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Protein
Submitted name:

Cell death regulator Mcl-1a

Gene

mcl1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • protein heterodimerization activity Source: ZFIN

GO - Biological processi

  • chordate embryonic development Source: ZFIN
  • negative regulation of apoptotic process Source: ZFIN
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: ZFIN
  • negative regulation of mitotic nuclear division Source: ZFIN
  • regulation of apoptotic process Source: ZFIN
  • regulation of mitotic nuclear division Source: ZFIN
  • tissue homeostasis Source: ZFIN
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Cell death regulator Mcl-1aImported
Submitted name:
Mcl-1aImported
Gene namesi
Name:mcl1aImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-000511-7. mcl1a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei236 – 25419HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

GO - Molecular functioni

  • protein heterodimerization activity Source: ZFIN

Protein-protein interaction databases

STRINGi7955.ENSDARP00000098601.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG4728. Eukaryota.
ENOG41123S0. LUCA.
HOVERGENiHBG003527.
KOiK02539.

Family and domain databases

InterProiIPR013281. Apop_reg_Mc1.
IPR002475. Bcl2-like.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PRINTSiPR01866. APOPREGMCL1.
PR01862. BCL2FAMILY.
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9I9N3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSLDFRRT ATMSFFAQGV QTPTLKTCVE DELDGYTEEE EAPLKRLRPG
60 70 80 90 100
TNGLKGLQLD GRFVSATDGS LPTTPDPEEL DYAELERDTR QLLLDFYRTH
110 120 130 140 150
TGMCPVDRKL HHAIPTMKRV VDNILVKHQI AYKGMIQRLQ LDSQPASLDF
160 170 180 190 200
IRCIASTMFK DGVTNWGRIA SLVAFGAVVC SRLKELQQDQ CVERVAEQIS
210 220 230 240 250
SYLTSEQQDW ILKNKSWHGF VEFFHQEDVE SVVRHGLLAL VGCAGIGAGL

AFLIR
Length:255
Mass (Da):28,662
Last modified:October 1, 2000 - v1
Checksum:iD7B44E6DC0C01EF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231016 mRNA. Translation: AAF66961.1.
AF302805 mRNA. Translation: AAK00290.1.
PIRiJC7567.
RefSeqiNP_571674.1. NM_131599.1.
UniGeneiDr.33208.

Genome annotation databases

GeneIDi58122.
KEGGidre:58122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231016 mRNA. Translation: AAF66961.1.
AF302805 mRNA. Translation: AAK00290.1.
PIRiJC7567.
RefSeqiNP_571674.1. NM_131599.1.
UniGeneiDr.33208.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000098601.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi58122.
KEGGidre:58122.

Organism-specific databases

CTDi58122.
ZFINiZDB-GENE-000511-7. mcl1a.

Phylogenomic databases

eggNOGiKOG4728. Eukaryota.
ENOG41123S0. LUCA.
HOVERGENiHBG003527.
KOiK02539.

Family and domain databases

InterProiIPR013281. Apop_reg_Mc1.
IPR002475. Bcl2-like.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PRINTSiPR01866. APOPREGMCL1.
PR01862. BCL2FAMILY.
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of a novel nuclear Bcl-2 family protein, zfMcl-1a, in zebrafish embryo."
    Chen M.C., Gong H.Y., Cheng C.Y., Wang J.P., Hong J.R., Wu J.L.
    Biochem. Biophys. Res. Commun. 279:725-731(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Genes with homology to mammalian apoptosis regulators identified in zebrafish."
    Inohara N., Nunez G.
    Cell Death Differ. 7:509-510(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Chen M.-C., Gong H.-Y., Tseng C.-I., Wang J.-P., Wu J.-L.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9I9N3_DANRE
AccessioniPrimary (citable) accession number: Q9I9N3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.