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Protein
Submitted name:

Prion protein

Gene

PrP

Organism
Anas platyrhynchos (Mallard) (Anas boschas)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionPrionImported
LigandCopperSAAS annotation, Metal-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Prion proteinImported
Gene namesi
Name:PrPImported
OrganismiAnas platyrhynchos (Mallard) (Anas boschas)Imported
Taxonomic identifieri8839 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeAnseriformesAnatidaeAnas

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Amyloid, Cell membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500432713825 – 272Sequence analysisAdd BLAST248

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Subunit structurei

Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization.SAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ9I8G1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini126 – 141Prion/Doppel_prot_b-ribbon_domInterPro annotationAdd BLAST16

Sequence similaritiesi

Belongs to the prion family.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

HOVERGENiHBG008260.

Family and domain databases

Gene3Di1.10.790.10. 1 hit.
InterProiView protein in InterPro
IPR000817. Prion.
IPR036924. Prion/Doppel_b-ribbon_dom_sf.
IPR022416. Prion/Doppel_prot_b-ribbon_dom.
IPR025860. Prion_N_dom.
PANTHERiPTHR10502:SF134. PTHR10502:SF134. 1 hit.
PfamiView protein in Pfam
PF00377. Prion. 1 hit.
PF11587. Prion_bPrPp. 1 hit.
SMARTiView protein in SMART
SM00157. PRP. 1 hit.
SUPFAMiSSF54098. SSF54098. 1 hit.
PROSITEiView protein in PROSITE
PS00291. PRION_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9I8G1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARLLTTCCL LALLLAACTD VALSKKGKGK PSGGGWGAGS HRQPSYPRQP
60 70 80 90 100
GYRHNPGYPH NPGYPHNPGY PHNPGYPHNP GYPQNPGYPH NPGYPGWGQG
110 120 130 140 150
YNPSSGGSYH NQKPWKPPKT NFKHVAGAAA AGAVVGGLGG YAMGRVMSGM
160 170 180 190 200
SYRFDSPDEY RWWNENSARY PNRVYYRDYS SPVSQDVFVA DCFNITVTEY
210 220 230 240 250
SIGPAAKKNT SEAVPAANQT DVETENKVVT KVIREVCVQQ YREYRLASGI
260 270
QLHPADTWLA VLLLLTTLFA MH
Length:272
Mass (Da):29,813
Last modified:October 1, 2000 - v1
Checksum:i6C7C5F0AE5FD5F13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF283319 Genomic DNA. Translation: AAF82604.1.

Similar proteinsi

Entry informationi

Entry nameiQ9I8G1_ANAPL
AccessioniPrimary (citable) accession number: Q9I8G1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: November 22, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)