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Protein

Tumor necrosis factor receptor type 1-associated DEATH domain protein

Gene

tradd

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Adapter molecule for tnfrsf1a that specifically associates with the cytoplasmic domain of activated tnfrsf1a mediating its interaction with fadd.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiR-DRE-3371378. Regulation by c-FLIP.
R-DRE-5218900. CASP8 activity is inhibited.
R-DRE-5357786. TNFR1-induced proapoptotic signaling.
R-DRE-5357905. Regulation of TNFR1 signaling.
R-DRE-5357956. TNFR1-induced NFkappaB signaling pathway.
R-DRE-69416. Dimerization of procaspase-8.
R-DRE-75893. TNF signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor type 1-associated DEATH domain protein
Short name:
TNFR1-associated DEATH domain protein
Alternative name(s):
TNFRSF1A-associated via death domain protein
Gene namesi
Name:traddImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-000511-5. tradd.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 293293Tumor necrosis factor receptor type 1-associated DEATH domain proteinPRO_0000291659Add
BLAST

Proteomic databases

PaxDbiQ9I9N5.
PRIDEiQ9I9N5.

Expressioni

Gene expression databases

BgeeiQ9I9N5.

Interactioni

Subunit structurei

Heterodimer with tnfrsf1a.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000052344.

Structurei

3D structure databases

ProteinModelPortaliQ9I9N5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini200 – 29091DeathPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi156 – 17116Nuclear export signalBy similarityAdd
BLAST
Motifi216 – 22914Nuclear localization signalBy similarityAdd
BLAST

Domaini

Requires the intact death domain to associate with tnfrsf1a.By similarity

Sequence similaritiesi

Contains 1 death domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IF81. Eukaryota.
ENOG4111IRA. LUCA.
GeneTreeiENSGT00390000002016.
HOGENOMiHOG000059664.
HOVERGENiHBG054083.
InParanoidiQ9I9N5.
KOiK03171.
OMAiLRFCGRQ.
OrthoDBiEOG7QRQVQ.
PhylomeDBiQ9I9N5.
TreeFamiTF331882.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.30.70.680. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR009095. TRADD_N.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF09034. TRADD_N. 1 hit.
[Graphical view]
ProDomiPD182470. TRADD_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00005. DEATH. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF55044. SSF55044. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9I9N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSIDTKRLN DSNASDRALS GCAVLFLGCS SLEHNFLSLY KDERGKFSVF
60 70 80 90 100
KVIKLTLSDS VGGLEGYEIL KLHDADPYLG VELKFMAMPP CQRFLESYAC
110 120 130 140 150
GSLTQFLSQH ASRLLALPDG VEIETQLKAG VHTLDHSLQD IEICLDHIRQ
160 170 180 190 200
SQPVRLRDDE VTQLEQQLQN SYGPPSQPPQ ELPRNCFLFQ KRVFDDRPLT
210 220 230 240 250
PADQQRFAAH VGRDWKRVGR ALQKNCRALK GPAIDNLAYE YEREGLYEQA
260 270 280 290
YQLLGRFIQS EGRSAKLSRL ISALEETKMT SMAEIMLGIQ PRD
Length:293
Mass (Da):33,151
Last modified:October 1, 2000 - v1
Checksum:i5B797643D1CE2DC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231014 Genomic DNA. Translation: AAF66959.1.
BC083425 mRNA. Translation: AAH83425.1.
RefSeqiNP_571682.1. NM_131607.2.
UniGeneiDr.105498.

Genome annotation databases

EnsembliENSDART00000052345; ENSDARP00000052344; ENSDARG00000036057.
GeneIDi58130.
KEGGidre:58130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231014 Genomic DNA. Translation: AAF66959.1.
BC083425 mRNA. Translation: AAH83425.1.
RefSeqiNP_571682.1. NM_131607.2.
UniGeneiDr.105498.

3D structure databases

ProteinModelPortaliQ9I9N5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000052344.

Proteomic databases

PaxDbiQ9I9N5.
PRIDEiQ9I9N5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000052345; ENSDARP00000052344; ENSDARG00000036057.
GeneIDi58130.
KEGGidre:58130.

Organism-specific databases

CTDi8717.
ZFINiZDB-GENE-000511-5. tradd.

Phylogenomic databases

eggNOGiENOG410IF81. Eukaryota.
ENOG4111IRA. LUCA.
GeneTreeiENSGT00390000002016.
HOGENOMiHOG000059664.
HOVERGENiHBG054083.
InParanoidiQ9I9N5.
KOiK03171.
OMAiLRFCGRQ.
OrthoDBiEOG7QRQVQ.
PhylomeDBiQ9I9N5.
TreeFamiTF331882.

Enzyme and pathway databases

ReactomeiR-DRE-3371378. Regulation by c-FLIP.
R-DRE-5218900. CASP8 activity is inhibited.
R-DRE-5357786. TNFR1-induced proapoptotic signaling.
R-DRE-5357905. Regulation of TNFR1 signaling.
R-DRE-5357956. TNFR1-induced NFkappaB signaling pathway.
R-DRE-69416. Dimerization of procaspase-8.
R-DRE-75893. TNF signaling.

Miscellaneous databases

PROiQ9I9N5.

Gene expression databases

BgeeiQ9I9N5.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.30.70.680. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR009095. TRADD_N.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF09034. TRADD_N. 1 hit.
[Graphical view]
ProDomiPD182470. TRADD_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00005. DEATH. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF55044. SSF55044. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genes with homology to mammalian apoptosis regulators identified in zebrafish."
    Inohara N., Nunez G.
    Cell Death Differ. 7:509-510(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: OvaryImported.

Entry informationi

Entry nameiTRADD_DANRE
AccessioniPrimary (citable) accession number: Q9I9N5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.