Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9I9M2 (NOS_SQUAC) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nitric oxide synthase

Short name=NOS
EC=1.14.13.39
OrganismSqualus acanthias (Spiny dogfish)
Taxonomic identifier7797 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiSqualimorphiiSqualiformesSqualidaeSqualus

Protein attributes

Sequence length212 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body By similarity.

Catalytic activity

2 L-arginine + 3 NADPH + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O.

Cofactor

Heme group By similarity.

Binds 1 FAD By similarity.

Binds 1 FMN By similarity.

Sequence similarities

Belongs to the NOS family.

Contains 1 flavodoxin-like domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›212›212Nitric oxide synthase
PRO_0000170948

Regions

Domain60 – ›212›153Flavodoxin-like
Nucleotide binding186 – ›212›27FMN By similarity
Region30 – 5021Calmodulin-binding Potential

Experimental info

Non-terminal residue11
Non-terminal residue2121

Sequences

Sequence LengthMass (Da)Tools
Q9I9M2 [UniParc].

Last modified August 30, 2002. Version 2.
Checksum: 3A6B115A679E6CFF

FASTA21223,651
        10         20         30         40         50         60 
LNYQLSPSFE YQSDPWFTHV WKGVNGTPTK KRAIGFKKLA KAVKFSTKLM GQAMAKRVKA 

        70         80         90        100        110        120 
TILYATETGK SQVYAKTLCE IFKHAFDAKV MSMDEYDIVH LEHEALVLVV TSTFGNGDPP 

       130        140        150        160        170        180 
ENGEKFGSAL MEIRHPSSNS AERKSYKVRF NSVSSYSDSR KSSSDEPEHK DNFESTGPLA 

       190        200        210 
NVRFSAFGLG SRAYPHFCAF ARAVDTLLEE LG 

« Hide

References

[1]Farmerie W.G., Holland K.P., Catches J.S., Morrison-Shetlar A.I., Claiborne J.B. III, Edwards S.L., Evans D.H.
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Gill.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF232227 mRNA. Translation: AAF36405.2.

3D structure databases

ProteinModelPortalQ9I9M2.
SMRQ9I9M2. Positions 55-212.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.360. 2 hits.
InterProIPR001094. Flavdoxin.
IPR008254. Flavodoxin/NO_synth.
IPR029039. Flavoprotein-like.
[Graphical view]
PfamPF00258. Flavodoxin_1. 1 hit.
[Graphical view]
PRINTSPR00369. FLAVODOXIN.
SUPFAMSSF52218. SSF52218. 1 hit.
PROSITEPS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNOS_SQUAC
AccessionPrimary (citable) accession number: Q9I9M2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: August 30, 2002
Last modified: June 11, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families