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Q9I9E8

- Q9I9E8_DANRE

UniProt

Q9I9E8 - Q9I9E8_DANRE

Protein
Submitted name:

E4tf1-60 transcription factor

Gene

gabpa

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    Keywords - Ligandi

    DNA-bindingUniRule annotation

    Enzyme and pathway databases

    ReactomeiREACT_220389. Transcriptional activation of mitochondrial biogenesis.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    E4tf1-60 transcription factorImported
    Submitted name:
    GA-binding protein transcription factor, alpha subunitImported
    Submitted name:
    Gabpa proteinImported
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:gabpaImported
    Synonyms:e4tfImported
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 9

    Organism-specific databases

    ZFINiZDB-GENE-011010-2. gabpa.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-KW

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ETS family.UniRule annotation
    Contains 1 ETS DNA-binding domain.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117307.
    HOGENOMiHOG000285952.
    HOVERGENiHBG051687.
    InParanoidiQ9I9E8.
    KOiK09441.
    OMAiGIPYDPV.
    TreeFamiTF350537.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    1.10.150.50. 1 hit.
    InterProiIPR000418. Ets_dom.
    IPR024668. GABP_asu_N.
    IPR003118. Pointed_dom.
    IPR013761. SAM/pointed.
    IPR016312. TF_GA-bd_asu.
    IPR029071. Ubiquitin-rel_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00178. Ets. 1 hit.
    PF11620. GABP-alpha. 1 hit.
    PF02198. SAM_PNT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001703. GABP_alpha. 1 hit.
    PRINTSiPR00454. ETSDOMAIN.
    SMARTiSM00413. ETS. 1 hit.
    SM00251. SAM_PNT. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    PS51433. PNT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9I9E8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKSETEEMI EIEIDGREKQ ECLEEGIEEQ TITAAELITQ DIDINEPIGN    50
    LKKLLEPRLQ IPLDGYDICL QDIQLHPDHS LFDQGVKTDG TVQLSVQIVT 100
    KPGEEKLNIL EIVKPVETVE VVIDPDAAAG EEAHLVEDGQ VIAVERAALP 150
    DETSEQVTRW AAALEGYRKE QVRLNIPYDP VQWTADQVIH WAVWVMKEFG 200
    IDEMEVGGIH IPGRQLCGFS QEEFLQRVPS GEILWSHLEL LRKYVLASQD 250
    QSQEATVTID QPVQIIPAPV QQATPTAIKV MKHNKTPRAP RISGEERSSP 300
    GNRTGNNGQI QLWQFLLELL TDKDSRDCIS WVGEEGEFKL NQPELVAQKW 350
    GQRKNKPTMN YEKLSRALRY YYDGDMISKV QGKRFVYKFV CDLRTLIGYS 400
    AAELNNLVTE CEQKKLARVQ LQGLGQPVNT VTLATATGQP VTTVTLAAAA 450
    LDKDS 455
    Length:455
    Mass (Da):51,045
    Last modified:October 1, 2000 - v1
    Checksum:iDC23A5927F566E7F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR759841 Genomic DNA. No translation available.
    AF257741 mRNA. Translation: AAF71747.1.
    BC055494 mRNA. Translation: AAH55494.1.
    BC066501 mRNA. Translation: AAH66501.1.
    BC165340 mRNA. Translation: AAI65340.1.
    RefSeqiNP_571662.1. NM_131587.1.
    XP_005167909.1. XM_005167852.1.
    XP_005167910.1. XM_005167853.1.
    UniGeneiDr.77675.

    Genome annotation databases

    EnsembliENSDART00000100700; ENSDARP00000091473; ENSDARG00000069289.
    ENSDART00000100701; ENSDARP00000091474; ENSDARG00000069289.
    GeneIDi58110.
    KEGGidre:58110.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR759841 Genomic DNA. No translation available.
    AF257741 mRNA. Translation: AAF71747.1 .
    BC055494 mRNA. Translation: AAH55494.1 .
    BC066501 mRNA. Translation: AAH66501.1 .
    BC165340 mRNA. Translation: AAI65340.1 .
    RefSeqi NP_571662.1. NM_131587.1.
    XP_005167909.1. XM_005167852.1.
    XP_005167910.1. XM_005167853.1.
    UniGenei Dr.77675.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000100700 ; ENSDARP00000091473 ; ENSDARG00000069289 .
    ENSDART00000100701 ; ENSDARP00000091474 ; ENSDARG00000069289 .
    GeneIDi 58110.
    KEGGi dre:58110.

    Organism-specific databases

    CTDi 2551.
    ZFINi ZDB-GENE-011010-2. gabpa.

    Phylogenomic databases

    GeneTreei ENSGT00750000117307.
    HOGENOMi HOG000285952.
    HOVERGENi HBG051687.
    InParanoidi Q9I9E8.
    KOi K09441.
    OMAi GIPYDPV.
    TreeFami TF350537.

    Enzyme and pathway databases

    Reactomei REACT_220389. Transcriptional activation of mitochondrial biogenesis.

    Miscellaneous databases

    NextBioi 20892362.
    PROi Q9I9E8.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    1.10.150.50. 1 hit.
    InterProi IPR000418. Ets_dom.
    IPR024668. GABP_asu_N.
    IPR003118. Pointed_dom.
    IPR013761. SAM/pointed.
    IPR016312. TF_GA-bd_asu.
    IPR029071. Ubiquitin-rel_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00178. Ets. 1 hit.
    PF11620. GABP-alpha. 1 hit.
    PF02198. SAM_PNT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001703. GABP_alpha. 1 hit.
    PRINTSi PR00454. ETSDOMAIN.
    SMARTi SM00413. ETS. 1 hit.
    SM00251. SAM_PNT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    PS51433. PNT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "An e4tf cDNA from Zebrafish (Danio rerio)."
      Slavov D.B., Gardiner K.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Whole bodyImported.
    3. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: KidneyImported.
    4. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PCR rescueImported.
    5. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: TuebingenImported.
    6. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TuebingenImported.

    Entry informationi

    Entry nameiQ9I9E8_DANRE
    AccessioniPrimary (citable) accession number: Q9I9E8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2000
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3