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Reviewed, UniProtKB/Swiss-Prot Q9I8N6 (CSF1R_DANRE)

Last modified June 16, 2009. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Macrophage colony-stimulating factor 1 receptor
      Short name=CSF-1-R
    EC=2.7.10.1
Alternative name(s):
    Fms proto-oncogene homolog
Gene names
Name: csf1r
Synonyms: fms
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

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Protein attributes

Sequence length977 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Protein tyrosine-kinase transmembrane receptor for CSF1. Ref.1

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.

Contains 5 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 protein kinase domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 977959Macrophage colony-stimulating factor 1 receptor
PRO_0000249006

Regions

Topological domain19 – 519501Extracellular Potential
Transmembrane520 – 54021 Potential
Topological domain541 – 977437Cytoplasmic Potential
Domain22 – 10988Ig-like C2-type 1
Domain120 – 19879Ig-like C2-type 2
Domain213 – 30593Ig-like C2-type 3
Domain316 – 40792Ig-like C2-type 4
Domain408 – 513106Ig-like C2-type 5
Domain584 – 917334Protein kinase
Nucleotide binding590 – 5989ATP By similarity
Compositional bias379 – 3824Poly-Leu

Sites

Active site7811Proton acceptor By similarity
Binding site6181ATP By similarity

Amino acid modifications

Modified residue7011Phosphotyrosine; by autocatalysis By similarity
Modified residue8121Phosphotyrosine; by autocatalysis By similarity
Glycosylation981N-linked (GlcNAc...) Potential
Glycosylation1011N-linked (GlcNAc...) Potential
Glycosylation1541N-linked (GlcNAc...) Potential
Glycosylation1631N-linked (GlcNAc...) Potential
Glycosylation2441N-linked (GlcNAc...) Potential
Glycosylation2861N-linked (GlcNAc...) Potential
Glycosylation2981N-linked (GlcNAc...) Potential
Glycosylation3611N-linked (GlcNAc...) Potential
Glycosylation4241N-linked (GlcNAc...) Potential
Glycosylation4551N-linked (GlcNAc...) Potential
Disulfide bond48 ↔ 92 By similarity
Disulfide bond138 ↔ 187 By similarity
Disulfide bond234 ↔ 289 By similarity
Disulfide bond430 ↔ 495 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q9I8N6-1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: C91A2F339E746A58

FASTA977110,188
        10         20         30         40         50         60 
MFFALLFLIG ILLGQVQGWS EPRIRLSSGA LAGTDVILES GSPLQLVCEG DGPVTFLPRL 

        70         80         90        100        110        120 
AKHKRYISKE VGKIRSFRVE KTTVDFTGTY KCVYMNGNDS NLSSSVHVFV RDSRVLFVSP 

       130        140        150        160        170        180 
STSLRYVRKE GEDLLLPCLL TDPEATDFTF RMDNGSAAPY GMNITYDPRK GVLIRNVHPG 

       190        200        210        220        230        240 
FNADYICCAR IGGAEKVSKI FSINIIQRLR FPPYVYLKRN EYVKLVGERL QISCTTNNPN 

       250        260        270        280        290        300 
FYYNVTWTHS SRMLPKAEEK STMEGDRLAI ESILTIPSVQ LSHTGNITCT GQNEAGANSS 

       310        320        330        340        350        360 
TTQLLVVEEP YIRLSPKLSS KLTHRGLSIE VSEGDDVDLG VLIEAYPPLT SHKWETPTSH 

       370        380        390        400        410        420 
NASLPENRFF NHNDRYEALL LLKRLNFEEI GQYTLNVKNS MKSASITFDI KMYTKPVARV 

       430        440        450        460        470        480 
KWENVTTLSC RSYGYPAPSI LWYQCTGIRT TCPENTTDLQ PIQTQTVEFQ KESFGAVGVE 

       490        500        510        520        530        540 
SVLTVGPNRR MTVVCVAFNL VGQGSDTFSM EVSDQIFTSA MCGSTVAMVV LGLLLIFMIY 

       550        560        570        580        590        600 
KYKQKPRYEI RWKIIEATNG NNYTFIDPTQ LPYNEKWEFP RDKLKLGKTL GAGAFGKVVE 

       610        620        630        640        650        660 
ATAYGLGKED NITRVAVKML KASAHPDERE ALMSELKILS HLGQHKNIVN LLGACTHGGP 

       670        680        690        700        710        720 
VLVITEYCCH GDLLNFLRSK AENFLNFVMT IPNFPEPMTD YKNVSTERMF VRSDSGISST 

       730        740        750        760        770        780 
CSDHYLDMRP VTSRPTNSAL DSSSECQEDS WPLDMDDLLR FSSQVAQGLD FLAAKNCIHR 

       790        800        810        820        830        840 
DVAARNVLLT NSRVAKICDF GLARDIMNDS NYVVKGNARL PVKWMAPESI FECVYTVQSD 

       850        860        870        880        890        900 
VWSYGIMLWE IFSLGKSPYP NILVDSKFYK MIKCGYQMSR PDFAPPEMYT IMKMCWNLDA 

       910        920        930        940        950        960 
AERPTFSKIS QMIQRMLGET SEQQDTQEYK NIPTEAEAEQ QLESCDPVKH EDESFETSCD 

       970 
QEEEDQPLMK PNNYQFC

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References

[1]"An orthologue of the kit-related gene fms is required for development of neural crest-derived xanthophores and a subpopulation of adult melanocytes in the zebrafish, Danio rerio."
Parichy D.M., Ransom D.G., Paw B., Zon L.I., Johnson S.L.
Development 127:3031-3044(2000) [PubMed: 10862741] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
Strain: AB.

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Cross-references

Sequence databases

AF240639 mRNA. Translation: AAF76872.1.
IPIIPI00484881.
RefSeqNP_571747.1.
UniGeneDr.133025

3D structure databases

HSSPHSSP built from PDB template 1RJB based on UniProtKB P36888.
SMRQ9I8N6. Positions 545-919.
ModBaseSearch...

Proteomic databases

PRIDEQ9I8N6.

Genome annotation databases

EnsemblENSDARG00000007889. Danio rerio. [Contig view]
GeneID64274.
KEGGdre:64274.

Organism-specific databases

ZFINZDB-GENE-001205-1. csf1r.

Phylogenomic databases

HOVERGENQ9I8N6.

Enzyme and pathway databases

BRENDA2.7.10.1. 96826.

Family and domain databases

InterProIPR013151. Ig.
IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_BS.
IPR001824. Recept_tyr_kinase-III_CS.
IPR001245. Tyr_pkinase.
IPR008266. Tyr_pkinase_AS.
IPR016243. TyrPK_CSF1-R.
IPR009134. VEGFR_N.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 2 hits.
PfamPF00047. ig. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFPIRSF000615. TyrPK_CSF1-R. 1 hit.
PRINTSPR01832. VEGFRECEPTOR.
ProDomPD000001. Prot_kinase. 2 hits.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00240. RECEPTOR_TYR_KIN_III. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameCSF1R_DANRE
AccessionPrimary (citable) accession number: Q9I8N6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: October 1, 2000
Last modified: June 16, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectZebrafish annotation project

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents