Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Bax

Gene

baxa

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • positive regulation of apoptotic process Source: ZFIN
  • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: ZFIN
  • response to cadmium ion Source: ZFIN
  • response to methylmercury Source: ZFIN
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DRE-114294. Activation, translocation and oligomerization of BAX.

Names & Taxonomyi

Protein namesi
Submitted name:
BaxImported
Submitted name:
Baxa proteinImported
Submitted name:
Bcl2-associated X protein, aImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:baxaImported
Synonyms:baxImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 3

Organism-specific databases

ZFINiZDB-GENE-000511-6. baxa.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei171 – 18919HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000023687.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IWQJ. Eukaryota.
ENOG4112738. LUCA.
GeneTreeiENSGT00730000111112.
HOGENOMiHOG000095178.
HOVERGENiHBG003606.
KOiK02159.
OMAiTIINWTI.
OrthoDBiEOG70GMGD.
TreeFamiTF315834.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PRINTSiPR01862. BCL2FAMILY.
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9I9N4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPSGGGDT GSGNDQILDL GAALLNNFVY ERVRRHGDRD AEVTRSQLGG
60 70 80 90 100
VELCDPSHKR LAQCLQQIGD ELDGNAQLQS MLNNSNLQPT QDVFIRVARE
110 120 130 140 150
IFSDGKFNWG RVVALFYFAC RLVIKAISTR VPDIIRTIIS WTMSYIQEHV
160 170 180 190
INWIREQGGW DGIRSYFGTP TWQTVGVFLA GVITTALVIR KM
Length:192
Mass (Da):21,401
Last modified:October 1, 2000 - v1
Checksum:i8A71A630A56FDC32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR388062 Genomic DNA. No translation available.
AF231015 Genomic DNA. Translation: AAF66960.1.
BC055592 mRNA. Translation: AAH55592.1.
BC164990 mRNA. Translation: AAI64990.1.
RefSeqiNP_571637.1. NM_131562.2.
UniGeneiDr.78968.

Genome annotation databases

EnsembliENSDART00000011691; ENSDARP00000023687; ENSDARG00000020623.
GeneIDi58081.
KEGGidre:58081.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR388062 Genomic DNA. No translation available.
AF231015 Genomic DNA. Translation: AAF66960.1.
BC055592 mRNA. Translation: AAH55592.1.
BC164990 mRNA. Translation: AAI64990.1.
RefSeqiNP_571637.1. NM_131562.2.
UniGeneiDr.78968.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000023687.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000011691; ENSDARP00000023687; ENSDARG00000020623.
GeneIDi58081.
KEGGidre:58081.

Organism-specific databases

CTDi58081.
ZFINiZDB-GENE-000511-6. baxa.

Phylogenomic databases

eggNOGiENOG410IWQJ. Eukaryota.
ENOG4112738. LUCA.
GeneTreeiENSGT00730000111112.
HOGENOMiHOG000095178.
HOVERGENiHBG003606.
KOiK02159.
OMAiTIINWTI.
OrthoDBiEOG70GMGD.
TreeFamiTF315834.

Enzyme and pathway databases

ReactomeiR-DRE-114294. Activation, translocation and oligomerization of BAX.

Miscellaneous databases

NextBioi20892340.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PRINTSiPR01862. BCL2FAMILY.
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genes with homology to mammalian apoptosis regulators identified in zebrafish."
    Inohara N., Nunez G.
    Cell Death Differ. 7:509-510(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Whole bodyImported.
  3. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PCR rescueImported.
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  5. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ9I9N4_DANRE
AccessioniPrimary (citable) accession number: Q9I9N4
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: May 11, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.