ID TBX20_DANRE Reviewed; 446 AA. AC Q9I9K7; Q9I8L6; DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2000, sequence version 1. DT 27-MAR-2024, entry version 132. DE RecName: Full=T-box transcription factor TBX20; DE Short=T-box protein 20; DE AltName: Full=H15-related T-box transcription factor hrT; GN Name=tbx20; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE. RX PubMed=10656766; DOI=10.1006/dbio.1999.9571; RA Griffin K.J.P., Stoller J., Gibson M., Chen S., Yelon D., Stainier D.Y., RA Kimelman D.; RT "A conserved role for H15-related T-box transcription factors in zebrafish RT and Drosophila heart formation."; RL Dev. Biol. 218:235-247(2000). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE. RX PubMed=10906473; DOI=10.1016/s0925-4773(00)00346-4; RA Ahn D.-G., Ruvinsky I., Oates A.C., Silver L.M., Ho R.K.; RT "tbx20, a new vertebrate T-box gene expressed in the cranial motor neurons RT and developing cardiovascular structures in zebrafish."; RL Mech. Dev. 95:253-258(2000). CC -!- FUNCTION: Transcriptional regulator that may play a very early role in CC the differentiation of the cardiac precursors. CC {ECO:0000269|PubMed:10656766}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}. CC -!- DEVELOPMENTAL STAGE: During development, expressed in embryonic CC structures of both mesodermal and ectodermal origins, including the CC heart, cranial motor neurons and the roof of the dorsal aorta. CC Prominently associated with heart formation and continuously expressed CC in the myocardial lineage from the initiation of myocardial CC differentiation through to formation of the differentiated, two CC chambered heart. First detected in anterior lateral plate mesoderm CC (ALPM) and by the 5- to 10-somite stages, strongly expressed in ALPM CC and in two bilateral groups of mesenchymal cells close to the anterior CC notochord and in a crescent of lateral plate adjacent to the tail. At CC the 6- to 8- and 12- to 14-somite stages, expressed throughout the CC ALPM. Between the 10 and 15-somite stages, expressed throughout the CC myocardium. At the 18-somite stage, expressed in the loosely packed CC mesenchymal cells in the midline immediately anterior to the heart CC fields. Later expression seen in the cardiac cone, cardiac tube and CC ventricle. {ECO:0000269|PubMed:10656766, ECO:0000269|PubMed:10906473}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF239664; AAF42957.1; -; mRNA. DR EMBL; AF253325; AAF64322.1; -; mRNA. DR RefSeq; NP_571581.2; NM_131506.2. DR AlphaFoldDB; Q9I9K7; -. DR SMR; Q9I9K7; -. DR STRING; 7955.ENSDARP00000026669; -. DR PaxDb; 7955-ENSDARP00000089658; -. DR GeneID; 57936; -. DR KEGG; dre:57936; -. DR AGR; ZFIN:ZDB-GENE-000427-7; -. DR CTD; 57057; -. DR ZFIN; ZDB-GENE-000427-7; tbx20. DR eggNOG; KOG3586; Eukaryota. DR HOGENOM; CLU_014430_7_1_1; -. DR InParanoid; Q9I9K7; -. DR OMA; EDGHTTH; -. DR OrthoDB; 5323209at2759; -. DR PhylomeDB; Q9I9K7; -. DR PRO; PR:Q9I9K7; -. DR Proteomes; UP000000437; Chromosome 16. DR Bgee; ENSDARG00000005150; Expressed in ganglionic layer of retina and 36 other cell types or tissues. DR ExpressionAtlas; Q9I9K7; baseline. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0001525; P:angiogenesis; IMP:ZFIN. DR GO; GO:0001568; P:blood vessel development; IMP:ZFIN. DR GO; GO:0060038; P:cardiac muscle cell proliferation; IMP:ZFIN. DR GO; GO:0001708; P:cell fate specification; IBA:GO_Central. DR GO; GO:0035844; P:cloaca development; IMP:ZFIN. DR GO; GO:0035050; P:embryonic heart tube development; IMP:ZFIN. DR GO; GO:0035162; P:embryonic hemopoiesis; IMP:ZFIN. DR GO; GO:0007507; P:heart development; IMP:ZFIN. DR GO; GO:0001947; P:heart looping; IMP:ZFIN. DR GO; GO:0003313; P:heart rudiment development; IMP:ZFIN. DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IMP:ZFIN. DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro. DR GO; GO:0060043; P:regulation of cardiac muscle cell proliferation; IMP:ZFIN. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR GO; GO:0001570; P:vasculogenesis; IMP:ZFIN. DR CDD; cd20193; T-box_TBX20-like; 1. DR Gene3D; 2.60.40.820; Transcription factor, T-box; 1. DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf. DR InterPro; IPR046360; T-box_DNA-bd. DR InterPro; IPR036960; T-box_sf. DR InterPro; IPR001699; TF_T-box. DR InterPro; IPR018186; TF_T-box_CS. DR PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1. DR PANTHER; PTHR11267:SF190; T-BOX TRANSCRIPTION FACTOR TBX20; 1. DR Pfam; PF00907; T-box; 1. DR PRINTS; PR00937; TBOX. DR SMART; SM00425; TBOX; 1. DR SUPFAM; SSF49417; p53-like transcription factors; 1. DR PROSITE; PS01283; TBOX_1; 1. DR PROSITE; PS01264; TBOX_2; 1. DR PROSITE; PS50252; TBOX_3; 1. PE 2: Evidence at transcript level; KW Developmental protein; DNA-binding; Nucleus; Reference proteome; KW Transcription; Transcription regulation. FT CHAIN 1..446 FT /note="T-box transcription factor TBX20" FT /id="PRO_0000262693" FT DNA_BIND 108..287 FT /note="T-box" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00201" FT REGION 50..80 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT CONFLICT 96 FT /note="M -> K (in Ref. 2; AAF64322)" FT /evidence="ECO:0000305" FT CONFLICT 148 FT /note="L -> P (in Ref. 2; AAF64322)" FT /evidence="ECO:0000305" FT CONFLICT 196 FT /note="L -> S (in Ref. 2; AAF64322)" FT /evidence="ECO:0000305" FT CONFLICT 262..263 FT /note="AV -> CR (in Ref. 2; AAF64322)" FT /evidence="ECO:0000305" FT CONFLICT 368 FT /note="G -> D (in Ref. 2; AAF64322)" FT /evidence="ECO:0000305" SQ SEQUENCE 446 AA; 49303 MW; 8E51B49DA37B1244 CRC64; MEYTSSPKPQ LSSRANAFSI AALMSSGKTK DKESEENTIK PLEQFVEKSS CHPNLGDLPP LETHSDFSSG GGTGSGAPLC TEPLIPTTPG VPSEEMAKIS CSLETKELWD KFHELGTEMI ITKSGRRMFP TIRVSFSGVD PDAKYIVLMD IVPVDNKRYR YAYHRSSWLV AGKADPPLPA RLYVHPDSPF TGEQLLKQMV SFEKVKLTNN ELDQHGHIIL NSMHKYQPRV HIIKKKDHTA SLLNLKSEEF RTFVFTETVF TAVTAYQNQL ITRLKIDSNP FAKGFRDSSR LTDIERESVE SLIHKHSYAR SPIRTYAGDE ETLGEEGHSA HSRGSAFTAS DNLSLSSWVT TTSGFSGFQH PQSLSAIGTS TASLASPLPH PIQGSLPPYS RLGMPLTPSA LASSMQATGP TFPSFHMPRY HHYFQQGPYA AIQGLRHSST VMTPFV //