SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9I9K7

- TBX20_DANRE

UniProt

Q9I9K7 - TBX20_DANRE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
T-box transcription factor TBX20
Gene
tbx20
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcriptional regulator that may play a very early role in the differentiation of the cardiac precursors.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi108 – 287180T-box
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-box transcription factor TBX20
Short name:
T-box protein 20
Alternative name(s):
H15-related T-box transcription factor hrT
Gene namesi
Name:tbx20
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 16

Organism-specific databases

ZFINiZDB-GENE-000427-7. tbx20.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446T-box transcription factor TBX20
PRO_0000262693Add
BLAST

Expressioni

Developmental stagei

During development, expressed in embryonic structures of both mesodermal and ectodermal origins, including the heart, cranial motor neurons and the roof of the dorsal aorta. Prominently associated with heart formation and continuously expressed in the myocardial lineage from the initiation of myocardial differentiation through to formation of the differentiated, two chambered heart. First detected in anterior lateral plate mesoderm (ALPM) and by the 5- to 10-somite stages, strongly expressed in ALPM and in two bilateral groups of mesenchymal cells close to the anterior notochord and in a crescent of lateral plate adjacent to the tail. At the 6- to 8- and 12- to 14-somite stages, expressed throughout the ALPM. Between the 10 and 15-somite stages, expressed throughout the myocardium. At the 18-somite stage, expressed in the loosely packed mesenchymal cells in the midline immediately anterior to the heart fields. Later expression seen in the cardiac cone, cardiac tube and ventricle.2 Publications

Gene expression databases

BgeeiQ9I9K7.

Structurei

3D structure databases

ProteinModelPortaliQ9I9K7.
SMRiQ9I9K7. Positions 103-287.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG272513.
GeneTreeiENSGT00740000115189.
HOGENOMiHOG000286000.
HOVERGENiHBG067710.
InParanoidiQ9I9K7.
KOiK10185.
OrthoDBiEOG7GN2PM.
PhylomeDBiQ9I9K7.

Family and domain databases

Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiPF00907. T-box. 1 hit.
[Graphical view]
PRINTSiPR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9I9K7-1 [UniParc]FASTAAdd to Basket

« Hide

MEYTSSPKPQ LSSRANAFSI AALMSSGKTK DKESEENTIK PLEQFVEKSS    50
CHPNLGDLPP LETHSDFSSG GGTGSGAPLC TEPLIPTTPG VPSEEMAKIS 100
CSLETKELWD KFHELGTEMI ITKSGRRMFP TIRVSFSGVD PDAKYIVLMD 150
IVPVDNKRYR YAYHRSSWLV AGKADPPLPA RLYVHPDSPF TGEQLLKQMV 200
SFEKVKLTNN ELDQHGHIIL NSMHKYQPRV HIIKKKDHTA SLLNLKSEEF 250
RTFVFTETVF TAVTAYQNQL ITRLKIDSNP FAKGFRDSSR LTDIERESVE 300
SLIHKHSYAR SPIRTYAGDE ETLGEEGHSA HSRGSAFTAS DNLSLSSWVT 350
TTSGFSGFQH PQSLSAIGTS TASLASPLPH PIQGSLPPYS RLGMPLTPSA 400
LASSMQATGP TFPSFHMPRY HHYFQQGPYA AIQGLRHSST VMTPFV 446
Length:446
Mass (Da):49,303
Last modified:October 1, 2000 - v1
Checksum:i8E51B49DA37B1244
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti96 – 961M → K in AAF64322. 1 Publication
Sequence conflicti148 – 1481L → P in AAF64322. 1 Publication
Sequence conflicti196 – 1961L → S in AAF64322. 1 Publication
Sequence conflicti262 – 2632AV → CR in AAF64322. 1 Publication
Sequence conflicti368 – 3681G → D in AAF64322. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF239664 mRNA. Translation: AAF42957.1.
AF253325 mRNA. Translation: AAF64322.1.
RefSeqiNP_571581.1. NM_131506.1.
UniGeneiDr.8231.

Genome annotation databases

EnsembliENSDART00000017185; ENSDARP00000026669; ENSDARG00000005150.
GeneIDi57936.
KEGGidre:57936.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF239664 mRNA. Translation: AAF42957.1 .
AF253325 mRNA. Translation: AAF64322.1 .
RefSeqi NP_571581.1. NM_131506.1.
UniGenei Dr.8231.

3D structure databases

ProteinModelPortali Q9I9K7.
SMRi Q9I9K7. Positions 103-287.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000017185 ; ENSDARP00000026669 ; ENSDARG00000005150 .
GeneIDi 57936.
KEGGi dre:57936.

Organism-specific databases

CTDi 57057.
ZFINi ZDB-GENE-000427-7. tbx20.

Phylogenomic databases

eggNOGi NOG272513.
GeneTreei ENSGT00740000115189.
HOGENOMi HOG000286000.
HOVERGENi HBG067710.
InParanoidi Q9I9K7.
KOi K10185.
OrthoDBi EOG7GN2PM.
PhylomeDBi Q9I9K7.

Miscellaneous databases

NextBioi 20891950.
PROi Q9I9K7.

Gene expression databases

Bgeei Q9I9K7.

Family and domain databases

Gene3Di 2.60.40.820. 1 hit.
InterProi IPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view ]
PANTHERi PTHR11267. PTHR11267. 1 hit.
Pfami PF00907. T-box. 1 hit.
[Graphical view ]
PRINTSi PR00937. TBOX.
SMARTi SM00425. TBOX. 1 hit.
[Graphical view ]
SUPFAMi SSF49417. SSF49417. 1 hit.
PROSITEi PS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A conserved role for H15-related T-box transcription factors in zebrafish and Drosophila heart formation."
    Griffin K.J.P., Stoller J., Gibson M., Chen S., Yelon D., Stainier D.Y., Kimelman D.
    Dev. Biol. 218:235-247(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
  2. "tbx20, a new vertebrate T-box gene expressed in the cranial motor neurons and developing cardiovascular structures in zebrafish."
    Ahn D.-G., Ruvinsky I., Oates A.C., Silver L.M., Ho R.K.
    Mech. Dev. 95:253-258(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiTBX20_DANRE
AccessioniPrimary (citable) accession number: Q9I9K7
Secondary accession number(s): Q9I8L6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi