Mothers against decapentaplegic homolog 1

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Q9I8V2 (SMAD1_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 81. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Mothers against decapentaplegic homolog 1
Short name=MAD homolog 1
Short name=Mothers against DPP homolog 1

Alternative name(s):
SMAD family member 1
Short name=SMAD 1
Short name=Smad1

Gene names

Name:	smad1
Synonyms:	madh1

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	472 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in ventralization. May mediate Bmp2b signaling during embryonic dorsal-ventral pattern formation, and may itself be a transcriptional target for Smad5-mediated Bmp2b signaling. Ref.1 Ref.2
Subunit structure	May form trimers with another Smad1 and the co-Smad Smad4 By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity. Note: In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with Smad4 By similarity.
Developmental stage	Zygotically expressed. First detected 1 h after the midblastula transition. During gastrulation, expression is restricted to ventral regions. Later, expressed in the somites, eyes and a subset of dorsal cells in the hindbrain. Levels increase until the end of gastrulation and then remain high. Ref.1 Ref.2
Sequence similarities	Belongs to the dwarfin/SMAD family. Contains 1 MH1 (MAD homology 1) domain. Contains 1 MH2 (MAD homology 2) domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	BMP signaling pathway Inferred from genetic interaction Ref.1. Source: UniProtKB embryonic pattern specification Inferred from mutant phenotype Ref.1. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transforming growth factor beta receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell transcription factor complex Inferred from electronic annotation. Source: InterPro
Molecular function	sequence-specific DNA binding transcription factor activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 472

472

Mothers against decapentaplegic homolog 1

PRO_0000090851

Regions

Domain

12 – 136

125

MH1

Domain

278 – 472

195

MH2

Compositional bias

39 – 45

Poly-Lys

Compositional bias

133 – 258

126

Pro-rich

Experimental info

Sequence conflict

G → V in AAF06361. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

Q9I8V2 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 84E53B60ADB71BC9
Show »

FASTA

472

53,066

        10         20         30         40         50         60 
MNVTSLFSFT SPAVKRLLGW KQGDEEEKWA EKAVDALVKK LKKKKGAMEE LERALSCPGQ 

        70         80         90        100        110        120 
PSNCVTIPRS LDGRLQVSHR KGLPHVIYCR VWRWPDLQSH HELKALECCE FPFGSKQKDV 

       130        140        150        160        170        180 
CINPYHYKRV DSPVLPPVLV PRNSEFNAKL SMLPRFRNPL HQTEPPMPQN ATFPDSFPQQ 

       190        200        210        220        230        240 
PANALPFTPN SPTNSYPSSP NSGTGSTATF PHSPSSSDPG SPFQMPETPP PAYMPPEEPM 

       250        260        270        280        290        300 
TQDCPQPMDT NLLAPNLPLE ISNRTDVHPV AYQEPKHWCS IVYYELNNRV GEAFLASSTS 

       310        320        330        340        350        360 
VLVDGFTDPS NNRNRFCLGL LSNVNRNSTI ENTRRHIGKG VHLYYVGGEV YAECLSDSSI 

       370        380        390        400        410        420 
FVQSRNCNYH HGFHPTTVCK IPSRCSLKIF NNQEFAELLA QSVNHGFEAV YELTKMCTIR 

       430        440        450        460        470 
MSFVKGWGAK YHRQDVTSTP CWIEIHLHGP LQWLDKVLTQ MGSPHNPISS VS

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References

[1]	"Smad1 and smad5 have distinct roles during dorsoventral patterning of the zebrafish embryo." Dick A., Meier A., Hammerschmidt M. Dev. Dyn. 216:285-298(1999) [PubMed: 10590480] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE. Strain: AB. Tissue: Embryo.
[2]	"Characterization of zebrafish smad1, smad2 and smad5: the amino-terminus of Smad1 and Smad5 is required for specific function in the embryo." Mueller F., Blader P., Rastegar S., Fischer N., Knoechel W., Straehle U. Mech. Dev. 88:73-88(1999) [PubMed: 10525190] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF174434 mRNA. Translation: AAF82402.1. AF167985 mRNA. Translation: AAF06361.1.
IPI	IPI00485633.
RefSeq	NP_571431.1. NM_131356.1.
UniGene	Dr.76928.
3D structure databases
ProteinModelPortal	Q9I8V2.
SMR	Q9I8V2. Positions 9-132, 276-472.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9I8V2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	30628.
KEGG	dre:30628.
Organism-specific databases
CTD	4086.
ZFIN	ZDB-GENE-991119-8. smad1.
Phylogenomic databases
GeneTree	ENSGT00600000084186.
HOVERGEN	HBG053353.
InParanoid	Q9I8V2.
OrthoDB	EOG4HDSTH.
Gene expression databases
ArrayExpress	Q9I8V2.
Bgee	Q9I8V2.
Family and domain databases
InterPro	IPR003619. MAD_homology1_Dwarfin-type. IPR013019. MAD_homology_MH1. IPR017855. SMAD_dom-like. IPR001132. SMAD_dom_Dwarfin-type. IPR008984. SMAD_FHA_domain. [Graphical view]
Gene3D	G3DSA:3.90.520.10. MAD_MH1. 1 hit. G3DSA:2.60.200.10. MH2_Dwarfin-type. 1 hit.
KO	K04676.
Pfam	PF03165. MH1. 1 hit. PF03166. MH2. 1 hit. [Graphical view]
SMART	SM00523. DWA. 1 hit. SM00524. DWB. 1 hit. [Graphical view]
SUPFAM	SSF56366. MAD_MH1. 1 hit. SSF49879. SMAD_FHA. 1 hit.
PROSITE	PS51075. MH1. 1 hit. PS51076. MH2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SMAD1_DANRE

Accession

Primary (citable) accession number: Q9I8V2
Secondary accession number(s): Q9PUQ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	October 1, 2000
Last modified:	December 14, 2011
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents