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Q9I993

- BCDO1_CHICK

UniProt

Q9I993 - BCDO1_CHICK

Protein

Beta,beta-carotene 15,15'-monooxygenase

Gene

BCMO1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Symmetrically cleaves beta-carotene into two molecules of retinal. The reaction proceeds in three stages, epoxidation of the 15,15'-double bond, hydration of the double bond leading to ring opening, and oxidative cleavage of the diol formed.

    Catalytic activityi

    Beta-carotene + O2 = 2 all-trans-retinal.

    Cofactori

    Binds 1 Fe2+ ion per subunit.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi172 – 1721Iron; catalyticBy similarity
    Metal bindingi236 – 2361Iron; catalyticBy similarity
    Metal bindingi307 – 3071Iron; catalyticBy similarity
    Metal bindingi512 – 5121Iron; catalyticBy similarity

    GO - Molecular functioni

    1. beta-carotene 15,15'-monooxygenase activity Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW
    3. monooxygenase activity Source: UniProtKB-KW

    GO - Biological processi

    1. retinoid metabolic process Source: UniProtKB
    2. retinol metabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-17624.
    ReactomeiREACT_197071. Retinoid metabolism and transport.
    UniPathwayiUPA00912.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta,beta-carotene 15,15'-monooxygenase (EC:1.14.99.36)
    Alternative name(s):
    Beta-carotene dioxygenase 1
    Gene namesi
    Name:BCMO1
    Synonyms:BCDO
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 11

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 526526Beta,beta-carotene 15,15'-monooxygenasePRO_0000143936Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000008671.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the carotenoid oxygenase family.Curated

    Phylogenomic databases

    eggNOGiCOG3670.
    GeneTreeiENSGT00500000044783.
    HOGENOMiHOG000232156.
    HOVERGENiHBG050679.
    InParanoidiQ9I993.
    KOiK00515.
    OMAiITENYIV.
    OrthoDBiEOG7353WB.
    PhylomeDBiQ9I993.
    TreeFamiTF314019.

    Family and domain databases

    InterProiIPR004294. Carotenoid_Oase.
    [Graphical view]
    PANTHERiPTHR10543. PTHR10543. 1 hit.
    PfamiPF03055. RPE65. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9I993-1 [UniParc]FASTAAdd to Basket

    « Hide

    METIFNRNKE EHPEPIKAEV QGQLPTWLQG VLLRNGPGMH TIGDTKYNHW    50
    FDGLALLHSF TFKNGEVYYR SKYLRSDTYN CNIEANRIVV SEFGTMAYPD 100
    PCKNIFAKAF SYLSHTIPEF TDNCLINIMK TGDDYYATSE TNFIRKIDPQ 150
    TLETLDKVDY SKYVAVNLAT SHPHYDSAGN ILNMGTSIVD KGRTKYVLFK 200
    IPSSVPEKEK KKSCFKHLEV VCSIPSRSLL QPSYYHSFGI TENYIVFIEQ 250
    PFKLDIVKLA TAYIRGVNWA SCLSFHKEDK TWFHFVDRKT KKEVSTKFYT 300
    DALVLYHHIN AYEEDGHVVF DIVAYRDNSL YDMFYLKKLD KDFEVNNKLT 350
    SIPTCKRFVV PLQYDKDAEV GSNLVKLPTS ATAVKEKDGS IYCQPEILCE 400
    GIELPRVNYD YNGKKYKYVY ATEVQWSPVP TKIAKLNVQT KEVLHWGEDH 450
    CWPSEPIFVP SPDAREEDEG VVLTCVVVSE PNKAPFLLIL DAKTFKELGR 500
    ATVNVEMHLD LHGMFIPQND LGAETE 526
    Length:526
    Mass (Da):60,385
    Last modified:October 1, 2000 - v1
    Checksum:i82C6EAAF75FE345B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ271386 mRNA. Translation: CAB90825.1.
    RefSeqiNP_989966.1. NM_204635.1.
    UniGeneiGga.41.

    Genome annotation databases

    EnsembliENSGALT00000008685; ENSGALP00000008671; ENSGALG00000005408.
    GeneIDi395346.
    KEGGigga:395346.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ271386 mRNA. Translation: CAB90825.1 .
    RefSeqi NP_989966.1. NM_204635.1.
    UniGenei Gga.41.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000008671.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000008685 ; ENSGALP00000008671 ; ENSGALG00000005408 .
    GeneIDi 395346.
    KEGGi gga:395346.

    Organism-specific databases

    CTDi 53630.

    Phylogenomic databases

    eggNOGi COG3670.
    GeneTreei ENSGT00500000044783.
    HOGENOMi HOG000232156.
    HOVERGENi HBG050679.
    InParanoidi Q9I993.
    KOi K00515.
    OMAi ITENYIV.
    OrthoDBi EOG7353WB.
    PhylomeDBi Q9I993.
    TreeFami TF314019.

    Enzyme and pathway databases

    UniPathwayi UPA00912 .
    BioCyci MetaCyc:MONOMER-17624.
    Reactomei REACT_197071. Retinoid metabolism and transport.

    Miscellaneous databases

    NextBioi 20815431.
    PROi Q9I993.

    Family and domain databases

    InterProi IPR004294. Carotenoid_Oase.
    [Graphical view ]
    PANTHERi PTHR10543. PTHR10543. 1 hit.
    Pfami PF03055. RPE65. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Strain: LSL Lohmann.
      Tissue: Duodenum.
    2. "Expression pattern and localization of beta,beta-carotene 15,15'-dioxygenase in different tissues."
      Wyss A., Wirtz G.M., Woggon W.D., Brugger R., Wyss M., Friedlein A., Riss G., Bachmann H., Hunziker W.
      Biochem. J. 354:521-529(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: LSL Lohmann.
      Tissue: Duodenum.

    Entry informationi

    Entry nameiBCDO1_CHICK
    AccessioniPrimary (citable) accession number: Q9I993
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3