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Protein

Parvalbumin-2

Gene

pvalb2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi52Calcium 1By similarity1
Metal bindingi54Calcium 1By similarity1
Metal bindingi56Calcium 1By similarity1
Metal bindingi58Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi60Calcium 1By similarity1
Metal bindingi63Calcium 1By similarity1
Metal bindingi91Calcium 2By similarity1
Metal bindingi93Calcium 2By similarity1
Metal bindingi95Calcium 2By similarity1
Metal bindingi102Calcium 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi52 – 631Add BLAST12
Calcium bindingi91 – 1022Add BLAST12

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Parvalbumin-2
Alternative name(s):
Parvalbumin beta
Gene namesi
Name:pvalb2
Synonyms:pvalb, pvalbl
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 12

Organism-specific databases

ZFINiZDB-GENE-000322-4. pvalb2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000736052 – 109Parvalbumin-2Add BLAST108

Proteomic databases

PaxDbiQ9I8V0.
PRIDEiQ9I8V0.

Expressioni

Gene expression databases

BgeeiENSDARG00000002768.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000020027.

Structurei

3D structure databases

ProteinModelPortaliQ9I8V0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 74EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini78 – 109EF-hand 2PROSITE-ProRule annotationAdd BLAST32

Sequence similaritiesi

Belongs to the parvalbumin family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000008690.
HOGENOMiHOG000037438.
HOVERGENiHBG107490.
InParanoidiQ9I8V0.
OMAiNMAFAGI.
OrthoDBiEOG091G0XK0.
PhylomeDBiQ9I8V0.
TreeFamiTF332342.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9I8V0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFAGILKDE DVAAALKDCA AADSFNYKNF FAKVGLSAKS PDDIKKAFFV
60 70 80 90 100
IDQDKSGFIE EDELKLFLQN FSAGARALTD AETKAFLSAG DSDGDGKIGV

DEFALLVKA
Length:109
Mass (Da):11,622
Last modified:January 23, 2007 - v3
Checksum:iBFD3F9F9A0FC59C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180888 mRNA. Translation: AAF78471.1.
BC093135 mRNA. Translation: AAH93135.1.
RefSeqiNP_571591.1. NM_131516.2.
UniGeneiDr.460.

Genome annotation databases

EnsembliENSDART00000010144; ENSDARP00000020027; ENSDARG00000002768.
ENSDART00000143534; ENSDARP00000115580; ENSDARG00000002768.
GeneIDi58028.
KEGGidre:58028.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180888 mRNA. Translation: AAF78471.1.
BC093135 mRNA. Translation: AAH93135.1.
RefSeqiNP_571591.1. NM_131516.2.
UniGeneiDr.460.

3D structure databases

ProteinModelPortaliQ9I8V0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000020027.

Proteomic databases

PaxDbiQ9I8V0.
PRIDEiQ9I8V0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000010144; ENSDARP00000020027; ENSDARG00000002768.
ENSDART00000143534; ENSDARP00000115580; ENSDARG00000002768.
GeneIDi58028.
KEGGidre:58028.

Organism-specific databases

CTDi58028.
ZFINiZDB-GENE-000322-4. pvalb2.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000008690.
HOGENOMiHOG000037438.
HOVERGENiHBG107490.
InParanoidiQ9I8V0.
OMAiNMAFAGI.
OrthoDBiEOG091G0XK0.
PhylomeDBiQ9I8V0.
TreeFamiTF332342.

Miscellaneous databases

PROiQ9I8V0.

Gene expression databases

BgeeiENSDARG00000002768.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRV2_DANRE
AccessioniPrimary (citable) accession number: Q9I8V0
Secondary accession number(s): Q567L1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.