Last modified:June 7, 2004 - v2
Checksum:i35CB30971553718F
GO

Sequence cautioni

The sequence AAI07846.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti134 – 1341I → V in AAI07846 (Ref. 3) Curated
Sequence conflicti272 – 2721P → T in CAD52128 (PubMed:23594743).Curated
Sequence conflicti272 – 2721P → T in CAD58776 (PubMed:23594743).Curated
Sequence conflicti400 – 4001E → K in AAF36695 (PubMed:10693807).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226612 mRNA. Translation: AAF36695.1.
AL591593 Genomic DNA. Translation: CAD43474.1.
AL672145 Genomic DNA. Translation: CAD58776.1.
AL672118 Genomic DNA. Translation: CAD52128.1.
AL731861 Genomic DNA. Translation: CAD61076.1.
BC107845 mRNA. Translation: AAI07846.1. Sequence problems.
RefSeqiNP_571704.1. NM_131629.1.
UniGeneiDr.81317.

Genome annotation databases

GeneIDi58153.
KEGGidre:58153.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226612 mRNA. Translation: AAF36695.1.
AL591593 Genomic DNA. Translation: CAD43474.1.
AL672145 Genomic DNA. Translation: CAD58776.1.
AL672118 Genomic DNA. Translation: CAD52128.1.
AL731861 Genomic DNA. Translation: CAD61076.1.
BC107845 mRNA. Translation: AAI07846.1. Sequence problems.
RefSeqiNP_571704.1. NM_131629.1.
UniGeneiDr.81317.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000000250.

Proteomic databases

PaxDbiQ9I9R3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi58153.
KEGGidre:58153.

Organism-specific databases

CTDi30061.
ZFINiZDB-GENE-000511-8. slc40a1.

Phylogenomic databases

eggNOGiKOG2601. Eukaryota.
ENOG410XS3F. LUCA.
HOGENOMiHOG000234273.
HOVERGENiHBG055582.
InParanoidiQ9I9R3.
KOiK14685.
PhylomeDBiQ9I9R3.

Miscellaneous databases

PROiQ9I9R3.

Family and domain databases

InterProiIPR009716. Ferroportin-1.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF06963. FPN1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  2. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.
  3. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-251.
    Tissue: Heart.

Entry informationi

Entry nameiS40A1_DANRE
AccessioniPrimary (citable) accession number: Q9I9R3
Secondary accession number(s): Q3B729
, Q7ZZ51, Q8AW23, Q8AW28, Q8JFW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: June 8, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.