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Q9I9M2

- NOS_SQUAC

UniProt

Q9I9M2 - NOS_SQUAC

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Protein
Nitric oxide synthase
Gene
N/A
Organism
Squalus acanthias (Spiny dogfish)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body By similarity.

Catalytic activityi

2 L-arginine + 3 NADPH + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O.

Cofactori

Heme group By similarity.
Binds 1 FAD By similarity.
Binds 1 FMN By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi186 – ›212›27FMN By similarity
Add
BLAST

GO - Molecular functioni

  1. FMN binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. nitric-oxide synthase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Calmodulin-binding, FAD, Flavoprotein, FMN, Heme, Iron, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Nitric oxide synthase (EC:1.14.13.39)
Short name:
NOS
OrganismiSqualus acanthias (Spiny dogfish)
Taxonomic identifieri7797 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiSqualimorphiiSqualiformesSqualidaeSqualus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›212›212Nitric oxide synthase
PRO_0000170948Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9I9M2.
SMRiQ9I9M2. Positions 55-212.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini60 – ›212›153Flavodoxin-like
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni30 – 5021Calmodulin-binding Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the NOS family.

Family and domain databases

Gene3Di3.40.50.360. 2 hits.
InterProiIPR001094. Flavdoxin.
IPR008254. Flavodoxin/NO_synth.
IPR029039. Flavoprotein-like.
[Graphical view]
PfamiPF00258. Flavodoxin_1. 1 hit.
[Graphical view]
PRINTSiPR00369. FLAVODOXIN.
SUPFAMiSSF52218. SSF52218. 1 hit.
PROSITEiPS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9I9M2-1 [UniParc]FASTAAdd to Basket

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LNYQLSPSFE YQSDPWFTHV WKGVNGTPTK KRAIGFKKLA KAVKFSTKLM    50
GQAMAKRVKA TILYATETGK SQVYAKTLCE IFKHAFDAKV MSMDEYDIVH 100
LEHEALVLVV TSTFGNGDPP ENGEKFGSAL MEIRHPSSNS AERKSYKVRF 150
NSVSSYSDSR KSSSDEPEHK DNFESTGPLA NVRFSAFGLG SRAYPHFCAF 200
ARAVDTLLEE LG 212
Length:212
Mass (Da):23,651
Last modified:August 30, 2002 - v2
Checksum:i3A6B115A679E6CFF
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei212 – 2121

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF232227 mRNA. Translation: AAF36405.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF232227 mRNA. Translation: AAF36405.2 .

3D structure databases

ProteinModelPortali Q9I9M2.
SMRi Q9I9M2. Positions 55-212.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.360. 2 hits.
InterProi IPR001094. Flavdoxin.
IPR008254. Flavodoxin/NO_synth.
IPR029039. Flavoprotein-like.
[Graphical view ]
Pfami PF00258. Flavodoxin_1. 1 hit.
[Graphical view ]
PRINTSi PR00369. FLAVODOXIN.
SUPFAMi SSF52218. SSF52218. 1 hit.
PROSITEi PS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Farmerie W.G., Holland K.P., Catches J.S., Morrison-Shetlar A.I., Claiborne J.B. III, Edwards S.L., Evans D.H.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Gill.

Entry informationi

Entry nameiNOS_SQUAC
AccessioniPrimary (citable) accession number: Q9I9M2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: August 30, 2002
Last modified: June 11, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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