SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9I993

- BCDO1_CHICK

UniProt

Q9I993 - BCDO1_CHICK

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Beta,beta-carotene 15,15'-monooxygenase
Gene
BCMO1, BCDO
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Symmetrically cleaves beta-carotene into two molecules of retinal. The reaction proceeds in three stages, epoxidation of the 15,15'-double bond, hydration of the double bond leading to ring opening, and oxidative cleavage of the diol formed.

Catalytic activityi

Beta-carotene + O2 = 2 all-trans-retinal.

Cofactori

Binds 1 Fe2+ ion per subunit.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi172 – 1721Iron; catalytic By similarity
Metal bindingi236 – 2361Iron; catalytic By similarity
Metal bindingi307 – 3071Iron; catalytic By similarity
Metal bindingi512 – 5121Iron; catalytic By similarity

GO - Molecular functioni

  1. beta-carotene 15,15'-monooxygenase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW
  3. monooxygenase activity Source: UniProtKB-KW

GO - Biological processi

  1. retinoid metabolic process Source: UniProtKB
  2. retinol metabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17624.
ReactomeiREACT_197071. Retinoid metabolism and transport.
UniPathwayiUPA00912.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta,beta-carotene 15,15'-monooxygenase (EC:1.14.99.36)
Alternative name(s):
Beta-carotene dioxygenase 1
Gene namesi
Name:BCMO1
Synonyms:BCDO
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 11

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Beta,beta-carotene 15,15'-monooxygenase
PRO_0000143936Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000008671.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3670.
GeneTreeiENSGT00500000044783.
HOGENOMiHOG000232156.
HOVERGENiHBG050679.
InParanoidiQ9I993.
KOiK00515.
OMAiITENYIV.
OrthoDBiEOG7353WB.
PhylomeDBiQ9I993.
TreeFamiTF314019.

Family and domain databases

InterProiIPR004294. Carotenoid_Oase.
[Graphical view]
PANTHERiPTHR10543. PTHR10543. 1 hit.
PfamiPF03055. RPE65. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9I993-1 [UniParc]FASTAAdd to Basket

« Hide

METIFNRNKE EHPEPIKAEV QGQLPTWLQG VLLRNGPGMH TIGDTKYNHW    50
FDGLALLHSF TFKNGEVYYR SKYLRSDTYN CNIEANRIVV SEFGTMAYPD 100
PCKNIFAKAF SYLSHTIPEF TDNCLINIMK TGDDYYATSE TNFIRKIDPQ 150
TLETLDKVDY SKYVAVNLAT SHPHYDSAGN ILNMGTSIVD KGRTKYVLFK 200
IPSSVPEKEK KKSCFKHLEV VCSIPSRSLL QPSYYHSFGI TENYIVFIEQ 250
PFKLDIVKLA TAYIRGVNWA SCLSFHKEDK TWFHFVDRKT KKEVSTKFYT 300
DALVLYHHIN AYEEDGHVVF DIVAYRDNSL YDMFYLKKLD KDFEVNNKLT 350
SIPTCKRFVV PLQYDKDAEV GSNLVKLPTS ATAVKEKDGS IYCQPEILCE 400
GIELPRVNYD YNGKKYKYVY ATEVQWSPVP TKIAKLNVQT KEVLHWGEDH 450
CWPSEPIFVP SPDAREEDEG VVLTCVVVSE PNKAPFLLIL DAKTFKELGR 500
ATVNVEMHLD LHGMFIPQND LGAETE 526
Length:526
Mass (Da):60,385
Last modified:October 1, 2000 - v1
Checksum:i82C6EAAF75FE345B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ271386 mRNA. Translation: CAB90825.1.
RefSeqiNP_989966.1. NM_204635.1.
UniGeneiGga.41.

Genome annotation databases

EnsembliENSGALT00000008685; ENSGALP00000008671; ENSGALG00000005408.
GeneIDi395346.
KEGGigga:395346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ271386 mRNA. Translation: CAB90825.1 .
RefSeqi NP_989966.1. NM_204635.1.
UniGenei Gga.41.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000008671.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000008685 ; ENSGALP00000008671 ; ENSGALG00000005408 .
GeneIDi 395346.
KEGGi gga:395346.

Organism-specific databases

CTDi 53630.

Phylogenomic databases

eggNOGi COG3670.
GeneTreei ENSGT00500000044783.
HOGENOMi HOG000232156.
HOVERGENi HBG050679.
InParanoidi Q9I993.
KOi K00515.
OMAi ITENYIV.
OrthoDBi EOG7353WB.
PhylomeDBi Q9I993.
TreeFami TF314019.

Enzyme and pathway databases

UniPathwayi UPA00912 .
BioCyci MetaCyc:MONOMER-17624.
Reactomei REACT_197071. Retinoid metabolism and transport.

Miscellaneous databases

NextBioi 20815431.
PROi Q9I993.

Family and domain databases

InterProi IPR004294. Carotenoid_Oase.
[Graphical view ]
PANTHERi PTHR10543. PTHR10543. 1 hit.
Pfami PF03055. RPE65. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Strain: LSL Lohmann.
    Tissue: Duodenum.
  2. "Expression pattern and localization of beta,beta-carotene 15,15'-dioxygenase in different tissues."
    Wyss A., Wirtz G.M., Woggon W.D., Brugger R., Wyss M., Friedlein A., Riss G., Bachmann H., Hunziker W.
    Biochem. J. 354:521-529(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: LSL Lohmann.
    Tissue: Duodenum.

Entry informationi

Entry nameiBCDO1_CHICK
AccessioniPrimary (citable) accession number: Q9I993
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi