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Q9I9K7

- TBX20_DANRE

UniProt

Q9I9K7 - TBX20_DANRE

Protein

T-box transcription factor TBX20

Gene

tbx20

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Transcriptional regulator that may play a very early role in the differentiation of the cardiac precursors.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi108 – 287180T-boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-box transcription factor TBX20
    Short name:
    T-box protein 20
    Alternative name(s):
    H15-related T-box transcription factor hrT
    Gene namesi
    Name:tbx20
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 16

    Organism-specific databases

    ZFINiZDB-GENE-000427-7. tbx20.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 446446T-box transcription factor TBX20PRO_0000262693Add
    BLAST

    Expressioni

    Developmental stagei

    During development, expressed in embryonic structures of both mesodermal and ectodermal origins, including the heart, cranial motor neurons and the roof of the dorsal aorta. Prominently associated with heart formation and continuously expressed in the myocardial lineage from the initiation of myocardial differentiation through to formation of the differentiated, two chambered heart. First detected in anterior lateral plate mesoderm (ALPM) and by the 5- to 10-somite stages, strongly expressed in ALPM and in two bilateral groups of mesenchymal cells close to the anterior notochord and in a crescent of lateral plate adjacent to the tail. At the 6- to 8- and 12- to 14-somite stages, expressed throughout the ALPM. Between the 10 and 15-somite stages, expressed throughout the myocardium. At the 18-somite stage, expressed in the loosely packed mesenchymal cells in the midline immediately anterior to the heart fields. Later expression seen in the cardiac cone, cardiac tube and ventricle.2 Publications

    Gene expression databases

    BgeeiQ9I9K7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9I9K7.
    SMRiQ9I9K7. Positions 103-287.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 T-box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG272513.
    GeneTreeiENSGT00740000115189.
    HOGENOMiHOG000286000.
    HOVERGENiHBG067710.
    InParanoidiQ9I9K7.
    KOiK10185.
    OrthoDBiEOG7GN2PM.
    PhylomeDBiQ9I9K7.

    Family and domain databases

    Gene3Di2.60.40.820. 1 hit.
    InterProiIPR008967. p53-like_TF_DNA-bd.
    IPR001699. TF_T-box.
    IPR018186. TF_T-box_CS.
    [Graphical view]
    PANTHERiPTHR11267. PTHR11267. 1 hit.
    PfamiPF00907. T-box. 1 hit.
    [Graphical view]
    PRINTSiPR00937. TBOX.
    SMARTiSM00425. TBOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF49417. SSF49417. 1 hit.
    PROSITEiPS01283. TBOX_1. 1 hit.
    PS01264. TBOX_2. 1 hit.
    PS50252. TBOX_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9I9K7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEYTSSPKPQ LSSRANAFSI AALMSSGKTK DKESEENTIK PLEQFVEKSS    50
    CHPNLGDLPP LETHSDFSSG GGTGSGAPLC TEPLIPTTPG VPSEEMAKIS 100
    CSLETKELWD KFHELGTEMI ITKSGRRMFP TIRVSFSGVD PDAKYIVLMD 150
    IVPVDNKRYR YAYHRSSWLV AGKADPPLPA RLYVHPDSPF TGEQLLKQMV 200
    SFEKVKLTNN ELDQHGHIIL NSMHKYQPRV HIIKKKDHTA SLLNLKSEEF 250
    RTFVFTETVF TAVTAYQNQL ITRLKIDSNP FAKGFRDSSR LTDIERESVE 300
    SLIHKHSYAR SPIRTYAGDE ETLGEEGHSA HSRGSAFTAS DNLSLSSWVT 350
    TTSGFSGFQH PQSLSAIGTS TASLASPLPH PIQGSLPPYS RLGMPLTPSA 400
    LASSMQATGP TFPSFHMPRY HHYFQQGPYA AIQGLRHSST VMTPFV 446
    Length:446
    Mass (Da):49,303
    Last modified:October 1, 2000 - v1
    Checksum:i8E51B49DA37B1244
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti96 – 961M → K in AAF64322. (PubMed:10906473)Curated
    Sequence conflicti148 – 1481L → P in AAF64322. (PubMed:10906473)Curated
    Sequence conflicti196 – 1961L → S in AAF64322. (PubMed:10906473)Curated
    Sequence conflicti262 – 2632AV → CR in AAF64322. (PubMed:10906473)Curated
    Sequence conflicti368 – 3681G → D in AAF64322. (PubMed:10906473)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF239664 mRNA. Translation: AAF42957.1.
    AF253325 mRNA. Translation: AAF64322.1.
    RefSeqiNP_571581.1. NM_131506.1.
    UniGeneiDr.8231.

    Genome annotation databases

    EnsembliENSDART00000017185; ENSDARP00000026669; ENSDARG00000005150.
    GeneIDi57936.
    KEGGidre:57936.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF239664 mRNA. Translation: AAF42957.1 .
    AF253325 mRNA. Translation: AAF64322.1 .
    RefSeqi NP_571581.1. NM_131506.1.
    UniGenei Dr.8231.

    3D structure databases

    ProteinModelPortali Q9I9K7.
    SMRi Q9I9K7. Positions 103-287.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000017185 ; ENSDARP00000026669 ; ENSDARG00000005150 .
    GeneIDi 57936.
    KEGGi dre:57936.

    Organism-specific databases

    CTDi 57057.
    ZFINi ZDB-GENE-000427-7. tbx20.

    Phylogenomic databases

    eggNOGi NOG272513.
    GeneTreei ENSGT00740000115189.
    HOGENOMi HOG000286000.
    HOVERGENi HBG067710.
    InParanoidi Q9I9K7.
    KOi K10185.
    OrthoDBi EOG7GN2PM.
    PhylomeDBi Q9I9K7.

    Miscellaneous databases

    NextBioi 20891950.
    PROi Q9I9K7.

    Gene expression databases

    Bgeei Q9I9K7.

    Family and domain databases

    Gene3Di 2.60.40.820. 1 hit.
    InterProi IPR008967. p53-like_TF_DNA-bd.
    IPR001699. TF_T-box.
    IPR018186. TF_T-box_CS.
    [Graphical view ]
    PANTHERi PTHR11267. PTHR11267. 1 hit.
    Pfami PF00907. T-box. 1 hit.
    [Graphical view ]
    PRINTSi PR00937. TBOX.
    SMARTi SM00425. TBOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49417. SSF49417. 1 hit.
    PROSITEi PS01283. TBOX_1. 1 hit.
    PS01264. TBOX_2. 1 hit.
    PS50252. TBOX_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A conserved role for H15-related T-box transcription factors in zebrafish and Drosophila heart formation."
      Griffin K.J.P., Stoller J., Gibson M., Chen S., Yelon D., Stainier D.Y., Kimelman D.
      Dev. Biol. 218:235-247(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
    2. "tbx20, a new vertebrate T-box gene expressed in the cranial motor neurons and developing cardiovascular structures in zebrafish."
      Ahn D.-G., Ruvinsky I., Oates A.C., Silver L.M., Ho R.K.
      Mech. Dev. 95:253-258(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiTBX20_DANRE
    AccessioniPrimary (citable) accession number: Q9I9K7
    Secondary accession number(s): Q9I8L6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3