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Protein

Tumor necrosis factor receptor type 1-associated DEATH domain protein

Gene

tradd

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Adapter molecule for tnfrsf1a that specifically associates with the cytoplasmic domain of activated tnfrsf1a mediating its interaction with fadd.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-DRE-3371378 Regulation by c-FLIP
R-DRE-5213460 RIPK1-mediated regulated necrosis
R-DRE-5218900 CASP8 activity is inhibited
R-DRE-5357786 TNFR1-induced proapoptotic signaling
R-DRE-5357905 Regulation of TNFR1 signaling
R-DRE-5357956 TNFR1-induced NFkappaB signaling pathway
R-DRE-69416 Dimerization of procaspase-8
R-DRE-75893 TNF signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor type 1-associated DEATH domain protein
Short name:
TNFR1-associated DEATH domain protein
Alternative name(s):
TNFRSF1A-associated via death domain protein
Gene namesi
Name:traddImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-000511-5 tradd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002916591 – 293Tumor necrosis factor receptor type 1-associated DEATH domain proteinAdd BLAST293

Proteomic databases

PaxDbiQ9I9N5

Expressioni

Gene expression databases

BgeeiENSDARG00000036057
ExpressionAtlasiQ9I9N5 baseline

Interactioni

Subunit structurei

Heterodimer with tnfrsf1a.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000052344

Structurei

3D structure databases

ProteinModelPortaliQ9I9N5
SMRiQ9I9N5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini200 – 290DeathPROSITE-ProRule annotationAdd BLAST91

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi156 – 171Nuclear export signalBy similarityAdd BLAST16
Motifi216 – 229Nuclear localization signalBy similarityAdd BLAST14

Domaini

Requires the intact death domain to associate with tnfrsf1a.By similarity

Phylogenomic databases

eggNOGiENOG410IF81 Eukaryota
ENOG4111IRA LUCA
GeneTreeiENSGT00390000002016
HOGENOMiHOG000059664
HOVERGENiHBG054083
InParanoidiQ9I9N5
KOiK03171
OMAiFCGRQPC
OrthoDBiEOG091G0DXR
PhylomeDBiQ9I9N5
TreeFamiTF331882

Family and domain databases

Gene3Di3.30.70.680, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR035712 TRADD
IPR009095 TRADD_N
IPR036729 TRADD_N_sf
PANTHERiPTHR14913 PTHR14913, 2 hits
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF09034 TRADD_N, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD182470 TRADD_N, 1 hit
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF55044 SSF55044, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9I9N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSIDTKRLN DSNASDRALS GCAVLFLGCS SLEHNFLSLY KDERGKFSVF
60 70 80 90 100
KVIKLTLSDS VGGLEGYEIL KLHDADPYLG VELKFMAMPP CQRFLESYAC
110 120 130 140 150
GSLTQFLSQH ASRLLALPDG VEIETQLKAG VHTLDHSLQD IEICLDHIRQ
160 170 180 190 200
SQPVRLRDDE VTQLEQQLQN SYGPPSQPPQ ELPRNCFLFQ KRVFDDRPLT
210 220 230 240 250
PADQQRFAAH VGRDWKRVGR ALQKNCRALK GPAIDNLAYE YEREGLYEQA
260 270 280 290
YQLLGRFIQS EGRSAKLSRL ISALEETKMT SMAEIMLGIQ PRD
Length:293
Mass (Da):33,151
Last modified:October 1, 2000 - v1
Checksum:i5B797643D1CE2DC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231014 Genomic DNA Translation: AAF66959.1
BC083425 mRNA Translation: AAH83425.1
RefSeqiNP_571682.1, NM_131607.2
UniGeneiDr.105498

Genome annotation databases

EnsembliENSDART00000052345; ENSDARP00000052344; ENSDARG00000036057
GeneIDi58130
KEGGidre:58130

Similar proteinsi

Entry informationi

Entry nameiTRADD_DANRE
AccessioniPrimary (citable) accession number: Q9I9N5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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