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Q9I9M2

- NOS_SQUAC

UniProt

Q9I9M2 - NOS_SQUAC

Protein

Nitric oxide synthase

Gene
N/A
Organism
Squalus acanthias (Spiny dogfish)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 2 (30 Aug 2002)
      Previous versions | rss
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    Functioni

    Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.By similarity

    Catalytic activityi

    2 L-arginine + 3 NADPH + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O.

    Cofactori

    Heme group.By similarity
    Binds 1 FAD.By similarity
    Binds 1 FMN.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi186 – ›212›27FMNPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. FMN binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. nitric-oxide synthase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Calmodulin-binding, FAD, Flavoprotein, FMN, Heme, Iron, Metal-binding, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nitric oxide synthase (EC:1.14.13.39)
    Short name:
    NOS
    OrganismiSqualus acanthias (Spiny dogfish)
    Taxonomic identifieri7797 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiSqualimorphiiSqualiformesSqualidaeSqualus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›212›212Nitric oxide synthasePRO_0000170948Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ9I9M2.
    SMRiQ9I9M2. Positions 55-212.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini60 – ›212›153Flavodoxin-likePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni30 – 5021Calmodulin-bindingSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the NOS family.Curated
    Contains 1 flavodoxin-like domain.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di3.40.50.360. 2 hits.
    InterProiIPR001094. Flavdoxin.
    IPR008254. Flavodoxin/NO_synth.
    IPR029039. Flavoprotein-like.
    [Graphical view]
    PfamiPF00258. Flavodoxin_1. 1 hit.
    [Graphical view]
    PRINTSiPR00369. FLAVODOXIN.
    SUPFAMiSSF52218. SSF52218. 1 hit.
    PROSITEiPS50902. FLAVODOXIN_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q9I9M2-1 [UniParc]FASTAAdd to Basket

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    LNYQLSPSFE YQSDPWFTHV WKGVNGTPTK KRAIGFKKLA KAVKFSTKLM    50
    GQAMAKRVKA TILYATETGK SQVYAKTLCE IFKHAFDAKV MSMDEYDIVH 100
    LEHEALVLVV TSTFGNGDPP ENGEKFGSAL MEIRHPSSNS AERKSYKVRF 150
    NSVSSYSDSR KSSSDEPEHK DNFESTGPLA NVRFSAFGLG SRAYPHFCAF 200
    ARAVDTLLEE LG 212
    Length:212
    Mass (Da):23,651
    Last modified:August 30, 2002 - v2
    Checksum:i3A6B115A679E6CFF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei212 – 2121

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF232227 mRNA. Translation: AAF36405.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF232227 mRNA. Translation: AAF36405.2 .

    3D structure databases

    ProteinModelPortali Q9I9M2.
    SMRi Q9I9M2. Positions 55-212.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.360. 2 hits.
    InterProi IPR001094. Flavdoxin.
    IPR008254. Flavodoxin/NO_synth.
    IPR029039. Flavoprotein-like.
    [Graphical view ]
    Pfami PF00258. Flavodoxin_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00369. FLAVODOXIN.
    SUPFAMi SSF52218. SSF52218. 1 hit.
    PROSITEi PS50902. FLAVODOXIN_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Farmerie W.G., Holland K.P., Catches J.S., Morrison-Shetlar A.I., Claiborne J.B. III, Edwards S.L., Evans D.H.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Gill.

    Entry informationi

    Entry nameiNOS_SQUAC
    AccessioniPrimary (citable) accession number: Q9I9M2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2002
    Last sequence update: August 30, 2002
    Last modified: October 1, 2014
    This is version 74 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3