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Q9I8U0

- COX41_THUOB

UniProt

Q9I8U0 - COX41_THUOB

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Protein

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Gene
N/A
Organism
Thunnus obesus (Bigeye tuna)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase subunit IV isoform 1
Short name:
COX IV-1
OrganismiThunnus obesus (Bigeye tuna)
Taxonomic identifieri8241 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPelagiariaScombriformesScombridaeThunnus

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2222MitochondrionBy similarityAdd
BLAST
Chaini23 – 169147Cytochrome c oxidase subunit 4 isoform 1, mitochondrialPRO_0000006092Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9I8U0.
SMRiQ9I8U0. Positions 26-169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase IV family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG051087.

Family and domain databases

Gene3Di1.10.442.10. 1 hit.
InterProiIPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view]
PfamiPF02936. COX4. 1 hit.
[Graphical view]
PRINTSiPR01873. CYTCOXIDASE4.
SUPFAMiSSF81406. SSF81406. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9I8U0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLATGALSLV GKRAISTSVC LRGGHGVAKV EEYTLPAYFD RRENPLPDIC
60 70 80 90 100
YVQALSPEQQ SLKEKEKGSW AALSNEEKIA LYRISFKQSF AEMNKGSSEW
110 120 130 140 150
KSVVGGMLFF IGFTGLVVLW QRKYVYGAVP HTFDPEYKAK ELQRMLDMRI
160
NPVEGFSAHW DYENKQWKK
Length:169
Mass (Da):19,277
Last modified:October 1, 2000 - v1
Checksum:iF1ED066C2790FE0B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF204870 mRNA. Translation: AAF79933.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF204870 mRNA. Translation: AAF79933.1 .

3D structure databases

ProteinModelPortali Q9I8U0.
SMRi Q9I8U0. Positions 26-169.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG051087.

Family and domain databases

Gene3Di 1.10.442.10. 1 hit.
InterProi IPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view ]
Pfami PF02936. COX4. 1 hit.
[Graphical view ]
PRINTSi PR01873. CYTCOXIDASE4.
SUPFAMi SSF81406. SSF81406. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "New isoforms of cytochrome c oxidase subunit IV in tuna fish."
    Huettemann M.
    Biochim. Biophys. Acta 1492:242-246(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart, Liver and Muscle.

Entry informationi

Entry nameiCOX41_THUOB
AccessioniPrimary (citable) accession number: Q9I8U0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3