Reviewed, UniProtKB/Swiss-Prot Q9I930 (FUCL2_ANGJA)

Names and origin

Protein names	Recommended name:     Fucolectin-2
Organism	Anguilla japonica (Japanese eel)
Taxonomic identifier	7937 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Anguilliformes › Anguillidae › Anguilla

Protein attributes

Sequence length	180 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens. Ref.1
Subunit structure	Homotrimer By similarity. UniProtKB Q7SIC1
Subcellular location	Secreted › extracellular space. Ref.1
Tissue specificity	Parenchymal hepatocytes. Ref.1
Miscellaneous	Binds 1 calcium ion per monomer By similarity.
Sequence similarities	Belongs to the fucolectin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Ligand	Calcium Lectin Metal-binding
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	cell adhesion Inferred from electronic annotation. Source: InterPro regulation of cellular defense response Ref.1 Traceable author statement. Source: UniProtKB regulation of complement activation, lectin pathway Ref.1 Traceable author statement. Source: UniProtKB
Cellular component	extracellular space Ref.1 Inferred from direct assay. Source: UniProtKB
Molecular function	calcium ion binding Inferred from sequence or structural similarity. Source: UniProtKB fucose binding Ref.1 Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 180	158	Fucolectin-2		PRO_0000223933
Regions
	Region	31 – 179	149	F5/8 type C-like
	Region	49 – 50	2	Antigenic glycan By similarity UniProtKB Q7SIC1
	Region	104 – 105	2	Antigenic glycan By similarity UniProtKB Q7SIC1
	Motif	101 – 103	3	Cell attachment site
Sites
	Metal binding	58	1	Calcium; via carbonyl oxygen By similarity UniProtKB Q7SIC1
	Metal binding	61	1	Calcium By similarity UniProtKB Q7SIC1
	Metal binding	63	1	Calcium; via carbonyl oxygen By similarity UniProtKB Q7SIC1
	Metal binding	72	1	Calcium By similarity UniProtKB Q7SIC1
	Metal binding	168	1	Calcium; via carbonyl oxygen By similarity UniProtKB Q7SIC1
	Metal binding	169	1	Calcium By similarity UniProtKB Q7SIC1
	Binding site	69	1	Antigenic glycan By similarity UniProtKB Q7SIC1
	Binding site	75	1	Antigenic glycan By similarity UniProtKB Q7SIC1
	Binding site	101	1	Antigenic glycan By similarity UniProtKB Q7SIC1
	Binding site	108	1	Antigenic glycan By similarity UniProtKB Q7SIC1
Amino acid modifications
	Disulfide bond	73 ↔ 168		By similarity UniProtKB Q7SIC1
	Disulfide bond	104 ↔ 105		By similarity UniProtKB Q7SIC1
	Disulfide bond	130 ↔ 146		By similarity UniProtKB Q7SIC1

Sequences

	Sequence		Length	Mass (Da)
	Q9I930-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: D572D09AED85C206	FASTA	180	19,776
	10 20 30 40 50 60 MKVKMIMLLF QILAILTLKS DSADVPDGYI QENVALRGRA TQSAQLRGEH AGISHASNAI 70 80 90 100 110 120 DGNRDSYFYH GSCSHTEGDN PLWRVDLLQV YTITSVTITN RGDCCGERIS GARILIGKHL 130 140 150 160 170 180 ENNGINNPEC STINIMAAGE TRTFHCPQPM IGRYVTVYLP KTGTLHLCEV EVNVLFPAPC

References

[1]

"Multiplicity, structures, and endocrine and exocrine natures of eel fucose-binding lectins." Honda S., Kashiwagi M., Miyamoto K., Takei Y., Hirose S. J. Biol. Chem. 275:33151-33157(2000) [PubMed: 10924498] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB037868 mRNA. Translation: BAB03524.1.
3D structure databases
SMR	Q9I930. Positions 25-178.
ModBase	Search...
Protein family/group databases
CAZy	CBM47. Carbohydrate-Binding Module Family 47.
Phylogenomic databases
HOVERGEN	Q9I930.
Family and domain databases
InterPro	IPR000421. Coagulation_factor_5/8-type_C. IPR006585. FTP1. [Graphical view]
Pfam	PF00754. F5_F8_type_C. 1 hit. [Graphical view]
SMART	SM00607. FTP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FUCL2_ANGJA

Accession

Primary (citable) accession number: Q9I930

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2006
Last sequence update:	October 1, 2000
Last modified:	April 14, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)