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Protein

T-box transcription factor TBX20

Gene

tbx20

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional regulator that may play a very early role in the differentiation of the cardiac precursors.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi108 – 287T-boxPROSITE-ProRule annotationAdd BLAST180

GO - Molecular functioni

GO - Biological processi

  • blood vessel development Source: ZFIN
  • cardiac muscle cell proliferation Source: ZFIN
  • cloaca development Source: ZFIN
  • embryonic heart tube development Source: ZFIN
  • embryonic hemopoiesis Source: ZFIN
  • heart development Source: ZFIN
  • heart looping Source: ZFIN
  • heart rudiment development Source: ZFIN
  • negative regulation of transcription, DNA-templated Source: ZFIN
  • regulation of cardiac muscle cell proliferation Source: ZFIN
  • transcription, DNA-templated Source: UniProtKB-KW
  • vasculogenesis Source: ZFIN

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
T-box transcription factor TBX20
Short name:
T-box protein 20
Alternative name(s):
H15-related T-box transcription factor hrT
Gene namesi
Name:tbx20
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 16

Organism-specific databases

ZFINiZDB-GENE-000427-7 tbx20

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002626931 – 446T-box transcription factor TBX20Add BLAST446

Proteomic databases

PaxDbiQ9I9K7

Expressioni

Developmental stagei

During development, expressed in embryonic structures of both mesodermal and ectodermal origins, including the heart, cranial motor neurons and the roof of the dorsal aorta. Prominently associated with heart formation and continuously expressed in the myocardial lineage from the initiation of myocardial differentiation through to formation of the differentiated, two chambered heart. First detected in anterior lateral plate mesoderm (ALPM) and by the 5- to 10-somite stages, strongly expressed in ALPM and in two bilateral groups of mesenchymal cells close to the anterior notochord and in a crescent of lateral plate adjacent to the tail. At the 6- to 8- and 12- to 14-somite stages, expressed throughout the ALPM. Between the 10 and 15-somite stages, expressed throughout the myocardium. At the 18-somite stage, expressed in the loosely packed mesenchymal cells in the midline immediately anterior to the heart fields. Later expression seen in the cardiac cone, cardiac tube and ventricle.2 Publications

Gene expression databases

BgeeiENSDARG00000005150
ExpressionAtlasiQ9I9K7 baseline

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000089658

Structurei

3D structure databases

ProteinModelPortaliQ9I9K7
SMRiQ9I9K7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3586 Eukaryota
ENOG410Y98J LUCA
GeneTreeiENSGT00760000118897
HOGENOMiHOG000286000
HOVERGENiHBG067710
InParanoidiQ9I9K7
KOiK10185
OMAiTVMTPFV
OrthoDBiEOG091G0I8R
PhylomeDBiQ9I9K7

Family and domain databases

CDDicd00182 TBOX, 1 hit
Gene3Di2.60.40.820, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR036960 T-box_sf
IPR001699 TF_T-box
IPR018186 TF_T-box_CS
PANTHERiPTHR11267 PTHR11267, 1 hit
PfamiView protein in Pfam
PF00907 T-box, 1 hit
PRINTSiPR00937 TBOX
SMARTiView protein in SMART
SM00425 TBOX, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS01283 TBOX_1, 1 hit
PS01264 TBOX_2, 1 hit
PS50252 TBOX_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9I9K7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYTSSPKPQ LSSRANAFSI AALMSSGKTK DKESEENTIK PLEQFVEKSS
60 70 80 90 100
CHPNLGDLPP LETHSDFSSG GGTGSGAPLC TEPLIPTTPG VPSEEMAKIS
110 120 130 140 150
CSLETKELWD KFHELGTEMI ITKSGRRMFP TIRVSFSGVD PDAKYIVLMD
160 170 180 190 200
IVPVDNKRYR YAYHRSSWLV AGKADPPLPA RLYVHPDSPF TGEQLLKQMV
210 220 230 240 250
SFEKVKLTNN ELDQHGHIIL NSMHKYQPRV HIIKKKDHTA SLLNLKSEEF
260 270 280 290 300
RTFVFTETVF TAVTAYQNQL ITRLKIDSNP FAKGFRDSSR LTDIERESVE
310 320 330 340 350
SLIHKHSYAR SPIRTYAGDE ETLGEEGHSA HSRGSAFTAS DNLSLSSWVT
360 370 380 390 400
TTSGFSGFQH PQSLSAIGTS TASLASPLPH PIQGSLPPYS RLGMPLTPSA
410 420 430 440
LASSMQATGP TFPSFHMPRY HHYFQQGPYA AIQGLRHSST VMTPFV
Length:446
Mass (Da):49,303
Last modified:October 1, 2000 - v1
Checksum:i8E51B49DA37B1244
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96M → K in AAF64322 (PubMed:10906473).Curated1
Sequence conflicti148L → P in AAF64322 (PubMed:10906473).Curated1
Sequence conflicti196L → S in AAF64322 (PubMed:10906473).Curated1
Sequence conflicti262 – 263AV → CR in AAF64322 (PubMed:10906473).Curated2
Sequence conflicti368G → D in AAF64322 (PubMed:10906473).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239664 mRNA Translation: AAF42957.1
AF253325 mRNA Translation: AAF64322.1
RefSeqiNP_571581.2, NM_131506.2
UniGeneiDr.8231

Genome annotation databases

EnsembliENSDART00000017185; ENSDARP00000026669; ENSDARG00000005150
GeneIDi57936
KEGGidre:57936

Similar proteinsi

Entry informationi

Entry nameiTBX20_DANRE
AccessioniPrimary (citable) accession number: Q9I9K7
Secondary accession number(s): Q9I8L6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health