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Q9I8U0 (COX41_THUOB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase subunit IV isoform 1
Short name=COX IV-1
OrganismThunnus obesus (Bigeye tuna)
Taxonomic identifier8241 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiEuteleosteiNeoteleosteiAcanthomorphaAcanthopterygiiPercomorphaPerciformesScombroideiScombridaeThunnus

Protein attributes

Sequence length169 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Mitochondrion inner membrane.

Sequence similarities

Belongs to the cytochrome c oxidase IV family.

Ontologies

Keywords
   Cellular componentMembrane
Mitochondrion
Mitochondrion inner membrane
   DomainTransit peptide
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Cellular_componentmitochondrial inner membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncytochrome-c oxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2222Mitochondrion By similarity
Chain23 – 169147Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
PRO_0000006092

Sequences

Sequence LengthMass (Da)Tools
Q9I8U0 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: F1ED066C2790FE0B

FASTA16919,277
        10         20         30         40         50         60 
MLATGALSLV GKRAISTSVC LRGGHGVAKV EEYTLPAYFD RRENPLPDIC YVQALSPEQQ 

        70         80         90        100        110        120 
SLKEKEKGSW AALSNEEKIA LYRISFKQSF AEMNKGSSEW KSVVGGMLFF IGFTGLVVLW 

       130        140        150        160 
QRKYVYGAVP HTFDPEYKAK ELQRMLDMRI NPVEGFSAHW DYENKQWKK 

« Hide

References

[1]"New isoforms of cytochrome c oxidase subunit IV in tuna fish."
Huettemann M.
Biochim. Biophys. Acta 1492:242-246(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart, Liver and Muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF204870 mRNA. Translation: AAF79933.1.

3D structure databases

ProteinModelPortalQ9I8U0.
SMRQ9I8U0. Positions 26-169.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG051087.

Family and domain databases

Gene3D1.10.442.10. 1 hit.
InterProIPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view]
PfamPF02936. COX4. 1 hit.
[Graphical view]
PRINTSPR01873. CYTCOXIDASE4.
SUPFAMSSF81406. SSF81406. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCOX41_THUOB
AccessionPrimary (citable) accession number: Q9I8U0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families