Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9I9K7 (TBX20_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
T-box transcription factor TBX20

Short name=T-box protein 20
Alternative name(s):
H15-related T-box transcription factor hrT
Gene names
Name:tbx20
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length446 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcriptional regulator that may play a very early role in the differentiation of the cardiac precursors. Ref.1

Subcellular location

Nucleus Potential.

Developmental stage

During development, expressed in embryonic structures of both mesodermal and ectodermal origins, including the heart, cranial motor neurons and the roof of the dorsal aorta. Prominently associated with heart formation and continuously expressed in the myocardial lineage from the initiation of myocardial differentiation through to formation of the differentiated, two chambered heart. First detected in anterior lateral plate mesoderm (ALPM) and by the 5- to 10-somite stages, strongly expressed in ALPM and in two bilateral groups of mesenchymal cells close to the anterior notochord and in a crescent of lateral plate adjacent to the tail. At the 6- to 8- and 12- to 14-somite stages, expressed throughout the ALPM. Between the 10 and 15-somite stages, expressed throughout the myocardium. At the 18-somite stage, expressed in the loosely packed mesenchymal cells in the midline immediately anterior to the heart fields. Later expression seen in the cardiac cone, cardiac tube and ventricle. Ref.1 Ref.2

Sequence similarities

Contains 1 T-box DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 446446T-box transcription factor TBX20
PRO_0000262693

Regions

DNA binding108 – 287180T-box

Experimental info

Sequence conflict961M → K in AAF64322. Ref.2
Sequence conflict1481L → P in AAF64322. Ref.2
Sequence conflict1961L → S in AAF64322. Ref.2
Sequence conflict262 – 2632AV → CR in AAF64322. Ref.2
Sequence conflict3681G → D in AAF64322. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9I9K7 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 8E51B49DA37B1244

FASTA44649,303
        10         20         30         40         50         60 
MEYTSSPKPQ LSSRANAFSI AALMSSGKTK DKESEENTIK PLEQFVEKSS CHPNLGDLPP 

        70         80         90        100        110        120 
LETHSDFSSG GGTGSGAPLC TEPLIPTTPG VPSEEMAKIS CSLETKELWD KFHELGTEMI 

       130        140        150        160        170        180 
ITKSGRRMFP TIRVSFSGVD PDAKYIVLMD IVPVDNKRYR YAYHRSSWLV AGKADPPLPA 

       190        200        210        220        230        240 
RLYVHPDSPF TGEQLLKQMV SFEKVKLTNN ELDQHGHIIL NSMHKYQPRV HIIKKKDHTA 

       250        260        270        280        290        300 
SLLNLKSEEF RTFVFTETVF TAVTAYQNQL ITRLKIDSNP FAKGFRDSSR LTDIERESVE 

       310        320        330        340        350        360 
SLIHKHSYAR SPIRTYAGDE ETLGEEGHSA HSRGSAFTAS DNLSLSSWVT TTSGFSGFQH 

       370        380        390        400        410        420 
PQSLSAIGTS TASLASPLPH PIQGSLPPYS RLGMPLTPSA LASSMQATGP TFPSFHMPRY 

       430        440 
HHYFQQGPYA AIQGLRHSST VMTPFV 

« Hide

References

[1]"A conserved role for H15-related T-box transcription factors in zebrafish and Drosophila heart formation."
Griffin K.J.P., Stoller J., Gibson M., Chen S., Yelon D., Stainier D.Y., Kimelman D.
Dev. Biol. 218:235-247(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
[2]"tbx20, a new vertebrate T-box gene expressed in the cranial motor neurons and developing cardiovascular structures in zebrafish."
Ahn D.-G., Ruvinsky I., Oates A.C., Silver L.M., Ho R.K.
Mech. Dev. 95:253-258(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF239664 mRNA. Translation: AAF42957.1.
AF253325 mRNA. Translation: AAF64322.1.
RefSeqNP_571581.1. NM_131506.1.
UniGeneDr.8231.

3D structure databases

ProteinModelPortalQ9I9K7.
SMRQ9I9K7. Positions 103-287.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000017185; ENSDARP00000026669; ENSDARG00000005150.
GeneID57936.
KEGGdre:57936.

Organism-specific databases

CTD57057.
ZFINZDB-GENE-000427-7. tbx20.

Phylogenomic databases

eggNOGNOG272513.
GeneTreeENSGT00740000115189.
HOGENOMHOG000286000.
HOVERGENHBG067710.
InParanoidQ9I9K7.
KOK10185.
OrthoDBEOG7GN2PM.
PhylomeDBQ9I9K7.

Gene expression databases

BgeeQ9I9K7.

Family and domain databases

Gene3D2.60.40.820. 1 hit.
InterProIPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERPTHR11267. PTHR11267. 1 hit.
PfamPF00907. T-box. 1 hit.
[Graphical view]
PRINTSPR00937. TBOX.
SMARTSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMSSF49417. SSF49417. 1 hit.
PROSITEPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20891950.
PROQ9I9K7.

Entry information

Entry nameTBX20_DANRE
AccessionPrimary (citable) accession number: Q9I9K7
Secondary accession number(s): Q9I8L6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families