Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Platelet-derived growth factor C

Gene

PDGFC

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, in angiogenesis and blood vessel development (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei225 – 2262CleavageCurated
Sitei231 – 2322CleavageSequence Analysis
Sitei234 – 2352CleavageSequence Analysis

GO - Biological processi

  1. activation of transmembrane receptor protein tyrosine kinase activity Source: Ensembl
  2. cellular response to amino acid stimulus Source: Ensembl
  3. embryo development Source: InterPro
  4. organ morphogenesis Source: Ensembl
  5. platelet-derived growth factor receptor signaling pathway Source: Ensembl
  6. positive regulation of cell division Source: UniProtKB-KW
  7. positive regulation of DNA replication Source: Ensembl
  8. positive regulation of fibroblast proliferation Source: Ensembl
  9. regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Enzyme and pathway databases

ReactomeiREACT_258033. Signaling by PDGF.

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet-derived growth factor C
Short name:
PDGF-C
Alternative name(s):
Spinal cord-derived growth factor
Cleaved into the following 2 chains:
Platelet-derived growth factor C, receptor-binding form
Short name:
PDGFC receptor-binding form
Gene namesi
Name:PDGFC
Synonyms:SCDGF
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 4

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. extracellular space Source: Ensembl
  4. extracellular vesicular exosome Source: Ensembl
  5. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 345Platelet-derived growth factor C, receptor-binding formPRO_0000343878
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 345323Platelet-derived growth factor C, latent formPRO_0000343877Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi104 ↔ 124PROSITE-ProRule annotation
Disulfide bondi250 ↔ 294PROSITE-ProRule annotation
Disulfide bondi274 – 274Interchain (with C-286)PROSITE-ProRule annotation
Disulfide bondi280 ↔ 335PROSITE-ProRule annotation
Disulfide bondi286 – 286Interchain (with C-274)PROSITE-ProRule annotation
Disulfide bondi287 ↔ 337PROSITE-ProRule annotation

Post-translational modificationi

Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after basic residues in the hinge region (region connecting the CUB and growth factor domains) gives rise to the receptor-binding form (By similarity).By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9I946.

Expressioni

Developmental stagei

Expression increases in the spinal cord from E4 to E16, with the highest level detected between E12 and E16. Expression rapidly decreases after hatching.1 Publication

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB (By similarity).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015259.

Structurei

3D structure databases

ProteinModelPortaliQ9I946.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 163118CUBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.Curated
Contains 1 CUB domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG74970.
GeneTreeiENSGT00390000005171.
HOGENOMiHOG000261610.
HOVERGENiHBG057324.
InParanoidiQ9I946.
KOiK05450.
OMAiDCVCRGN.
OrthoDBiEOG7VB2FN.
PhylomeDBiQ9I946.
TreeFamiTF332130.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
2.60.120.290. 1 hit.
InterProiIPR000859. CUB_dom.
IPR029034. Cystine-knot_cytokine.
IPR029817. PDGF-C.
IPR000072. PDGF/VEGF_dom.
[Graphical view]
PANTHERiPTHR10127:SF570. PTHR10127:SF570. 1 hit.
PfamiPF00431. CUB. 1 hit.
PF00341. PDGF. 1 hit.
[Graphical view]
SMARTiSM00042. CUB. 1 hit.
SM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF57501. SSF57501. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9I946-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLGLLLLT SALAGRRHGA AAESDLSSKF SFPGAKEQNG VQDPQHEKII
60 70 80 90 100
TVTSNGSIHS PKFPHTYPRN TVLVWRLVAV DENVWIQLTF DERFGLEDPE
110 120 130 140 150
DDICKYDFVE VEEPSDGTVL GRWCGSSSVP SRQISKGNQI RIRFVSDEYF
160 170 180 190 200
PSQPGFCIHY TLLVPHHTEA PSPSSLPPSA LPLDVLNNAV AGFSTVEELI
210 220 230 240 250
RYLEPDRWQL DLEDLYRPTW QLLGKAYIHG RKSRVVDLNL LKEEVRLYSC
260 270 280 290 300
TPRNFSVSLR EELKRTDTIF WPLCLLVKRC GGNCACCHQN CNECQCIPTK
310 320 330 340
VTKKYHEVLQ LKPRSGVRGL HKSLTDVPLE HHEECDCVCK GNSEG
Length:345
Mass (Da):38,940
Last modified:October 1, 2000 - v1
Checksum:i97ACEA992BF5128C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033829 mRNA. Translation: BAB03265.1.
RefSeqiNP_990052.1. NM_204721.2.
UniGeneiGga.1907.

Genome annotation databases

EnsembliENSGALT00000015275; ENSGALP00000015259; ENSGALG00000009378.
GeneIDi395469.
KEGGigga:395469.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033829 mRNA. Translation: BAB03265.1.
RefSeqiNP_990052.1. NM_204721.2.
UniGeneiGga.1907.

3D structure databases

ProteinModelPortaliQ9I946.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015259.

Proteomic databases

PaxDbiQ9I946.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000015275; ENSGALP00000015259; ENSGALG00000009378.
GeneIDi395469.
KEGGigga:395469.

Organism-specific databases

CTDi56034.

Phylogenomic databases

eggNOGiNOG74970.
GeneTreeiENSGT00390000005171.
HOGENOMiHOG000261610.
HOVERGENiHBG057324.
InParanoidiQ9I946.
KOiK05450.
OMAiDCVCRGN.
OrthoDBiEOG7VB2FN.
PhylomeDBiQ9I946.
TreeFamiTF332130.

Enzyme and pathway databases

ReactomeiREACT_258033. Signaling by PDGF.

Miscellaneous databases

NextBioi20815550.
PROiQ9I946.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
2.60.120.290. 1 hit.
InterProiIPR000859. CUB_dom.
IPR029034. Cystine-knot_cytokine.
IPR029817. PDGF-C.
IPR000072. PDGF/VEGF_dom.
[Graphical view]
PANTHERiPTHR10127:SF570. PTHR10127:SF570. 1 hit.
PfamiPF00431. CUB. 1 hit.
PF00341. PDGF. 1 hit.
[Graphical view]
SMARTiSM00042. CUB. 1 hit.
SM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF57501. SSF57501. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A novel gene derived from developing spinal cords, SCDGF, is a unique member of the PDGF/VEGF family."
    Hamada T., Ui-Tei K., Miyata Y.
    FEBS Lett. 475:97-102(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
    Strain: White leghorn.
    Tissue: Spinal cord.

Entry informationi

Entry nameiPDGFC_CHICK
AccessioniPrimary (citable) accession number: Q9I946
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: October 1, 2000
Last modified: March 4, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.