Reviewed, UniProtKB/Swiss-Prot Q9I8S4 (DCOR2_XENLA)

Names and origin

Protein names

Recommended name:
    Ornithine decarboxylase 2
      Short name=ODC 2
      Short name=xODC2
    EC=4.1.1.17

Gene names

Name:	odc1-B
Synonyms:	odc2

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	456 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-ornithine = putrescine + CO2.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.
Developmental stage	Expression is first detected at the animal pole at stage 9. During neurula stages it is found both in the extreme anterior and posterior part of the dorsal body axis. In tailbud stages the expression is further shifted to both the tail and head areas and gradually restricted to distinct tissues: forebrain, inner layer of epidermis of the head area, stomodeal-hypophyseal anlage, frontal gland, ear vesicle, branchial arches, the front tip of neural tube and proctodeum.
Sequence similarities	Belongs to the Orn/Lys/Arg decarboxylase class-II family.

Ontologies

Keywords
Biological process	Polyamine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Gene Ontology (GO)
Biological process	polyamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ornithine decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 456	456	Ornithine decarboxylase 2		PRO_0000149897
Sites
	Active site	357	1	Proton donor; shared with dimeric partner By similarity
Amino acid modifications
	Modified residue	68	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9I8S4-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 78A0BFBC6FED27FE	FASTA	456	50,637
	10 20 30 40 50 60 MQGYIQESDF NLVEEGFLAR DLMEEIINEV SQTEDRDAFF VADLGDVVRK HLRFLKALPR 70 80 90 100 110 120 VKPFYAVKCN SSKGVVKILA ELGAGFDCAS KTEIELVQDV GVAPERIIYA NPCKQISQIK 130 140 150 160 170 180 YAAKNGVQMM TFDNEVELSK VSRSHPNARM VLRIATDDSK SSARLSVKFG APLKSCRRLL 190 200 210 220 230 240 EMAKNLSVDV IGVSFHVGSG CTDSKAYTQA ISDARLVFEM ASEFGYKMWL LDIGGGFPGT 250 260 270 280 290 300 EDSKIRFEEI AGVINPALDM YFPESSDVQI IAEPGRYYVA SAFSLAVNVI AKKEVEHSVS 310 320 330 340 350 360 DDEENESSKS IMYYVNDGVY GSFNCLVFDH AHPKPILHKK PSPDQPLYTS SLWGPTCDGL 370 380 390 400 410 420 DQIAERVQLP ELHVGDWLLF ENMGAYTIAA SSNFNGFQQS PVHYAMPRAA WKAVQLLQRG 430 440 450 LQQTEEKENV CTPMSCGWEI SDSLCFTRTF AATSII

References

[1]	"Tissue-specific expression of an ornithine decarboxylase paralogue, XODC2, in Xenopus laevis." Cao Y., Zhao H., Hollemann T., Chen Y., Grunz H. Mech. Dev. 102:243-246(2001) [PubMed: 11287202] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF217544 mRNA. Translation: AAF27628.2.
RefSeq	NP_001079692.1.
UniGene	Xl.8949
3D structure databases
SMR	Q9I8S4. Positions 6-418.
ModBase	Search...
Genome annotation databases
GeneID	379379.
KEGG	xla:379379.
Phylogenomic databases
HOVERGEN	Q9I8S4.
Enzyme and pathway databases
BRENDA	4.1.1.17. 648.
Family and domain databases
InterPro	IPR009006. Ala_racemase/Decarboxylase_C. IPR000183. De-COase2. IPR002433. Orn_de-COase. [Graphical view]
Pfam	PF02784. Orn_Arg_deC_N. 1 hit. PF00278. Orn_DAP_Arg_deC. 1 hit. [Graphical view]
PRINTS	PR01179. ODADCRBXLASE. PR01182. ORNDCRBXLASE.
PROSITE	PS00878. ODR_DC_2_1. 1 hit. PS00879. ODR_DC_2_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCOR2_XENLA

Accession

Primary (citable) accession number: Q9I8S4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
Last sequence update:	October 1, 2000
Last modified:	January 19, 2010
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project