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Protein

Bcl-2-related ovarian killer protein

Gene

BOK

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Induces apoptosis in a manner dependent on BAX and BAK.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-related ovarian killer protein
Gene namesi
Name:BOK
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Single-pass membrane protein By similarity
  • Golgi apparatus membrane By similarity; Single-pass membrane protein By similarity

  • Note: The transmembrane domain is necessary and sufficient for Golgi and ER targeting.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei190 – 21021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213Bcl-2-related ovarian killer proteinPRO_0000143089Add
BLAST

Proteomic databases

PaxDbiQ9I8I2.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000009257.

Structurei

3D structure databases

ProteinModelPortaliQ9I8I2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi32 – 4413BH4Add
BLAST
Motifi67 – 8317BH3Add
BLAST
Motifi113 – 13220BH1Add
BLAST
Motifi165 – 17915BH2Add
BLAST

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4728. Eukaryota.
ENOG41123S0. LUCA.
HOGENOMiHOG000290675.
HOVERGENiHBG050709.
InParanoidiQ9I8I2.
KOiK02561.
PhylomeDBiQ9I8I2.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR026298. Blc2_fam.
IPR026309. BOK.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF48. PTHR11256:SF48. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PRINTSiPR01862. BCL2FAMILY.
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9I8I2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVLRRSSVF AAEVMEVFDR SPTDKELVSQ AKALCRDYIN SRLIRAGVSW
60 70 80 90 100
SKPEHNTPVP GGKLAEVSAI LLRLGDELEY IRPNVYRNIA RQLNISLHSE
110 120 130 140 150
TVVTDAFLAV AAQIFTAGIT WGKVVSLYAV AAGLAVDCVR HAQPAMVHTI
160 170 180 190 200
VDCLGEFVRK TLVTWLKRRG GWADITKCVV STDPSLRSHW LVAAVCSFGH
210
FLKAIFFVLL PER
Length:213
Mass (Da):23,620
Last modified:October 1, 2000 - v1
Checksum:iB3AF7049F25442E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF275944 mRNA. Translation: AAF81282.1.
AF290888 mRNA. Translation: AAG01182.1.
RefSeqiNP_990037.1. NM_204706.1.
UniGeneiGga.3811.

Genome annotation databases

GeneIDi395445.
KEGGigga:395445.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF275944 mRNA. Translation: AAF81282.1.
AF290888 mRNA. Translation: AAG01182.1.
RefSeqiNP_990037.1. NM_204706.1.
UniGeneiGga.3811.

3D structure databases

ProteinModelPortaliQ9I8I2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000009257.

Proteomic databases

PaxDbiQ9I8I2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395445.
KEGGigga:395445.

Organism-specific databases

CTDi666.

Phylogenomic databases

eggNOGiKOG4728. Eukaryota.
ENOG41123S0. LUCA.
HOGENOMiHOG000290675.
HOVERGENiHBG050709.
InParanoidiQ9I8I2.
KOiK02561.
PhylomeDBiQ9I8I2.

Miscellaneous databases

NextBioi20815529.
PROiQ9I8I2.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR026298. Blc2_fam.
IPR026309. BOK.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF48. PTHR11256:SF48. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PRINTSiPR01862. BCL2FAMILY.
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolutionarily conserved Bok proteins in the Bcl-2 family."
    Zhang H., Holzgreve W., De Geyter C.
    FEBS Lett. 480:311-313(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterization and expression of Bok in the hen ovary."
    Mills E.M., Johnson A.L., Bridgham J.T.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiBOK_CHICK
AccessioniPrimary (citable) accession number: Q9I8I2
Secondary accession number(s): Q9DGJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 1, 2000
Last modified: February 17, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.