Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9I946

- PDGFC_CHICK

UniProt

Q9I946 - PDGFC_CHICK

Protein

Platelet-derived growth factor C

Gene

PDGFC

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, in angiogenesis and blood vessel development By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei225 – 2262CleavageCurated
    Sitei231 – 2322CleavageSequence Analysis
    Sitei234 – 2352CleavageSequence Analysis

    GO - Biological processi

    1. activation of transmembrane receptor protein tyrosine kinase activity Source: Ensembl
    2. cellular response to amino acid stimulus Source: Ensembl
    3. organ morphogenesis Source: Ensembl
    4. platelet-derived growth factor receptor signaling pathway Source: Ensembl
    5. positive regulation of cell division Source: UniProtKB-KW
    6. positive regulation of DNA replication Source: Ensembl
    7. positive regulation of fibroblast proliferation Source: Ensembl
    8. regulation of peptidyl-tyrosine phosphorylation Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein, Growth factor, Mitogen

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Platelet-derived growth factor C
    Short name:
    PDGF-C
    Alternative name(s):
    Spinal cord-derived growth factor
    Cleaved into the following 2 chains:
    Platelet-derived growth factor C, receptor-binding form
    Short name:
    PDGFC receptor-binding form
    Gene namesi
    Name:PDGFC
    Synonyms:SCDGF
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 4

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. extracellular space Source: Ensembl
    3. membrane Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 345Platelet-derived growth factor C, receptor-binding formPRO_0000343878
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 345323Platelet-derived growth factor C, latent formPRO_0000343877Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi104 ↔ 124PROSITE-ProRule annotation
    Disulfide bondi250 ↔ 294PROSITE-ProRule annotation
    Disulfide bondi274 – 274Interchain (with C-286)PROSITE-ProRule annotation
    Disulfide bondi280 ↔ 335PROSITE-ProRule annotation
    Disulfide bondi286 – 286Interchain (with C-274)PROSITE-ProRule annotation
    Disulfide bondi287 ↔ 337PROSITE-ProRule annotation

    Post-translational modificationi

    Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after basic residues in the hinge region (region connecting the CUB and growth factor domains) gives rise to the receptor-binding form By similarity.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9I946.

    Expressioni

    Developmental stagei

    Expression increases in the spinal cord from E4 to E16, with the highest level detected between E12 and E16. Expression rapidly decreases after hatching.1 Publication

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked. Interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000015259.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9I946.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 163118CUBPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PDGF/VEGF growth factor family.Curated
    Contains 1 CUB domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG74970.
    GeneTreeiENSGT00390000005171.
    HOGENOMiHOG000261610.
    HOVERGENiHBG057324.
    InParanoidiQ9I946.
    KOiK05450.
    OMAiDCVCRGN.
    OrthoDBiEOG7VB2FN.
    PhylomeDBiQ9I946.
    TreeFamiTF332130.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    2.60.120.290. 1 hit.
    InterProiIPR000859. CUB_dom.
    IPR029034. Cystine-knot_cytokine.
    IPR000072. PDGF/VEGF_dom.
    [Graphical view]
    PfamiPF00431. CUB. 1 hit.
    PF00341. PDGF. 1 hit.
    [Graphical view]
    SMARTiSM00042. CUB. 1 hit.
    SM00141. PDGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF49854. SSF49854. 1 hit.
    SSF57501. SSF57501. 1 hit.
    PROSITEiPS01180. CUB. 1 hit.
    PS50278. PDGF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9I946-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLLGLLLLT SALAGRRHGA AAESDLSSKF SFPGAKEQNG VQDPQHEKII    50
    TVTSNGSIHS PKFPHTYPRN TVLVWRLVAV DENVWIQLTF DERFGLEDPE 100
    DDICKYDFVE VEEPSDGTVL GRWCGSSSVP SRQISKGNQI RIRFVSDEYF 150
    PSQPGFCIHY TLLVPHHTEA PSPSSLPPSA LPLDVLNNAV AGFSTVEELI 200
    RYLEPDRWQL DLEDLYRPTW QLLGKAYIHG RKSRVVDLNL LKEEVRLYSC 250
    TPRNFSVSLR EELKRTDTIF WPLCLLVKRC GGNCACCHQN CNECQCIPTK 300
    VTKKYHEVLQ LKPRSGVRGL HKSLTDVPLE HHEECDCVCK GNSEG 345
    Length:345
    Mass (Da):38,940
    Last modified:October 1, 2000 - v1
    Checksum:i97ACEA992BF5128C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033829 mRNA. Translation: BAB03265.1.
    RefSeqiNP_990052.1. NM_204721.2.
    UniGeneiGga.1907.

    Genome annotation databases

    EnsembliENSGALT00000015275; ENSGALP00000015259; ENSGALG00000009378.
    GeneIDi395469.
    KEGGigga:395469.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033829 mRNA. Translation: BAB03265.1 .
    RefSeqi NP_990052.1. NM_204721.2.
    UniGenei Gga.1907.

    3D structure databases

    ProteinModelPortali Q9I946.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000015259.

    Proteomic databases

    PaxDbi Q9I946.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000015275 ; ENSGALP00000015259 ; ENSGALG00000009378 .
    GeneIDi 395469.
    KEGGi gga:395469.

    Organism-specific databases

    CTDi 56034.

    Phylogenomic databases

    eggNOGi NOG74970.
    GeneTreei ENSGT00390000005171.
    HOGENOMi HOG000261610.
    HOVERGENi HBG057324.
    InParanoidi Q9I946.
    KOi K05450.
    OMAi DCVCRGN.
    OrthoDBi EOG7VB2FN.
    PhylomeDBi Q9I946.
    TreeFami TF332130.

    Miscellaneous databases

    NextBioi 20815550.
    PROi Q9I946.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    2.60.120.290. 1 hit.
    InterProi IPR000859. CUB_dom.
    IPR029034. Cystine-knot_cytokine.
    IPR000072. PDGF/VEGF_dom.
    [Graphical view ]
    Pfami PF00431. CUB. 1 hit.
    PF00341. PDGF. 1 hit.
    [Graphical view ]
    SMARTi SM00042. CUB. 1 hit.
    SM00141. PDGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49854. SSF49854. 1 hit.
    SSF57501. SSF57501. 1 hit.
    PROSITEi PS01180. CUB. 1 hit.
    PS50278. PDGF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel gene derived from developing spinal cords, SCDGF, is a unique member of the PDGF/VEGF family."
      Hamada T., Ui-Tei K., Miyata Y.
      FEBS Lett. 475:97-102(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
      Strain: White leghorn.
      Tissue: Spinal cord.

    Entry informationi

    Entry nameiPDGFC_CHICK
    AccessioniPrimary (citable) accession number: Q9I946
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3