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Protein
Submitted name:

E4tf1-60 transcription factor

Gene

gabpa

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_316211. Transcriptional activation of mitochondrial biogenesis.

Names & Taxonomyi

Protein namesi
Submitted name:
E4tf1-60 transcription factorImported
Submitted name:
GA-binding protein transcription factor, alpha subunitImported
Submitted name:
Gabpa proteinImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:gabpaImported
Synonyms:e4tfImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Chromosome 9

Organism-specific databases

ZFINiZDB-GENE-011010-2. gabpa.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000091474.

Family & Domainsi

Sequence similaritiesi

Belongs to the ETS family.UniRule annotation
Contains 1 ETS DNA-binding domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000118907.
HOGENOMiHOG000285952.
HOVERGENiHBG051687.
OMAiGIPYDPV.
TreeFamiTF350537.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR024668. GABP_asu_N.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR016312. TF_GA-bd_asu.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF11620. GABP-alpha. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PIRSFiPIRSF001703. GABP_alpha. 1 hit.
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9I9E8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKSETEEMI EIEIDGREKQ ECLEEGIEEQ TITAAELITQ DIDINEPIGN
60 70 80 90 100
LKKLLEPRLQ IPLDGYDICL QDIQLHPDHS LFDQGVKTDG TVQLSVQIVT
110 120 130 140 150
KPGEEKLNIL EIVKPVETVE VVIDPDAAAG EEAHLVEDGQ VIAVERAALP
160 170 180 190 200
DETSEQVTRW AAALEGYRKE QVRLNIPYDP VQWTADQVIH WAVWVMKEFG
210 220 230 240 250
IDEMEVGGIH IPGRQLCGFS QEEFLQRVPS GEILWSHLEL LRKYVLASQD
260 270 280 290 300
QSQEATVTID QPVQIIPAPV QQATPTAIKV MKHNKTPRAP RISGEERSSP
310 320 330 340 350
GNRTGNNGQI QLWQFLLELL TDKDSRDCIS WVGEEGEFKL NQPELVAQKW
360 370 380 390 400
GQRKNKPTMN YEKLSRALRY YYDGDMISKV QGKRFVYKFV CDLRTLIGYS
410 420 430 440 450
AAELNNLVTE CEQKKLARVQ LQGLGQPVNT VTLATATGQP VTTVTLAAAA

LDKDS
Length:455
Mass (Da):51,045
Last modified:October 1, 2000 - v1
Checksum:iDC23A5927F566E7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR759841 Genomic DNA. No translation available.
AF257741 mRNA. Translation: AAF71747.1.
BC055494 mRNA. Translation: AAH55494.1.
BC066501 mRNA. Translation: AAH66501.1.
BC165340 mRNA. Translation: AAI65340.1.
RefSeqiNP_571662.1. NM_131587.1.
XP_005167909.1. XM_005167852.2.
XP_005167910.1. XM_005167853.2.
UniGeneiDr.77675.

Genome annotation databases

EnsembliENSDART00000100700; ENSDARP00000091473; ENSDARG00000069289.
ENSDART00000100701; ENSDARP00000091474; ENSDARG00000069289.
GeneIDi58110.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR759841 Genomic DNA. No translation available.
AF257741 mRNA. Translation: AAF71747.1.
BC055494 mRNA. Translation: AAH55494.1.
BC066501 mRNA. Translation: AAH66501.1.
BC165340 mRNA. Translation: AAI65340.1.
RefSeqiNP_571662.1. NM_131587.1.
XP_005167909.1. XM_005167852.2.
XP_005167910.1. XM_005167853.2.
UniGeneiDr.77675.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000091474.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000100700; ENSDARP00000091473; ENSDARG00000069289.
ENSDART00000100701; ENSDARP00000091474; ENSDARG00000069289.
GeneIDi58110.

Organism-specific databases

CTDi2551.
ZFINiZDB-GENE-011010-2. gabpa.

Phylogenomic databases

GeneTreeiENSGT00760000118907.
HOGENOMiHOG000285952.
HOVERGENiHBG051687.
OMAiGIPYDPV.
TreeFamiTF350537.

Enzyme and pathway databases

ReactomeiREACT_316211. Transcriptional activation of mitochondrial biogenesis.

Miscellaneous databases

NextBioi20892362.
PROiQ9I9E8.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR024668. GABP_asu_N.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR016312. TF_GA-bd_asu.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF11620. GABP-alpha. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PIRSFiPIRSF001703. GABP_alpha. 1 hit.
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "An e4tf cDNA from Zebrafish (Danio rerio)."
    Slavov D.B., Gardiner K.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Whole bodyImported.
  3. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: KidneyImported.
  4. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PCR rescueImported.
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  6. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ9I9E8_DANRE
AccessioniPrimary (citable) accession number: Q9I9E8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: June 24, 2015
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.