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Q9I8U0

- COX41_THUOB

UniProt

Q9I8U0 - COX41_THUOB

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Protein
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Gene
N/A
Organism
Thunnus obesus (Bigeye tuna)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase subunit IV isoform 1
Short name:
COX IV-1
OrganismiThunnus obesus (Bigeye tuna)
Taxonomic identifieri8241 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPelagimorphariaScombriformesScombridaeThunnus

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2222Mitochondrion By similarity
Add
BLAST
Chaini23 – 169147Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
PRO_0000006092Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9I8U0.
SMRiQ9I8U0. Positions 26-169.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG051087.

Family and domain databases

Gene3Di1.10.442.10. 1 hit.
InterProiIPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view]
PfamiPF02936. COX4. 1 hit.
[Graphical view]
PRINTSiPR01873. CYTCOXIDASE4.
SUPFAMiSSF81406. SSF81406. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9I8U0-1 [UniParc]FASTAAdd to Basket

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MLATGALSLV GKRAISTSVC LRGGHGVAKV EEYTLPAYFD RRENPLPDIC    50
YVQALSPEQQ SLKEKEKGSW AALSNEEKIA LYRISFKQSF AEMNKGSSEW 100
KSVVGGMLFF IGFTGLVVLW QRKYVYGAVP HTFDPEYKAK ELQRMLDMRI 150
NPVEGFSAHW DYENKQWKK 169
Length:169
Mass (Da):19,277
Last modified:October 1, 2000 - v1
Checksum:iF1ED066C2790FE0B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF204870 mRNA. Translation: AAF79933.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF204870 mRNA. Translation: AAF79933.1 .

3D structure databases

ProteinModelPortali Q9I8U0.
SMRi Q9I8U0. Positions 26-169.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG051087.

Family and domain databases

Gene3Di 1.10.442.10. 1 hit.
InterProi IPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view ]
Pfami PF02936. COX4. 1 hit.
[Graphical view ]
PRINTSi PR01873. CYTCOXIDASE4.
SUPFAMi SSF81406. SSF81406. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "New isoforms of cytochrome c oxidase subunit IV in tuna fish."
    Huettemann M.
    Biochim. Biophys. Acta 1492:242-246(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart, Liver and Muscle.

Entry informationi

Entry nameiCOX41_THUOB
AccessioniPrimary (citable) accession number: Q9I8U0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: October 1, 2000
Last modified: June 11, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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