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Q9I993

- BCDO1_CHICK

UniProt

Q9I993 - BCDO1_CHICK

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Protein

Beta,beta-carotene 15,15'-monooxygenase

Gene

BCO1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Symmetrically cleaves beta-carotene into two molecules of retinal. The reaction proceeds in three stages, epoxidation of the 15,15'-double bond, hydration of the double bond leading to ring opening, and oxidative cleavage of the diol formed.

Catalytic activityi

Beta-carotene + O2 = 2 all-trans-retinal.

Cofactori

Binds 1 Fe2+ ion per subunit.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi172 – 1721Iron; catalyticBy similarity
Metal bindingi236 – 2361Iron; catalyticBy similarity
Metal bindingi307 – 3071Iron; catalyticBy similarity
Metal bindingi512 – 5121Iron; catalyticBy similarity

GO - Molecular functioni

  1. beta-carotene 15,15'-monooxygenase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW
  3. monooxygenase activity Source: UniProtKB-KW

GO - Biological processi

  1. retinoid metabolic process Source: UniProtKB
  2. retinol metabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17624.
ReactomeiREACT_197071. Retinoid metabolism and transport.
UniPathwayiUPA00912.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta,beta-carotene 15,15'-monooxygenase (EC:1.14.99.36)
Alternative name(s):
Beta-carotene dioxygenase 1
Beta-carotene oxygenase 1By similarity
Gene namesi
Name:BCO1By similarity
Synonyms:BCDO, BCMO1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 11

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Beta,beta-carotene 15,15'-monooxygenasePRO_0000143936Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000008671.

Family & Domainsi

Sequence similaritiesi

Belongs to the carotenoid oxygenase family.Curated

Phylogenomic databases

eggNOGiCOG3670.
GeneTreeiENSGT00500000044783.
HOGENOMiHOG000232156.
HOVERGENiHBG050679.
InParanoidiQ9I993.
KOiK00515.
OMAiITENYIV.
OrthoDBiEOG7353WB.
PhylomeDBiQ9I993.
TreeFamiTF314019.

Family and domain databases

InterProiIPR004294. Carotenoid_Oase.
[Graphical view]
PANTHERiPTHR10543. PTHR10543. 1 hit.
PfamiPF03055. RPE65. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9I993-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METIFNRNKE EHPEPIKAEV QGQLPTWLQG VLLRNGPGMH TIGDTKYNHW
60 70 80 90 100
FDGLALLHSF TFKNGEVYYR SKYLRSDTYN CNIEANRIVV SEFGTMAYPD
110 120 130 140 150
PCKNIFAKAF SYLSHTIPEF TDNCLINIMK TGDDYYATSE TNFIRKIDPQ
160 170 180 190 200
TLETLDKVDY SKYVAVNLAT SHPHYDSAGN ILNMGTSIVD KGRTKYVLFK
210 220 230 240 250
IPSSVPEKEK KKSCFKHLEV VCSIPSRSLL QPSYYHSFGI TENYIVFIEQ
260 270 280 290 300
PFKLDIVKLA TAYIRGVNWA SCLSFHKEDK TWFHFVDRKT KKEVSTKFYT
310 320 330 340 350
DALVLYHHIN AYEEDGHVVF DIVAYRDNSL YDMFYLKKLD KDFEVNNKLT
360 370 380 390 400
SIPTCKRFVV PLQYDKDAEV GSNLVKLPTS ATAVKEKDGS IYCQPEILCE
410 420 430 440 450
GIELPRVNYD YNGKKYKYVY ATEVQWSPVP TKIAKLNVQT KEVLHWGEDH
460 470 480 490 500
CWPSEPIFVP SPDAREEDEG VVLTCVVVSE PNKAPFLLIL DAKTFKELGR
510 520
ATVNVEMHLD LHGMFIPQND LGAETE
Length:526
Mass (Da):60,385
Last modified:October 1, 2000 - v1
Checksum:i82C6EAAF75FE345B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ271386 mRNA. Translation: CAB90825.1.
RefSeqiNP_989966.1. NM_204635.1.
UniGeneiGga.41.

Genome annotation databases

EnsembliENSGALT00000008685; ENSGALP00000008671; ENSGALG00000005408.
GeneIDi395346.
KEGGigga:395346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ271386 mRNA. Translation: CAB90825.1 .
RefSeqi NP_989966.1. NM_204635.1.
UniGenei Gga.41.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000008671.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000008685 ; ENSGALP00000008671 ; ENSGALG00000005408 .
GeneIDi 395346.
KEGGi gga:395346.

Organism-specific databases

CTDi 103175958.

Phylogenomic databases

eggNOGi COG3670.
GeneTreei ENSGT00500000044783.
HOGENOMi HOG000232156.
HOVERGENi HBG050679.
InParanoidi Q9I993.
KOi K00515.
OMAi ITENYIV.
OrthoDBi EOG7353WB.
PhylomeDBi Q9I993.
TreeFami TF314019.

Enzyme and pathway databases

UniPathwayi UPA00912 .
BioCyci MetaCyc:MONOMER-17624.
Reactomei REACT_197071. Retinoid metabolism and transport.

Miscellaneous databases

NextBioi 20815431.
PROi Q9I993.

Family and domain databases

InterProi IPR004294. Carotenoid_Oase.
[Graphical view ]
PANTHERi PTHR10543. PTHR10543. 1 hit.
Pfami PF03055. RPE65. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Strain: LSL Lohmann.
    Tissue: Duodenum.
  2. "Expression pattern and localization of beta,beta-carotene 15,15'-dioxygenase in different tissues."
    Wyss A., Wirtz G.M., Woggon W.D., Brugger R., Wyss M., Friedlein A., Riss G., Bachmann H., Hunziker W.
    Biochem. J. 354:521-529(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: LSL Lohmann.
    Tissue: Duodenum.

Entry informationi

Entry nameiBCDO1_CHICK
AccessioniPrimary (citable) accession number: Q9I993
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3