Q9I9C0 (Q9I9C0_TRASC) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Major prion protein RuleBase RU003882

Gene names

Name:

prnp EMBL CAB81568.1

Organism

Trachemys scripta (Red-eared slider turtle) (Pseudemys scripta) EMBL CAB81568.1

Taxonomic identifier

34903 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Testudines › Cryptodira › Testudinoidea › Emydidae › Trachemys

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the prion family. RuleBase RU003882

Ontologies

Keywords
Cellular component	Amyloid Cell membrane SAAS SAAS022416 RuleBase RU003882 Membrane
Domain	Repeat SAAS SAAS022416 Signal EMBL CAB81568.1
Molecular function	Prion RuleBase RU003882 EMBL CAB81568.1
PTM	Disulfide bond SAAS SAAS022416
Technical term	3D-structure PDB 1U5L
Gene Ontology (GO)
Biological process	protein homooligomerization Inferred from electronic annotation. Source: InterPro
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential EMBL CAB81568.1
	Chain	25 – 270	246	prion protein EMBL CAB81568.1		PRO_5000065436

Sequences

	Sequence		Length	Mass (Da)
	Q9I9C0 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: E37DCB9F6F885850	FASTA	270	30,149
	10 20 30 40 50 60 MGRYRLTCWI VVLLVVMWSD VSFSKKGKGK GGGGGNTGSN RNPNYPSNPG YPQNPGYPRN 70 80 90 100 110 120 PSYPHNPAYP PNPAYPPNPG YPHNPSYPRN PSYPQNPGYP GGGGQHYNPA GGGTNFKNQK 130 140 150 160 170 180 PWKPDKPKTN MKAMAGAAAA GAVVGGLGGY ALGSAMSGMR MNFDRPEERQ WWNENSNRYP 190 200 210 220 230 240 NQVYYKEYND RSVPEGRFVR DCLNNTVTEY KIDPNENQNV TQVEVRVMKQ VIQEMCMQQY 250 260 270 QQYQLASGVK LLSDPSLMLI IMLVIFFVMH

References

[1]	"cDNA cloning of turtle prion protein." Simonic T., Duga S., Strumbo B., Asselta R., Ceciliani F., Ronchi S. FEBS Lett. 469:33-38(2000) [PubMed: 10708751] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Liver EMBL CAB81568.1.
[2]	"Prion protein NMR structures of chickens, turtles, and frogs." Calzolai L., Lysek D.A., Perez D.R., Guentert P., Wuethrich K. Proc. Natl. Acad. Sci. U.S.A. 102:651-655(2005) [PubMed: 15647366] [Abstract] Cited for: STRUCTURE BY NMR OF 143-248.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AJ245488 mRNA. Translation: CAB81568.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1U5L	NMR	-	A	143-248	[»]

ProteinModelPortal

Q9I9C0.

SMR

Q9I9C0. Positions 141-247.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Phylogenomic databases

HOVERGEN

HBG008260.

Family and domain databases

InterPro

IPR000817. Prion.
IPR022416. Prion/Doppel_prot_b-ribbon_dom.
[Graphical view]

Gene3D

G3DSA:1.10.790.10. Prion. 1 hit.

PANTHER

PTHR11522. Prion. 1 hit.

Pfam

PF00377. Prion. 1 hit.
[Graphical view]

SMART

SM00157. PRP. 1 hit.
[Graphical view]

SUPFAM

SSF54098. Prion. 1 hit.

PROSITE

PS00291. PRION_1. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q9I9C0_TRASC

Accession

Primary (citable) accession number: Q9I9C0

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2000
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)