Reviewed, UniProtKB/Swiss-Prot Q9I8W8 (AL1A2_TAEGU)

Names and origin

Protein names

Recommended name:
    Retinal dehydrogenase 2
      Short name=RALDH 2
      Short name=RalDH2
    EC=1.2.1.36
Alternative name(s):
    Aldehyde dehydrogenase family 1 member A2
    Retinaldehyde-specific dehydrogenase type 2
      Short name=RALDH(II)
    zRalDH

Gene names

Name:	ALDH1A2
Synonyms:	RALDH2

Organism

Taeniopygia guttata (Zebra finch) (Poephila guttata)

Taxonomic identifier

59729 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Passeriformes › Passeroidea › Estrildidae › Estrildinae › Taeniopygia

Protein attributes

Sequence length	517 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently By similarity. It is responsible for the ability of brain sites to synthesize retinoic acid. Its activity in the high vocal center (HVC) is required for the song of juvenile zebra finches to become stereotyped.
Catalytic activity	Retinal + NAD+ + H2O = retinoate + NADH.
Pathway	Cofactor metabolism; retinol metabolism.
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm.
Tissue specificity	Expressed in the high vocal center (HVC) which integrates auditory and motor activities and constitutes a nodal nucleus on the song system. Ref.1
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	retinal dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 517	517	Retinal dehydrogenase 2		PRO_0000225600
Regions
	Nucleotide binding	263 – 268	6	NAD By similarity
Sites
	Active site	286	1	Proton acceptor By similarity
	Active site	320	1	Nucleophile By similarity
	Site	187	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9I8W8-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: D842A2A1BF4DA109	FASTA	517	56,596
	10 20 30 40 50 60 MTSSKIEMPG EVKADPAALM ASLHLLPSPT LNLEIKYTKI FINNEWQNSE SGRIFPVYNP 70 80 90 100 110 120 ATGEQICDIQ EADKVDTDKA VRAARLAFSL GSVWRRMDAS ERGHLLDKLA DLVERDRAIL 130 140 150 160 170 180 ATMESLNSGK PFLQAFYVDL QGVIKTLRYY AGWADKIHGM TIPVDGDYFT FTRHEPIGVC 190 200 210 220 230 240 GQIIPWNFPL LMFAWKIAPA LCCGNTVVIK PAEQTPLSAL YMGALIKEAG FPPGVVNILP 250 260 270 280 290 300 GFGPIVGAAI ASHVGIDKIA FTGSTEVGKL IQEAAGRSNL KRVTLELGGK SPNIIFADAD 310 320 330 340 350 360 LDYAVEQAHQ GVFFNQGQCC TAGSRIYVEE SIYEEFVRKS VKRAKRKIVG SPFDPTTEQG 370 380 390 400 410 420 PQIDKKQYNK ILELIQSGIT EGAKLECGGK GLGRKGFFIE PTVFSNVTDD MRIAKEEIFG 430 440 450 460 470 480 PVQEILRFKT MDEVIERANN SDFGLVAAVF TNDINKALTV SSAMQAGTVW INCYNALNAQ 490 500 510 SPFGGSKSGN GREMGECGLR EYSEVKTVTI KIPQENS

References

[1]	"Site-specific retinoic acid production in the brain of adult songbirds." Denisenko-Nehrbass N.I., Jarvis E., Scharff C., Nottebohm F., Mello C.V. Neuron 27:359-370(2000) [PubMed: 10985355] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF162770 mRNA. Translation: AAF80471.1.
RefSeq	NP_001070153.1.
UniGene	Tgu.6744
3D structure databases
HSSP	HSSP built from PDB template 1BI9 based on UniProtKB Q63639.
ModBase	Search...
Genome annotation databases
Ensembl	ENSTGUG00000006178. Taeniopygia guttata. [Contig view]
GeneID	751771.
KEGG	tgu:751771.
Phylogenomic databases
HOVERGEN	Q9I8W8.
Family and domain databases
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AL1A2_TAEGU

Accession

Primary (citable) accession number: Q9I8W8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)