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Protein

Platelet-derived growth factor C

Gene

PDGFC

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, in angiogenesis and blood vessel development (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Enzyme and pathway databases

ReactomeiR-GGA-186797. Signaling by PDGF.

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet-derived growth factor C
Short name:
PDGF-C
Alternative name(s):
Spinal cord-derived growth factor
Cleaved into the following 2 chains:
Platelet-derived growth factor C, receptor-binding form
Short name:
PDGFC receptor-binding form
Gene namesi
Name:PDGFC
Synonyms:SCDGF
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 4

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000343878? – 345Platelet-derived growth factor C, receptor-binding form
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000034387723 – 345Platelet-derived growth factor C, latent formAdd BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi55N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi104 ↔ 124PROSITE-ProRule annotation
Disulfide bondi250 ↔ 294PROSITE-ProRule annotation
Disulfide bondi274Interchain (with C-286)PROSITE-ProRule annotation
Disulfide bondi280 ↔ 335PROSITE-ProRule annotation
Disulfide bondi286Interchain (with C-274)PROSITE-ProRule annotation
Disulfide bondi287 ↔ 337PROSITE-ProRule annotation

Post-translational modificationi

Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after basic residues in the hinge region (region connecting the CUB and growth factor domains) gives rise to the receptor-binding form (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei225 – 226CleavageCurated2
Sitei231 – 232CleavageSequence analysis2
Sitei234 – 235CleavageSequence analysis2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9I946.

Expressioni

Developmental stagei

Expression increases in the spinal cord from E4 to E16, with the highest level detected between E12 and E16. Expression rapidly decreases after hatching.1 Publication

Gene expression databases

BgeeiENSGALG00000009378.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015259.

Structurei

3D structure databases

ProteinModelPortaliQ9I946.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 163CUBPROSITE-ProRule annotationAdd BLAST118

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.Curated
Contains 1 CUB domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IETQ. Eukaryota.
ENOG410XQ91. LUCA.
GeneTreeiENSGT00390000005171.
HOGENOMiHOG000261610.
HOVERGENiHBG057324.
InParanoidiQ9I946.
KOiK05450.
OMAiDCVCRGN.
OrthoDBiEOG091G0BFZ.
PhylomeDBiQ9I946.
TreeFamiTF332130.

Family and domain databases

CDDicd00041. CUB. 1 hit.
cd00135. PDGF. 1 hit.
Gene3Di2.10.90.10. 1 hit.
2.60.120.290. 1 hit.
InterProiIPR000859. CUB_dom.
IPR029034. Cystine-knot_cytokine.
IPR029817. PDGF-C.
IPR000072. PDGF/VEGF_dom.
[Graphical view]
PANTHERiPTHR11633:SF5. PTHR11633:SF5. 1 hit.
PfamiPF00431. CUB. 1 hit.
PF00341. PDGF. 1 hit.
[Graphical view]
SMARTiSM00042. CUB. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF57501. SSF57501. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9I946-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLGLLLLT SALAGRRHGA AAESDLSSKF SFPGAKEQNG VQDPQHEKII
60 70 80 90 100
TVTSNGSIHS PKFPHTYPRN TVLVWRLVAV DENVWIQLTF DERFGLEDPE
110 120 130 140 150
DDICKYDFVE VEEPSDGTVL GRWCGSSSVP SRQISKGNQI RIRFVSDEYF
160 170 180 190 200
PSQPGFCIHY TLLVPHHTEA PSPSSLPPSA LPLDVLNNAV AGFSTVEELI
210 220 230 240 250
RYLEPDRWQL DLEDLYRPTW QLLGKAYIHG RKSRVVDLNL LKEEVRLYSC
260 270 280 290 300
TPRNFSVSLR EELKRTDTIF WPLCLLVKRC GGNCACCHQN CNECQCIPTK
310 320 330 340
VTKKYHEVLQ LKPRSGVRGL HKSLTDVPLE HHEECDCVCK GNSEG
Length:345
Mass (Da):38,940
Last modified:October 1, 2000 - v1
Checksum:i97ACEA992BF5128C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033829 mRNA. Translation: BAB03265.1.
RefSeqiNP_990052.1. NM_204721.2.
UniGeneiGga.1907.

Genome annotation databases

EnsembliENSGALT00000015275; ENSGALP00000015259; ENSGALG00000009378.
GeneIDi395469.
KEGGigga:395469.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033829 mRNA. Translation: BAB03265.1.
RefSeqiNP_990052.1. NM_204721.2.
UniGeneiGga.1907.

3D structure databases

ProteinModelPortaliQ9I946.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015259.

Proteomic databases

PaxDbiQ9I946.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000015275; ENSGALP00000015259; ENSGALG00000009378.
GeneIDi395469.
KEGGigga:395469.

Organism-specific databases

CTDi56034.

Phylogenomic databases

eggNOGiENOG410IETQ. Eukaryota.
ENOG410XQ91. LUCA.
GeneTreeiENSGT00390000005171.
HOGENOMiHOG000261610.
HOVERGENiHBG057324.
InParanoidiQ9I946.
KOiK05450.
OMAiDCVCRGN.
OrthoDBiEOG091G0BFZ.
PhylomeDBiQ9I946.
TreeFamiTF332130.

Enzyme and pathway databases

ReactomeiR-GGA-186797. Signaling by PDGF.

Miscellaneous databases

PROiQ9I946.

Gene expression databases

BgeeiENSGALG00000009378.

Family and domain databases

CDDicd00041. CUB. 1 hit.
cd00135. PDGF. 1 hit.
Gene3Di2.10.90.10. 1 hit.
2.60.120.290. 1 hit.
InterProiIPR000859. CUB_dom.
IPR029034. Cystine-knot_cytokine.
IPR029817. PDGF-C.
IPR000072. PDGF/VEGF_dom.
[Graphical view]
PANTHERiPTHR11633:SF5. PTHR11633:SF5. 1 hit.
PfamiPF00431. CUB. 1 hit.
PF00341. PDGF. 1 hit.
[Graphical view]
SMARTiSM00042. CUB. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF57501. SSF57501. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPDGFC_CHICK
AccessioniPrimary (citable) accession number: Q9I946
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.