Q9I931 (FUCL1_ANGJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Fucolectin-1
Organism	Anguilla japonica (Japanese eel)
Taxonomic identifier	7937 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Anguilliformes › Anguillidae › Anguilla

Protein attributes

Sequence length	178 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens. Ref.1
Subunit structure	Homotrimer By similarity. UniProtKB Q7SIC1
Subcellular location	Secreted › extracellular space Ref.1.
Tissue specificity	Parenchymal hepatocytes. Ref.1
Miscellaneous	Binds 1 calcium ion per monomer By similarity.
Sequence similarities	Belongs to the fucolectin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Ligand	Calcium Lectin Metal-binding
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	cell adhesion Inferred from electronic annotation. Source: InterPro regulation of cellular defense response Traceable author statement Ref.1. Source: UniProtKB regulation of complement activation, lectin pathway Traceable author statement Ref.1. Source: UniProtKB
Cellular component	extracellular space Inferred from direct assay Ref.1. Source: UniProtKB
Molecular function	calcium ion binding Inferred from sequence or structural similarity. Source: UniProtKB fucose binding Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 178	158	Fucolectin-1		PRO_0000223932
Regions
	Region	29 – 178	150	F5/8 type C-like
	Region	47 – 48	2	Antigenic glycan By similarity UniProtKB Q7SIC1
	Region	103 – 104	2	Antigenic glycan By similarity UniProtKB Q7SIC1
	Motif	100 – 102	3	Cell attachment site
Sites
	Metal binding	35	1	Calcium; via carbonyl oxygen By similarity UniProtKB Q7SIC1
	Metal binding	59	1	Calcium By similarity UniProtKB Q7SIC1
	Metal binding	61	1	Calcium; via carbonyl oxygen By similarity UniProtKB Q7SIC1
	Metal binding	70	1	Calcium By similarity UniProtKB Q7SIC1
	Metal binding	167	1	Calcium; via carbonyl oxygen By similarity UniProtKB Q7SIC1
	Metal binding	168	1	Calcium By similarity UniProtKB Q7SIC1
	Binding site	46	1	Antigenic glycan By similarity UniProtKB Q7SIC1
	Binding site	73	1	Antigenic glycan By similarity UniProtKB Q7SIC1
	Binding site	100	1	Antigenic glycan By similarity UniProtKB Q7SIC1
	Binding site	107	1	Antigenic glycan By similarity UniProtKB Q7SIC1
Amino acid modifications
	Disulfide bond	71 ↔ 167		By similarity UniProtKB Q7SIC1
	Disulfide bond	103 ↔ 104		By similarity UniProtKB Q7SIC1
	Disulfide bond	129 ↔ 145		By similarity UniProtKB Q7SIC1

Sequences

	Sequence		Length	Mass (Da)
	Q9I931 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 58BBB6A8EAEC4E48	FASTA	178	19,295
	10 20 30 40 50 60 MKVKTIMLLF QILAISTIKS ADVPNRYIQE NVAVRGKATQ STLPSGAGAV LSLPGFAIDG 70 80 90 100 110 120 NRDSDFSHGS CSHTTNSPNP WWRVDLLQLY TITSVTITNR GDCCGERISG ARILIGNSLE 130 140 150 160 170 NNGINNPACS VIGSMETGET RTFHCPQPMI GRYVTVYLPK TEVLQLCEVE VNALLPVN

References

[1]	"Multiplicity, structures, and endocrine and exocrine natures of eel fucose-binding lectins." Honda S., Kashiwagi M., Miyamoto K., Takei Y., Hirose S. J. Biol. Chem. 275:33151-33157(2000) [PubMed: 10924498] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB037867 mRNA. Translation: BAB03523.1.
3D structure databases
ProteinModelPortal	Q9I931.
SMR	Q9I931. Positions 23-176.
ModBase	Search...
Protein family/group databases
CAZy	CBM47. Carbohydrate-Binding Module Family 47.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG066195.
Family and domain databases
InterPro	IPR000421. Coagulation_fac_5/8-C_type_dom. IPR006585. FTP1. IPR008979. Galactose-bd-like. [Graphical view]
Pfam	PF00754. F5_F8_type_C. 1 hit. [Graphical view]
SMART	SM00607. FTP. 1 hit. [Graphical view]
SUPFAM	SSF49785. Gal_bind_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FUCL1_ANGJA

Accession

Primary (citable) accession number: Q9I931

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2006
Last sequence update:	October 1, 2000
Last modified:	October 19, 2011
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program