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Protein

V-type proton ATPase 116 kDa subunit a isoform 1

Gene

ATP6V0A1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase 116 kDa subunit a isoform 1
Short name:
V-ATPase 116 kDa isoform a1
Alternative name(s):
Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1
Gene namesi
Name:ATP6V0A1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 388388CytoplasmicSequence analysisAdd
BLAST
Transmembranei389 – 40719HelicalSequence analysisAdd
BLAST
Topological domaini408 – 4092VacuolarSequence analysis
Transmembranei410 – 42617HelicalSequence analysisAdd
BLAST
Topological domaini427 – 44115CytoplasmicSequence analysisAdd
BLAST
Transmembranei442 – 47130HelicalSequence analysisAdd
BLAST
Topological domaini472 – 53564VacuolarSequence analysisAdd
BLAST
Transmembranei536 – 55520HelicalSequence analysisAdd
BLAST
Topological domaini556 – 57318CytoplasmicSequence analysisAdd
BLAST
Transmembranei574 – 59421HelicalSequence analysisAdd
BLAST
Topological domaini595 – 63945VacuolarSequence analysisAdd
BLAST
Transmembranei640 – 65920HelicalSequence analysisAdd
BLAST
Topological domaini660 – 72566CytoplasmicSequence analysisAdd
BLAST
Transmembranei726 – 75025HelicalSequence analysisAdd
BLAST
Topological domaini751 – 77121VacuolarSequence analysisAdd
BLAST
Transmembranei772 – 81039HelicalSequence analysisAdd
BLAST
Topological domaini811 – 83828CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2683.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 838838V-type proton ATPase 116 kDa subunit a isoform 1PRO_0000318901Add
BLAST

Proteomic databases

PaxDbiQ9I8D0.
PRIDEiQ9I8D0.

Expressioni

Tissue specificityi

Detected in brain (at protein level). Highest expression in brain, intermediate levels in kidney, and relatively low levels in bone and liver.1 Publication

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000005145.

Chemistry

BindingDBiQ9I8D0.

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase 116 kDa subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2189. Eukaryota.
COG1269. LUCA.
HOGENOMiHOG000037059.
HOVERGENiHBG014606.
InParanoidiQ9I8D0.
KOiK02154.
PhylomeDBiQ9I8D0.

Family and domain databases

InterProiIPR002490. V-ATPase_116kDa_su.
IPR026028. V-type_ATPase_116kDa_su_euka.
[Graphical view]
PANTHERiPTHR11629. PTHR11629. 1 hit.
PfamiPF01496. V_ATPase_I. 1 hit.
[Graphical view]
PIRSFiPIRSF001293. ATP6V0A1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9I8D0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGELFRSEEM TLAQLFLQSE AAYCCVSELG ELGKVQFRDL NPDVNVFQRK
60 70 80 90 100
FVNEVRRCEE MDRKLRFVEK EIKKANIPIM DTGENPEVPF PRDMIDLEAN
110 120 130 140 150
FEKIENELKE INTNQEALKR NFLELTELKF ILRKTQQFFD EMADPDLLEE
160 170 180 190 200
SSSLLEPSEM GRGAPLRLGF VAGVINRERI PTFERMLWRV CRGNVFLRQA
210 220 230 240 250
EIENPLEDPV TGDYVHKSVF IIFFQGDQLK NRVKKICEGF RASLYPCPET
260 270 280 290 300
PQERKEMASG VNTRIDDLQM VLNQTEDHRQ RVLQAAAKNI RVWFIKVRKM
310 320 330 340 350
KAIYHTLNLC NIDVTQKCLS AEVWCPVADL DSIQFALRRG TEHSGSTVPS
360 370 380 390 400
ILNRMQTNQT PPTYNKTNKF TCGFQNIVDA YGIGTYREIN PAPYTIITFP
410 420 430 440 450
FLFAVMFGDF GHGILMTLIA IWMVLRESRI LSQKSDNEMF STVFSGRYII
460 470 480 490 500
LLMGLFSTYT GLIYNDCFSK SLNMFGSSWS VRPMFSKANW SDELLKTTPL
510 520 530 540 550
LQLDPAEAGV FGGPYPFGID PIWNIANNKL AFLNSFKMKM SVILGIIHML
560 570 580 590 600
FGVMLSLLNH IYFKKPLNIY LGFIPEMIFM SSLFGYLVIL IFYKWTAYDA
610 620 630 640 650
HTSKEAPSPL IHFINMFLFS YGDTSNKMLY RGQKGIQCFL VVVALLCVPW
660 670 680 690 700
MLVAKPLVLR HQYLRRKHLG THNFGGIRVG NGPTEEDAEI IQHDQLSTHS
710 720 730 740 750
EEGEEPTEDE VFDFADTVVY QAIHTIEYCL GCISNTASYL RLWALSLAHA
760 770 780 790 800
QLSEVLWTMV IHTGLSVRSL AGGFGLVFIF AAFATLTVAI LLVMEGLSAF
810 820 830
LHALRLHWIE FQNKFYTGTG FKFLPFSFDP IREGKFDD
Length:838
Mass (Da):95,984
Last modified:October 1, 2000 - v1
Checksum:iF629DAA90759C66F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ289019 mRNA. Translation: CAB93527.1.
RefSeqiNP_990055.1. NM_204724.2.
UniGeneiGga.42835.

Genome annotation databases

GeneIDi395474.
KEGGigga:395474.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ289019 mRNA. Translation: CAB93527.1.
RefSeqiNP_990055.1. NM_204724.2.
UniGeneiGga.42835.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000005145.

Chemistry

BindingDBiQ9I8D0.
ChEMBLiCHEMBL2683.

Proteomic databases

PaxDbiQ9I8D0.
PRIDEiQ9I8D0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395474.
KEGGigga:395474.

Organism-specific databases

CTDi535.

Phylogenomic databases

eggNOGiKOG2189. Eukaryota.
COG1269. LUCA.
HOGENOMiHOG000037059.
HOVERGENiHBG014606.
InParanoidiQ9I8D0.
KOiK02154.
PhylomeDBiQ9I8D0.

Miscellaneous databases

NextBioi20815555.
PROiQ9I8D0.

Family and domain databases

InterProiIPR002490. V-ATPase_116kDa_su.
IPR026028. V-type_ATPase_116kDa_su_euka.
[Graphical view]
PANTHERiPTHR11629. PTHR11629. 1 hit.
PfamiPF01496. V_ATPase_I. 1 hit.
[Graphical view]
PIRSFiPIRSF001293. ATP6V0A1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Properties of three isoforms of the 116-kDa subunit of vacuolar H+-ATPase from a single vertebrate species. Cloning, gene expression and protein characterization of functionally distinct isoforms in Gallus gallus."
    Mattsson J.P., Li X., Peng S.-B., Nilsson F., Andersen P., Lundberg L.G., Stone D.K., Keeling D.J.
    Eur. J. Biochem. 267:4115-4126(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY, TISSUE SPECIFICITY.
    Tissue: Brain.

Entry informationi

Entry nameiVPP1_CHICK
AccessioniPrimary (citable) accession number: Q9I8D0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2000
Last modified: February 17, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.