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Q9I8X3

- FGFR3_DANRE

UniProt

Q9I8X3 - FGFR3_DANRE

Protein

Fibroblast growth factor receptor 3

Gene

fgfr3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway By similarity.By similarity

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

    Enzyme regulationi

    Present in an inactive conformation in the absence of bound ligand. Ligand binding leads to dimerization and activation by autophosphorylation on tyrosine residues By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei496 – 4961ATPPROSITE-ProRule annotation
    Active sitei605 – 6051Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi466 – 4749ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. fibroblast growth factor-activated receptor activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. positive regulation of cell proliferation Source: InterPro
    3. skeletal system development Source: InterPro

    Keywords - Molecular functioni

    Kinase, Receptor, Transferase, Tyrosine-protein kinase

    Keywords - Biological processi

    Apoptosis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor receptor 3 (EC:2.7.10.1)
    Short name:
    FGFR-3
    Gene namesi
    Name:fgfr3
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-000816-1. fgfr3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 800780Fibroblast growth factor receptor 3PRO_0000249205Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi55 ↔ 101PROSITE-ProRule annotation
    Glycosylationi77 – 771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi169 ↔ 221PROSITE-ProRule annotation
    Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi255 – 2551N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi268 ↔ 332PROSITE-ProRule annotation
    Glycosylationi287 – 2871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi308 – 3081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis
    Modified residuei635 – 6351Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei636 – 6361Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei712 – 7121Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei748 – 7481Phosphotyrosine; by autocatalysisBy similarity

    Post-translational modificationi

    Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiQ9I8X3.

    Expressioni

    Developmental stagei

    Expression occurs in the axial mesoderm, the diencephalon, the anterior hindbrain and the anterior spinal cord. In the hindbrain, a differential expression was detected at several levels of intensity, with the highest expression in the posterior rhombomere 1 that is morphologically distinct from the anterior part, which develops into the cerebellum.1 Publication

    Interactioni

    Subunit structurei

    Monomer. Homodimer after ligand binding By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9I8X3.
    SMRiQ9I8X3. Positions 143-354, 446-744.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 363343ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini385 – 800416CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei364 – 38421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 122102Ig-like C2-type 1Add
    BLAST
    Domaini144 – 23794Ig-like C2-type 2Add
    BLAST
    Domaini246 – 348103Ig-like C2-type 3Add
    BLAST
    Domaini460 – 739280Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The second and third Ig-like domains directly interact with fibroblast growth factors (FGF) and heparan sulfate proteoglycans.By similarity

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    HOVERGENiHBG000345.
    InParanoidiQ9I8X3.
    KOiK05094.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    InterProiIPR028176. FGF_rcpt_3.
    IPR016248. FGF_rcpt_fam.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PANTHERiPTHR24416:SF128. PTHR24416:SF128. 1 hit.
    PfamiPF07679. I-set. 3 hits.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000628. FGFR. 1 hit.
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00408. IGc2. 3 hits.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50835. IG_LIKE. 3 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9I8X3-1 [UniParc]FASTAAdd to Basket

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    MVPLCLLLYL ATLVFPPVYS AHLLSPEPTD WVSSEVEVFL EDYVAGVGDT    50
    VVLSCTPQDF LLPIVWQKDG DAVSSSNRTR VGQKALRIIN VSYEDSGVYS 100
    CRHAHKSMLL SNYTVKVIDS LSSGDDEDYD EDEDEAGNGN AEAPYWTRSD 150
    RMEKKLLAVP AANTVKFRCP AAGNPTPSIH WLKNGKEFKG EQRMGGIKLR 200
    HQQWSLVMES AVPSDRGNYT CVVQNKYGSI KHTYQLDVLE RSPHRPILQA 250
    GLPANQTVVV GSDVEFHCKV YSDAQPHIQW LKHIEVNGSQ YGPNGAPYVN 300
    VLKTAGINTT DKELEILYLT NVSFEDAGQY TCLAGNSIGY NHHSAWLTVL 350
    PAVEMEREDD YADILIYVTS CVLFILTMVI IILCRMWINT QKTLPAPPVQ 400
    KLSKFPLKRQ VSLESNSSMN SNTPLVRIAR LSSSDGPMLP NVSELELPSD 450
    PKWEFTRTKL TLGKPLGEGC FGQVVMAEAI GIDKEKPNKP LTVAVKMLKD 500
    DGTDKDLSDL VSEMEMMKMI GKHKNIINLL GACTQDGPLY VLVEYASKGN 550
    LREYLRARRP PGMDYSFDTC KIPNETLTFK DLVSCAYQVA RGMEYLASKK 600
    CIHRDPAARN VLVTEDNVMK IADFGLARDV HNIDYYKKTT NGRLPVKWMA 650
    PEALFDRVYT HQSDVWSYGV LLWEIFTLGG SPYPGIPVEE LFKLLKEGHR 700
    MDKPANCTHE LYMIMRECWH AVPSQRPTFR QLVEDHDRVL SMTSTDEYLD 750
    LSVPFEQYSP TCPDSNSTCS SGDDSVFAHD PLPEEPCLPK HHHSNGVIRT 800
    Length:800
    Mass (Da):89,716
    Last modified:October 1, 2000 - v1
    Checksum:i8092DC0272A5BAD1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF157560 mRNA. Translation: AAF80344.1.
    RefSeqiNP_571681.1. NM_131606.1.
    UniGeneiDr.10434.

    Genome annotation databases

    GeneIDi58129.
    KEGGidre:58129.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF157560 mRNA. Translation: AAF80344.1 .
    RefSeqi NP_571681.1. NM_131606.1.
    UniGenei Dr.10434.

    3D structure databases

    ProteinModelPortali Q9I8X3.
    SMRi Q9I8X3. Positions 143-354, 446-744.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9I8X3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 58129.
    KEGGi dre:58129.

    Organism-specific databases

    CTDi 2261.
    ZFINi ZDB-GENE-000816-1. fgfr3.

    Phylogenomic databases

    eggNOGi COG0515.
    HOVERGENi HBG000345.
    InParanoidi Q9I8X3.
    KOi K05094.

    Miscellaneous databases

    NextBioi 20892380.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    InterProi IPR028176. FGF_rcpt_3.
    IPR016248. FGF_rcpt_fam.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    PANTHERi PTHR24416:SF128. PTHR24416:SF128. 1 hit.
    Pfami PF07679. I-set. 3 hits.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000628. FGFR. 1 hit.
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00408. IGc2. 3 hits.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50835. IG_LIKE. 3 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "fgfr3 and regionalization of anterior neural tube in zebrafish."
      Sleptsova-Friedrich I., Li Y., Emelyanov A., Ekker M., Korzh V., Ge R.
      Mech. Dev. 102:213-217(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiFGFR3_DANRE
    AccessioniPrimary (citable) accession number: Q9I8X3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3