Reviewed,
UniProtKB/Swiss-Prot Q9I8S4 (DCOR2_XENLA)
Last modified
January 19, 2010.
Version 52.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ornithine decarboxylase 2 Short name=ODC 2 Short name=xODC2 EC=4.1.1.17 | ||||
| Gene names |
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| Organism | Xenopus laevis (African clawed frog) | ||||
| Taxonomic identifier | 8355 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Protein attributes
| Sequence length | 456 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | L-ornithine = putrescine + CO2. |
| Cofactor | Pyridoxal phosphate By similarity. |
| Pathway | |
| Developmental stage | Expression is first detected at the animal pole at stage 9. During neurula stages it is found both in the extreme anterior and posterior part of the dorsal body axis. In tailbud stages the expression is further shifted to both the tail and head areas and gradually restricted to distinct tissues: forebrain, inner layer of epidermis of the head area, stomodeal-hypophyseal anlage, frontal gland, ear vesicle, branchial arches, the front tip of neural tube and proctodeum. |
| Sequence similarities | Belongs to the Orn/Lys/Arg decarboxylase class-II family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Polyamine biosynthesis |
| Ligand | Pyridoxal phosphate |
| Molecular function | Decarboxylase Lyase |
| Gene Ontology (GO) | |
| Biological process | polyamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | ornithine decarboxylase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 456 | 456 | Ornithine decarboxylase 2 | PRO_0000149897 | |||||
Sites | |||||||||
| Active site | 357 | 1 | Proton donor; shared with dimeric partner By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 68 | 1 | N6-(pyridoxal phosphate)lysine By similarity | ||||||
Sequences
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References
| [1] | "Tissue-specific expression of an ornithine decarboxylase paralogue, XODC2, in Xenopus laevis." Cao Y., Zhao H., Hollemann T., Chen Y., Grunz H. Mech. Dev. 102:243-246(2001) [PubMed: 11287202] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF217544 mRNA. Translation: AAF27628.2. |
| RefSeq | NP_001079692.1. |
| UniGene | Xl.8949 |
3D structure databases | |
| SMR | Q9I8S4. Positions 6-418. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 379379. |
| KEGG | xla:379379. |
Phylogenomic databases | |
| HOVERGEN | Q9I8S4. |
Enzyme and pathway databases | |
| BRENDA | 4.1.1.17. 648. |
Family and domain databases | |
| InterPro | IPR009006. Ala_racemase/Decarboxylase_C. IPR000183. De-COase2. IPR002433. Orn_de-COase. [Graphical view] |
| Pfam | PF02784. Orn_Arg_deC_N. 1 hit. PF00278. Orn_DAP_Arg_deC. 1 hit. [Graphical view] |
| PRINTS | PR01179. ODADCRBXLASE. PR01182. ORNDCRBXLASE. |
| PROSITE | PS00878. ODR_DC_2_1. 1 hit. PS00879. ODR_DC_2_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DCOR2_XENLA | ||||||||
| Accession | Primary (citable) accession number: Q9I8S4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Xenopus annotation project | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


